성노현

교수

성노현 Seong, Rho Hyun

성노현
연구분야
면역학 분자생물학
1. T-cell Differentiation in the thymus
● Genetic and epigenetic control of T cell differentiation
● Control of thymocyte selection by transcription factors and chromatin remodeling complex

2. Differentiation of regulatory T-cells and Th17 cells in the periphery
● Control of regulatory T-cell development by transcription factors and chromatin remodeling complex
● Signaling factors regulating the differentiation and function of colonic Treg and Th17 cells

3. Regulation of early hematopoietic cell differentiation in the bone marrow
● Control of early B cell differentiation by chromatin remodeling complex and hematopoietic stromal cell factors
● Control of peripheral B cell differentiation by signaling factors

4. Genetic and epigenetic analysis of disease development
● Intestinal Bowel Diseases, Liver diseases using liver organoid culture
학력/경력
학력
  • - 2003.4-현재 정교수
  • - 1997.2-2003.3 부교수
  • - 1993.3-1997.2 조교수
  • - 1983.10-1990.1 박사 : 스탠포드대학교
  • - 1981.3-1983.2 석사: 서울대학교 대학원 동물학과
  • - 1977.3-1981.2 학사: 서울대학교 동물학과
경력
  • - 1994.12-1996.11 학술간사, 한국동물학회
  • - 1995.12-현재 이사, 대한면역학회
  • - 1996.12-현재 이사, 한국동물학회
  • - 1996.12-2000.11 편집간사, 한국생물과학협회지
  • - 1997.4-2003.5 위원, 서울대학교 국제백신연구소 설립추진기획단
  • - 1999.1-2003.1 장장, 서울대학교 실험동물사육장
  • - 2001.1-2002.12 편집간사, Molecules and Cells ( 한국분자세포생물학회지)
  • - 2002.5-2007.3 국제연구자문위원, 국제백신연구소
  • - 2003.3-2006.2 설립추진위원/기획운영부장, 서울대학교 생명공학공동연구원
  • - 2004.1-현재 이사/상임이사/감사, 국제백신연구소 한국후원회
  • - 2005.6-2014.2 소장, 세포기능제어연구센터(SRC)
  • - 2005.1-2005.12 총무운영위원, 한국분자세포생물학회
  • - 2007.1-2008.12 사무총장, 제9회 세계세포생물학회 조직위원회
  • - 2010.1-2010.12 학술위원장, 한국분자세포생물학회
  • - 2011.3-2012.2 회장, 교육과학기술부 지원 우수연구센터(S/ERC) 소장 협의회
  • - 2012.2-2012.7 학부장, 서울대학교 생명과학부
  • - 2012.7-2014.7 처장/산학협력단장, 서울대학교 연구처
  • - 2013-2016 국제연구자문위원, 국제백신연구소
  • - 2015.1-2017.12 편집위원장, Molecules and Cells (한국분자세포생물학회지)
  • - 2015.4-현재 소장, 서울대학교 유전공학연구소
주요논문
  1. S. Lee, J. Kim, H. Min, R.H. Seong. 2020. RORgt-driven TH17 Cell Differentiation Requires Epigenetic Control by the Swi/Snf Chromatin Remodeling Complex. iScience 23, 101106
  2. S. Hwang, C. Lee, K. Park, S. Oh, S. Jeon, B. Kang, Y. Kim, J. Oh, S.H. Jeon, Masanobu Satake, Ichiro Taniuchi, H. Lee & R.H. Seong. 2020. Twist2 promotes CD8+ T-cell differentiation by repressing ThPOK expression. Cell Death Diff https://doi.org/10.1038/s41418-020-0560-x
  3. W. Kim, E. Kim, H. Min, M.G. Kim, Verena B. Eisenbeis, Amit K. Dutta, Igor Pavlovic, Henning J. Jessen, S. Kim, and R.H. Seong. 2019. Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 25;116(26):12952-12957.
  4. Lee S, Park K, Kim J, Min H, Seong RH. 2018. Foxp3 expression in induced regulatory T cells is stabilized by C/EBP in inflammatory environments.. EMBO Rep. 19(12):e45995
  5. Kim, E., J. Beon, S. Lee, S.J. Park, H. Ahn, M.G. Kim, J.E. Park, W. Kim, J.-M. Yuk, S.-J Kang, S.-H Lee, E.-K. Jo, R.H. Seong*, S. Kim*. 2017. Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6" for publication. Science Advances. 3(4) e1602296 DOI: 10.1126/sciadv.1602296. (*co-corresponding authors).
  6. Choi, J., Y.-K. Kim, K. Park, D.-W. Kim, V.N. Kim and R.H. Seong. 2016. MicroRNA-139 controls proliferation and differentiation of myeloid progenitors and is associated with hematopoietic malignancy. Blood 128(17):2117-2129.
  7. Oh, S., J. Oh, C. Lee, S.-J. Oh, S. Jeon, S.-S. Hwang, Y. Lee, and R.H. Seong. 2016. Expression of twist2 is controlled by T-cell receptor signaling and determines the survival and death during thymocyte selection. Cell Death Diff. 23(11) 1804-1814.
  8. Jeon, S. and R.H. Seong. 2016. Anteroposterior limb skeletal patterning requires the bifurcating function of SWI/SNF chromatin remodeling complex in Hedgehog pathway. PLoS Genetics. 12(3): e1005915. doi:10.1371 /journal.pgen.1005915.
  9. Choi, J., S. Jeon, S. Choi, K. Park, and R.H. Seong. 2015. The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression. Proc. Natl. Acad. Sci. 112(7):E718-27, 112(46):E6409.