Autophagy (자가포식작용) 분자기전 규명과 질병 연구

# Introduction

Definition : Auto (Self) Phagy (Eating)
- 세포는 기아상태(starvation)가 되면 autophagy를 통하여 에너지원을 만듦으로써 세포가 생존할 수
있도록 한다.

Targets of autophagic degradation : 오래된 단백질, 단백질 집합체(Protein aggregates)
손상된 세포내 소기관, 세포 내 침투한 병원균,바이러스


Categorization of autophagy



# Macroautophagy, how it works ?




# How autophagy formed?

- 현재까지 30여 개의 autophagy-related (ATG) gene의 발견되었으며 이들은 진핵생물에서 모두 보존 되어있다.
- ATG 유전자들이 autophagosome이 만들어 지는 곳 (isolation membrane)으로 모인 후, elongation이 일어난다.
- ATG 유전자들에 의해 autophagosome이 만들어지면 LC3를 제외한 나머지 ATG 유전자들은 autophagosome에서 detech 된다. 따라서 LC3는 autophagosome의 marker로 사용된다.

- Two ubiquitin like conjugation systems


# Related Diseases

@ Cancer




@ Neurodegenerative Diseases




@ Immunology




# Publications

Guidelines for the use and interpretation of assays for monitoring autophagy. Klionsky DJ et al. Autophagy. 2012 Apr

Dimethyl sulfoxide reduces hepatomcellular lipid accumulation through autophagy induction. Song YM, Song SO, Jung YK, Kang ES, Cha BS, Lee HC, Lee BW. Autophagy. 2012 Jul

Molecules and their functions in autophagy. Pyo JO, Nah J, Jung YK. Exp Mol Med. 2012 Feb

IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of auotphagy flux Lee H, Noh JY, Oh Y, Kim Y, Chang JW, Chung CW, Lee ST, Kim M, Ryu H, Jung YK. Hum Mol Genet. 2012 Jan

Lithium rescues the impaired autophagy process in CbCln3 (Δex7/8Δex7/8) cerebellar cells and reduces neuronal vulnerability to cell death via IMPase inhibition. Chang JW, Choi H, Cotman SL, Jung YK. J Neurochem. 2011 Feb

Selective induction of catalase-mediated autophagy by dihydrocapsaicin in lung cell lines. Choi CH, Jung YK, Sh SH. Free Radic Biol Med. 2010 Jul

Autophagy induction by capsaicin in malignant human breast cells is modulated by p38 and extracellular signal-regulated mitogen-activated protein kinases and retards cell deaths by suppressing endoplasmic reticulum stress-mediated apoptosis. Choi CH, Jung YK, Sh SH. Mol Pharmacol. 2010 Jul

Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death. Pyo JO, Nah J, Kim HJ, Lee HJ, Heo J, Lee H, Jung YK. Autophagy. 2008 Apr

Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, Cho DH, Choi B, Lee H, Kim JH, Mizushima N, Oshumi Y, Jung YK. J Biol Chem. 2005 May