교수
정용근 Jung, Yong-Keun
연구분야
분자생물학
세포생물학
신경생물학
1. Isolation of apoptosis regulatory genes and mechanism study
2. Signaling pathway of oncogene and tumor suppressor in tumorigenesis
3. Functional discovery of Alzheimer's disease-associated genes
4. Autophagy and ageing regulation
5. High content screening for the discovery of genes and compounds
6. Diseases pathogenesis using transgenic and knockout mice model
7. Disease target validation and therapeutics
2. Signaling pathway of oncogene and tumor suppressor in tumorigenesis
3. Functional discovery of Alzheimer's disease-associated genes
4. Autophagy and ageing regulation
5. High content screening for the discovery of genes and compounds
6. Diseases pathogenesis using transgenic and knockout mice model
7. Disease target validation and therapeutics
학력/경력
학력
- - 1988.8 - 1993.1 박사: Albert Einstein College of Medicine
- - 1985.3 - 1987.2 석사: 서울대학교 분자생물학
- - 1978.3 - 1985.2 학사: 서울대학교 동물학
경력
- - 2016.4- Editor, Biochem Biophysical Res Communi
- - 2009.10- Director, Research and Education Center, BioMAX at SNUr
- - 2008.3- Creative Research Initiative (CRI)-Acceleration Research
- - 2007.10-2009.4 Director, Institute of Mol & Cell Biology at SNU
- - 2005. 9- Professor, Seoul National University, Life Science/Bio-Max, SNU
- - 2003.10-2005.8 Director, Department Chairman/BK21, GIST
- - 2001.6-2005.8 NRL
- - 1996.11-2005.8 Professor, GIST
- - 1993.7-1996.10 Postdoctoral fellow, Harvard Medical School
주요논문
- Kam TI, Park H, Gwon Y, Song S, Kim SH, Koon SW, Jo DG, and Jung YK. FcgRIIb-SHIP2 axis links amyloid-b to tau pathology by disrupting phosphoinositide metabolism in Alzheimer’s disease model. eLife (2016 Nov 11;5. pii: e18691. doi: 10.7554/eLife.18691) (2016)
- Kim H, Lee HJ, Oh Y, Choi SK, Hong SH, Kim HJ, Lee SY, Choi JW, Hwang DS, Kim KS, Kim HJ, Zhang J, Youn HJ, Noh DY, and Jung YK. The DUSP26 Phosphatase Activator Adenylate Kinase 2 Regulates FADD Phosphorylation for Cell Growth. Nat Commun. 2014;5: 3351.
- Kanga W, Hong SH, Lee HM, Kim NY, Lim YC, Le LT, Kim HC, Kim TY, Ashida H, Yokota A, Hah SS, Chun KH, Jung YK*, Yang JK*, Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme. Proc. Natl Acad. Sci USA 2014 Jan 7;111(1) *Co-corresponding author.
- Pyo JO, Yoo SM, Ahn HH, Nah JH, Hong SH, Kam TI, Jung S and Jung YK. Overexpression of Atg5 in mice activates autophagy and extends lifespan. Nat Commun. 2013 Aug 13;4:2300.
- Kam TI, Song S, Gwon Y, Park H, Yan JJ, Im I, Choi JW, Choi TY, Kim J, Song DG, Takai T, Kim YC, Kim KS, Choi SY, Choi S, Klein WL, and Jung YK. FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer’s disease J. Clin. Invest. 2013 Jul 1;123(7): 2791-802.