심지원

심지원

교수
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심지원

교수

심지원 Shim, Jiwon

심지원
연구분야
면역학 발달 및 발생생물학 유전학

Our research interests focus on exploring the long-range regulation of hematopoiesis via sensory perception and unexpected immune cell functions beyond their typical roles in innate immunity. Through our study, We aim to address the following fundamental questions in biology:
  1) How do multiple organs interact together to maintain homeostatic balance in animals?
  2) How do stem/progenitor cells coordinate their development in response to environmental changes?
  3) Do immune cells function in the non-immunological context?
  4) How can primitive immune cells of myeloid lineage evolve into colossally diverse vertebrate immune cells?

학력/경력
학력
  • - 2008 서울대학교 생명과학부 박사
  • - 2004 연세대학교 생물학과 석사
  • - 2002 연세대학교 생화학과 학사
경력
  • - 2025-현재 교수, 서울대학교 생명과학부
  • - 2014-2025 조교수, 부교수, 교수, 한양대학교 생명과학과
  • - 2009-2014 Postdoctoral Fellow, UCLA, MCDB
  • - 2008 박사후연구원, 서울대학교 유전공학연구소
주요논문
  1. M Shin*, E Chang*, D Lee*, N Kim, B Cho, N Cha, F Koranteng, JJ Song, and J Shim (2024) Drosophila immune cells transport oxygen through PPO2 protein phase transition, Nature, 631, 350-359
  2. B Cho, M Shin, E Chang, S Son, I Shin, and J Shim (2024) S-nitrosylation-triggered unfolded protein response maintains hematopoietic progenitors in Drosophila, Developmental Cell, 59(8), 1075-1090
  3. SH Yoon, B Cho, D Lee, H Kim, J Shim* and JW Nam* (2023) Molecular traces of Drosophila hemocytes reveal transcriptomic conservation with vertebrate myeloid cells, PLOS Genetics, 19(12), e1011077 (*Co-corresponding authors)
  4. H Li#, J Janssens#, M De Waegeneer, SS Kolluru, K Davie, V Gardeux, W Sealens, F David, M Brbic, J Leskovec, C McLaguphlin, Q Xie, R Jones, K Brueckner, J Shim, SG Tattikota, F Schnorrer, K Rust, T Nystul, Z Carvalho-Santos, C Ribeiro, S Pal, TM Przytycka, A Allen, S Goodwin, CW Berry, MT Fuller, H White-Cooper, E Matunis, S DiNardo, A Galenza, LE O’Brien, JAT Dow, H Jasper, B Oliver, N Perrimon*, B Deplancke*, S Quake*, L Luo*, and S Aerts*, FCA Consortium (2022) Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly, Science, 375 (6584): eabk2432
  5. S Madhwal, M Shin, M Joshi, A Kapoor, P MR R ehman, K Gor, J Shim* and T Mukherjee* (2020) Metabolic control of immune-competency by odors in Drosophila, eLife, 10, e60376 (*Co-corresponding authors)
  6. B Cho*, SH Yoon*, D Lee, F Koranteng, SG Tattikota, N Cha, M Shin, H Do, Y Hu, SY Oh, SJ Moon, N Perrimon, JW Nam*, and J Shim* (2020) Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila, Nature Communications, 11(1), 4483 (*Co-corresponding authors)
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