김현아

부교수

김현아 Joy Kim

김현아
연구분야
분자생물학 생화학 세포생물학
Our research goals are to elucidate the molecular mechanisms of membrane protein biogenesis, folding and assembly in eukaryotic cells. Some of the fundamental questions that we attempt to answer are:
1. How does the translocation machinery recognize and sort transmembrane segments into the membrane?
2. Which part(s)/subunit(s) of the translocation machinery mediates recognition and insertion of transmembrane segments?
3. How similar or different the molecular mechanism of membrane protein insertion is in different subcellular organelles?
We use Saccharomyces cerevisiae as a model organism, and yeast genetics, molecular and cell biology techniques.
학력/경력
학력
  • - 1996~2001 박사: Physiology and Biophysics SUNY Stony Brook, USA
  • - 1991~1995 학사: Biochemistry UC Davis, USA
경력
  • - 2015.03.~ 부교수, 서울대학교 생명과학부
  • - 2009.03.~2015.02. 조교수, 서울대학교 생명과학부
  • - 2006.01.~2009.02. Group leader, Center for Biomembrane Research
  • - 2001.12.~2005.12. Postdoctoral fellow, Stockholm University, Sweden
주요논문
  1. Yim C, Chung Y, Kim J, Nilsson I, Kim JS, Kim H. Spc1 regulates the signal peptidase-mediated processing of membrane proteins. J Cell Sci. 2021 Jul 1;134(13):jcs258936. doi: 10.1242/jcs.258936. Epub 2021 Jul 9. PMID: 34125229; PMCID: PMC8277137.
  2. Jung SJ, Kim JEH, Junne T, Spiess M, Kim H. Cotranslational Targeting and Posttranslational Translocation can Cooperate in Spc3 Topogenesis. J Mol Biol. 2021 Sep 3;433(18):167109. doi: 10.1016/j.jmb.2021.167109. Epub 2021 Jun 18. PMID: 34153287.
  3. Lee S, Lee H, Yoo S, Ieva R, van der Laan M, von Heijne G, Kim H. The Mgr2 subunit of the TIM23 complex regulates membrane insertion of marginal stop-transfer signals in the mitochondrial inner membrane. FEBS Lett. 2020 Mar;594(6):1081-1087. doi: 10.1002/1873-3468.13692. Epub 2019 Dec 8. PMID: 31764998.
  4. Jung SJ, Jung Y, Kim H. Proper insertion and topogenesis of membrane proteins in the ER depend on Sec63. Biochim Biophys Acta Gen Subj. 2019 Sep;1863(9):1371-1380. doi: 10.1016/j.bbagen.2019.06.005. Epub 2019 Jun 10. PMID: 31195072.
  5. Yim C, Jung SJ, Kim JEH, Jung Y, Jeong SD, Kim H. Profiling of signal sequence characteristics and requirement of different translocation components. Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt A):1640-1648. doi: 10.1016/j.bbamcr.2018.08.018. Epub 2018 Aug 29. PMID: 30327205.