Seoul National University Biological Sciences Website

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Laboratory of Biochemistry and Cell Biology

Biochem Biophys Res Commun.

SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking CHFR mediated ubiquitination and degradation of its major components.. Jung I, Sohn DH, Choi J, Kim JM, Jeon S, Seol JH, Seong RH. (2012). Biochem Biophys Res Commun., 418(3), 512.

Biochemical and Biophysical Research Communications

CHFR is negatively regulated by SUMOylation-mediated ubiquitylation. Bae SJ, Kwon YE, Kim M*, Seol JH* (2013). Biochemical and Biophysical Research Communications, 433(2), 194.

SUMOylation negatively regulates the stability of CHFR tumor suppressor. Kwon YE, Bae SJ, Kim M*, Seol JH* (2013). Biochemical and Biophysical Research Communications, 430(1), 213.

CHFR functions as a ubiquitin ligase for HLTF to regulate its stability and functions. Kim, J. M., Cho, E. N., Kwon, Y. E., Bae, S. J., Kim, M.*, Seol, J. H.* (2010). Biochemical and Biophysical Research Communications, 395(4), 515-520.

Interaction of SOCS3 with NonO attenuates IL-1beta-dependent MUC8 gene expression.. Song, K. S., Kim, K., Chung, K. C., Seol, J. H., Yoon, J. H. (2008). Biochemical and Biophysical Research Communications, 377(3), 946-951.

Deubiquitination of Chfr, a checkpoint protein, by USP7/HAUSP regulates its stability and activity. Oh, Y. M., Yoo, S. J., Seol, J. H. (2007). Biochemical and Biophysical Research Communications, 357(3), 615-619.

The conserved WRPW motif of Hes6 mediates proteasomal degradation. Kang, S. A., Seol, J. H., Kim, J. (2005). Biochemical and Biophysical Research Communications, 332(1), 33-36.

LonR9 carrying a single Glu614 to Lys mutation inhibits the ATP-dependent protease La (Lon) by forming mixed oligomeric complexe. Oh, J. Y., Eun, Y. M., Yoo, S. J., Seol, J. H., Seong, I. S., Lee, C. S., and Chung, C. H. (1998). Biochemical and Biophysical Research Communications, 250(1), 32-35.

Characterization of energy-dependent proteases in bacteria. Chung, C. H., Yoo, S. J., and Seol, J. H. (1997). Biochemical and Biophysical Research Communications, 241(4), 613-616.

ATP binding, but not its hydrolysis, is required for assembly and proteolytic activity of the HslVU protease in Escherichia coli. Yoo, S. J. Seol, J. H., Seong, I. S., Kang, M. S., and Chung, C. H. (1997). Biochemical and Biophysical Research Communications, 238(2), 581-585.

Poly-L-lysine activates both peptide and ATP hydrolysis by the ATP-dependent HslVU protease in Escherichia coli. Yoo, S. J., Seol, J. H., Kang, M. S., and Chung, C. H. (1996). Biochemical and Biophysical Research Communications, 229(2), 531-535.

Requirement of ATP-hydrolysis for ClpA/ClpP complex, the ATP-dependent protease Ti in Escherichia coli. Seol, J. H., Woo, K. M., Kang, M. S., Ha, D. B., and Chung, C. H. (1995). Biochemical and Biophysical Research Communications, 217(1), 41-51.

clpX encoding an alternative ATP-binding subunit of protease Ti (Clp) can be expressed independently from clpP in Escherichia coli. Yoo, S. J., Seol, J. H., Kang, M. S., Ha, D. B., and Chung, C. H. (1994). Biochemical and Biophysical Research Communications, 203(2), 798-804.

Protease Do is essential for survival of Escherichia coli at high temperatures: its identity with the htrA gene product. Seol, J. H., Woo, S. K., Jung, E. M., Yoo, S. J., Lee, C. S., Kim, K., Tanaka, K., Ichihara, A., Ha, D. B., and Chung, C. H. (1991). Biochemical and Biophysical Research Communications, 176(2), 730-736.

Biological Chemistry

Site-directed mutagenesis of the Cys residues in ClpA, the ATPase component of protease Ti (ClpAP) in Escherichia coli. Seol, J. H., Kwon, J. A., Kang, M. S., and Chung, C. H. (1997). Biological Chemistry, 378(10), 1205-1209.

Protease Ti (Clp), a multi-component ATP-dependent protease in Escherichia coli.. Chung, C. H., Seol, J. H., and Kang, M. S. (1996). Biological Chemistry, 377(9), 549-554.

Cancer Research

NADPH oxidase 1 activity and ROS generation are regulated by Grb2/Cbl-mediated proteasomal degradation of NoxO1 in colon cancer cells.. Joo JH, Oh H, Kim M, An EJ, Kim RK, Lee SY, Kang DH, Kang SW, Park CK, Kim H, Lee SJ, Lee D*, Seol JH*, Bae YS*. (2016). Cancer Research, (), .

Cell

Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Shou, W., Seol, J. H., Shevchenko, A., Baskerville, C., Moazed, D., Chen, Z. W., Jang, J., Shevchenko, A., Charbonneau, H., and Deshaies, R. J. (1999). Cell, 97(2), 233-244.

Cell Death Differ.

Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme.. Oh KH, Yang SW, Park JM, Seol JH, Iemura S, Natsume T, Murata S, Tanaka K, Jeon YJ, Chung CH. (2011). Cell Death Differ., 18(8), 1326-36.

Cell host and microbe

Inflammation-Modulated Metabolic Reprogramming Is Required for DUOX-Dependent Gut Immunity in Drosophila. Lee K, Cho KC, Kim BR, Jang IH, Nam KB, Kwon YE, Kim M, Hyeon DY, Hwang DH, Seol JH, Lee WJ (2018). Cell host and microbe, 23(3), 338-352.

Diabetes

SUMO-specific protease 2 (SENP2) is an important regulator of fatty acid metabolism in skeletal muscle.. Koo YD, Choi JW, Kim M, Chae S, Ahn BY, Kim M, Oh BC, Hwang D, Seol JH, Kim YB, Park YJ, Chung SS, Park KS. (2015). Diabetes, 64(7), 2420.

European Journal of Biochemistry

The heat-shock protein HslVU from Escherichia coli is a protein-activated ATPase as well as an ATP-dependent proteinase. Seol, J. H., Yoo, S. J., Shin, D. H., Shim, Y. K., Kang, M. S., Goldberg, A. L., and Chung, C. H. (1997). European Journal of Biochemistry, 247(3), 1143-1150.

FEBS Letters

ATP-dependent degradation of SulA, a cell division inhibitor, by the HslVU protease in Escherichia coli.. Seong, I. S., Oh, J. Y., Yoo, S. J., Seol, J. H., and Chung, C. H. (1999). FEBS Letters, 456(1), 211-214.

Mutagenesis of two N-terminal Thr and five Ser residues in HslV, the proteolytic component of the ATP-dependent HslVU protease. Yoo, S. J., Shim, Y. K., Seong, I. S., Seol, J. H., Kang, M. S., and Chung, C. H. (1997). FEBS Letters, 412(1), 57-60.

Mutational analysis of the ATP-binding site in HslU, the ATPase component of HslVU protease in Escherichia coli. Shin, D. H., Yoo, S. J., Shim, Y. K., Seol, J. H., Kang, M. S., and Chung, C. H. (1996). FEBS Letters, 398(2-3), 151-154.

Hydrolysis of IciA protein, an inhibitor of DNA replication initiation, by protease Do in Escherichia coli. Yoo, S. J., Seol, J. H., Woo, S. K., Suh, S. W., Hwang, D. S., Ha, D. B., and Chung, C. H. (1993). FEBS Letters, 327(1), 17-20.

Molecular cloning of the Ecotin gene in Escherichia coli. Lee, H. R., Seol, J. H., Kim, O. M., Lee, C. S., Suh, S. W., Hong, Y. M., Tanaka, K., Ichihara, A., Ha, D. B., and Chung, C. H. (1991). FEBS Letters, 287(1-2), 53-56.

Na+, K+-specific inhibition of protein and peptide hydrolyses by proteasome from human hepatoma tissues. Seol, J. H., Park, S. C., Ha, D. B., Tanaka, K., Ichihara, A., and Chung, C. H. (1989). FEBS Letters, 247(2), 197-200.

Genes & Development

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34. Seol, J. H., Feldman, R. M. R., Zachariae, W., Shevchenko, A., Correll, C. C., Lyapina, S., Chi, Y., Galova, M., Claypool, J., Sandmeyer, S., Nasmyth, K., Shevchenko, A., and Deshaies, R. J. (1999). Genes & Development, 13(12), 1614-1626.

J Clin Invest.

Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15.. Jeon YJ, Jo MG, Yoo HM, Hong SH, Park JM, Ka SH, Oh KH, Seol JH, Jung YK, Chung CH. (2012). J Clin Invest., 122(7), 2622-36.

J Mol Biol. 2013

Structural Alteration in the Pore Motif of the Bacterial 20S Proteasome Homolog HslV Leads to Uncontrolled Protein Degradation.. Park E, Lee JW, Yoo HM, Ha BH, An JY, Jeon YJ, Seol JH, Eom SH, Chung CH. (2013). J Mol Biol. 2013, (), .

Mol Cell.

Modification of PCNA by ISG15 Plays a Crucial Role in Termination of Error-Prone Translesion DNA Synthesis.. Park JM, Yang SW, Yu KR, Ka SH, Lee SW, Seol JH, Jeon YJ, Chung CH. (2014). Mol Cell., 54(4), 626-638.

Mol Cells

SUMO modification of NZFP mediates transcriptional repression through TBP binding.. Kim M, Chen Z, Shim MS, Lee MS, Kim JE, Kwon YE, Yoo TJ, Kim JY, Bang JY, Carlson BA, Seol JH, Hatfield DL, Lee BJ. (2013). Mol Cells, 35(1), 70-8.

Molecular & Cellular Proteomics

Applicability of tandem affinity purification MudPIT to pathway proteimics in yeast. Graumann, J., Dunipace, L. A., Seol, J.H., McDonald, H. W., Yates, J. R., Wold, B. J., and Deshaies, R. J. (2004). Molecular & Cellular Proteomics, 3(3), 226-237.

Charting the protein complexome in yeast by mass spectrometry. Deshaies, R. J., Seol, J. H., McDonald, H. W., Cope, G., Lyapina, S., Shevchenko, A., Shevchenko, A., Verma, R., and Yates, J. (2002). Molecular & Cellular Proteomics, 1(1), 3-10.

Molecular and Cellular Biology

Skp1p and the F-box protein Rcy1p form a non-SCF complex involved in recycling of the SNARE Snc1p in yeast. Galan, J-M., Wiederkehr, A., Seol, J. H., Deshaies, R. J., Riezman, H., and Peter, M. (2001). Molecular and Cellular Biology, 21(9), 3105-3117.

Molecular Biology of the Cell

Filamin B serves as a molecular scaffold for type I interferon-induced c-Jun NH2-terminal kinase signaling pathway. Jeon, Y. J., Choi, J. S., Lee, J. Y., Yu, K. R., Ka, S. H., Cho, Y., Choi, E. J., Baek, S. H., Seol, J. H., Park, D., Bang, O. S., Chung, C. H. (2008). Molecular Biology of the Cell, 19(12), 5116-5130.

Molecules and Cells

Nuclear localization of Chfr is crucial for its checkpoint function. Kwon, Y. E., Kim, Y. S., Oh, Y. M., Seol, J. H. (2009). Molecules and Cells, 27(3), 359-363.

Nucleotide triphosphates inhibit the degradation of unfolded proteins by HslV peptidase. Lee, J. W., Park, E., Bang, O., Eom, S. H., Cheong, G. W., Chung, C. H., Seol, J. H. (2007). Molecules and Cells, 23(2), 252-257.

Nat Commun

TUSC3 regulates ERMA-mediated Mg2+ uptake for synaptic function and neurodevelopment. Park GR, Kim NH, Kim SY, Lee HJ, Li CM, Seol JH, Choi SY, Jung YK (2025). Nat Commun, 16(1), 9752.

Nat Commun.

Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification.. Park JH, Yang SW, Park JM, Ka SH, Kim JH, Kong YY, Jeon YJ, Seol JH*, Chung CH*. (2016). Nat Commun., 7(), 12513.

Nature

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., Guo, M. (2006). Nature, 441(7097), 1162-1166.

Nature Cell Biology

Chfr is linked to tumour metastasis through the downregulation of HDAC1. Oh, Y. M., Kwon, Y. E., Kim, J. M., Bae, S. J., Lee, B. K., Yoo, S. J., Chung, C. H., Deshaies, R. J., Seol, J. H. (2009). Nature Cell Biology, 11(3), 295-302.

SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination. Lee, M. H., Lee, S. W., Lee, E. J., Choi, S. J., Chung, S. S., Lee, J. I., Cho, J. M., Seol, J. H., Baek, S. H., Kim, K. I., Chiba, T., Tanaka, K., Bang, O. S., Chung, C. H. (2006). Nature Cell Biology, 8(12), 1424-1431.

Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly. Seol, J. H., Shevchenko, A., Shevchenko, A., and Deshaies, R. J. (2001). Nature Cell Biology, 3(4), 384-391.

NATURE COMMUNICATIONS

NEDD4 controls intestinal stem cell homeostasis by regulating the Hippo signalling pathway. Bae SJ^, Kim M^, Kim SH, Kwon YE, Lee JH, Kim J, Chung CH, Lee WJ*, Seol JH*. (2015). NATURE COMMUNICATIONS, 6(), 6314.

Neoplasia

Deleterious c-Cbl Exon Skipping Contributes to Human Glioma. Seong MW, Ka SH, Park JH, Park JH, Yoo HM, Yang SW, Park JM, Park D, Lee ST, Seol JH*, Chung CH* (2015). Neoplasia, 17(6), 518-524.

PLoS ONE

Repression of FLOWERING LOCUS T chromatin by functionally redundant histone H3 lysine 4 demethylases in Arabidopsis. Jeong, J. H., Song, H. R., Ko, J. H., Jeong, Y. M., Kwon, Y. E., Seol, J. H., Amasino, R. M., Noh, B., Noh, Y. S. (2009). PLoS ONE, 4(11), e8033.

Proceedings of the National Academy of Sciences

HslV-HslU: a novel ATP-dependent protease complex in Escherichia coli related to the eukaryotic proteasome. Rohrwild, M., Coux, O., Huang, H. C., Moerschell, R. P., Yoo, S. J., Seol, J. H., Chung, C. H., and Goldberg, A. L. (1996). Proceedings of the National Academy of Sciences, 93(12), 5808-5813.

Rapid Commun Mass Spectrom.

Analysis of the biochemical role of Lys-11 in polyubiquitin chain formation using quantitative mass spectrometry.. Jung JW, Bae SJ, Kang GY, Kim KH, Yeo WS, Park SH, Seol JH, Yi EC, Kim KP. (2013). Rapid Commun Mass Spectrom., 27(2), 339-46.

Scientific Reports

CHFR negatively regulates SIRT1 activity upon oxidative stress.. Kim M, Kwon YE, Song JO, Bae SJ, Seol JH (2016). Scientific Reports, 6(), 37578.

The EMBO Journal

An essential complementary role of NF-kappaB pathway to microbicidal oxidants in Drosophila gut immunity. Ryu, J. H., Ha, E. M., Oh, C. T., Seol, J. H., Brey, P. T., Jin, I., Lee, D. G., Kim, J., Lee, D., Lee, W. J. (2006). The EMBO Journal, 25(15), 3693-3701.

The ATP-dependent CodWX (HslVU) protease in Bacillus subtilis is an N-terminal serine protease. Kang, M. S., Lim, B. K., Seong, I. S., Seol, J. H., Tanahashi, N., Tanaka, K., and Chung, C. H. (2001). The EMBO Journal, 20(4), 734-742.

The Journal of Biological Chemistry

HslVU ATP-dependent protease utilizes maximally six among twelve threonine active sites during proteolysis. Lee, J. W., Park, E., Jeong, M. S., Jeon, Y. J., Eom, S. H., Seol, J. H., Chung, C. H. (2009). The Journal of Biological Chemistry, 284(48), 33475-33484.

Binding of MG132 or deletion of the Thr active sites in HslV subunits increases the affinity of HslV protease for HslU ATPase and makes this interaction nucleotide-independent. Park, E., Lee, J. W., Eom, S. H., Seol, J. H., Chung, C. H. (2008). The Journal of Biological Chemistry, 283(48), 33258-33266.

Two novel ubiquitin-fold modifier 1 (Ufm1)-specific Proteases, UfSP1 and UfSP2. Kang, S. H., Kim, G. R., Seong, M., Baek, S. H., Seol, J. H., Bang, O. S., Ovaa, H. , Tatsumi, K. , Komatsu, M., Tanaka, K., Chung, C. H. (2007). The Journal of Biological Chemistry, 282(8), 5256-5262.

The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis induce. Huh, J. R., Foe, I., Muro, I., Chen, C. H., Seol, J. H., Yoo, S. J., Guo, M., Park, J. M., Hay, B. A. (2007). The Journal of Biological Chemistry, 282(3), 2056-2068.

Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1. Choi, S. J., Chung, S. S., Rho, E. J., Lee, H. W., Lee, M. H., Choi, H. S., Seol, J. H., Baek, S. H., Bang, O. S., Chung, C. H. (2006). The Journal of Biological Chemistry, 281(41), 30669-30677.

BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of DAXX for ubiquitination by Cul3-based ubiquitin ligase.. Kwon, J. E., La, M., Oh, K. H., Oh, Y. M., Kim, G. R., Seol, J. H., Baek, S. H., Chiba, T., Tanaka, K., Bang, O. S., Joe, C. O., Chung, C. H. (2006). The Journal of Biological Chemistry, 281(18), 12664-12672.

Role of the GYVG pore motif of HslU ATPase in protein unfolding and translocation for degradation by HslV peptidase.. Park, E., Rho, Y. M., Koh, O. J., Ahn, S. W., Seong, I. S., Song, J. J., Bang, O., Seol, J. H., Wang, J., Eom, S. H., Chung, C. H. (2005). The Journal of Biological Chemistry, 280(24), 22892-22898.

Effects of the Cys Mutations on Structure and Function of the ATP-dependent HslVU Protease in Escherichia coli. Yoo, S. J., Kim, H. H., Shin, D. H., Lee, C. S., Seong, I. S., Seol, J. H., Shimbara, N., Tanaka, K., and Chung, C. H. (1998). The Journal of Biological Chemistry, 273(36), 22929-22935.

Purification and characterization of the heat shock proteins HslV and HslU that form a new ATP-dependent protease in Escherichia coli. Yoo, S. J., Seol, J. H., Shin, D. H., Rohrwild, M., Kang, M. S., Tanaka, K., Goldberg, A. L., and Chung, C. H. (1996). The Journal of Biological Chemistry, 271(24), 14035–14040.

Distinctive roles of the two ATP-binding sites in ClpA, the ATPase component of protease Ti in Escherichia coli. Seol, J. H., Baek, S. H., Kang, M. S., Ha, D. B., and Chung, C. H. (1995). The Journal of Biological Chemistry, 270(14), 8087-8092.

The P1 reactive site methionine residue of Ecotin is not crucial for its specificity on target proteases. Seong, I. S., Lee, H. R., Seol, J. H., Park, S. K., Lee, C. S., Suh, S. W., Hong, Y. M., Kang, M. S., Ha, D. B., and Chung, C. H. (1994). The Journal of Biological Chemistry, 269(34), 21915-21918.

The 65-kDa protein derived from the internal translational initiation site of the clpA gene inhibits the ATP-dependent protease Ti in Escherichia coli. Seol, J. H., Yoo, S. J., Kim, K. I., Kang, M. S., Ha, D. B., and Chung, C. H. (1994). The Journal of Biological Chemistry, 269(47), 29468-29473.

Site-directed mutagenesis of the dual translational initiation site of the clpB gene in Escherichia coli and characterization of its gene products. Park, S. K., Kim, K. I., Woo, K. M., Seol, J. H., Tanaka, K., Ichihara, A., Ha, D. B., and Chung, C. H. (1993). The Journal of Biological Chemistry, 268(27), 20170-20174.