황대희

Professor

Hwang, Daehee

  • Major : Systems Biology
  • Lab. : Lab of Systems biology and medicine (SBM)
  • Office : 504-320
  • Office Tel. : +82-2-880-7522
  • Lab Tel. : +82-2-880-7526
  • Email : daehee@snu.ac.kr

황대희
Research
Bioinformatics
Our lab aims to develop systems biology approaches to prioritize key relevant information for diagnosis and therapy of refractory diseases (cancer, cardiovascular disease, diabetes, auto-immune disease, neurodegenerative disease, etc.) from global omics (genomics, proteomics, metabolomics, etc.) data. Such key relevant information includes diagnostic/therapeutic molecular targets for refractory diseases or signaling/transcriptional/epigenetic regulators or pathways underlying molecular mechanisms for biological phenomena. Recently, we are developing a big omics data-based network model that can be used for precision medicine. Specifically, we have been mapping gene/transcript/protein information from all genomic and proteomic data generated from 14 major cancers with good quality into a multi-layered network model. This network model represents associations among molecules across multiple information domains (mutation, epigenetic modification, mRNA/protein abundance, protein modification, etc.). By analyzing this multi-layered network model, we can identify cellular pathways (called network modules) that can govern operation of the network model in association with prognosis and survival of patients. Genomic and proteomic information from individual patients are be then spanned by the key network modules in the network model. For a patient for whom a doctor cannot determine an optimal therapeutic option, we can search for a set of patients with similar clinical symptoms to those of the patient, and these patients can be prioritized based on activities of these key network modules. The patient can be then treated with the therapeutic option used for the top patients identified through the prioritization. The multi-layered network model can thus serve as a useful tool to facilitate the success of precision medicine.
Education/Career
Education
  • - 1990-1996 학사: POSTECH, Department of Chemical Eng.
  • - 1999-2003 박사: MIT, Department of Chemical Eng.
Career
  • - 2006-2013 Assistance/Associate Professor, School of Interdisciplinary Bioscience and Biotechnology/Department of Chemical Eng., POSTECH
  • - 2013-2019 Professor, Department of New Biology, DGIST
  • - 2019-present Professor, School of Biological Sciences, Seoul National University
Publications
  1. D. Mun*, J. Bhin*, S. Kim*, H. Kim*, J.H. Jung*, Y. Jung, Y.E. Jang, J.M. Park, H. Kim, Y. Jung, H. Lee, J. Bae, S. Back, S. Kim, J. Kim, H. Park, H. Li, K. Hwang, Y.S. Park, J.H. Yook, B.S. Kim, S.Y. Kwon, S.W. Ryu, D.Y. Park, T.Y. Jeon, D.H. Kim, J. Lee, S. Han, K.S. Song, D. Park, J.W. Park, H. Rodriguez, J. Kim, H. Lee, K.P. Kim, E.G. Yang#, H.K. Kim#, E. Paek#, S. Lee#, S. Lee#, and D. Hwang#. Proteogenomic characterization of human early onset gastric cancer. Cancer Cell, 6, 6810 (2019).
  2. M.J. Kwon*, M.H. Han*, J.A. Bagley, D.Y. Hyeon, B.S. Ko, Y.M. Lee, I.J. Cha, S.Y. Kim, D.Y. Kim, H.M. Kim, D. Hwang#, S.B. Lee#, and Y.N. Jan#. Coiled coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects. PNAS, 115, E10748-E10757 (2018).
  3. Y. Kim, J. Jang, S. Choi* and D. Hwang*. TEMPI: Probabilistic modeling Time-Evolving differential PPI net-works with MultiPle Information. Bioinformatics, ECCB spatial edition 30, 17, i453-i460 (2014).
  4. S. Lee*, J. Lee*, S. Chae*, Y. Moon*, H. Lee, B. Park, E.G. Yang, D. Hwang#, and H. Park#. Multi-dimensional histone methylations for coordinated regulation of gene expression under hypoxia. Nucleic Acids Research, 45,20, 11643-11657(2017)
  5. K. Boo, J. Bhin, Y. Jeon, J. Kim, H.R. Shin, J. Park, K. Kim, C.Rok. Kim, H. Jang, I. Kim, V.N. Kim, D. Hwang*, H. Lee*, and S.H. Baek*. Pontin functions as an essential coactivator for Oct4-dependent lincRNA expression in mouse embryonic stem cells. Nature Communications, 6, 6810, doi: 10.1038/ncomms7810 (2015).