A unifying theme of our lab’s research is to understand how animals and cells respond to various stresses and maintain homeostasis. In particular, we are pursuing our interests by studying autophagy and cellular senescence, two general stress responses that are closely involved in many age-associated diseases including aging itself and cancer. Our lab is employing genetics, molecular biology, biochemistry, genomics, and cell biology to elucidate 1) the selective autophagy network and 2) the senescence regulatory network in detail. We believe that our research will eventually pave the way to treat devastating human diseases and enhance human health. Our current topics are as follows.
1. Elucidation of the molecular mechanisms by which selective autophagy regulates the GATA4-Senescence-Associated Secretory Phenotype (SASP) pathway.
2. Identification of potential downstream targets of GATA4 that regulate senescence phenotypes.
3. Determination of potential in vivo roles of the GATA4-SASP pathway during tumorigenesis and aging.4. Examination of the stress-specific regulation of selective autophagy, senescence, and the SASP.
- Kim J, Lee Y, Jeon T, Kim MS, and Kang C# (2021) A cells are created equal in the sight of autophagy: selective autophagy maintains homeostasis in senescent cells. Autophagy in press
- Lee Y*, Kim J*, Kim MS*, Kwon Y, Shin S, Yi H, Kim H, Chang MJ, Chang CB, Kang SB, Kim VN, Kim JH, Kim JS, Elledge SJ, and Kang C# (2021) Coordinate Regulation of the Senescent State by Selective Autophagy. Dev Cell 56(10), 1512-1525
- Kim J*, Lee Y*, Roh K, Kim MS, and Kang C# (2021) Targeting the stress support network regulated by autophagy and senescence for cancer treatment. Adv Cancer Res 150, 75-112
- Kang C# (2019) Senolytics and Senostatics: A Two-Pronged Approach to Target Cellular Senescence for Delaying Aging and Age-Related Diseases. Mol Cells 42(12), 821-827
- Kwon Y, Kim JW, Jeoung JA, Kim MS, and Kang C# (2017) Autophagy is pro-senescence when seen in close-up, but anti-senescence in long-shot. Mol Cells 40(9), 607-612
- Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, and Elledge SJ (2015) The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science 349, aaa5612.