Laboratory of Stress Response and Aging

Laboratory of Stress Response and Aging

Seoul National University
Laboratory of Stress Response and Aging

Laboratory of Stress Response and Aging

Seoul National University
Laboratory of Stress Response and Aging

Laboratory of Stress Response and Aging

Seoul National University

Publications+ more

(2017) Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program, Genes Dev
(2017) Autophagy Is Pro-Senescence When Seen in Close-Up, but Anti-Senescence in Long-Shot, Mol Cells
(2016) How autophagy both activates and inhibits cellular senescence, Autophagy
(2016) A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM–p53 signaling, Genes Dev
(2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), Autophagy

Welcome to the
"Laboratory of Stress Response and Aging"

Coping with stress is essential for all organisms, and several stress responses have been evolved to maintain homeostasis. Autophagy and cellular senescence are critical as 1) they respond to many different types of stress and 2) they are closely involved in many human diseases including age-associated diseases, aging itself, and cancer. Our goal is to better understand autophagy and cellular senescence that may provide avenues of therapeutic intervention for the treatment of such devastating human diseases and have important implications for human health. Cellular senescence is a terminal program of growth arrest triggered by many stresses, and similar to apoptosis, it acts intrinsically as a tumor suppressive mechanism by limiting further proliferation of damaged cells. Furthermore, in contrast to apoptosis that mainlyacts cell-autonomously, cellular senescence can also function cell-nonautonomously to coordinate homeostasis responses;