성노현

Professor

Seong, Rho Hyun

성노현
Research
Immunology Molecular Biology
1. T-cell Differentiation in thymus
● Control of cell differentiation and proliferation of thymocytes by pre-TCR and TCR signaling
● Control of positive and negative selection by chromatin remodeling complex
2. Biogenesis of regulatory T-cells
● Control of regulatory T-cell development by chromatin remodeling complex
3. Role of transcription factor,Twist2 in T cell development
● Control of Positive and negative selection in thymus
● Control of CD4 T cell differentiation via regulation of ThPok, Gata-3 and Runx-3
4. Neural development and early progenitor cells differentiation
● Role of chromatin remodeling complex for hippocampus development and Hematopoiesis
Education/Career
Education
  • - 2003.4-Present Professor
  • - 1997.2-2003.3 Associate Professor
  • - 1993.3-1997.2 Assistant Professor
  • - 1983.10-1990.1 Ph.D. : Stanford University, U.S.A.
  • - 1981.3-1983.2 Master
  • - 1977.3-1981.2 Bachelor
Career
  • - 2007.1-Present Secretary General, The World Society of Cell Biology Organizing Committee
  • - 2005.1-2005.12 General Affairs Operator, Korean Society for Molecular and Cellular Biology
  • - 2005-Present RCFC Director, Research Center of Cell Function Control appointed by Ministry of Science and Technology / Science Foundation
  • - 2004.1-Present Director, Korea Aid Association of National Vaccine Research Center
  • - 2003.3-2005.12 Bio-MAX Institute Project Operation Department Head, Seoul National University Bio-MAX Institute
  • - 2003. 4 - Present Professor, School of Biological Sciences, Seoul National University
  • - 2002.5-2007.4 International Research Advisor, International Vaccine Research Center
  • - 2001.1-2002.12 Editor, Molecules and Cells (Journal of Korean Society for Molecular and Cellular Biology)
  • - 1999.1-2003.1 Director, Seoul National University SPF
  • - 1997.4-2003.3 Associate Professor, Seoul National University Institute of Molecular Biology and Genetics
  • - 1996.12-Present Board Chairman, Korean Zoology Association
  • - 1996.12-2000.11 Editor, Journal of Association of Korean Biological Sciences
  • - 1995.12-Present Board Chairman, Korean Immunology Association
  • - 1994.12-1996.11 Scientific Organizer, Korean Zoology Association
  • - 1993.3-1997.3 Assistant Professor, Seoul National University Institute of Molecular Biology and Genetics
Publications
  1. S. Lee, J. Kim, H. Min, R.H. Seong. 2020. RORgt-driven TH17 Cell Differentiation Requires Epigenetic Control by the Swi/Snf Chromatin Remodeling Complex. iScience 23, 101106
  2. S. Hwang, C. Lee, K. Park, S. Oh, S. Jeon, B. Kang, Y. Kim, J. Oh, S.H. Jeon, Masanobu Satake, Ichiro Taniuchi, H. Lee & R.H. Seong. 2020. Twist2 promotes CD8+ T-cell differentiation by repressing ThPOK expression. Cell Death Diff https://doi.org/10.1038/s41418-020-0560-x
  3. W. Kim, E. Kim, H. Min, M.G. Kim, Verena B. Eisenbeis, Amit K. Dutta, Igor Pavlovic, Henning J. Jessen, S. Kim, and R.H. Seong. 2019. Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 25;116(26):12952-12957.
  4. Lee S, Park K, Kim J, Min H, Seong RH. 2018. Foxp3 expression in induced regulatory T cells is stabilized by C/EBP in inflammatory environments.. EMBO Rep. 19(12):e45995
  5. Kim, E., J. Beon, S. Lee, S.J. Park, H. Ahn, M.G. Kim, J.E. Park, W. Kim, J.-M. Yuk, S.-J Kang, S.-H Lee, E.-K. Jo, R.H. Seong*, S. Kim*. 2017. Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6" for publication. Science Advances. 3(4) e1602296 DOI: 10.1126/sciadv.1602296. (*co-corresponding authors).
  6. Choi, J., Y.-K. Kim, K. Park, D.-W. Kim, V.N. Kim and R.H. Seong. 2016. MicroRNA-139 controls proliferation and differentiation of myeloid progenitors and is associated with hematopoietic malignancy. Blood 128(17):2117-2129.
  7. Oh, S., J. Oh, C. Lee, S.-J. Oh, S. Jeon, S.-S. Hwang, Y. Lee, and R.H. Seong. 2016. Expression of twist2 is controlled by T-cell receptor signaling and determines the survival and death during thymocyte selection. Cell Death Diff. 23(11) 1804-1814.
  8. Jeon, S. and R.H. Seong. 2016. Anteroposterior limb skeletal patterning requires the bifurcating function of SWI/SNF chromatin remodeling complex in Hedgehog pathway. PLoS Genetics. 12(3): e1005915. doi:10.1371 /journal.pgen.1005915.
  9. Choi, J., S. Jeon, S. Choi, K. Park, and R.H. Seong. 2015. The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression. Proc. Natl. Acad. Sci. 112(7):E718-27, 112(46):E6409.