Professor
Seok, Yeong-Jae
Research
Biochemistry
Microbiology
1. Glucose signaling in bacteria
● New roles of PTS proteins in E. coli and V. vulnificus
● Regulation of PTS expression by glucose and other metabolites
2. Bacterial pathogenesis
● Roles of PTS proteins in bacterial pathogenesis
● Ligand fishing of new factors affecting bacterial pathogenesis
3. Exploration of new bacterial signaling systems
● Functional study of the nitrogen-metabolic PTS
● Elucidation of targets regulated by the new phosphotransferase system
4. Regulation of global gene expression in bacteria
● Mechanism of carbon catabolite repression in gram-negative bacteria
● Regulation of global gene expression by the nitrogen-matabolic PTS
● New roles of PTS proteins in E. coli and V. vulnificus
● Regulation of PTS expression by glucose and other metabolites
2. Bacterial pathogenesis
● Roles of PTS proteins in bacterial pathogenesis
● Ligand fishing of new factors affecting bacterial pathogenesis
3. Exploration of new bacterial signaling systems
● Functional study of the nitrogen-metabolic PTS
● Elucidation of targets regulated by the new phosphotransferase system
4. Regulation of global gene expression in bacteria
● Mechanism of carbon catabolite repression in gram-negative bacteria
● Regulation of global gene expression by the nitrogen-matabolic PTS
Education/Career
Education
- - 1987.3 - 199.2 Ph.D.: Microbiology, Seoul National University
- - 1985.3 - 1987.2 Master's
- - 1981.3 - 1985.2 Bachelor's
Career
- - 2007.3 - 2009.3 Head of Microbiology Research Center, Seoul National University
- - 2007.04 - Present Professor, School of Biological Sciences, Seoul National University
- - 2001.10 - 2007.3 Associate Professor, School of Biological Sciences, Seoul National University
- - 1997.9 - 2001.09 Assistant Professor, Microbiology, Seoul National University
Publications
- Kim HM, Yoon CK, Ham HI, Seok YJ*, Park YH* (2018) Stimulation of Vibrio vulnificus pyruvate kinase in the presence of glucose to cope with H2O2 stress generated by its competitors. Frontiers in Microbiology 9: 1112
- Lee JW, Park YH, Seok YJ (2018) Rsd balances (p)ppGpp level by stimulating the hydrolase activity of SpoT during carbon source downshift in Escherichia coli. Proc Natl Acad Sci USA 115(29): E6845-E6854.
- Lee CR, Park YH, Kim YR, Seok YJ (2019) Determination of protein phosphorylation by polyacrylamide gel electrophoresis. J Microbiol 57(2): 93-100.
- Park S, Yoon J, Lee CR, Lee JY, Kim YR, Jang KS, Lee KH, Seok YJ (2019) Polar landmark protein HubP recruits flagella assembly protein FapA under glucose limitation in Vibrio vulnificus. Mol Microbiol 112(1): 266-279
- Choe M, Min H, Park YH, Kim YR, Woo JS, Seok YJ (2019) Structural insight into glucose repression of the mannitol operon. Sci Rep 9: 13930
- Heo K, Park YH, Lee KA, Kim J, Ham HI, Kim BG, Lee WJ, Seok YJ (2019) Sugar-mediated regulation of a c-di-GMP phosphodiesterase in Vibrio cholerae. Nature Comm 10(1): 5358