Laboratory of Microbial Physiology

Laboratory of Microbial Physiology

Seoul National University
Laboratory of Microbial Physiology

Laboratory of Microbial Physiology

Seoul National University
Laboratory of Microbial Physiology

Laboratory of Microbial Physiology

Seoul National University

Publications+ more

(2023) Highly Efficient Nitrogen-Fixing Microbial Hydrogel Devicefor Sustainable Solar Hydrogen Production, Adv. Mater.
(2023) HPr prevents FruR-mediated facilitation of RNA polymerase binding to the fru promoter in Vibrio cholerae, Nucleic Acids Res.
(2023) Effect of Clostridium butyricum on High-Fat Diet-Induced Intestinal Inflammation and Production of Short-Chain Fatty Acids, Dig. Dis. Sci.
(2022) Phosphotransferase system sugars immediately induce mutations of Cra in an Escherichia coli ptsH mutant, Environ. Microbiol.
(2022) A mannose-sensing AraC-type transcriptional activator regulates cell–cell aggregation of Vibrio cholerae, npj Biofilms and Microbiomes

Welcome to the
"Laboratory of Microbial Physiology"

Research overview Bacteria have the capacity to efficiently adapt to environmental changes by sensing the availability of nutrients. Because glucose is one of the most abundant carbon sources in the environment, it is the most favored carbohydrate in most organisms. Although different organisms employ different uptake systems for glucose, many organisms, including yeasts and E. coli, show preferential growth on glucose when presented with mixtures of glucose and other carbon sources. It is known that glucose, sensed by its transporters or metabolizing enzymes, inhibits the uptake of certain other sugars into the cell or represses the synthesis of enzymes required to grow on those alternative carbon sources such as lactose. In most bacteria, glucose and many other carbohydrates are transported via the phosphoenolpyruvate (PEP):sugar phosphotransferase system (PTS). This multi-component system carries out a PEP-dependent transport and phosphorylation of numerous sugars (group translocation; Fig. 1).