Laboratory of Microbial Physiology

Laboratory of Microbial Physiology

Seoul National University
Laboratory of Microbial Physiology

Laboratory of Microbial Physiology

Seoul National University
Laboratory of Microbial Physiology

Laboratory of Microbial Physiology

Seoul National University

Publications+ more

(2018) Rsd balances (p)ppGpp level by stimulating the hydrolase activity of SpoT during carbon source downshift in Escherichia coli, PNAS
(2018) Stimulation of Vibrio vulnificus Pyruvate Kinase in the Presence of Glucose to Cope With H2O2 Stress Generated by Its Competitors, frontiers in Microbiology
(2017) The general PTS component HPr determines the preference for glucose over mannitol., Sci Rep.
(2016) Glucose induces delocalization of a flagellar biosynthesis protein from the flagellated pole, molecular microbiology
(2015) Structural basis for the sequestration of the anti-σ(70) factor Rsd from σ(70) by the histidine-containing phosphocarrier protein HPr., Acta Crystallogr D Biol Crystallogr.

Welcome to the
"Laboratory of Microbial Physiology"

Research overview Bacteria have the capacity to efficiently adapt to environmental changes by sensing the availability of nutrients. Because glucose is one of the most abundant carbon sources in the environment, it is the most favored carbohydrate in most organisms. Although different organisms employ different uptake systems for glucose, many organisms, including yeasts and E. coli, show preferential growth on glucose when presented with mixtures of glucose and other carbon sources. It is known that glucose, sensed by its transporters or metabolizing enzymes, inhibits the uptake of certain other sugars into the cell or represses the synthesis of enzymes required to grow on those alternative carbon sources such as lactose. In most bacteria, glucose and many other carbohydrates are transported via the phosphoenolpyruvate (PEP):sugar phosphotransferase system (PTS). This multi-component system carries out a PEP-dependent transport and phosphorylation of numerous sugars (group translocation; Fig. 1).