Seoul National University Biological Sciences Website

발표논문

Laboratory of Genes and Development

2024

Daehan Lee, Bo Yun Lee, Myung-Kyu Choi, Nari Kim, Junho Lee (2024). Role of gustatory neurons opposing TGF-β in regulating nictation behavior in Caenorhabditis elegans. Journal of Biosciences, 49(95), .

Hyunji Lee, Hiroyuki Niida, Sanghyun Sung, Junho Lee (2024). Haplotype-resolved de novo assembly revealed unique characteristics of alternative lengthening of telomeres in mouse embryonic stem cells. Nucleic Acids Research, (), .

Heeseung Yang, Daehan Lee, Heekyeong Kim, Daniel E. Cook, Young-Ki Paik, Erik C. Andersen, and Junho Lee (2024). Glial expression of a steroidogenic enzyme underlies natural variation in hitchhiking behavior. PNAS, 121(28), .

Hyunsoo Yim, Daniel T. Choe, J. Alexander Bae, Myung-kyu Choi, Hae-Mook Kang, Ken C. Q. Nguyen, Soungyub Ahn, Sang-kyu Bahn, Heeseung Yang, David H. Hall, Jinseop S. Kim & Junho Lee (2024). Comparative connectomics of dauer reveals developmental plasticity. Nature Communications, 15(1), .

2023

Jiseon Lim, Wonjoo Kim, Jun Kim and Junho Lee (2023). Telomeric repeat evolution in the phylum Nematoda revealed by high-quality genome assemblies and subtelomere structures. Genome Research, 33(11), 1947-1957.

Daisy S Lim, Jun Kim, Wonjoo Kim, Nari Kim, Sang-Hee Lee, Daehan Lee, Junho Lee (2023). daf-42 is an evolutionarily young gene essential for dauer development in Caenorhabditis elegans. Genetics, 224(4), .

Sanghyun Sung, Eunkyeong Kim, Hiroyuki Niida, Chuna Kim, Junho Lee (2023). Distinct characteristics of two types of alternative lengthening of telomeres in mouse embryonic stem cells. Nucleic Acids Research, (), .

Hyunji Lee, Jun Kim, Junho Lee (2023). Benchmarking datasets for assembly-based variant calling using high-fidelity long reads. BMC Genomics, 148(), .

2022

Sangwon Son, Myung-Kyu Choi, Daisy S Lim, Jaegal Shim, Junho Lee (2022). A genetic screen for aldicarb resistance of Caenorhabditiselegans dauer larvae uncovers 2 alleles of dach-1, a cytochrome P450 gene. G3, 12(12), .

Bo Yun Lee, Jun Kim, Junho Lee (2022). Intraspecific de novo gene birth revealed by presence–absence variant genes in Caenorhabditis elegans. NAR Genomics and Bioinformatics, 4(2), .

Soungyub Ahn, Heeseung Yang, Sangwon Son Hyun Sik Lee, Dongjun Park, Hyunsoo Yim, Hee-Jung Choi, Peter Swoboda,, Junho Lee (2022). The C. elegans regulatory factor X (RFX) DAF-19M module: A shift from general ciliogenesis to cell-specific ciliary and behavioral specialization. Cell Reports, 39(2), .

2021

Jiseon Lim, Jun Kim, Junho Lee (2021). Natural variation in reproductive timing and X-chromosome nondisjunction in Caenorhabditis elegans. G3, 11(12), .

Eunkyeong Kim, Jun Kim, Chuna Kim, and Junho Lee (2021). Long-read sequencing and de novo genome assemblies reveal complex chromosome end structures caused by telomere dysfunction at the single nucleotide level. Nucleic Acids Research, 49(6), 3338–3353.

Chuna Kim, Sanghyun Sung, Jong-Seo Kim, Hyunji Lee, Yoonseok Jung, Sanghee Shin, Eunkyeong Kim, Jenny J. Seo, Jun Kim, Daeun Kim, Hiroyuki Niida, V. Narry Kim, Daechan Park and Junho Lee (2021). Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells. Nature Communications, 12(), 1097.

2020

Heeseung Yang, Bo Yun Lee, Hyunsoo Yim and Junho Lee (2020). Neurogenetics of nictation, a dispersal strategy in nematodes. Journal of Neurogenetics, (), .

Chuna Kim, Sanghyun Sung, Jun Kim and Junho Lee (2020). Repair and Reconstruction of Telomeric and Subtelomeric Regions and Genesis of New Telomeres: Implications for Chromosome Evolution. BioEssays, (), .

2019

Hanee Lee, Junsu Kang, Soungyub Ahn and Junho Lee (2019). The Hippo Pathway Is Essential for Maintenance of Apicobasal Polarity in the Growing Intestine of Caenorhabditis elegans. Genetics, (), .

Chuna Kim, Jun Kim, Sunghyun Kim, Daniel E. Cook, Kathryn S. Evans, Erik C. Andersen, and Junho Lee (2019). Long-read sequencing reveals intra-species tolerance of substantial structural variations and new subtelomere formation in C. elegans. Genome research, (), .

2018

Hanee Lee, Junsu Kang and Junho Lee (2018). Involvement of YAP-1, the Homolog of Yes-Associated Protein, in the Wnt-Mediated Neuronal Polarization in Caenorhabditis elegans. G3, 8(8), .

Richaud, Aurélien, Gaotian Zhang, Daehan Lee, Junho Lee, and Marie-Anne Félix. (2018). The Local Co-existence Pattern of Selfing Genotypes in Caenorhabditis elegans Natural Metapopulations. Genetics, 208(2), .

2017

Daehan Lee, Heeseung Yang, Jun Kim, Shannon Brady, Stefan Zdraljevic, Mostafa Zamanian, Heekyeong Kim, Young-ki Paik, Leonid Kruglyak, Erik C. Andersen & Junho Lee (2017). The genetic basis of natural variation in a phoretic behavior. Nature Communications, 8(273), .

2016

Jung Hyun Lee, Ji Seul Han, Jinuk Kong, Yul Ji, Xuchao Lv, Junho Lee, Peng Li and Jae Bum Kim* (2016). Protein Kinase A subunit balance regulates lipid metabolism in Caenorhabditis elegans and mammalian adipocytes. The Journal of Biological Chemistry, (), .

Beomseok Seo, Junho Lee (2016). Observation and Quantification of Telomere and Repetitive Sequences Using Fluorescence In Situ Hybridization (FISH) with PNA Probes in Caenorhabditis elegans. Journal of Visualized Experiments, 114(e54224), .

Chuna Kim, Sanghyun Sung & Junho Lee (2016). Internal genomic regions mobilized for telomere maintenance in C. elegans. Worm, 5(1), e1146856.

Myung-Kyu Choi, Sangwon Son, Mingi Hong, Min Sung Choi, Jae Young Kwon, Junho Lee (2016). Maintenance of Membrane Integrity and Permeability Depends on a Patched-Related Protein in C. elegans. Genetics, (), .

2015

B. Seo, C. Kim, M. Hills, S. Sung, H. Kim, E. Kim, D. S. Lim, H. S. Oh, R. M. Choi, J. Chun, J. Shim, J. Lee (2015). Telomere maintenance through recruitment of internal genomic regions. Nature Communications, 6(), 8189.

Lee, D., Lee, H., Choi, M. K., Park, S., Lee, J. (2015). Nictation Assays for Caenorhabditis and Other Nematodes. Bio-Protocol, 5(7), e1433.

2014

Lee JH, Kong J, Jang JY, Han JS, Ji Y, Lee J, Kim JB (2014). Lipid Droplet Protein LID-1 Mediates ATGL-1-Dependent Lipolysis during Fasting in Caenorhabditis elegans. Mol Cell Biol., 34(22), 4165-4176.

2013

Cho SW, Lee J, Carroll D, Kim JS, Lee J (2013). Heritable gene knockout in Caenorhabditis elegans by direct injection of Cas9-sgRNA ribonucleoproteins. Genetics, 195(3), 1177-1180.

Lee K, Shim J, Lee J, Lee J (2013). Identification of Genes Interacting with rnt-1 Through Large-Scale RNAi Screening in Caenorhabditis elegans. G3 (Bethesda), 3(10), 1779-1784.

Schroeder NE, Androwski RJ, Rashid A, Lee H, Lee J, Barr MM (2013). Dauer-Specific Dendrite Arborization in C. elegans Is Regulated by KPC-1/Furin. Curr Biol., 23(16), 1527-1535.

Park JH, Ahn S, Kim S, Lee J, Nam JW, Shin C (2013). Degradome sequencing reveals an endogenous microRNA target in C. elegans. FEBS Lett., 587(7), 964-969.

Lee J, Lee J (2013). Hypoxia-inducible Factor-1 (HIF-1)-independent Hypoxia Response of the Small Heat Shock Protein hsp-16.1 Gene Regulated by Chromatin-remodeling Factors in the Nematode Caenorhabditis elegans. J Biol Chem., 288(3), 1582-1589.

2012

An YJ, Xu WJ, Jin X, Wen H, Kim H, Lee J, Park S (2012). Metabotyping of the C. elegans sir-2.1 Mutant Using in Vivo Labeling and (13)C-Heteronuclear Multidimensional NMR Metabolomics. ACS Chem Biol., (), .

Lee K, Shim J, Bae J, Kim YJ, Lee J. (2012). Stabilization of RNT-1 Protein, Runt-related Transcription Factor (RUNX) Protein Homolog of Caenorhabditis elegans, by Oxidative Stress through Mitogen-activated Protein Kinase Pathway. J Biol Chem., 287(13), 10444-10452.

Lee H, Choi MK, Lee D, Kim HS, Hwang H, Kim H, Park S, Paik YK, Lee J. (2012). Nictation, a dispersal behavior of the nematode Caenorhabditis elegans, is regulated by IL2 neurons. Nat Neurosci., 15(), 107-112.

2011

Kang J, Bai Z, Zegarek MH, Grant BD, Lee J. (2011). Essential roles of snap-29 in C. elegans. Dev Biol., 355(1), 77-88.

Choi B, Kang J, Park YS, Lee J, Cho NJ. (2011). A possible role for FRM-1, a C. elegans FERM family protein, in embryonic development. Mol Cells., 31(5), 451-459.

Sohn Y, Choi MK, Ahn YY, Lee J, Jeong J. (2011). Topological Cluster Analysis Reveals the Systemic Organization of the Caenorhabditis elegans Connectome. PLoS Comput Biol., 7(5), Epub.

2010

Cho SC, Park MC, Keam B, Choi JM, Cho Y, Hyun S, Park SC, Lee J. (2010). DDS, 4,4'-diaminodiphenylsulfone, extends organismic lifespan. PNAS, 107(45), 19326-19331.

Park MC, Park D, Lee EK, Park T, Lee J. (2010). Genomic analysis of the telomeric length effect on organismic lifespan in Caenorhabditis elegans. Biochem Biophys Res Commun, 396(2), 382-387.

Min K, Kang J, Lee J. (2010). A modified feeding RNAi method for simultaneous knock-down of more than one gene in Caenorhabditis elegans. Biotechniques., 48(3), 229-232.

2009

Kang J, Shin D, Yu JR, Lee J. (2009). Lats kinase is involved in the intestinal apical membrane integrity in the nematode Caenorhabditis elegans. Development., 136(16), 2705-2715.

Jo H, Shim J, Lee JH, Lee J, Kim JB (2009). IRE-1 and HSP-4 contribute to energy homeostasis via fasting-induced lipases in C. elegans. Cell Metab., 9(5), 440-448.

Nam S, Min K, Hwang H, Lee HO, Lee JH, Yoon J, Lee H, Park S, Lee J (2009). Control of Rapsyn Stability by the CUL-3-containing E3 Ligase Complex. J Biol Chem., 284(12), 8195-8206.

2008

Ko E, Lee J, Lee H (2008). Essential role of brc-2 in chromosome integrity of germ cells in C. elegans. Mol Cells., (), .

Hong M, Choi MK, Lee J. (2008). The anesthetic action of ethanol analyzed by genetics in Caenorhabditis elegans. Biochem Biophys Res Commun., (), .

Shim J, Lee J (2008). Regulation of rnt-1 expression mediated by the opposing effects of BRO-1 and DBL-1 in the nematode Caenorhabditis elegans. Biochem Biophys Res Commun., (), .

2005

Im SH, Lee J. (2005). PLP-1 binds nematode double-stranded telomeric DNA. Mol Cells., (), .

Shim J, Lee J. (2005). The AP-3 clathrin-associated complex is essential for embryonic and larval development in Caenorhabditis elegans. Mol Cells., (), .

Lee EY, Shim YH, Chitwood DJ, Hwang SB, Lee J, Paik YK (2005). Cholesterol-producing transgenic Caenorhabditis elegans lives longer due to newly acquired enhanced stress resistance. Biochem Biophys Res Commun., (), .

Kim TH, Hwang SB, Jeong PY, Lee J, Cho JW. (2005). Requirement of tyrosylprotein sulfotransferase-A for proper cuticle formation in the nematode C. elegans. FEBS Lett., (), .

2004

Hong M, Kwon JY, Shim J, Lee J. (2004). Differential hypoxia response of hsp-16 genes in the nematode. J Mol Biol., (), .

Ji YJ, Nam S, Jin YH, Cha EJ, Lee KS, Choi KY, Song HO, Lee J, Bae SC, Ahnn J. (2004). RNT-1, the C. elegans homologue of mammalian RUNX transcription factors, regulates body size and male tail development.. Dev Biol.., (), .

Lee GE, Yu EY, Cho CH, Lee J, Muller MT, Chung IK.. (2004). DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase... J Biol Chem., (), .

Joeng KS, Song EJ, Lee KJ, Lee J. (2004). Long lifespan in worms with long telomeric DNA. Nat Genet., (), .

Lee J, Ahnn J, Bae SC.. (2004). Homologs of RUNX and CBF beta/PEBP2 beta in C. elegans... Oncogene., (), .

Kwon JY, Hong M, Choi MS, Kang S, Duke K, Kim S, Lee S, Lee J.. (2004). Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans... Genomics, (), .

Lee J, Nam S, Hwang SB, Hong M, Kwon JY, Joeng KS, Im SH, Shim J, Park MC. (2004). Functional genomic approaches using the nematode Caenorhabditis elegans as a model system... J Biochem Mol Biol., (), .

2003

Im SH, Lee J.. (2003). Identification of HMG-5 as a double-stranded telomeric DNA-binding protein in the nematode Caenorhabditis elegans... FEBS Lett., (), .

Hwang SB, Lee J. (2003). Neuron cell type-specific SNAP-25 expression driven by multiple regulatory elements in the nematode Caenorhabditis elegans.. J Mol Biol., (), .

Kim SH, Hwang SB, Chung IK, Lee J.. (2003). Sequence-specific binding to telomeric DNA by CEH-37, a homeodomain protein in the nematode Caenorhabditis elegans.. J Biol Chem., (), .

Shim J, Im SH, Lee J. (2003). Tissue-specific expression, heat inducibility, and biological roles of two hsp16 genes in Caenorhabditis elegans. FEBS Lett., (), .

2002

Nam S, Jin YH, Li QL, Lee KY, Jeong GB, Ito Y, Lee J, Bae SC.. (2002). Expression pattern, regulation, and biological role of runt domain transcription factor, run, in Caenorhabditis elegans.. Mol Cell Biol., (), .

2000

Hopper NA, Lee J, Sternberg PW. (2000). ARK-1 inhibits EGFR signaling in C. elegans.. Mol Cell., (), .

Shim J, Lee J. (2000). Molecular genetic analysis of apm-2 and aps-2, genes encoding medium and small chains of AP-2 clathrin associated-protein complex in C. elegans.. Mol Cells., (), .

1999

Kwon JY, Park JM, Gim BS, Han SJ, Lee J, Kim YJ. (1999). Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation.. PNAS, (), .

1995

Sternberg, P.W., Lesa, G., Lee, J., Katz, W.S., Yoon, C., Clandinin, T.R., Huang, L.S., Chamberlin, H.M., Jongeward, G. (1995). LET-23-mediated signal transduction during Caenorhabditis elegans development.. Mol Reprod Dev., (), .

Yoon, C.H., Lee, J., Jongeward, G.D., Sternberg, P.W. (1995). Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl.. Science, (), .

1994

Lee J, Jongeward GD, Sternberg PW (1994). unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein.. Genes Dev, (), .