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세미나 담당교수 : 2021-2학기 강찬희(chanhee.kang@snu.ac.kr), 정충원(cwjeong@snu.ac.kr), 천종식(jchun@snu.ac.kr)
조 교 : 홍석영(880-4418, young.hong023@snu.ac.kr)
호암교수회관 : 5572, 교수회관: 5241, 두레미담: 9358, 라쿠치나: 1631.

[초청강연] Stable memory with dynamic engram

2022-06-08l 조회수 166

일시: 2022-06-10 11:00 ~ 13:00
발표자: Jin-Hee Han (Dept. of Biological Sciences, KAIST)
담당교수: 생명과학부
장소: https://snu-ac-kr.zoom.us/j/97429456635
Title: Stable memory with dynamic engram

Memories are thought to be encoded and stored in a collection of cells sparsely
distributed across wide brain areas. There has been a controversy about where such
cell ensembles are stable. In my talk, I will present a recent study in mice from our
lab that demonstrates a shift in cell ensembles supporting a memory in the lateral
amygdala by relearning of fear conditioning. By re-learning, originally recruited cell
ensembles become dispensable for memory retrieval accompanied with a reduction
of synaptic transmission and loss of dendritic spines. Despite the decreased
connectivity, direct activation of these neurons still can induce memory recall. Cell
ensembles active during re-learning within the lateral amygdala are required for
retrieval of the re-learned fear memory, indicating a shift in cell ensembles by re-
learning. These results support a dynamic nature of cell ensembles supporting
memory.