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세미나 담당교수 : 2021-2학기 강찬희(chanhee.kang@snu.ac.kr), 정충원(cwjeong@snu.ac.kr), 천종식(jchun@snu.ac.kr)
조 교 : 홍석영(880-8827, young.hong023@snu.ac.kr)
호암교수회관 : 5572, 교수회관: 5241, 두레미담: 9358, 라쿠치나: 1631.

[초청강연] To divide or differentiate: Transcription factor-orchestrated cell cycle switch from proliferative- to terminal division in stomatal development

2021-10-18l 조회수 206

일시: 2021-10-22 11:00 ~ 13:00
발표자: Soon-Ki Han (DGIST New Biology)
담당교수: 생명과학부
장소: https://snu-ac-kr.zoom.us/j/82445497381
Differentiation of specialized cell types from self-renewing progenitors requires precise cell
cycle control. Plant stomata are generated through asymmetric divisions of a stem-cell-like
precursor meristemoid followed by the single symmetric division that creates an adjustable
pore surrounded by paired guard cells. The stomatal-lineage-specific transcription factor
MUTE terminates the asymmetric divisions and triggers differentiation. However, the role of
cell cycle machinery in this transition remains unknown. Through time-lapse imaging, we
discover that the symmetric division is slower than the asymmetric division. We identify a
plant-specific cyclin-dependent kinase inhibitor, SIAMESE-RELATED4 (SMR4), as a
molecular brake that decelerates cell cycle during this transition. SMR4 is directly induced by
MUTE and transiently accumulates in differentiating meristemoids. SMR4 physically and
functionally associates with CYCD3;1 and extends 1, a MUTE-induced G1 cyclin, and permits the
symmetric division. Our work unravels a molecular framework of the proliferation-to-
differentiation switch within the stomatal lineage and suggests that a timely proliferative cell
cycle is critical for the stomatal fate specification.

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