세미나/행사

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세미나 담당교수 : 2021-1학기 임영운(ywlim@snu.ac.kr), 황대희(daehee@snu.ac.kr), 최명환(choim@snu.ac.kr)
조 교 : 윤창규(880-8827, yoon891023@snu.ac.kr)
호암교수회관 : 5572, 교수회관: 5241, 두레미담: 9358, 라쿠치나: 1631.

[초청강연] 유망과학자 세미나

2021-07-16l 조회수 105

일시: 2021-07-19 11:00 ~ 13:00
발표자: 오수환
담당교수: 생명과학부
장소: https://snu-ac-kr.zoom.us/j/86921149508

Speaker: Soohwan Oh, Ph.D. (University of California, San Diego)

Seminar title: Enhancer Activation, Release and Retargeting in Transcription

Abstract: Eukaryotic genome is hierarchically organized and spatially segregated into distinct compartments, ranging from Enhancer-Promoter looping which is cell type-specific, to micrometer scale chromosomal territories, which is largely preserved across multiple cell types in each organism. Enhancer-Promoter looping events have been widely observed and the fine-tuned coordination between enhancers and promoters is a fundamental tenant of gene transcriptional control. Self-associating chromosomal domains known as topologically associated domains (TADs) restrict Enhancer-Promoter contacts and this constraint of functional interactions within TADs seems critical to ensure proper gene regulation.

Here I report interesting findings on how genome organization affects transcription.

1) Estrogen-regulated enhancer and coding gene activation through critical chromatin structure regulators Condensin Complex I and II.

2) Activation of an enhancer via genetic deletion or mutation of gene promoters. Intriguingly, the super-active enhancers switch their promoter target, causing other genes in the same contact domain to be activated, a target switching process that we referred to as “enhancer release and retargeting” (ERR). Integrative analyses of cancer mutations, the ">

3) Observation of Liquid-Liquid phase separation (LLPS) sensitive TAD boundaries and properties of transcriptional units within them.