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세미나 담당교수 : 2021-2학기 강찬희(chanhee.kang@snu.ac.kr), 정충원(cwjeong@snu.ac.kr), 천종식(jchun@snu.ac.kr)
조 교 : 홍석영(880-8827, young.hong023@snu.ac.kr)
호암교수회관 : 5572, 교수회관: 5241, 두레미담: 9358, 라쿠치나: 1631.

[초청강연] Metabolism-Linked Epigenetics in Stem Cells

2021-05-24l 조회수 434

일시: 2021-05-24 17:00 ~ 19:00
발표자: Hong-Duk Youn, Ph.D. (Department of Biomedical Sciences, SNU)
담당교수: 윤홍덕
장소: https://snu-ac-kr.zoom.us/j/82005286641
Metabolism-Linked Epigenetics in Stem Cells

Embryonic stem cells (ESCs) undergo coordinated epigenetic and metabolic changes to differentiate properly. Transcription factors and epigenetic modifiers control the transcriptional variability for ESC lineage commitment.
Epigenetic modifiers have been known to utilize the metabolites such as acetyl-CoA, SAM, alpha-ketoglutarate, which means that epigenetic modifications are deeply correlated with cellular metabolism. We have tried to understand how metabolism (or metabolic enzymes) affect(s) the epigenetic states in stem cells for proper differentiation.
In this talk, we discuss how two metabolic enzymes (Ctbp2, Psat1) connect the epigenetic and transcriptional program for ESCs to be differentiated.