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세미나 담당교수 : 2021-2학기 강찬희(chanhee.kang@snu.ac.kr), 정충원(cwjeong@snu.ac.kr), 천종식(jchun@snu.ac.kr)
조 교 : 홍석영(880-8827, young.hong023@snu.ac.kr)
호암교수회관 : 5572, 교수회관: 5241, 두레미담: 9358, 라쿠치나: 1631.

[초청강연] Nuclear receptors: Strategies for new therapeutic interventions againstnonalcoholic fatty liver diseases

2021-05-18l 조회수 489

일시: 2021-05-17 17:00 ~ 19:00
발표자: Mi-Ock Lee, Ph.D. (College of Pharmacy, SNU)
담당교수: 이미옥
장소: https://snu-ac-kr.zoom.us/j/83017447435

Nuclear receptors: Strategies for new therapeutic interventions against nonalcoholic fatty liver diseases

Mi-Ock Lee, Ph.D.
College of Pharmacy, Seoul National University, Korea

Non-alcoholic steatohepatitis (NASH) is closely associated with the metabolic complications as a result of overnutrition, including obesity and insulin resistance. Despite recent advances in understanding the pathogenesis of NASH, there are no Food and Drug Administration-approved pharmacotherapeutics that specifically target NASH. Retinoic acid-related orphan receptor  (ROR) belongs to the nuclear hormone receptor superfamily that regulates diverse target genes that are associated with the regulation of lipid and cholesterol metabolic pathways in experimental animals and in human patients. Previously, we showed that activation of ROR dramatically attenuated diet-induced hepatic steatosis and inflammation in diet-induced NASH mouse models. Also, we demonstrated that ROR is a regulator of mitochondrial quality control in response to metabolic input. Importantly, the function of ROR is controlled by a synthetic ligand, JC1-40, which improved symptoms of NASH in mice. Today, I will show evidences that ROR and its lipidic ligands control M2 response of KCs under metabolic stress, and discuss the associated molecular mechanisms. Our data could provide new insights into the clinical application of the nuclear receptors and lipid mediators for the treatment of NASH.