[초청강연] Targeting bacterial nanomachinery: Visualizing host-pathogen interactions in situ

Targeting bacterial nanomachinery: Visualizing host-pathogen interactions in situ
The “Resolution Revolution” by single particle cryo-electron microscopy (cryo-EM) allowed
high-resolution structural analysis of macromolecules that have been challenging to tackle with
Xray crystallography and NMR. The next “revolution” in biology will be led by approaches that
directly reveal high-resolution details of critical processes in their native context. Cryo-electron
tomography (cryo-ET) is a uniquely suited imaging technique to determine in-situ structures, and
thereby also mechanisms, of macromolecular complexes. Our lab utilizes advanced cryo-ET
techniques to study how bacterial pathogens use complex multiprotein nanomachines to inject
bacterial substrate into target cells to achieve infection and survival.