Seoul National University Biological Sciences Website

Publications

Laboratory of Virology

2023

Barış Genç, Boram Nho, Hana Seung, Benjamin Helmold, Huiwon Park, Öge Gözütok, Seunghyun Kim, Jinil Park, Sanghyun Ye, Haneul Lee, Nayeon Lee, Seung-Shin Yu, Sunyoung Kim, Junghun Lee & Hande Özdinler (2023). Novel rAAV vector mediated intrathecal HGF delivery has an impact on neuroimmune modulation in the ALS motor cortex with TDP-43 pathology. Gene Therapy, 30(), 560–574.

2022

Jaeman Lee, Kyeong-Ryang Ko, Nayeon Lee, Sojin Kim, Seung-shin Yu, Sunyoung Kim and Junghun Lee (2022). Construction of Plasmid DNA Expressing Two Isoforms of Insulin-Like Growth Factor-1 and Its Effects on Skeletal Muscle Injury Models. Human Gene Therapy, 33(23-24), 1305-1314.

Nayeon Lee, Sunyoung Kim, Junghun Lee (2022). Impairment of peripheral nerve regeneration by insufficient activation of the HGF/c-Met/c-Jun pathway in aged mice. Heliyon, 8(11), .

Nayeon Lee, Boram Nho, Kyeong Ryang Ko, Sunyoung Kim and Junghun Lee (2022). Gabapentin inhibits the analgesic effects and nerve regeneration process induced by hepatocyte growth factor (HGF) in a peripheral nerve injury model: Implication for the use of VM202 and gabapentinoids for peripheral neuropathy. Molecular and Cellular Neurosciences, 122(), 103767.

Min-Ha Choi, Tae-Sik Jang, Hyeonwoo Kim, Inhoe Ku, Junghun Lee, Jae-Gyun Jeong, Sunyoung Kim and Ji-Ung Park (2022). An agonistic monoclonal antibody targeting cMet attenuates inflammation and upregulates collagen synthesis and angiogenesis in Type 2 diabetic mouse wounds. Plastic and Reconstructive Surgery, 150(3), 572e-583e.

Boram Nho, Kyeong Ryang Ko, Sunyoung Kim and Junghun Lee (2022). Intramuscular injection of a plasmid DNA vector expressing hepatocyte growth factor (HGF) ameliorated pain symptoms by controlling the expression of pro-inflammatory cytokines in the dorsal root ganglion. Biochemical and Biophysical Research Communications, 607(), 60-66.

2021

Nayeon Lee, Mi-Young Lee, Junghun Lee, Sang Ho Kwon, Hana Seung, Jaegook Lim and Sunyoung Kim (2021). Hepatocyte growth factor induces pErk and pSTAT3 (Ser 727) to promote mitochondrial activity and neurite outgrowth in primary dorsal root ganglion cultures. NeuroReport, 32(6), 525-530.

Wonwoo Lee, Chang Hyung Lee, Jungkyu Lee, Yoonseon Jeong, Jong-Hyung Park, In-Jeong Nam, Doo Suk Lee, Hyun Myung Lee, Jaehyun Lee, Nayoung Yun, Jisun Song, Sooyeon Choi, Sunyoung Kim (2021). Botanical formulation, TADIOS, alleviates lipopolysaccharide(LPS)-Induced acute lung injury in mice via modulation of the Nrf2-HO-1 signaling pathway. Journal of Ethnopharmacology, 270(), 113795.

Nayeon Lee, Sang Hwan Lee, Junghun Lee, Mi-Young Lee, Jaegook Lim, Subin Kim, Sunyoung Kim (2021). Hepatocyte growth factor is necessary for efficient outgrowth of injured peripheral axons in in vitro culture system and in vivo nerve crush mouse model. Biochemistry and Biophysics Reports, 26(), 100973.

2020

Jung Nam An, Lilin Li, Junghun Lee, Seung‐Shin Yu, Jin Hyuk Kim, Jeonghwan Lee, Yong Chul Kim, Dong Ki Kim, Yun Kyu Oh, Chun Soo Lim, Yon Su Kim, Sunyoung Kim, Seung Hee Yang, Jung Pyo Lee (2020). Urinary cMet as a prognostic marker in immunoglobulin A nephropathy. Journal of Cellular and Molecular Medicine, 24(19), 11158-11169.

Seonung Lim, Hyun-keun Kim, Wonwoo Lee, Sunyoung Kim (2020). Botanical preparation HX109 inhibits macrophage-mediated activation of prostate epithelial cells through the CCL4-STAT3 pathway: implication for the mechanism underlying HX109 suppression of prostate hyperplasia. Heliyon, 6(6), e04267.

Jung Nam An, Lilin Li, Junghun Lee, Seung‐Shin Yu, Jeonghwan Lee, Yong Chul Kim, Dong Ki Kim, Yun Kyu Oh, Chun Soo Lim, Yon Su Kim, Sunyoung Kim, Seung Hee Yang, Jung Pyo Lee (2020). cMet agonistic antibody attenuates apoptosis in ischaemia-reperfusion-induced kidney injury. Journal of Cellular and Molecular Medicine, 20(10), 5640-5651.

2019

S.H. Lee, N. Lee, S. Kim, J. Lee, W. Choi, S.S. Yu, J.H. Kime, S. Kim (2019). Intramuscular delivery of HGF-expressing recombinant AAV improves muscle integrity and alleviates neurological symptoms in the nerve crush and SOD1-G93A transgenic mouse models. Biochemical and Biophysical Research Communications, 517(3), 452-457.

Y.C Kim, J. Lee, J.N An, J.H Kim, Y-W Choi, L. Li, S.H Kwon, M-Y Lee, B. Lee, J-G Jeong, S-S Yu, C.S Lim, Y.S Kim, S. Kim, S.H Yang and J.P Lee (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports, 9(1), 13495.

S.H. Lee, S. Kim, N. Lee, J. Lee, S.S. Yu, J.H. Kim and S. Kim (2019). Intrathecal delivery of recombinant AAV1 encoding hepatocyte growth factor improves motor functions and protects neuromuscular system in the nerve crush and SOD1-G93A transgenic mouse models. Acta Neuropathologica Communications, 2019(7), 14.

W. Choi, J. Lee, J. Lee, S.H. Lee, S. Kim (2019). Hepatocyte Growth Factor Regulates Macrophage Transition to the M2 Phenotype and Promotes Murine Skeletal Muscle Regeneration. Frontiers in Physiology, 10(), 914.

W. Lee, Y. Jeong, J-H Park, C. H. Lee, N. Yun, D. S. Lee, I-J Nam, J-D Kim, K. D. Yoon, M. Son and S. Kim (2019). Water-Soluble Extract from Actinidia arguta (Siebold & Zucc.) Planch. ex Miq. and Perilla frutescens (L.) Britton, ACTPER, Ameliorates a Dry Skin-Induced Itch in a Mice Model and Promotes Filaggrin Expression by Activating the AhR Signaling in HaCaT Cells. Nutrients, 11(6), 1366.

H-K Kim, S. Lim, M-J Bae, W. Lee, and S. Kim (2019). PG102 Upregulates IL-37 through p38, ERK, and Smad3 Pathways in HaCaT Keratinocytes. Mediators of inflammation, 2019(), 1-9.

2018

S. Lim, W. Lee, D.S Lee, I-J Nam, N. Yun, Y. Jeong, T. Jeong, T. Rho and S. Kim (2018). Botanical Formulation HX109 Ameliorates TP-Induced Benign Prostate Hyperplasia in Rat Model and Inhibits Androgen Receptor Signaling by Upregulating Ca2+/CaMKKβ and ATF3 in LNCaP Cells. Nutrients, 10(12), 1946.

N. Lee, J. Lee, S.H Lee, S. Kim and S. Kim (2018). Disproportionately high levels of HGF induce the degradation of the c-met receptor through the proteasomal degradation pathway. Biochemical and Biophysical Research Communications, 505(3), 925-930.

H-K Kim, M.J. Bae, S. Lim, W. Lee and S. Kim (2018). A Water-Soluble Extract from Actinidia arguta Ameliorates Psoriasis-Like Skin Inﬂammation in Mice by Inhibition of Neutrophil Inﬁltration. Nutrients, 10(10), 1399.

KR Ko, J. Lee, B. Nho, and S. Kim (2018). c-Fos is necessary for HGF-mediated gene regulation and cell migration in Schwann cells. Biochemical and Biophysical Research Communications, 503(4), 2855-2860.

W. W. Lee, K. R. Ko, H. K. Kim, D. S. Lee, I. J. Nam, S. Lim and S. Kim (2018). Dehydrodiconiferyl Alcohol Inhibits Osteoclast Differentiation and Ovariectomy-Induced Bone Loss through Acting as an Estrogen Receptor Agonist.. Journal of Natural Products, 81(6), 1343-1356.

K.R Ko, J.Lee, D.H Lee, B. R Nho, and S. Kim (2018). Hepatocyte Growth Factor (HGF) Promotes Peripheral Nerve Regeneration by Activating Repair Schwann Cells. A naturesearch journal, (), .

B. R Nho, J.Lee, J. Lee, K.R Ko, S.J Lee, and S. Kim (2018). Effective control of neuropathic pain by transient expression of hepatocyte growth factor in a mouse chronic constriction injury model. The FASEB Journal, Published Online(), .

W. W. Lee, K. R. Ko, H. K. Kim, S. Lim and S. Kim. (2018). Dehydrodiconiferyl alcohol promotes BMP-2-induced osteoblastogenesis through its agonistic effects on estrogen receptor. Biochemical and Biophysical Research Communications, (), .

W.S Choi, J.Lee, J.M Lee, K.R Ko, and S. Kim (2018). Hepatocyte growth factor regulates miR-206-HDAC4 cascade to control the neurogenic muscle atrophy following surgical denervation in mice. Molecular Therapy-Nucleic Acids, In press(), .

2016

J. Lee, S. Kim (2016). Regulation of CCAAT/enhancer-binding protein (C/EBP) α in human-cytomegalovirus-infected fibroblasts. Archives of Virology, (), .

M-J Bae, S. Lim, D. S. Lee, K. R. Ko, W. Lee and S. Kim (2016). Water soluble extracts from Actinidia arguta, PG102, attenuates house dust mite-induced murine atopic dermatitis by inhibiting the mTOR pathway with Treg generation.. Journal of ethnopharmacology, 193(), 96-106.

M-J Bae, H-K Kim, S. Lim, S-Y Lee, H. S. Shin, J-E Kim, S-H Im and S. Kim (2016). Lactobacillus pentosus KF340 alleviates house dust mite-induced murine atopic dermatitis via the secretion of IL-10-producing splenic B10 cells.. Journal of functional foods, 26(), 258–267.

2015

J. Lee, J. Choi, W. Lee, K. Ko and S. Kim (2015). Dehydrodiconiferyl alcohol (DHCA) modulates the differentiation of Th17 and Th1 cells and suppresses experimental autoimmune encephalomyelitis. Mol Immunol, 68(2), 434-444.

D.S. Lee, B.N. Kim, S. Lim, J. Lee, J. Kim, J-G Jeong and S. Kim (2015). Effective suppression of nitric oxide production by HX106N through transcriptional control of heme oxygenase-1. Experimental Biology and Medicine, 240(9), 1136-46.

J.Ahn, J.Lee and S.Kim (2015). Interferon-gamma inhibits the neuronal differentiation of neural progenitor cells by inhibiting the expression of Neurogenin2 via the JAK/STAT1 pathway. Biochem Biophys Res Commun, 466(1), 52-59.

J. Lee, J. Choi and S. Kim (2015). Effective suppression of pro-inflammatory molecules by DHCA via IKK-NF-κB pathway, in vitro and in vivo. British Journal of Pharmacology, 172(13), 3353-69.

2014

J. Lee and S. Kim (2014). Upregulation of heme oxygenase-1 expression by dehydrodiconiferyl alcohol (DHCA) through the AMPK-Nrf2 dependent pathway. Toxicology and Applied Pharmacology, 281(1), 87-100.

Doo Suk Lee, Jae-Gyun Jeong and Sunyoung Kim (2014). Effects of HX106N, a Water-Soluble Botanical Formulation on Scopolamine-Induced Memory Impairment in Mice. Korean J. Food & Nutr., 27(4), .

Jiwon Jang*, Sung-Hyun Byun*, Dasol Han, Junsub Lee, Juwan Kim, Nayeon Lee, Inhee Kim, Soojeong Park, Soobong Ha, Mookwang Kwon, Jyhyun Ahn, Woo-Jae Chung, Dae-Hyuk Kweon, Jae Youl Cho, Sunyoung Kim, and Keejung Yoon (2014). Notch intracellular domain deficient in nuclear localization activity retains the ability to enhance neural stem cell character and block neurogenesis in mammalian brain development. Stem Cells and Development, 23(23), 2841-2850.

Jyhyun Ahn, Jiwon Jang, Junsub Lee, Seo-ho Oh, Junghun Lee, Keejung Yoon, and Sunyoung Kim (2014). GSK3β, but not GSK3α, inhibits the neuronal differentiation of neural progenitor cells as a downstream target of mTORC1. Stem Cells and Development, 23(10), 1121-1133.

Lee DS, Choi J, Kim SH, Kim S. (2014). Ameliorating effects of HX106N, a water-soluble botanical formulation, on Aβ25-35-induced memory impairment and oxidative stress in mice. Biol Pharm Bull., 37(6), 954-960.

2013

Jiwon Jang, Jyhyun Ahn, Nayeon Lee, Seong-Tae Kim, Dae-Hyuk Kweon, Jae Youl Cho, Kye Won Park, Sunyoung Kim, and Keejung Yoon (2013). Ultrasound Backscatter Microscopy Image-Guided Intraventricular Gene Delivery at Murine Embryonic Age 9.5 and 10.5 Produces Distinct Transgene Expression Patterns at the Adult Stage. Molecular Imaging, 1(12(8)), 485-90.

J. Lee, K. Koh, Y-E Kim, J-H Ahn and S. Kim (2013). Upregulation of Nrf2 expression by human cytomegalovirus infection protects host cells from oxidative stress. Journal of General Virology, 94(), 1658-68.

J. Choi, J. Lee, SH Kim, J. Kim and S. Kim (2013). PG201 downregulates the production of nitrite by upregulating heme oxygenase-1 expression through the control of phosphatidylinositol 3-kinase and NF-E2-related factor 2. Nitric Oxide, 33(), 42-55.

D. Kim, SH Kim, E-S Hong, E-J Kwon, M-J Kim, C-W Kim, S-H Cho and S. Kim (2013). Reconstitution of anti-allergic activities of PG102 derived from Actinidia arguta by combining synthetic chemical compounds. Experimental Biology and Medicine, 238(), 631-640.

2012

S. Wu, Y. Zhang, L. Xu, Y. Dai, Y. Teng, S. Ma, S-H Ho, J-M Kim, SS Yu, S. Kim and S. Song (2012). Multicenter, randomized study of genetically modified recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in cancer patients receiving chemotherapy. Supportiv Care in Cancer, 20(8), 1875-1884.

J. Jang, J. Lee, K-Y Lee, S-T Kwon, S. Kim and K. Yoon (2012). Polycation-mediated enhancement of retroviral transduction efficiency depends on target cell types and pseudotyping Env proteins. Neurochemistry International, 60(8), 846-51.

J. Choi, SH Kim and S. Kim (2012). Suppressive effects of PG201, an anti-arthritic botanical formulation, on LPS-induced inflammatory mediators in Raw264.7 cells. Experimental Biology and Medicine, 237(5), 499-508.

J. Lee, D. Kim, J. Choi, H. Choi, J. Ryu, J. Jeong, S-J Park, SH Kim and S. Kim (2012). Dehydrodiconiferyl alcohol isolated from Cucurbita moschata shows anti-adipogenic and anti-lipogenic effect in 3T3-L1 cells and primary mouse embryonic fibroblasts. Journal of Biological Chemistry, 287(12), 8839-8851.

2011

Y. Gu, J. Zhang, L. Guo, S. Cui, X. Li, D. Ding, J-M Kim, S-H Ho, W. Hahn and S. Kim (2011). Phase I clinical study of naked DNA expressing two isoforms of hepatocyte growth factor to treat patients with critical limb ischemia. Journal of Gene Medicine, 13(11), 602-610.

W. Hahn, W-B Pyun, D-S Kim, W-S Yoo, S-D Lee, J-H Won, GJ Shin, J-M Kim and S. Kim (2011). Enhanced cardio-protective effects by coexpression of two isoforms of hepatocyte growth factor from naked plasmid DNA in a rat ischemic heart disease model. Journal of Gene Medicine, 13(10), 549-55.

SH Kim, S. Kim, SH Lee, HW Park, YS Chang, KU Min and SH Cho (2011). The effects of PG102, a water-soluble extract from Actinidia arguta, on serum total IgE levels: a double-blind, randomized, placebo-controlled exploratory clinical study. European Journal of Nutrition, 50(7), 523-529.

HJ Kang, CC Bartholomae, A. Paruzynski, A. Arens, S. Kim, SS Yu, Y. Hong, CW Joo, N-K Yoon, J-W Rhim, JG Kim, CV Kalle, M. Schmidt, S. Kim and HS Ahn (2011). Retroviral Gene Therapy for X-linked Chronic Granulomatous Disease: Results From Phase I/II Trial. Molecular Therapy, 19(11), 2092-2101.

J. Jang, J-T Lee, K. Lee, S. Kim, JY Kim and S. Kim (2011). Development of murine leukemia virus-based retroviral vectors with a minimum possibility of cis-activation. Gene Therapy, 18(3), 240-9.

D. Kim, SH Kim, SH Cho, K. Shin and S. Kim (2011). SOCS3 suppresses the expression of IL-4 cytokine by inhibiting the phosphorylation of c-Jun through the ERK signaling pathway in rat mast cell line RBL-2H3. Molecular Immunology, 48(5), 776-81.

Y. Jung, H. Ahn, DS Kim, YR Hwang, SH Ho, JM Kim, S. Kim, S. Ma and S. Kim (2011). Improvement of biological and pharmacokinetic features of human interleukin-11 by site-directed mutagenesis. Biochemical and Biophyscial Research Communications, 405(3), 399-404.

H. Chono, K. Matsumoto, H. Tsuda, N. Saito, K. Lee, S. Kim, H. Shibata, N. Ageyama, K. Terao, Y. Yasutomi, J. Mineno, S. Kim, M. Inouye and I. Kato (2011). Acquisition of HIV-1 Resistance in T Lymphocytes Using an ACA-Specific E. coli mRNA Interferase. Human Gene Therapy, 22(1), 35-43.

J. Jang, K. Yoon, DW Hwang, DS Lee and S. Kim (2011). A retroviral vector suitable for ultrasound image-guided gene delivery to mouse brain. Gene Therapy (In press, published online), (), .

2010

W‐B Pyun, W. Hahn, D‐S Kim, W‐S Yoo, S‐D Lee, J‐H Won, B‐S Rho, Z‐Y Park, J‐M Kim and S. Kim (2010). Naked DNA expressing two isoforms of hepatocyte growth factor induces collateral artery augmentation in a rabbit model of limb ischemia. Gene Therapy, 17(12), 1442-52.

2009

D. Kim, SH Kim, E-J Park, C-Y Kang and S. Kim (2009). Suppression of allergic diarrhea in murine OVA-induced food allergy model by PG102, a water-soluble extract prepared from Actinidia arguta. International Archives of Allergy and Immunology, 150(2), 164-171.

K. Koh, K. Lee, JH Ahn and S. Kim (2009). Human Cytomegalovirus Infection Downregulates the Expression of Glial Fibrillary Acidic Protein in Human Glioblastoma Cells, U373MG : Identification of Viral Genes and Protein Domains Involved. Journal of General Virology, 90(4), 954-62.

K. Koh, Y. Cha, S. Kim and J. Kim (2009). tBHQ inhibits LPS-induced microglial activation via Nrf2-mediated suppression of p38 phosphorylation. Biochemical and Biophyscial Research Communications, 380(3), 449-53.

D. Kim, SH Kim, EJ Park, CY Kang, SH Cho and S. Kim (2009). Anti-allergic effects of PG102, a water-soluble extract prepared from Actinidia arguta, in a murine OVA-induced asthma model. Clinical and Experimental Allergy, 39(2), 280-9.

2008

Y. Hong, SS Yu, NK Yoon, SJ Kang, JT Lee, S. Kim, JM Kim, K. Lee, JW Jang and S. Kim (2008). Development of an in vitro cell culture assay system for measuring the activation of a neighbouring gene by the retroviral vector. Journal of Gene Medicine, 10(8), 847-54.

S. Kim, Z. Peng and Y. Kaneda (2008). Current Status of Gene Therapy in Asia. Molecular Therapy, 16(2), 237-43.

2007

H. Choi, H. Eo, K. Park, M. Jin, EJ Park, SH Kim, JE Park and S. Kim (2007). A water-soluble extract from Cucurbita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse model. Biochemical and Biophyscial Research Communications, 359(3), 419-25.

E-J Park, K.C. Park, H. Eo, J. Seo, M. Son, K.H. Kim, Y-S Chang, S-H Cho, K-U Min, M. Jin and S. Kim (2007). Suppression of spontaneous dermatitis in NC/Nga murine model by PG102 isolated from Actinidia arguta. Journal of Investigative Dermatology, 127(5), 1154-60.

J-T Lee, S. S. Yu, V. N. Kim and S. Kim (2007). Control of Splicing Efficiency by the Mouse Histone H2a Element in an MLV-Based Retroviral Vector. Molecular Therapy, 15(1), 167-72.

2006

JM Kim, BK Lim, SH Ho, SH Yun, JO Shin, EM Park, DK Kim, S. Kim and ES Jeon (2006). TNFR-Fc fusion protein expressed by in vivo electroporation improves survival rates and myocardial injury in coxsackievirus induced murine myocarditis. Biochemical and Biophyscial Research Communications, 344(3), 765-771.

S. Kim, K. Lee, M-D Kim, S. Kang, C.W. Joo, J-M Kim, S.H. Kim, S.S. Yu and S. Kim (2006). Factors affecting the performance of different long terminal repeats in the retroviral vector. Biochemical and Biophyscial Research Communications, 343(4), 1017-1022.

S. Ho, H. Lee, D. Kim, J. Jeong, S. Kim S.S. Yu, Z. Jin, S. Kim and J. Kim (2006). Intrasplenic electro-transfer of IL-4 enciding plasmid DNA efficiently inhibits rat experimental allergic encephalomyelitis. Biochemical and Biophyscial Research Communications, 343(3), 816-824.

J.J. Choi, M. Jin, J.K. Lee, W.Y. Lee, Y-I Park, Y.N. Han and S. Kim (2006). Control of cytokine gene expression by PG101, a water-soluble extract prepared from Lentinus lepideus. Biochemical and Biophyscial Research Communications, 339(3), 880-887.

2005

E-J Park, B. Kim, H. Eo, K. Park, Y. Kim, H.J. Lee, M. Son, Y-S Chang, S-H Cho, S. Kim and M. Jin (2005). Control of IgE and selective Th1 and Th2 cytokines by PG102 isolated from Actinidia arguta. Journal of Allergy and Clinical Immunology, 116(5), 1151-1158.

K.C. Park, E.J. Park, E.R. Kim, Y. Kim, S.H. Chung, B.W. Cho, S. Kim and M. Jin (2005). Therapeutic effects of PG201, an ethanol extract from herbs, through cartilage protection on collagenase-induced arthritis in rabbits. Biochemical and Biophyscial Research Communications, 331(4), 1469-77.

K. Lee, K. Jeon, J.M.Kim, V.N.Kim, D.H.Choi, S.U.Kim and S.Kim (2005). Downregulation of GFAP, TSP-1 and p53 in human glioblastoma cell line, U373MG, by IE1 protein from human cytomegalovirus: Implications for the possible role of IE1 in the pathogenesis of glioma. Glia, 51(1), 1-12.

2004

J.G. Jeong, J.M. Kim, S.H, Ho, W. Hahn, S.S. Yu and S. Kim (2004). Electrotransfer of Human IL-1Ra into Skeletal Muscles Reduces the Incidence of Murine Collagen-induced Arthritis. Journal of Gene Medicine, 6(10), 1125-1133.

Y. Hong, K. Lee, S.S. Yu, S. Kim and S. Kim (2004). Factors affecting retrovirus-mediated gene transfer to human CD34+ cells. Journal of Gene Medicine, 6(7), 724-733.

S.Kim, E.J.Park, S.S.Yu and S.Kim (2004). Development of enzyme-linked immunosorbent assay for detecting antibodies to replication-competent murine leukemia virus. Journal of Virological Methods, 118(1), 1-7.

Y.S. Na, K.Yoon, J.G. Nam, B. Choi, J.S. Lee, I. Kato and S. Kim (2004). Nef from a primary isolate of human immunodeficiency virus type 1 lacking the EE(155) region shows decreased ability to downregulate CD4. Journal of General Virology, 85(6), 1451-61.

W. Hahn, S.H. Ho, J.G. Jeong, E.Y. Hahn, S.S. Yu, S. Kim and J.M. Kim (2004). Viral vector-mediated transduction of a modified thrombospondin-2 cDNA inhibits tumor growth and angiogenesis. Gene Therapy, 11(9), 739-45.

J. Lee, S. S. Yu, E. Han, S.J. Kim and S. Kim (2004). Engineering the Splice Acceptor for Improved Gene Expression and Viral Titer in an MLV-based Retroviral Vector. Gene Therapy, 11(), 94-9.

2003

J-M Kim, J-G Jeong, S-H Ho, W Hahn, E-J Park, S Kim, SS Yu, Y-W Lee and S Kim (2003). Protection against collagen-induced arthritis by intramuscular gene therapy with an expression plasmid for the interleukin-1 receptor antagonist. Gene Therapy, 10(18), 1543-1550.

J-M. Kim, S-H. Ho, W. Hahn, J-G. Jeong, E-J. Park, H-J. Lee, S. S. Yu, C-S Lee, Y-W. Lee and S. Kim (2003). Electro-gene therapy of collagen-induced arthritis by using an expression plasmid for the soluble p75 tumor necrosis factor receptor-Fc fusion protein. Gene Therapy, 10(15), 1216-1224.

M. Jin, H. Jeon, H. J. Jung, C-Y. Kang and S. Kim (2003). Enhancement of repopulation and hematopoiesis of bone marrow cells in irradiated mice by oral administration of PG101, a water-soluble extract from lentinus lepideus. Experimental Biology and Medicine, 228(6), 759-766.

M. Jin, H. J. Jung, J. J. Choi, H. Jeon, J. H. Oh, K. Yoon and S. Kim (2003). Activation of selective transcription factors and cytokines by water-soluble extract from Lentinus lepideus. Experimental Biology and Medicine, 228(6), 749-758.

. Shin, M. Jin, H. J. Jung, B. Kim, H. Jeon, J. J. Choi, J. M. Kim, B. W. Cho, S. H. Chung, Y. W. Lee, Y. W. Song and S. Kim (2003). Suppressive effect of PG201, an ethanol extract from herbs, on collagen-induced arthritis in mice. Rheumatology, 42(5), 665-672.

S. S. Yu, E. Han, Y. Hong, J. Lee and S. Kim (2003). Construction of a retroviral vector production system with the minimum possibility of a homologous recombination. Gene Therapy, 10(), 706-711.

Y. Hong, S. S. Yu, J. Kim, K. Lee, C. B. Whitley, Y. Sugimoto and S. Kim (2003). Construction of a high efficiency retroviral vector for gene therapy of Hunter’s syndrome. Journal of Gene Medicine, 5(), 18-29.

2002

S. H. Kim, E. Lechman, S.Kim, J. Nash, T. Oligino and P. D. Robbins (2002). Ex vivo gene delivery of IL-1 Ra and soluble sTNF Receptor confers a distal synergistic therapeutic effect in antigen-induced arthritis. Molecular Therapy, 6(5), 591-600.

S. H. Kim, S. Kim, T. Oligino and P. D. Robbins (2002). Effective treatment of established mouse collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express FasL. Molecular Therapy, 6(5), 584-590.

J. O. Jeong, J. Byun, E-S Jeon, H-C Gwon, Y. S. Lim, J. Park, S-J Yeo, Y. J. Lee, S. Kim and D-K Kim (2002). Improved expression by cytomegalovirus promoter/enhancer and behavior of vascular endothelial growth factor gene after myocardial injection of naked DNA. Experimental and Molecular Medicine, 34(4), 278-84.

Y.T. Lee, K.P. Jeon, J.T. Lee, S. Kim and V.N. Kim (2002). MicroRNA maturation: stepwise processing and subcellular localization. EMBO Journal, 21(17), 4663-4670.

Lim, B. K., S. C. Choe, J. O. Shin, S. H. Ho, J. M. Kim, S. S. Yu, S. Kim, and E. S. Jeon (2002). Local expression of interleukin-1 receptor antagonist by plasmid DNA improves mortality and decreases myocardial inflammation in experimental coxsackieviral myocarditis. Circulation, 105(11), 1278-81.

Kim, J. M., S. H. Ho, E. J. Park, W. Hahn, H. Cho, J. G. Jeong, Y. W. Lee, and S. Kim (2002). Angiostatin gene transfer as an effective treatment strategy in murine collagen-induced arthritis. Arthritis and Rheumatism, 46(3), 793-801.

2001

Yoon, K., J. G. Jeong, H. Yoon, J. S. Lee, and S. Kim (2001). Differential effects of primary human immunodeficiency virus type 1 nef sequences on downregulation of CD4 and MHC class I. Biochemical and Biophyscial Research Communications, 284(3), 638-42.

Gwon, H. C., J. O. Jeong, H. J. Kim, S. W. Park, S. H. Lee, S. J. Park, J. E. Huh, Y. Lee, S. Kim, and D. K. Kim (2001). The feasibility and safety of fluoroscopy-guided percutaneous intramyocardial gene injection in porcine heart. International Journal of Cardiology, 79(), 77-88.

Park, S. W., H. C. Gwon, J. O. Jeong, J. Byun, H. S. Kang, J. R. You, S. S. Cho, M. J. Lee, Y. Lee, S. Kim, and D. K. Kim (2001). Intracardiac echocardiographic guidance and monitoring during percutaneous endomyocardial gene injection in porcine heart. Human Gene Therapy, 12(8), 893-903.

Kang, W. K., C. Park, H. L. Yoon, W. S. Kim, S. N. Lee, S. Kim, P. D. Robbins, H. Tahara, M. T. Lotze, and C. H. Park (2001). Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: outcome of a phase I study. Human Gene Therapy, 12(6), 671-84.

Kim, S. H., S. Kim, C. H. Evans, S. C. Ghivizzani, T. Oligino, and P. D. Robbins (2001). Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4. Journal of Immunology, 166(5), 3499-505.

Yoon, K., J. G. Jeong, and S. Kim (2001). Stable expression of human immunodeficiency virus type 1 Nef confers resistance against Fas-mediated apoptosis. AIDS Research and Human Retroviruses, 17(2), 99-104.

2000

Yu, S. S., J. M. Kim, and S. Kim (2000). The 17 nucleotides downstream from the env gene stop codon are important for murine leukemia virus packaging. Journal of Virology, 74(18), 8775-80.

Yu, S. S., J. M. Kim, and S. Kim (2000). High efficiency retroviral vectors that contain no viral coding sequences. Gene Therapy, 7(9), 797-804.

Lee, Y., E. J. Park, S. S. Yu, D. K. Kim, and S. Kim (2000). Improved expression of vascular endothelial growth factor by naked DNA in mouse skeletal muscles: implication for gene therapy of ischemic diseases. Biochemical and Biophyscial Research Communications, 272(), 230-5.

Kim, S. H., C. H. Evans, S. Kim, T. Oligino, S. C. Ghivizzani, and P. D. Robbins (2000). Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4. Arthritis Research, 2(4), 293-302.

Kim, J. M., Y. Hong, and S. Kim (2000). Artificial recruitment of Sp1 or TBP can replace the role of IE1 in the synergistic transactivation by IE1 and IE2. Biochemical and Biophyscial Research Communications, 269(2), 302-8.

Laufs, S., S. H. Kim, S. Kim, N. Blau, and B. Thony (2000). Reconstitution of a metabolic pathway with triple-cistronic IRES- containing retroviral vectors for correction of tetrahydrobiopterin deficiency. Journal of Gene Medicine, 2(1), 22-31.

Kim, J. M., Y. Hong, K. Semba, and S. Kim (2000). Physical and functional interaction between the HCMV IE2 protein and the Wilms' tumor suppressor WT1. Biochemical and Biophyscial Research Communications, 267(1), 59-63.

Kim, J. M., Y. Hong, K. T. Jeang, and S. Kim (2000). Transactivation activity of the human cytomegalovirus IE2 protein occurs at steps subsequent to TATA box-binding protein recruitment. The Journal of General Virology, 81(1), 37-46.

Kim, S. H., S. Kim, and P. D. Robbins (2000). Retroviral vectors. Advances in Virus Research, 55(), 545-63.

Gambotto, A., S. H. Kim, S. Kim, and P. D. Robbins (2000). Methods for constructing and producing retroviral vectors. Methods in Molecular Biology, 135(), 495-508.

1999

Yoon, K., and S. Kim (1999). Lack of negative influence on the cellular transcription factors NF- kappaB and AP-1 by the nef protein of human immunodeficiency virus type 1. The Journal of General Virology, 80(11), 2951-6.

Kim, J. M., Y. Hong, S. Kim, M. H. Cho, M. Yoshida, K. T. Jeang, and W. Burns (1999). Sequences downstream of the RNA initiation site of the HTLV type I long terminal repeat are sufficient for trans-activation by human cytomegalovirus immediate-early proteins. AIDS Research and Human Retroviruses, 15(6), 545-50.

Kim, S., S. S. Yu, I. S. Lee, S. Ohno, J. Yim, and H. S. Kang (1999). Human cytomegalovirus IE1 protein activates AP-1 through a cellular protein kinase(s. The Journal of General Virology, 80(4), 961-9.

Lee, S., S. H. Kim, V. N. Kim, J. H. Hwang, M. Jin, J. Lee, and S. Kim (1999). Heterologous gene expression in avian cells: potential as a producer of recombinant proteins. Journal of Biomedical Science, 6(1), 8-17.

1998

Byun, J., J. M. Kim, P. D. Robbins, and S. Kim (1998). The selectable marker neo gene down-regulates gene expression from retroviral vectors containing an internal ribosome entry site. Gene Therapy, 5(10), 1441-4.

Yoon, K., H. W. Kestler, and S. Kim (1998). Growth properties of HSIVnef: HIV-1 containing the nef gene from pathogenic molecular clone SIVmac239. Virus Research, 57(1), 27-34.

Lee, H., S. Kim, M. Kang, W. Kim, and B. Cho (1998). Prevalence of human foamy virus-related sequences in the Korean population. Journal of Biomedical Science, 5(), 267-73.

Kim, S. H., S. S. Yu, J. S. Park, P. D. Robbins, C. S. An, and S. Kim (1998). Construction of retroviral vectors with improved safety, gene expression, and versatility. Journal of Virology, 72(2), 994-1004.

Kang, M. R., Y. K. Cho, J. Chun, Y. B. Kim, I. Lee, H. J. Lee, S. H. Kim, Y. K. Kim, K. Yoon, J. M. Yang, J. M. Kim, Y. O. Shin, C. Kang, J. S. Lee, K. W. Choi, D. G. Kim, W. M. Fitch, and S. Kim (1998). Phylogenetic analysis of the nef gene reveals a distinctive monophyletic clade in Korean HIV-1 cases. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 17(1), 58-68.

1996

Byun, J., J. M. Kim, S. H. Kim, J. Yim, P. D. Robbins, and S. Kim (1996). A simple and rapid method for the determination of recombinant retrovirus titer by G418 selection. Gene Therapy, 3(11), 1018-20.

Yoo, Y. D., C. J. Chiou, K. S. Choi, Y. Yi, S. Michelson, S. Kim, G. S. Hayward, and S. J. Kim (1996). The IE2 regulatory protein of human cytomegalovirus induces expression of the human transforming growth factor beta1 gene through an Egr-1 binding site. Journal of Virology, 70(10), 7062-70.

Byun, J., S. H. Kim, J. M. Kim, S. S. Yu, P. D. Robbins, J. Yim, and S. Kim (1996). Analysis of the relative level of gene expression from different retroviral vectors used for gene therapy. Gene Therapy, 3(9), 780-8.

Jin, M., S. Kim, and B. K. Kim (1996). Induction of B cell proliferation and NF-kappa B activation by a water soluble glycan from Lentinus lepideus. International Journal of Immunopharmacology, 18(8), 439-48.

Lee, S. G., S. Kim, P. D. Robbins, and B. G. Kim (1996). Optimization of environmental factors for the production and handling of recombinant retrovirus. Applied Microbiology and Biotechnology, 45(4), 477-83.

Kim, S., S. S. Yu, and V. N. Kim (1996). Essential role of NF-kappa B in transactivation of the human immunodeficiency virus long terminal repeat by the human cytomegalovirus 1E1 protein. The Journal of General Virology, 77(1), 83-91.

1995

Choi, K. S., S. J. Kim, and S. Kim (1995). The retinoblastoma gene product negatively regulates transcriptional activation mediated by the human cytomegalovirus IE2 protein. Virology, 208(2), 450-6.

1994

Cannon, P., S. H. Kim, C. Ulich, and S. Kim (1994). Analysis of Tat function in human immunodeficiency virus type 1- infected low-level-expression cell lines U1 and ACH-2. Journal of Virology, 68(3), 1993-7.

1993

Cannon, P. M., D. G. Tenen, M. B. Feinberg, H. S. Shin, and S. Kim (1993). Human immunodeficiency virus-1 infection of the human promyelocytic cell line HL-60: high frequency of low-level infection and effect of subsequent cell differentiation. Blood, 81(2), 437-45.

1992

Luo, L., Y. Li, P. M. Cannon, S. Kim, and C. Y. Kang (1992). Chimeric gag-V3 virus-like particles of human immunodeficiency virus induce virus-neutralizing antibodies. Proceedings of the National Academy of Sciences of the United States of America, 89(21), 10527-31.

Golden, M. P., S. Kim, S. M. Hammer, E. A. Ladd, P. A. Schaffer, N. DeLuca, and M. A. Albrecht (1992). Activation of human immunodeficiency virus by herpes simplex virus. The Journal of Infectious Diseases, 166(3), 494-9.

Lee, A. H., K. J. Lee, S. Kim, and Y. C. Sung (1992). Transactivation of human immunodeficiency virus type 1 long terminal repeat-directed gene expression by the human foamy virus bel1 protein requires a specific DNA sequence. Journal of Virology, 66(5), 3236-40.

Park, S. H., Y. M. Bae, T. J. Kim, I. S. Ha, S. Kim, J. G. Chi, and S. K. Lee (1992). HLA-DR expression in human fetal thymocytes. Human Immunology, 33(4), 294-8.

1991

Sakaguchi, M., B. Zenzie-Gregory, J. E. Groopman, S. T. Smale, and S. Y. Kim (1991). Alternative pathway for induction of human immunodeficiency virus gene expression: involvement of the general transcription machinery. Journal of Virology, 65(10), 5448-56.

Harbison, M. A., S. Y. Kim, J. M. Gillis, and S. M. Hammer (1991). Effect of the calcium channel blocker verapamil on human immunodeficiency virus type 1 replication in lymphoid cells. The Journal of Infectious Diseases, 164(1), 53-60.

Klotman, M. E., S. Kim, A. Buchbinder, A. DeRossi, D. Baltimore, and F. Wong-Staal (1991). Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes. Proceedings of the National Academy of Sciences of the United States of America, 88(11), 5011-5.

Mellor, J., C. Midgely, A. J. Kingsman, S. M. Kingsman, and S. Kim (1991). Transcriptional activation by upstream activator sequences requires distinct interactions with downstream elements in the yeast TRP1 promoter. Molecular and General Genetics, 225(2), 217-24.

1990

Smith, J. S., S. Y. Kim, and M. J. Roth (1990). Analysis of long terminal repeat circle junctions of human immunodeficiency virus type 1.. Journal of Virology, 64(12), 6286-90.

Kim, S., K. Ikeuchi, J. Groopman, and D. Baltimore (1990). Factors affecting cellular tropism of human immunodeficiency virus. Journal of Virology, 64(11), 5600-4.

Ikeuchi, K., S. Kim, R. A. Byrn, S. R. Goldring, and J. E. Groopman (1990). Infection of nonlymphoid cells by human immunodeficiency virus type 1 or type 2. Journal of Virology, 64(9), 4226-31.

1989

Kim, S., K. Ikeuchi, R. Byrn, J. Groopman, and D. Baltimor (1989). Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1. Proceedings of the National Academy of Sciences of the United States of America, 86(23), 9544-8.

Kim, S. Y., R. Byrn, J. Groopman, and D. Baltimore (1989). Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expression. Journal of Virology, 63(9), 3708-13.

Kim, S., R. Byrn, J. Groopman, and D. Baltimore (1989). Timing of DNA and RNA synthesis during a one-step growth cycle of HIV. UCLA Symposia on Molecular and Cellular Biology, New Series, 119(), 109-120.

1988

Kim, S. Y., S. L. Ang, D. B. Bloch, K. D. Bloch, Y. Kawahara, C. Tolman, R. Lee, J. G. Seidman, and E. J. Neer (1988). Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines. Proceedings of the National Academy of Sciences of the United States of America, 85(12), 4153-7.

Kim, S. Y., J. Mellor, A. J. Kingsman, and S. M. Kingsman (1988). An AT rich region of dyad symmetry is a promoter element in the yeast TRP1 gene. Molecular and General Genetics, 211(3), 472-6.

Neer, E. J., S. Y. Kim, S. L. Ang, D. B. Bloch, K. D. Bloch, Y. Kawahara, C. Tolman, R. Lee, D. Logothetis, D. Kim, and et al. (1988). Functions of G-protein subunits. Cold Spring Harbor symposia on Quantitative Biology, 53(1), 241-6.

1987

Harrison, S. M., K. L. Gearing, S. Y. Kim, A. J. Kingsman, and S. M. Kingsman (1987). Multiple cis-active elements in the long control region of bovine papillomavirus type 1 (BPV-1). Nucleic Acids Research, 15(24), 10267-84.

1986

Ogden, J. E., C. Stanway, S. Kim, J. Mellor, A. J. Kingsman, and S. M. Kingsman (1986). Efficient expression of the Saccharomyces cerevisiae PGK gene depends on an upstream activation sequence but does not require TATA sequences. Molecular and Cellular Biology, 6(12), 4335-43.

Kim, S., J. Mellor, A. J. Kingsman, and S. M. Kingsman (1986). Multiple control elements in the TRP1 promoter of Saccharomyces cerevisiae. Molecluar and Cell Biology, 6(12), 4251-8.

Osley, M. A., J. Gould, S. Kim, M. Y. Kane, and L. Hereford (1986). Identification of sequences in a yeast histone promoter involved in periodic transcription. Cell, 45(4), 537-544.

0

KY Kang, C. Moon, JH Ju, S-H Kim, H-Y Kim, S-H Park and S. Kim (0). A double-blind, randomized, placebo-controlled exploratory clinical study to assess the efficacy, dose responses, and safety of PG201 in patients with osteoarthritis of the knee. Submitted for publication, (), .