Laboratory of Stress Response and Aging

Laboratory of Stress Response and Aging

Seoul National University
Laboratory of Stress Response and Aging

Laboratory of Stress Response and Aging

Seoul National University
Laboratory of Stress Response and Aging

Laboratory of Stress Response and Aging

Seoul National University

Publications+ more

(2021) Coordinate Regulation of the Senescent State by Selective Autophagy, Developmental Cell
(2021) Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Advances in Cancer Research
(2021) UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy, Nature Communications
(2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition), Autophagy
(2020) Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains, Nature Communications

Welcome to the
"Laboratory of Stress Response and Aging"

Coping with stress is essential for all organisms, and several stress responses have been evolved to maintain homeostasis. Autophagy and cellular senescence are critical as 1) they respond to many different types of stress and 2) they are closely involved in many human diseases including age-associated diseases, aging itself, and cancer. Our goal is to better understand autophagy and cellular senescence that may provide avenues of therapeutic intervention for the treatment of such devastating human diseases and have important implications for human health. Cellular senescence is a terminal program of growth arrest triggered by many stresses, and similar to apoptosis, it acts intrinsically as a tumor suppressive mechanism by limiting further proliferation of damaged cells. Furthermore, in contrast to apoptosis that mainlyacts cell-autonomously, cellular senescence can also function cell-nonautonomously to coordinate homeostasis responses;