노성훈

Roh, Soung-hun

Assistant Professor

노성훈

Assistant Professor

Roh, Soung-hun

노성훈
Research
Biochemistry Biophysics Molecular Biology

Molecular machines and their assemblies range 10-100 nm in size and perform extremely complex but critical actions within the cell. Cryo-Electron microscopy (Cryo-EM) has now overcome many biophysical hurdles and finally become a major strategy in structural biology. Our research focus is driven by a diverse spectrum of challenging biological topics and to explore functional mechanism of molecular machines by achieving high resolution structures.

Education/Career
Education
  • - 08/2010-04/2015 Ph.D. Baylor College of Medicine, USA, Biochemistry and Molecular Biology
  • - 03/2001-02/2003 M.S. Gwang-Ju Institute of Science and Technology (GIST), South Korea, Life Science.
  • - 02/2001-03/1994 B.S. Gyung-Book National University, South Korea, Microbiology
Career
  • - 2018-Present Assistant Professor, School of Biological Sciences, Seoul National University
  • - 2017-2018 Postdoctoral Research Fellow, Stanford University
  • - 2015-2017 Postdoctoral Associate, Baylor College of Medicine
  • - 2004-2009 LG life Science co. ltd
Publications
  1. Walsh RW Jr*., Roh SH*, Gharpure A, Morales-Perez CL, Hibbs RE. “Structural principles of distinct assemblies of the human α4β2 nicotinic receptor.” Nature 2018. doi:10.1038/s41586-018-0081-7. PMID:29720657
  2. Roh SH, Stam NJ, Hryc CF, Couoh-Cardel S, Pintilie G, Chiu W, Wilkens S. “The 3.5-Å Cryo-EM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase Vo Proton Channel.” Molecular Cell. 2018. S1097-2765(18)30104-7. PMID:29526695
  3. Roh SH, Hryc CF, Jeong HH, Fei X, Jakana J, Lorimer GH, Chiu W. “Subunit conformational variation within individual GroEL oligomers resolved by Cryo-EM.” Proceedings of the National Academy of Sciences of the United States of America. 2017; 114(31):8259-8264. PMID: 28710336
  4. Roh SH, Kasembeli MM, Galaz-Montoya JG, Chiu W, Tweardy DJ. “Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions.” Biophysical journal. 2016; 110(11):2377-2385. PMID: 27276256
  5. Roh SH, Kasembeli M, Galaz-Montoya JG, Trnka M, Lau WC, Burlingame A, Chiu W, Tweardy DJ. “Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO.” The Journal of biological chemistry. 2016; 291(9):4732-41. PMID: 26706127