노성훈

Roh, Soung-hun

Associate Professor

노성훈

Associate Professor

Roh, Soung-hun

노성훈
Research
Biochemistry Biophysics Molecular Biology

Molecular machines and their assemblies range 10-100 nm in size and perform extremely complex but critical actions within the cell. Cryo-Electron microscopy (Cryo-EM) has now overcome many biophysical hurdles and finally become a major strategy in structural biology. Our research focus is driven by a diverse spectrum of challenging biological topics and to explore functional mechanism of molecular machines by achieving high resolution structures.

Education/Career
Education
  • - 08/2010-04/2015 Ph.D. Baylor College of Medicine, USA, Biochemistry and Molecular Biology
  • - 03/2001-02/2003 M.S. Gwang-Ju Institute of Science and Technology (GIST), South Korea, Life Science.
  • - 02/2001-03/1994 B.S. Gyung-Book National University, South Korea, Microbiology
Career
  • - 2022-present Associate Professor, School of Biological Sciences, Seoul National University
  • - 2018-2022 Assistant Professor, School of Biological Sciences, Seoul National University
  • - 2017-2018 Postdoctoral Research Fellow, Stanford University
  • - 2015-2017 Postdoctoral Associate, Baylor College of Medicine
  • - 2004-2009 LG life Science co. ltd
Publications
  1. A structural vista of phosducin-like PhLP2A-chaperonin TRiC cooperation during the ATP-driven folding cycle, Junsun Park, Hyunmin Kim, Daniel Gestaut, Seyeon Lim, Alexander Leitner, Judith Frydman*, Soung-Hun Roh*, Nature Comm 2024
  2. Structure of the human DICER-pre-miRNA complex in a dicing state, Young-Yoon Lee, Hansol Lee, Haedong Kim, V.Narry Kim*, Soung-Hun Roh*, Nature 2023
  3. Structural visualization of the tubulin folding pathway directed by eukaryotic chaperonin TRiC, Daniel Gestaut, Yanyan Zhao, Junsun Park, Boxue Ma, Alexander Leitner, Miranda Collier, Grigore Pintilie, Soung-Hun Roh*, Wah Chiu*, Judith Frydman*, Cell 2023
  4. Structural insights into ClpP protease side exit pore-opening by a pH drop coupled with substrate hydrolysis, Leehyeon Kim, Byung‐Gil Lee, Minki Kim, Min Kyung Kim, Do Hoon Kwon, Hyunmin Kim, Heike Brötz‐Oesterhelt, Soung‐Hun Roh*, Hyun Kyu Song*, The EMBO journal, 2022
  5. CryoEM Structures of Reconstituted V-ATPase and Oxr1-bound V1 Reveal Novel Mechanism of Regulation; Khan MD, Lee S, Couoh-Cardel S, Oot RA, Kim H, Wilkens S, Roh SH. The EMBO journal 2022