이현숙

Lee, Hyunsook

Professor
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이현숙

Professor

Lee, Hyunsook

이현숙
Research
Cell Biology Developmental Biology Genetics Genomics Molecular Biology
Roles of the tumor suppressor BRCA2 in DNA repair and cell cycle control.
Regulation of mitosis and the development of chromosome instability in cancer (CIN)
Telomere maintenance and cancer susceptibility
Development and analyses of mouse and zebrafish models for CIN type cancer.
Education/Career/Awards
Education
  • - 2000.08-2002.09 Wellcome Trust Postdoctoral Fellowship (Wellcome Trust Prize Award); Prof. David Kimelman; Univ. of Washington, Seattle. Dept. of Biochemistry
  • - 2000.01-2000.08 Wellcome Trust Postdoctoral Fellowship (Wellcome Trust Prize Award); Prof. Frank McKeon; Harvard Medical School, Dept. of Cell Biology
  • - 1996.10-1999.11 Ph.D. : Cambridge University (MRC, Lab of Molecular Biology), UK
  • - 1990.03-1992.02 Master : Seoul National University
  • - 1986.03-1990.02 Bachelor : Ewha womans University
Career
  • - 2021.02-present Head of Research, Seoul National University
  • - 2021.02-present Member, Institution of Gifted Education, Ministry of Education, Republic of Korea
  • - 2021.02-present External Advisor, Science & Technology Policy Institute
  • - 2020.08–2021.02 Visiting Researcher, Samsung Advanced Institute of Technology (SAIT)
  • - 2020.08–2023 Director, Suh Kyeongbae Foundation (SURF)
  • - 2019.10–2021.01 Member, Seoul National University Senate
  • - 2017-present FEBS Journal Editorial Board
  • - 2014-present Science Director/Member, Knowledge Awakening On Stage foundation (KAOS)
  • - 2014-2017 Human Frontiers Science Fellowship, Postdoctoral Fellowship Review Board
  • - 2014.6-present Associate Dean, College of Natural Sciences, Seoul National University
  • - 2013.9-present Professor, School of Biological Sciences, College of Natural Sciences, Seoul National University
  • - 2011-2016 Recipient Advisor, POSCO TJ Park Prize
  • - 2009-2017 Grant Advisor, POSCO Science Fellowship
  • - 2008.8-2009.7 Vice President, Basic Nursery School, Seoul National University
  • - 2004-2013.8 Associate Professor, School of Biological Sciences, College of Natural Sciences, Seoul National University
  • - 2002-2003 Research Assistant Professor, Molecular Biological Sciences, Ewha Womans University
  • - 2000-2002 Wellcome Trust Fellow Harvard Medical School/Univ. of Washington, Seattle
  • - 1992-1995 Senior Researcher, MokAm Life Sciences Research Center
Publications
  1. Choi E, Park P, Lee H, Lee Y, Kang G, Lee J, Han W, Lee H, Noh N, Lekomtsev S, Lee H. (2012) BRCA2 fine-tunes the spindle assembly checkpoint through reinforcement of BubR1 acetylation. Developmental Cell, 22(2), 295-308
  2. Min J, Choi ES, Hwang K, Kim J, Sampath S, Venkitaraman AR, Lee H. (2012) BRCA2 is required for the maintenance of telomere homeostasis. J. Biol Chem. 287(7), 5091-5101
  3. Lee YK, Park, NH and Lee H (2012) Prognostic Value of Alternative Lengthening of Telomeres-Associated Biomarkers in Uterine Sarcoma and Uterine Carcinosarcoma. International Journal of Gynecological Cancer. 22(3), 434-441
  4. Jeong KH, Jeong JY, Lee HO, Choi E, Lee H (2010) Inhibition of Plk1 Induces Mitotic Infidelity and Embryonic Growth Defects in Developing Zebrafish Embryos. Dev. Biol. 345(1), 34-48
  5. Choi E, Choi H, Choi JY, Kim J, Lee H (2009) BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing in mitosis. EMBO J. 28: 2077-2089.
  6. Lee J, Sung K, Joo SY, Jeong J, Kim SK, Lee H (2022). Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis. Nature Communications. 13, 3396.
List