Professor
Lee, Junho
Research
Developmental Biology
Genetics
Genomics
Molecular Biology
Neurobiology
Our lab utilizes molecular genetics of Caenorhabditis elegans to investigate molecular mechanisms of unanswered bological phenomena at the organismic level.
The topics that we are interested in include:
The topics that we are interested in include:
● Biology of animal dispersal strategy: nictation behavior of nematodes
● Developmental plasticity of the nervous system as a wholein C. elegans
● Alternative lengthening of telomeres in the nematode and mouse embryonic stem cells/ chromosome evolution
● Korean nematode collection for studying phenotypic diversity and novelty in evolution
● Establsihment of a new Caenorahditis genetics model using a new Korean nematode species
● Hippo signaling and premature neuronal aging
● RFX isoforms and a subrouine regulatory module for specific ciliated neuron sets
● Biological significance of Htt (Huntingtin) in the nematode
● Developmental plasticity of the nervous system as a wholein C. elegans
● Alternative lengthening of telomeres in the nematode and mouse embryonic stem cells/ chromosome evolution
● Korean nematode collection for studying phenotypic diversity and novelty in evolution
● Establsihment of a new Caenorahditis genetics model using a new Korean nematode species
● Hippo signaling and premature neuronal aging
● RFX isoforms and a subrouine regulatory module for specific ciliated neuron sets
● Biological significance of Htt (Huntingtin) in the nematode
Education/Career
Education
- - 1989. 9 - 1994. 6 Ph.D., Division of Biology, California Institute of Technology
- - 1987 - 1989 M.S., Department of Microbiology, Seoul National University
- - 1980 - 1986 B.S., Department of Microbiology, Seoul National University
Career
- - 2018.6 - Present President, The Research Institute of Basic Sciences, National Alliance of Research institutes of Basic Sciences
- - 2018. 6 - 2022.6 Dean, College of Natural Sciences, Seoul National University
- - 2016. 8 - 2017. 4 Dean of Student Affairs, Seoul National University
- - 2014. 6 - 2016. 6 Associate Dean of Academic Affairs, College of Natural Sciences, Seoul National University
- - 2012. 4 - 2015. 3 Director of Institute of Molecular Biology and Genetics, Seoul National University
- - 2009. 10 - Present Professor, School of Biological Sciences, Seoul National University
- - 2007 - 2011 Director of Institute of Molecular Biology and Genetics, Seoul National University
- - 2004. 9 - 2009. 9 Associate Professor, School of Biological Sciences, Seoul National University
- - 1995 - 2004 Assistant Professor / Associate Professor, Department of Biology, Yonsei University
- - 1994 - 1995 Post-Doctoral Fellow, University of California, Berkeley
Publications
- Hyunji Lee, Hiroyuki Niida, Sanghyun Sung, Junho Lee (2024). Haplotype-resolved de novo assembly revealed unique characteristics of alternative lengthening of telomeres in mouse embryonic stem cells. Nucleic Acids Research
- Heeseung Yang, Daehan Lee, Heekyeong Kim, Daniel E. Cook, Young-Ki Paik, Erik C. Andersen, and Junho Lee (2024). Glial expression of a steroidogenic enzyme underlies natural variation in hitchhiking behavior. PNAS
- Hyunsoo Yim, Daniel T. Choe, J. Alexander Bae, Myung-kyu Choi, Hae-Mook Kang, Ken C. Q. Nguyen, Soungyub Ahn, Sang-kyu Bahn, Heeseung Yang, David H. Hall, Jinseop S. Kim & Junho Lee (2024). Comparative connectomics of dauer reveals developmental plasticity. Nature Communications
- Jiseon Lim, Wonjoo Kim, Jun Kim and Junho Lee (2023). Telomeric repeat evolution in the phylum Nematoda revealed by high-quality genome assemblies and subtelomere structures. Genome Research
- Daisy S Lim, Jun Kim, Wonjoo Kim, Nari Kim, Sang-Hee Lee, Daehan Lee, Junho Lee (2023). daf-42 is an evolutionarily young gene essential for dauer development in Caenorhabditis elegans. Genetics