Emeritus Professor
Lee, Byeong Jae
Research
Bioinformatics
Genetics
Genomics
Molecular Biology
1. Molecular mechanism of selenoproteins
● Functional study of selenoproteins in human and Drosophila using RNA interference
● Study of transcriptional mechanism and regulation metabolism by selenoproteins
2. Isolation and functional analysis of novel transcriptional factor
● Isolation of novel zinc finger transcription factors in Xenopus
● Functional study of zinc finger transcription factors in Xenopus
3. Development of biopharmaceutical peptides
● Isolation and design of new antimicrobial peptides
● Study on the relationship between the activity and physico-chemical characteristics of antimicrobial peptides
4. Bioinformatics
● Optimized design of antimicrobial peptides using computing algorithms
● Functional study of selenoproteins in human and Drosophila using RNA interference
● Study of transcriptional mechanism and regulation metabolism by selenoproteins
2. Isolation and functional analysis of novel transcriptional factor
● Isolation of novel zinc finger transcription factors in Xenopus
● Functional study of zinc finger transcription factors in Xenopus
3. Development of biopharmaceutical peptides
● Isolation and design of new antimicrobial peptides
● Study on the relationship between the activity and physico-chemical characteristics of antimicrobial peptides
4. Bioinformatics
● Optimized design of antimicrobial peptides using computing algorithms
Education/Career
Education
- - 1981.3 - 1986.2 Ph.D. : Microbiology, Seoul National University
- - 1979.3 - 1981.2 Master
- - 1974.3 - 1978.2 Bachelor
Career
- - 2008 - Present Chairman, Interdisciplinary program in Bioinforrnatics, Seoul Natinal University,
- - 2007 - 2008 Visiting Professor, National Institute of Health, USA,
- - 2005 - 2007 Director, Institute of Molecular Biology and Genetics, Seoul National University
- - 2001 - Present Professor, Department of Life Science, Seoul Natinal University,
- - 1995 - 2001 Associate Professor, Institute of Genetic Engineering, Seoul Natinal University,
- - 1991 - 1995 Asistance Professor, National Cancer Institute, NIH, Bethesda, Maryland U.S.A.
- - 1989 - 1991 Visiting Associate, Laboratory of Experimental Carcinogenesis
- - 1986 - 1989 Visiting Fellow, National Cancer Institute, NIH, Bethesda, Maryland U.S.A.
Publications
- (2016) Ryuta Tobe*, Bradley A. Carlson*, Jang Hoe Huh*, Nadia P. Castro, Xue-Ming Xu, Petra A. Tsuji, Sang-Goo Lee,Jeyoung Bang, Ji-Woon Na, Young-Yun Kong, Daniel Beaglehole, Eileen Southon, Harold Seifried, Lino Tessarollo, David S. Salomon, Ulrich Schweizer, Vadim N. Gladyshev, Dolph L. Hatfield and Byeong Jae Lee : Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals. Biochemical J. 473, 2141–2154
- (2015) Tobe R, Carlson BA, Tsuji PA, Lee BJ, Gladyshev VN, Hatfield DL, : Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy. Cancers (Basel).10;7(4):2262-76
- (2015) Bang J, Huh JH, Na JW, Lu Q, Carlson BA, Tobe R, Tsuji PA, Gladyshev VN, Hatfield DL, Lee BJ., : Cell Proliferation and Motility Are Inhibited by G1 Phase Arrest in 15-kDa Selenoprotein-Deficient Chang Liver Cells.. Mol Cells.;38(5):457-65
- (2015) Jeyoung Bang , Mihyun Jang , Jang Hoe Huh , Ji-Woon Na , Myoungsup Shim , Bradley A. Carlson , Ryuta Tobe , Petra A. Tsuji , Vadim N. Gladyshev , Dolph L. Hatfield , Byeong Jae Lee,: Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway.. Biochem. Biophys. Res. Commun., Jan; 456:884-890
- (2015) Regina B Flohe et al., Diversity of selenium functions in health and disease. CRC press / Chapter 4. p55-79
- (2013) Kim M, Chen Z, Shim MS, Lee MS, Kim JE, Kwon YE, Yoo TJ, Kim JY, Bang JY, Carlson BA, Seol JH, Hatfield DL, Lee BJ., SUMO Modification of NZFP Mediates Transcriptional Repression through TBP Binding. Molecules and Cells