황수석

Hwang, Soo Seok

Assistant Professor
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황수석

Assistant Professor

Hwang, Soo Seok

황수석
Research
Biochemistry Bioinformatics Cell Biology Immunology Molecular Biology
T 세포는 신체의 가장 강력한 면역 세포로 알려져 있으나, 삶의 대부분 활성이 억제된 ‘휴지 상태 (quiescence)’를 유지하여 과도한 면역반응을 일으키지 않습니다. 이처럼 T 세포의 휴지 기전 (T cell quiescence)은 면역 체계를 정교하게 운용하기 위해 진화적으로 보존된 핵심적인 현상으로 여겨지지만, 아직까지 많은 부분이 미지의 영역으로 남아있습니다.

본 연구실에서는 T 세포의 기능 및 원리를 ‘휴지기’의 관점에서 재해석하는 혁신적인 연구를 선도하고자 합니다. 이를 위해 면역학, 분자생물학, 세포생물학, 생물정보학 등 다양한 최신 연구기법을 이용하여 다면체적인 연구를 수행할 것입니다. 최종적으로 T 세포 작동의 새로운 법칙과 체계를 구축하고 이를 다양한 면역질환과 암치료에 응용하여 인류의 건강 증진에 기여하고자 합니다.
Education/Career
Education
  • - 2007.02 - 2013.08 Ph.D. in Life Science, Sogang University
  • - 2001.02 - 2007.02 B.S. in Life Science / Business Administration, Sogang University (double major)
Career
  • - 2023.09 - present Assistant Professor, School of Biological Sciences, Seoul National University
  • - 2021.03 - 2023.08 Assistant Professor, Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine
  • - 2020.01 - 2021.01 Associate Research Scientist, Department of Immunobiology, Yale University School of Medicine, U.S.
  • - 2015.01 - 2020.01 Post-doctoral Fellow, Department of Immunobiology, Yale University School of Medicine, U.S.
  • - 2013.11 - 2014.12 Research Professor, Department of Life Science, Sogang University, South Korea.
Publications
  1. Hwang SS*, Lim J*, et al. “mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence” Science  (2020) Mar 13;367(6483):1255-1260. (*co-first) – Faculty 1000 Recommended paper
  2. Jang SW*, Hwang SS*, et al. “Homeobox protein Hhex negatively regulates Treg cells by inhibiting Foxp3 expression and function”  PNAS  (2019) Dec;116(51):25790-25799.
  3. Hwang SS*, et al. “RHS6 coordinately regulates the Th2 cytokine genes by recruiting GATA3, SATB1, and IRF4”  Allergy  (2017) May;72(5):772-782
  4. Hwang SS, et al. “YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity”  Nature Communications  (2016) 7:10789
  5. Hwang SS, et al. "Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation"  PNAS  (2012) 110(1):276-81
  6. Koh BH*, Hwang SS*, et al. "Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma"  PNAS  (2010) 107(23):10614-9
List