김현아

Associate Professor

Joy Kim

김현아
Research
Biochemistry Cell Biology Molecular Biology

Our research goals are to elucidate the molecular mechanisms of membrane protein biogenesis, folding and assembly in eukaryotic cells. Some of the fundamental questions that we attempt to answer are:
1. How does the translocation machinery recognize and sort transmembrane segments into the membrane?
2. Which part(s)/subunit(s) of the translocation machinery mediates recognition and insertion of transmembrane segments?
3. How similar or different the molecular mechanism of membrane protein insertion is in different subcellular organelles?
We use Saccharomyces cerevisiae as a model organism, and yeast genetics, molecular and cell biology techniques.

Education/Career
Education
  • - 1996~2001 Ph.D.: Physiology and Biophysics SUNY Stony Brook, USA
  • - 1991~1995 Bachelor: Biochemistry UC Davis, USA
Career
  • - 2015.03.~ Associate Professor, School of Biological Sciences, Seoul National University
  • - 2009.03.~2015.02. Assistant Professor, School of Biological Sciences, Seoul National University
  • - 2006.01.~2009.02. Group leader, Center for Biomembrane Research
  • - 2001.12.~2005.12. Postdoctoral fellow, Stockholm University, Sweden
Publications
  1. Yim C, Chung Y, Kim J, Nilsson I, Kim JS, Kim H. Spc1 regulates the signal peptidase-mediated processing of membrane proteins. J Cell Sci. 2021 Jul 1;134(13):jcs258936. doi: 10.1242/jcs.258936. Epub 2021 Jul 9. PMID: 34125229; PMCID: PMC8277137.
  2. Jung SJ, Kim JEH, Junne T, Spiess M, Kim H. Cotranslational Targeting and Posttranslational Translocation can Cooperate in Spc3 Topogenesis. J Mol Biol. 2021 Sep 3;433(18):167109. doi: 10.1016/j.jmb.2021.167109. Epub 2021 Jun 18. PMID: 34153287.
  3. Lee S, Lee H, Yoo S, Ieva R, van der Laan M, von Heijne G, Kim H. The Mgr2 subunit of the TIM23 complex regulates membrane insertion of marginal stop-transfer signals in the mitochondrial inner membrane. FEBS Lett. 2020 Mar;594(6):1081-1087. doi: 10.1002/1873-3468.13692. Epub 2019 Dec 8. PMID: 31764998.
  4. Jung SJ, Jung Y, Kim H. Proper insertion and topogenesis of membrane proteins in the ER depend on Sec63. Biochim Biophys Acta Gen Subj. 2019 Sep;1863(9):1371-1380. doi: 10.1016/j.bbagen.2019.06.005. Epub 2019 Jun 10. PMID: 31195072.
  5. Yim C, Jung SJ, Kim JEH, Jung Y, Jeong SD, Kim H. Profiling of signal sequence characteristics and requirement of different translocation components. Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt A):1640-1648. doi: 10.1016/j.bbamcr.2018.08.018. Epub 2018 Aug 29. PMID: 30327205.