Shin, Hyeyoung
Our lab aims to understand the neural mechanisms of perception. Perception is an inference of the most likely objects given sensory evidence and prior expectations about the sensory world. Yet, much of sensory neuroscience has focused on how the brain faithfully represents incoming sensory information. Our research seeks to reconstrue the goal of perception as inference rather than faithful representation, and thereby reinterpret theories of neural coding at multiple levels; from psychology-level computations to circuit-level algorithm, down to the molecular and biophysical level implementation. In this vein, a specific question that we aim to elucidate concerns the spatiotemporal scale of corticocortical communication across the sensory hierarchy. To this end, we employ an interdisciplinary approach, primarily leveraging techniques from systems neuroscience (e.g., two-photon imaging, two-photon holographic optogenetics, extracellular electrophysiology) and computational neuroscience (e.g., machine learning decoding of neural population activity, network simulation).
Education
- - 2013.09 - 2020.05 Ph.D. in Neuroscience, Brown University
- - 2009.03 - 2013.02 B.S. in Biotechnology, Yonsei University
Career
- - 2023.03 - present Assistant Professor, Seoul National University
- - 2019.10 - 2023.02 Postdoctoral Scholar, University of California, Berkeley
- Shin H, Ogando MB, Abdeladim L, Durand S, Belski H, Cabasco H, Loefler H, Bawany A, Hardcastle B, Wilkes J, Nguyen K, Suarez L, Johnson T, Han W, Ouellette B, Grasso C, Swapp J, Ha V, Young A, Caldejon S, Williford A, Groblewski P, Olsen S, Kiselycznyk C, Lecoq J, Adesnik H. Recurrent pattern completion drives the neocortical representation of sensory inference. bioRxiv. 2023 https://doi.org/10.1101/2023.06.05.543698
- Shin H, Adesnik H. Functional Roles of Cortical Inhibitory Interneurons (chapter in book titled “The Cerebral Cortex and Thalamus” by Usrey WM and Sherman SM)
- Abdeladim L*, Shin H*, Jagadisan UK*, Ogando MB, Adesnik H. Probing inter-areal computations with a cellular resolution two-photon holographic mesoscope. bioRxiv. 2023 https://doi.org/10.1101/2023.03.02.530875, *equal contributions
- Shin H, Moore CI. Persistent Gamma Spiking in SI Nonsensory Fast Spiking Cells Predicts Perceptual Success. Neuron. 2019 https://doi.org/10.1016/j.neuron.2019.06.014
- Shin H, Law R, Tsutsui S, Moore CI, Jones SR. The rate of transient beta frequency events predicts behavior across tasks and species. eLife. 2017 https://doi.org/10.7554/eLife.29086.001