[초청강연] Loss of epigenetic information as a cause of mammalian aging - 유망과학자세미나

Abstract
Loss of epigenetic information as a cause of mammalian aging

Jae-Hyun Yang
Paul F. Glenn Center for the Biology of Aging Research, Department of Genetics – Blavatnik Institute,
Harvard Medical School, Boston, MA 02115, USA

All living things experience entropy, manifested as a loss of inherited genetic and epigenetic
information. In mammals, epigenetic information is also lost over time, but what causes it to be
lost and whether it is a cause or a consequence of aging is not known. Using a system called
“ICE” (Inducible Changes to the Epigenome), we find the act of faithful DNA repair advances
aging at physiological, cognitive, and molecular levels, including erosion of the epigenetic
landscape, cellular exdifferentiation, senescence, and advancement of the DNA methylation
clock, which can be reversed by OSK-mediated rejuvenation. These data support a model in
which a loss of epigenetic information is a cause of aging in mammals.