Date: 2009-04-06 11:00 ~ 12:00
Speaker: 이화여대 생명약학부 김완규 교수
Professor: 허원기
Location: 28동 101호
Abstract: Protein-protein interaction(PPI) plays a critical role in most cellular processes and serves as a scaffold in both structural &functional organization of living system. First, protein interfaces of known 3D structure are classified according to their binding orientations. Nearly 6000 distinct interface types are classified, revealing several interesting aspects of interface evolution including interaction diversity, specificity and domain-fusion. The resulting classification (SCOPPI: Structural Classification of Protein-Protein Interfaces) has been useful as a framework for various interface studies. Second, the global structure of PPI network shows interesting characteristics such as scale-freeness (or power-law degree distribution) and hierarchical modularity. The structures of such networks underlie important features of biological systems, such as functional modularity, error-tolerance, and stability. It is not yet known how these network architectures originate or what driving forces underlie the observed network structure. Currently preferred model - gene duplication &divergence or preferential attachment model - is based only on network topologies but is not compatible with the unique age-distribution patterns observed in real yeast PPI networks. An alternative model (crystal growth model) is proposed based on known physical principles, which explains better the process of protein network evolution. - CV - 2002 PhD University of Cambridge 1997 Ms 서울대학교 미생물학과 1995 Bs 서울대학교 미생물학과 2006-2009 Post-doc Institue of Systems &Synthetic Biology, University of Texas at Austin 2004-2006 Researcer, Biotec, Technical University of Dresden 2000-2002 LG생명과학
