1. Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs
The study proposed and experimentally validation two additional features, target abundance and seed pairing stability, to improve the accuracy of microRNA target prediction.
(Separating the effects of seed-pairing stability and target-abundance on miRNA targeting proficiency (Garcia et al. 2011))
2. Selective degradation of host microRNAs by an intergenic HCMV noncoding RNA accelerates virus production
The study described the effect of noncoding RNAs from Human cytomegalovirus on the host cell during infection.
(Predicted secondary structure of miRNA decay element (Lee et al. 2013))
3. TALEN-based knockout library for human microRNAs
The study developed and experimentally validated large-scale microRNA knock-out libraries using the TALEN technique.
(Cellular and molecular impact of miRNA K.O. (Kim et al. 2013))
4. mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues
The study performed comparative analysis of mRNA repression by microRNA targeting in transient and steady states.
(Principles of microRNA-mediated repression dynamics (Eichorn et al. 2014))
5. Temporal landscape of microRNA-mediated host-virus crosstalk during productive human cytomegalovirus Infection
The study constructed and analyzed transcriptome data on a time course after host cell infection with the Human cytomegalovirus to better understand the host-viral interaction during Human cytomegalovirus infection.
(Emergent property and functional landscape of sub-temporal human targetome of viral miRNAs (Kim et al. 2015))
6. The brain-enriched microRNA miR-9-3p regulates synaptic plasticity and memory
The study described the role of miR-9-3p on synaptic plasticity and memory in neurons.
(Evolutionary conserved miR-9-3p target sequence within Dmd 3’UTR, Sim et al. 2016)
References
1. Garcia, D. M., Baek, D., Shin, C., Bell, G. W., Grimson, A., & Bartel, D. P. Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs. Nature structural & molecular biology (2011).
2. Lee, S., Song, J., Kim, S., Kim, J., Hong, Y., Kim, Y., ... Baek, D. & Ahn, K. Selective degradation of host MicroRNAs by an intergenic HCMV noncoding RNA accelerates virus production. Cell host & microbe (2013).
3. Kim, Y. K., Wee, G., Park, J., Kim, J., Baek, D., Kim, J. S., & Kim, V. N. TALEN-based knockout library for human microRNAs. Nature structural & molecular biology (2013).
4. Eichhorn, S. W., Guo, H., McGeary, S. E., Rodriguez-Mias, R. A., Shin, C., Baek, D., ... & Bartel, D. P. mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues. Molecular cell (2014).
5. Kim, S., Seo, D., Kim, D., Hong, Y., Chang, H., Baek, D., ... & Ahn, K. Temporal landscape of microRNA-mediated host-virus crosstalk during productive human cytomegalovirus infection. Cell host & microbe (2015).
6. Sim, S. E., Lim, C. S., Kim, J. I., Seo, D., Chun, H., Yu, N. K., ... Baek, D., … & Kim, T. The Brain-enriched microRNA miR-9-3p regulates synaptic plasticity and memory. The Journal of Neuroscience (2016).