Seoul National University Biological Sciences Website

논문

Laboratory of Structural Biology

Acta Biomaterialia

Aiman Sadaf, Seonghoon Kim, Hyoung Eun Bae, Haoqing Wang, Andreas Nygaard, Yuki Uegaki, Yang Du, Chastine F. Munk, Satoshi Katsube, Hyun Sung Lee, Jungnam Bae, Chul Won Choi, Hee-Jung Choi, Bernadette Byrne, Samuel H. Gellman, Lan Guan, Claus J. Loland, Brian K. Kobilka, Pil Seok Chae (2021). Conformationally flexible core-bearing detergents with a hydrophobic or hydrophilic pendant: Effect of pendant polarity on detergent conformation and membrane protein stability. Acta Biomaterialia, 128(), 393-407.

Acta. Crystallogr. F Struct. Biol. Commun.

Kang H., Bang I., Weis W. I., Choi. H. J. (2016). Purification, crystallization and initial crystallographic analysis of the α-catenin homologue HMP-1 from Caenorhabditis elegans. Acta. Crystallogr. F Struct. Biol. Commun., F72(), 234-239.

Choi H.J., Weis W.I. (2015). Purification, crystallization and preliminary X-ray diffraction studies of the β-catenin homolog HMP-2 from Caenorhabditis elegans.. Acta. Crystallogr. F Struct. Biol. Commun., F71(), 272-276.

Biomaterials

Ju-Chan Park*, Jumee Kim*, Hyun-Ki Jang, Seung-Yeon Lee, Keun-Tae Kim, Eun-Ji Kwon, Seokwoo Park, Hyun Sik Lee, Hyewon Choi, Seung-Yeol Park, Hee-Jung Choi, Soon-Jung Park, Sung-Hwan Moon, Sangsu Bae, Hyuk-Jin Cha (2022). Multiple isogenic GNE-myopathy modeling with mutation specific phenotypes from human pluripotent stem cells by base editors. Biomaterials, 282(), .

Biomolecules & Therapeutics

Yejing Jeong., Jinuk Kim, Hee-Jung Choi, Ka Young Chung (2021). Conformational Dynamics of Sclerostin-LRP6 Complex Analyzed by HDX-MS. Biomolecules & Therapeutics, 29(5), 527-535.

Cell

Choi H. J., Kim S., Mukhopadhyay P., Cho S., Woo J., Storz G., Ryu S. E. (2010). Structural basis of the redox switch in the OxyR transcription factor. Cell, 105(1), 103-113.

Cell Reports

Soungyub Ahn, Heeseung Yang, Sangwon Son, Hyun Sik Lee, Dongjun Park, Hyunsoo Yim, Hee-Jung Choi, Peter Swoboda, Junho Lee (2022). The C. elegans regulatory factor X (RFX) DAF-19M module: A shift from general ciliogenesis to cell-specific ciliary and behavioral specialization. Cell Reports, 39(2), .

Chang Rok Kim, Taichi Noda, Hyunkyung Kim, Gibeom Kim, Seongwan Park, Yongwoo Na, Seiya Oura, Keisuke Shimada, Injin Bang, Jun-Yeong Ahn, Yong Ryoul Kim, Se Kyu Oh, Hee-Jung Choi, Jong-Seo Kim, Inkyung Jung, Ho Lee, Yuki Okada, Masahito Ikawa, Sung Hee Baek (2020). PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis. Cell Reports, 32(4), .

Cell Structure

Chu M. L., Ahn V. E., Choi H. J., Daniels D. L., Nusse R., Weis W. I. (2013). Structural Studies of Wnts and identification of an LRP6 binding site.. Cell Structure, 21(7), 1235–1242.

Communications Biology

Seung-Bum Ko, Emiko Mihara, Yedarm Park, Kyeonghwan Roh, Chanhee Kang, Junichi Takagi, Injin Bang & Hee-Jung Choi (2022). Functional role of the Frizzled linker domain in the Wnt signaling pathway. Communications Biology, 5(421), .

Dev. Cell

Choi H.J., Loveless T., Lynch A.M., Bang I., Hardin J., Weis W.I. (2015). A conserved phosphorylation switch controls the interaction between cadherin and β-catenin in vitro and in vivo.. Dev. Cell, 33(1), 82-93.

Ahn V. E., Chu M. L., Choi H. J., Tran D., Abo A., Weis W. I. (2011). Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. Dev. Cell, 21(5), 862-873.

EMBO Reports

Jeesoo Kim, Sooyoung Hong, Hajin Lee, Hyun Sik Lee, Chaehee Park, Jinuk Kim, Wonpil Im, Hee-Jung Choi (2025). Structural insights into the selective recognition of RF-amide peptides by neuropeptide FF receptor 2. EMBO Reports, 26(9), 2413 - 2434.

Genes & Development

Hyun Sik Lee*, Injin Bang*, Junghyun You, Tae-Kyeong Jeong, Chang Rok Kim, Minsang Hwang, Jong-Seo Kim, Sung Hee Baek, Ji-Joon Song, Hee-Jung Choi (2023). Molecular basis for PHF7-mediated ubiquitination of histone H3. Genes & Development, (), .

Genome Biology and Evolution

Hobum Song, Seonhong Kim, Daisy Sunghee Lim, Hee-Jung Choi, Junho Lee (2025). Robust Binding Capability and Occasional Gene Loss of Telomere-Binding Proteins Underlying Telomere Evolution in Nematoda. Genome Biology and Evolution, 17(5), .

J. Biol. Chem.

Shao X.*, Kang H.*, Loveless T., Lee G. R., Seok C., Weis W. I., Choi H. J., Hardin J. (2017). Structural and functional characterization of the α-catenin·β-catenin binding interface in Caenorhabditis elegans reveals conserved requirements for cell-cell adhesion in metazoans. J. Biol. Chem., 292(40), 16477-16490.

Kang H.*, Bang I.*, Jin K.S., Lee B., Lee J., Shao X., Heier J. A., Kwiatkowski A. V., Nelson W. J., Hardin J., Weis W. I., and Choi H. J. (2017). Structural and Functional Characterization of Caenorhabditis elegans α-Catenin Reveals Constitutive Binding to β-Catenin and F-actin. J. Biol. Chem., 292(17), 7077-7086.

Pokutta S., Choi H. J., Ahlsen G., Hansen S. D., Weis W. I. (2014). Structural and thermodynamic characterization of cadherin·β-catenin·α-catenin complex formation. J. Biol. Chem., 289(), 13589-13601.

Dimitrova Y. N., Li J., Lee Y. T., Rios-Esteves J., Friedman D. B., Choi H. J., Weis W. I., Wang C. Y., Chazin W. J. (2010). Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1. J. Biol. Chem., 285(18), 13507-13516.

Choi H. J., Huber A. H., Weis W. I. (2010). Thermodynamics of beta-catenin-ligand interactions. J. Biol. Chem., 281(2), 1027-1038.

Choi H. J., Gross J. C., Pokutta S., Weis W. I. (2010). Interactions of plakoglobin and beta-catenin with desmosomalcadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes. J. Biol. Chem., 284(46), 31776-31788.

J. Mol. Biol.

Choi H. J., Weis W. I. (2011). Crystal structure of a rigid four-spectrin-repeat fragment of the human desmoplakin plakin domain.. J. Mol. Biol., 409(5), 800-812.

Choi H. J., Weis W. I. (2010). Structure of the armadillo repeat domain of plakophilin 1. J. Mol. Biol., 346(1), 367-376.

Journal of Cell Science

Hyunjeong Yoo, Taehyun Kim, Sungjin Ryu, Donghee Ko, Jeesoo Kim, Hee-Jung Choi, Yongdae Shin, Kunsoo Rhee (2025). Enhancement of CEP215/CDK5RAP2 dynamics for spindle pole assembly during mitosis. Journal of Cell Science, (), .

Journal of Molecular Biology

Donghee Ko*, Jeesoo Kim*, Kunsoo Rhee, Hee-Jung Choi (2020). Identification of a structurally dynamic domain for oligomer formation in rootletin. Journal of Molecular Biology, 432(13), 3915-3932.

Mol. Cells

Bang I., Choi H.J. (2015). Structural features of β2 adrenergic receptor: crystal structures and beyond.. Mol. Cells, 38(2), 105-111.

Molecules and Cells

Sangwoo Ham, Hyojung Kim, Seojin Hwang, Hyunook Kang, Seung Pil Yun, Sangjune Kim, Donghoon Kim, Hyun Sook Kwon, Yun-Song Lee, MyoungLae Cho, Heung-Mook Shin, Hee-Jung Choi, Ka Young Chung, Han Seok Ko, Gum Hwa Lee, Yunjong Lee (2019). Cell-Based Screen Using Amyloid Mimic β23 Expression Identifies Peucedanocoumarin III as a Novel Inhibitor of α-Synuclein and Huntingtin Aggregates. Molecules and Cells, 42(6), 480-494.

Nat. Struct. Biol.

Choi H. J., Park-Snyder S., Pascoe L. T., Green K. J., Weis W. I. (2010). Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure. Nat. Struct. Biol., 9(8), 612-620..

Nature

Rosenbaum D. M., Zhang C., Lyons J. A., Holl R., Aragao D., Arlow D. H., Rasmussen S. G., Choi H. J., Devree B. T., Sunahara R. K., Chae P. S., Gellman S. H., Dror R. O., Shaw D. E., Weis W. I., Caffrey M., Gmeiner P., Kobilka B. K. (2011). Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature, 469(7329), 236-240.

Rasmussen S. G., Choi H. J., Fung J. J., Pardon E., Casarosa P., Chae P. S., Devree B. T., Rosenbaum D. M., Thian F. S., Kobilka T. S., Schnapp A., Konetzki I., Sunahara R. K., Gellman S. H., Pautsch A., Steyaert J., Weis W. I., Kobilka B. K. (2011). Structure of a nanobody-stabilized active state of the β2 adrenoceptor. Nature, 469(7329), 175-180.

Bokoch M. P., Zou Y., Rasmussen S. G., Liu C. W., Nygaard R., Rosenbaum D. M., Fung J. J., Choi H. J., Thian F. S., Kobilka T. S., Puglisi J. D., Weis W. I., Pardo L., Prosser R. S., Mueller L., & Kobilka B. K (2010). Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature, 463(), 108-112.

Rasmussen S. G., Choi H. J., Rosenbaum D. M., Kobilka T. S., Thian F. S., Edwards P. C., Burghammer M., Ratnala V. R., Sanishvili R., Fischetti R. F., Schertler G. F., Weis W. I., Kobilka B.K. (2010). Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature, 450(7168), 383-387.

Nature Chemical Biology

Hyun-Kyu Choi*, Hyunook Kang*, Chanwoo Lee*, Hyun Gyu Kim, Ben Phillips, Soohyung Park, Charlotte Tumescheit, Sang Ah Kim, Hansol Lee, Soung-Hun Roh, Heedeok Hong, Martin Steinegger, Wonpil Im, Elizabeth Miller, Hee-Jung Choi, Tae-Young Yoon (2022). Evolutionary balance between foldability and functionality of a glucose transporter. Nature Chemical Biology, (), .

Nature Communications

Andrea Accogli, Saurabh Shakya, Taewoo Yang, Christine Insinna, Soo Yeon Kim, David Bell, Kirill R. Butov, Mariasavina Severino, Marcello Niceta, Marcello Scala, Hyun Sik Lee, Taekyeong Yoo, Jimmy Stauffer, Huijie Zhao, Chiara Fiorillo, Marina Pedemonte, Maria C. Diana, Simona Baldassari, Viktoria Zakharova, … Hee-Jung Choi, Murim Choi, Marco Tartaglia, Phillippe Youkharibache, Jong-Hee Chae, Valeria Capra, Sung-Gyoo Park & Christopher J. Westlake (2024). Variants in the WDR44 WD40-repeat domain cause a spectrum of ciliopathy by impairing ciliogenesis initiation. Nature Communications, 15(1), 365.

Chulwon Choi*, Jungnam Bae*, Seonghan Kim, Seho Lee, Hyunook Kang, Jinuk Kim, Injin Bang, Kiheon Kim, Won-Ki Huh, Chaok Seok, Hahnbeom Park, Wonpil Im, Hee-Jung Choi (2023). Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family. Nature Communications, 14(8105), .

Chaehee Park*, Jinuk Kim*, Seung-Bum Ko, Yeol Kyo Choi, Hyeongseop Jeong, Hyeonuk Woo, Hyunook Kang, Injin Bang , Sang Ah Kim, Tae-Young Yoon, Chaok Seok, Wonpil Im, Hee-Jung Choi (2022). Structural basis of neuropeptide Y signaling through Y1 receptor. Nature Communications, 13(853), .

Jinuk Kim, Wonhee Han, Taeyong Park, Eun Jin Kim, Injin Bang, Hyun Sik Lee, Yejin Jeong, Kyeonghwan Roh, Jeesoo Kim, Jong-Seo Kim, Chanhee Kang, Chaok Seok, Jin-Kwan Han, Hee-Jung Choi (2020). Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains. Nature Communications, 11(5357), .

Nucleic Acids Research

Chaehee Park, Xu Zheng, Chan Yang Park, Jeesoo Kim, Seul Ki Lee, Hyuk Won, Jinhyuk Choi, Yang-Gyun Kim, Hee-Jung Choi (2020). Dual conformational recognition by Z-DNA binding protein is important for the B-Z transition process. Nucleic Acids Research, 48(22), 12957–12971.

Sungryong Oh, Kyungjin Boo, Jaebeom Kim, Seon Ah Baek, Yoon Jeon, Junghyun You, Ho Lee, Hee-Jung Choi, Daechan Park, Ji Min Lee, Sung Hee Baek (2020). The chromatin-binding protein PHF6 functions as an E3 ubiquitin ligase of H2BK120 via H2BK12Ac recognition for activation of trophectodermal genes. Nucleic Acids Research, 48(16), 9037–9052.

Orphanet journal of rare diseases

Soo Yeon Kim*, Saebom Ko*, Hyunook Kang, Man Jin Kim, Jangsup Moon, Byung Chan Lim, Ki Joong Kim, Murim Choi, Hee-Jung Choi, Jong-Hee Chae (2022). Fatal systemic disorder caused by biallelic variants in FARSA. Orphanet journal of rare diseases, 17(1), 306.

Plos One

Kang H., Weiss T. M., Bang I., Weis W. I., Choi. H. J. (2016). Structure of the Intermediate Filament-Binding Region of Desmoplakin. Plos One, 11(1), e0147641.

PNAS

Injin Bang, Hee Ryung Kim, Andrew H. Beaven, Jinuk Kim, Seung-Bum Ko, Gyu Rie Lee, Wei Kan, Hasup Lee, Wonpil Im, Chaok Seok, Ka Young Chung, Hee-Jung Choi (2018). Biophysical and functional characterization of Norrin signaling through Frizzled4. PNAS, 115(35), 8787-8792.

Choi H. J., Pokutta S., Cadwell G. W., Bobkov A. A., Bankston L. A., Liddington R. C., Weis W. I. (2012). αE-catenin is an autoinhibited molecule that coactivates vinculin. PNAS, 109(22), 8576–8581.

Kwiatkowski A. V., Maiden S. L., Pokutta S., Choi H. J., Benjamin J. M., Lynch A. M., Nelson W. J., Weis W. I., Hardin J. (2010). In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans. PNAS, 107(33), 14591-14596.

Science

Hyun-Kyu Choi*, Duyoung Min*, Hyunook Kang*, Min Ju Shon, Sang-Hyun Rah, Hak Chan Kim, Hawoong Jeong, Hee-Jung Choi, James U. Bowie, Tae-Young Yoon (2019). Watching helical membrane proteins fold reveals a common N-to-C-terminal folding pathway. Science, 366(6469), 1150-1156.

Cherezov V., Rosenbaum D. M., Hanson M. A., Rasmussen S. G., Thian F. S., Kobilka T. S., Choi H. J., Kuhn P., Weis W. I., Kobilka B. K., Stevens R. C. (2010). High-Resolution Crystal Structure of an Engineered Human 2-Adrenergic G Protein–Coupled Receptor. Science, 318(5854), 1258-1265.

Rosenbaum D. M., Cherezov V., Hanson M. A., Rasmussen S. G., Thian F. S., Kobilka T. S., Choi H. J., Yao X. J., Weis W. I., Stevens R. C., Kobilka B. K. (2010). GPCR Engineering Yields High-Resolution Structural Insights into 2 Adrenergic Receptor Function. Science, 318(), 1266-1273.

Structure

Hyunook Kang*, Chaehee Park*, Yeol Kyo Choi, Jungnam Bae, Sohee Kwon, Jinuk Kim, Chulwon Choi, Chaok Seok, Wonpil Im, Hee-Jung Choi (2023). Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling. Structure, 31(1), 44-57.e6.

Hyunook Kang, Han-Sol Yang, Ah Young Ki, Seung-Bum Ko, Kwon Woo Kim, Chang Yong Shim, Kiae Kim, Hee-Jung Choi, Ka Young Chung (2020). Conformational Dynamics and Functional Implications of Phosphorylated b-Arrestins. Structure, 28(3), 314-323.

The EMBO Journal

Jinuk Kim*, Saebom Ko*, Chulwon Choi, Jungnam Bae, Hyeonsung Byeon, Chaok Seok, and Hee-Jung Choi (2025). Structural insights into small-molecule agonist recognition and activation of complement receptor C3aR. The EMBO Journal, 44(10), 2803 - 2826.