박상현 Park, Sang-Hyun

분자생물학 생화학 세포생물학
1. Investigation of molecular functions of scaffold proteins in MAP kinase pathways to elucidate the mechanism by which cellular signaling networks are regulated.

2. Artificial rewiring of the flow of information in cellular signaling networks using synthetic scaffold proteins.
: "Pathway Engineering"

3. Specific and systematic disruption of designated protein-protein interactions to manipulate cellular signaling.
 : "Pathway Disruption"
  • - 1993.9-1999.12 박사 : University of Wisconsin-Madison, Biochemistry
  • - 1989.3-1992.2 석사: 서울대학교 화학과
  • - 1985.3-1989.2 학사: 서울대학교 화학과
  • - 2012.3-2024.2 부교수, 서울대학교 생명과학부
  • - 2004.9-2012.2 조교수, 서울대학교 생명과학부
  • - 2000.1-2004.8 post-doc, University of California at San Francisco
  • - 1993.9-1999.12 Assitant, University of Wisconsin-Madison, Biochemistry
  • - 1992.6-1993.6 조교, 서울대학교 기초과학공동연구원
  1. Recent Publication (click)
  2. Lee NY, Lee JW, Kang GY, Park SH, Kim KP. (2019). Quantification of the Dynamic Phosphorylation Process of ERK Using Stable Isotope Dilution Selective Reaction Monitoring Mass Spectrometry. Proteomics, 19(17), 1900086.
  3. Moon J*, Ha J*, Park SH. (2017). Identification of PTPN1 as a novel negative regulator of the JNK MAPK pathway using a synthetic screening for pathway-specific phosphatases. Sci Rep., 7(1), 12974.
  4. Choi MY, Park SH (2016). Adjustable under-expression of yeast mating pathway proteins in Saccharomyces cerevisiae using a programmed ribosomal frameshift. Appl Microbiol Biotechnol., 100(11), 4997-5005.
  5. Ryu J, Park SH (2015). Simple synthetic protein scaffolds can create adjustable artificial MAPK circuits in yeast and mammalian cells. Sci. Signal., 8(383).
  6. Kang JW*, Lee NY*, Cho KC, Lee MY, Choi DY, Park SH, Kim KP. (2015). Analysis of nitrated proteins in Saccharomyces cerevisiae involved in mating signal transduction. Proteomics, 15(2-3), 580-590.