Seoul National University Biological Sciences Website

Publications

Laboratory of Molecular and Cellular Genetics

Advances in Experimental Medicine and Biology

Lee, J.S., Choi, H.J., and Baek, S.H. (2017). Sumoylation and Its Contribution to Cancer. Advances in Experimental Medicine and Biology, 963(17), 283-298.

Annual Review of Physiology

Baek, S. H. and Kim, K. I. (2014). Emerging Roles of Orphan Nuclear Receptors in Cancer. Annual Review of Physiology, 76(19), 177-195.

Autophagy

Klionsky, D.J., Abdel-Aziz, A.K., Abel, S., Agnello, M., Agostinis, P., Aizawa, S., Auberger, P., Baek, S.H., Barreiro, E., Buch, S., Budini, M., Cai, Q., Czaja, M.J., Dagda, R.K., Demarchi, F., Dikic, I., Fimina, G.M., Gewirtz, D.A., Hawkins, W.D., Jackson W.T., Kwon, Y.T., Lahiri, V., Lane, J.D., Lei, Y., Li, M., Liang, C., Loos, B., Martina, J.A., Martins, J.O., Mauthe, M., Metur, S.P., Mysorekar, I.U., Nazarko, T.Y., etc. (2021). Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy. Autophagy, 17(1), doi:10.1080/15548627.2020.1797280.

Shin, H-J., Kim, H.K., Kim, K.I., and Baek, S.H. (2016). Epigenetic and Transcriptional Regulation of Autophagy. Autophagy, 12(11), 2248-2249.

BBA - Gene Regulatory Mechanisms

Kim, D.H., Nam, H.J.*, and Baek, S.H.* (* co-corresponding authors) (2023). Post-translational Modifications of Lysine-Specific Demethylase 1. BBA - Gene Regulatory Mechanisms, 1866(4), 194968.

BBA-Molecular Basis of Disease

Kim, J.H., and Baek, S.H. (2009). Emerging Roles of Desumoylting Enzymes. BBA-Molecular Basis of Disease, 1792(3), 155-162.

Biochem J.

Baek, S.H., Park, K.C., Kim, K.I., Yoo, Y.J., Tanaka, K., Baker, R.T., and Chung, C.H. (1998). A Novel Family of Ubiquitin-specific Proteases in Chick Skeletal Muscle with Distinct Amino- and Carboxyl-terminal Extensions. Biochem J., 334(3), 677-684.

Biochem. Biophys. Res. Comm.

Kim, J.M., Choi, S.A., Kim, J.B., Kim, H.K.*, and Baek, S.H.* (* co-corresponding authors) (2020). Lysine-specific demethylase 3A is important for autophagic occurrence. Biochem. Biophys. Res. Comm., 526(1), 176-183.

Boo, K.J., Baek, S.H., and Lee, H. (2014). Pontin is Required for pre-TCR Signaling at the b-selection Checkpoint in T Cell Development. Biochem. Biophys. Res. Comm., 447(1), 44-50.

Kim, I.S., Lee, M.K., Park, J.H., Jeon, R.O., Baek, S.H., and Kim, K.I. (2014). βTrCP-mediated Ubiquitylation Regulates Protein Stability of Mis18β in a Cell Cycle-dependent Manner. Biochem. Biophys. Res. Comm., 443(1), 62-67.

Kim, B.G., Nam, H.J., Pyo, K.E., Jang, M.J., Kim, I.S., Kim, D.H., Boo, K.J., Lee, S.H., Yoon, J.B., Baek, S.H., and Kim, J.H. (2011). Breast Cancer Metastasis Suppressor 1 (BRMS1) is Destabilized by the Cul3-SPOP E3 Ubiquitin Ligase Complex. Biochem. Biophys. Res. Comm., 415(4), 720-726.

Choi, H.J., Lee, J.M., Kim, H.K., Nam, H.J., Shin, H-J.R., Kim, D.H., Ko, E.Y., Noh, D.Y., Kim, K.I., Kim, J.H., and Baek, S.H. (2010). Bcl3-dependent Stabilization of CtBP1 is Crucial for the Inhibition of Apoptosis and Tumor Progression in Breast Cancer. Biochem. Biophys. Res. Comm., 400(3), 396-402.

Kim, I.S., and Baek, S.H. (2010). Mouse Models for Breast Cancer Metastasis. Biochem. Biophys. Res. Comm., 394(3), 443-447.

Kim, B.G., Boo, K.J., Lee, J.S., Kim, K.I., Kim, W.H., Cho, H.J., Kim, H.S., and Baek, S.H. (2010). Identification of the KAI1 Metastasis Suppressor Gene as a Hypoxia Target Gene. Biochem. Biophys. Res. Comm., 393(1), 179-184.

Hwang, E.J., Lee, J.M., Jeong, J., Park, J.H., Yang, Y., Lim, J.S., Kim, J.H., Baek, S.H., and Kim, K.I. (2009). SUMOylation of RORa Potentiates Transcriptional Activation Function. Biochem. Biophys. Res. Comm., 378(3), 513-517.

Baek, S.H., Rosenfeld, M.G. (2004). Nuclear Receptor Coregulators: Their Modification Codes and Regulatory Mechanism by Translocation. Biochem. Biophys. Res. Comm., 319(3), 707-714.

Biochem. Biophys. Res. Commun.

Chung, C.H. and Baek, S.H. (1999). Deubiquitinating Enzymes: Their Diversity and Emerging Roles. Biochem. Biophys. Res. Commun., 266(3), 633-640.

Baek, S.H., Yoo, Y.J., Tanaka, K., and Chung, C.H. (1999). Molecular Cloning of Chick Ubiquitin C-terminal Hydrolase-6 Which is Highly Homologous to Human UCH-L3: Its Unusual Tissue Distribution and Substrate Specificity. Biochem. Biophys. Res. Commun., 264(1), 235-240.

Biochem. J.

Kim, K.I., Woo, K.M., Seong, I.S., Lee, J.W., Baek, S.H., Kang, M.S., and Chung, C.H. (1998). Mutational Analysis of the Two ATP-binding Sites in ClpB, a Heat Shock Protein with Protein-activated ATPase Activity in Escherichia Coli. Biochem. J., 333(3), 671-676.

Baek, S.H., Woo, S.K., Lee, J.I., Yoo, Y.J., Cho, J.M., Kang, M.S., Tanaka, K., and Chung, C.H. (1997). A New Deubiquitinating Enzyme, Ubiquitin C-terminal Hydrolase-8 in Chick Skeletal Muscle. Biochem. J., 325(2), 325-330.

Biochimica et Biophysica Acta-Molecular Cell Research

Park, K.C., Park, J.H., Baek, S.H., and Kim, K.I. (2020). Pontin-deficiency causes senescence in fibroblast cells and epidermal keratinocytes but induces apoptosis in cancer cells. Biochimica et Biophysica Acta-Molecular Cell Research, 1867(9), 118740.

Biol. Proc. Online

Lee, J.I., Woo, S.K., Kim, K.I., Park, K.C., Baek, S.H., Yoo, Y.J., and Chung, C.H. (1998). A Method for Assaying Deubiquitinating Enzymes. Biol. Proc. Online, 1(), 92-99.

BMB Reports

Oh, C.Y., Jeong, J.Y., Oh, S.K., Baek, S.H., and Kim K.I. (2020). Inhibition of LSD1 phosphorylation alleviates colitis symptoms induced by dextran sulfate sodium. BMB Reports, 53(7), 385-390.

Baek, S.H.*, and Kim, K.I.* (*co-corresponding author) (2016). Regulation of HIF-1α Stability by Lysine Methylation. BMB Reports, 49(5), 245-246.

Cancer Biology & Therapy

Tandrasasmita, O.M., Lee, J.S., Baek, S.H., and Tjandrawinata, R.R. (2010). Induction of Cellular Apoptosis in Human Breast Cancer by DLBS1425, a Phaleria Macrocarpa Compound Extract, via Downregulation of PI3-kinase/AKT Pathway. Cancer Biology & Therapy, 10(8), 814-823.

Cancer Lett.

Lee, J.S., Kim, K.I., and Baek, S.H. (2008). Nuclear Recpetors and Coregulators in Inflammation and Cancer. Cancer Lett., 267(2), 189-196.

Cancer Letters

Jang, M.J., Baek, S.H., Kim, J.H. (2011). UCH-L1 Promotes Cancer Metastasis in Prostate Cancer Cells through EMT Induction. Cancer Letters, 302(2011), 128-135.

Cell cycle

Hur, J., Baek, S.H.*, and Kim, H-S.* (* Co-corresponding authors) (2016). KAI1(CD82)-DARC(CD234) Axis in the Stem Cell Niche. Cell cycle, 15(15), 1945-1947.

Baek, S.H. (2006). A Novel Link between SUMO Modification and Cancer Metastasis. Cell Cycle, 5(14), 1492-1495.

CELL DEATH AND DIFFERENTIATION

Yu, Y.S., Kim, H.K.*, Kim, K.I.*, and Baek, S.H.* (* co-corresponding authors) (2023). Epigenetic regulation of autophagy by chromatin-modifying enzymes under nutrient stress. CELL DEATH AND DIFFERENTIATION, (), doi:10.1038/s41418-023-01154-9.

Cell Reports

Kim, C.R., Noda, T., Kim, H.K., Kim, G.B. Park, S.W., Na, Y.W., Oura, S., Shimada, K., Bang, I.J., Ahn, J.Y., Kim, Y.R., Oh, S.K., Choi, H.J., Kim, J.S., Jung, I.K., Lee, H., Okada, Y., Ikawa, M.*, and Baek, S.H.* (* co-corresponding authors) (2020). PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis. Cell Reports, 32(4), doi:10.1016/j.celrep.2020.107950.

Pyo, K.E., Kim, C.R., Lee, M.K., Kim, J.-S., Kim, K.I.*, and Baek, S.H.* (* co-corresponding authors) (2018). ULK1 O-GlcNAcylation is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation. Cell Reports, 25(10), 2878-2890.

Cell Stem Cell

Hur, J., Choi, J-I., Lee, H., Nham, P., Kim, T-W., Chae, C-W., Yun, J-Y., Kang, J-A., Kang, J., Lee, S.E., Yoon, C-H., Boo, K., Ham, S., Roh, T-Y., Jun, J.K., Lee, H., Baek, S.H.*, and Kim, H-S.* (* Co-corresponding authors) (2016). CD82/KAI1 Maintains Dormancy of Long-term Hematopoietic Stem Cells through Interaction with DARC-expressing Macrophage. Cell Stem Cell, 18(4), 508-521.

Cell

Baek, S.H., Zhu, P., Bourk, E.M., Ohgi, K.A., Garcia-Bassets, I., Sanjo, H., Akira, S., Kotol, P.F., Glass, C.K., Rosenfeld, M.G., and Rose, D.W. (2006). Macrophage/Cancer Cell Interactions Mediate Hormone Resistance Through a Conserved Nuclear Receptor Derepression Pathway. Cell, 124(3), 615-629.

Baek, S.H., Kioussi, C., Briata, P., Rose, D.W., Hamblet, N.S., Herman, T., Ruiz-Lozano, P., Lin, C., Gleiberman, A., Wang, J., Wang, D., Glass, C. K., Wynshaw-Boris, A., and Rosenfeld, M.G. (2002). Identification of a Wnt/Dvl/ beta-catenin to Pitx2 Pathway Reveals Molecular Mechanisms for Mediating Cell Type-specifc Proliferation during Development. Cell, 111(5), 673-685.

Baek, S.H., Ohgi, K.A., Rose, D.W., Koo, E.H., Glass, C.K., and Rosenfeld, M.G. (2002). Exchange of N-CoR Corepressor and Tip60 Coactivator Complexes Links Gene Expression by NF-kB and beta-amyloid Precursor Protein. Cell, 110(1), 55-67.

ChemMedChem

Oh, S.M., Nam, H.J., Park, J.M., Baek, S.H.*, and Park, S.B.*(*co-correspondingauthor) (2010). Development of a Benzopyran-Containing Androgen Receptor Antagonist to Treat Antiandrogen-Resistant Prostate Cancer. ChemMedChem, 5(4), 529-533.

Clinical Cancer Research

Park, M.S., Kim, W.K., Song, M., Park, M.H., Kim, H.K., Nam, H.J., Baek, S.H., and Kim, H.G. (2013). Protein Kinase C-delta-mediated Recycling of Active KIT in Colon Cancer. Clinical Cancer Research, 19(18), 4961-4971.

Cold Spring Harbor Symp. Quant. Biol.

Kioussi, C., Briata, P., Baek, S.H., Wynshaw-Boris, A., Rose, D.W., and Rosenfeld, M.G. (2002). Pitx Genes During Cardiovascular Development. Cold Spring Harbor Symp. Quant. Biol., 67(), 81-87.

Current Biology

Das, A., Boese, K.G., Tachibana, K., Baek, S.H., Lampson, M.A., Black, B. (2023). Centromere-specifying nucleosomes persist in aging mouse oocytes in the absence of nascent assembly. Current Biology, 33(17), 3759-3765.

Current Opinion in Physiology

Nam, H.J., and Baek, S.H. (2019). Epigenetic Regulation of the Hypoxic Response. Current Opinion in Physiology, 7(), doi:10.1016/j.cophys.2018.11.007.

Developmental Cell

Ahn, J-Y.*, Kim, S.M.*, Kim, C.R., Lee, J-H., Kim, J.M., Klompstra, T.M., Choi, Y.H., Jeon, Y., Na, Y.W., Kim J-S., Okada, Y., Lee, H., Kim, I.S.#, Kim, J.K.#, Koo, B-K.#, and Baek, S.H.# (* co-first authors, # co-corresponding authors) (2024). Dual function of PHF16 in reinstating homeostasis murine intestinal epithelium after crypt regeneration. Developmental Cell, 59(), doi:10.1016/j.devcel.2024.08.009.

Baek, S.H. (2008). When ATPases Pontin and Reptin Met Telomerases. Developmental Cell, 14(4), 459-461.

EMBOJ.

Lee, Y., Kim, M., Han, J., Yeom, K.H., Lee, S., Baek, S.H., and Kim, V.N. (2004). MicroRNA Genes are Transcribed by RNA Polymerase II. EMBOJ., 23(20), 4051-4060.

Experimental and Molecular Medicine

Lee, J.M., Kim, H.K.*, and Baek, S.H.* (* co-corresponding authors) (2021). Unraveling the physiological roles of retinoic acid receptor-related orphan receptor α. Experimental and Molecular Medicine, 53(2021), 1278-1286.

FASEB JOURNAL

Dela Paz, NG., Nguyen, H.D., Baek, S.H., Leo, C., Simeonidis, S., Rosenfeld, M.G., Collins, T, Rose, D.W. (2002). Regulation of Cytokine Inducible Gene Expression by Corepressor Translocation. FASEB JOURNAL, 16(4), 167.

FEBS Letters

Han, S.Y., Lee, M.J., Hong, Y.K., Hwang, S.J., Choi, G.H., Suh, Y.S. Park, S.H., Lee, S.J., Lee, S.-H., Chung, J.K., Baek, S.H., Cho, K.S. (2012). Tsp66E, the Drosophila KAI1 Homologue, and Tsp74F Function to Regulate Ovarian Follicle Cell and Wing Development by Stabilizing Integrin Localization. FEBS Letters, 586(22), 4031-4037.

Frontiers in Molecular Biosciences

Matias, P.M., Baek, S.H., Bandeiras, T.M., Dutta, A., Houry, W.A., Llorca, O., Rosenbaum, J. (2015). The AAA+ Proteins Pontin and Reptin Enter Adult Age: From Understanding Their Basic Biology to the Identification of Selective Inhibitors. Frontiers in Molecular Biosciences, 2(17), doi:10.3389/fmolb.2015.00017.

Genes & Dev.

Dasen, J.S., Barbera, J.P., Herman, T.S., Connell, S.O., Olson, L., Ju, B., Tollkuhn, J., Baek, S.H., Rose, D.W., and Rosenfeld, M.G. (2001). Temporal Regulation of a Paired-like Homeodomain Repressor/TLE Corepressor Complex and a Related Activator is Required for Pituitary Organogenesis. Genes & Dev., 15(23), 3193-3207.

GENES & DEVELOPMENT

Lee, H.S.*, Bang, I.J.*, You, J.H., Jeong, T.-K., Kim, C.R., Hwang, M.S., Kim, J.-S., Baek, S.H., Song, J.-J., and Choi, H.-J.(* co-first authors) (2023). Molecular basis for PHF7-mediated ubiquitination of histone H3. GENES & DEVELOPMENT, 37(), 1-14.

Int Rev Cell Mol Biol.

Kim, K.I., and Baek, S.H. (2009). Chapter 7 Small Ubiquitin-like Modifiers in Cell Malignancy and Metastasis. Int Rev Cell Mol Biol., 273(), 265-311.

J Biol Chem.

Kang, S.H., Kim, G.R., Seong, M., Baek, S.H., Seol, J.H., Bang, O.S., Ovaa, H., Tatsumi, K., Komatsu, M., Tanaka, K., and Chung, C.H. (2007). Two Novel Ubiquitin-fold Modifier1(Ufm1)-specific Proteases, UfSP1 and UfSP2. J Biol Chem., 282(8), 5256-5262.

Choi, S.J., Chung, S.S., Rho, E.J., Lee, H.W., Lee, M.H., Choi, H.S., Seol, J.H., Baek, S.H., Bang, O.S., Chung, C.H. (2006). Negative Modulation of RXRalpha Transcriptional Activity by SUMO Modification and Its Reversal by SUMO-specific Protease SUSP1. J Biol Chem., 281(41), 30669-30677.

Kwon, J.E., La, M., Oh, K.H., Oh, Y.M., Kim, G.R., Seol, J.H., Baek, S.H., Chiba, T., Tanaka, K., Bang, O.S., Joe, C.O., and Chung, C.H. (2006). BTB Domain-containing Speckle-type POZ Protein (SPOP) Serves as an Adaptor of DAXX for Ubiquitination by Cul3-based Ubiquitin Ligase. J Biol Chem., 281(18), 12664-12672.

J. Biochem.

Kawakami, T., Suzuki, T., Baek, S.H., Chung, C.H., Ichiyama, A., Omata, M., and Tanaka, K. (1999). Isolation and Characterization of Cytosolic and Membrane-bound Deubiquitinating Enzymes from Bovine Brain. J. Biochem., 126(3), 612-623.

Woo, S.K., Baek, S.H., Lee, J.I., Yoo, Y.J., Cho, J.M., Kang, M.S., and Chung, C.H. (1997). Purification and Characterization of a New Ubiquitin C-terminal Hydrolase (UCH-1) with Isopeptidase Activity from Chick Skeletal Muscle. J. Biochem., 121(4), 684-689.

J. Biol. Chem.

Kim, K.I., Baek, S.H., Jeon, Y.J., Nishimori, S., Suzuki, T., Uchida, S., Shimbara, N., Saitoh, H., Tanaka, K., and Chung, C.H. (2000). A New SUMO-1- specific Protease, SUSP1, That is Highly Expressed in Reproductive Organs. J. Biol. Chem., 275(19), 14102-14106.

Baek, S.H., Choi, K.S., Yoo, Y.J., Cho, J.M., Baker, R.T., Tanaka, K., and Chung, C.H. (1997). Molecular Cloning of a Novel Ubiquitin-specific Protease, UBP41, with Isopeptidase Activity in Chick Skeletal Muscle. J. Biol. Chem., 272(41), 25560-25565.

Kim, K.I., Baek, S.H., Hong, Y.M., Kang, M.S., Ha, D.B., Goldberg, A.L., and Chung, C.H. (1995). Purification and Characterization of Protease Ci, a Cytoplasmic Insulin-degrading Protease in Escherichia Coli. J. Biol. Chem., 270(50), 29799-29805.

Seol, J.H., Baek, S.H., Kang, M.S., Ha, D.B., and Chung, C.H. (1995). Distinctive Roles of the Two ATP-binding Sites in ClpA, the ATPase Component of Protease Ti in Escherichia Coli. J. Biol. Chem., 270(14), 8087-8092.

J. Cell Physiol.

Kim, K.I., Baek, S.H., and Chung, C.H. (2002). The Versatile Protein Tag: SUMO: It’s Enzymology and Biological Function. J. Cell Physiol., 191(3), 257-268.

Jounal of Immunology

Yim, H.Y., Park, C.K., Lee, Y.D., Arimoto, K-I., Jeon, R., Baek, S.H., Zhang, D-E., Kim, H-H., and Kim, K.I. (2016). Elevated Response to Type I IFN Enhances RANKL-Mediated Osteoclastogenesis in Usp18-Knockout Mice. Jounal of Immunology, 196(9), 3887-3895.

Journal of Biomedical Science

Kim, D.H., Kim, K.I.*, and Baek, S.H.* (* co-corresponding authors) (2021). Roles of Lysine-Specific Demethylase 1 (LSD1) in Homeostasis and Diseases. Journal of Biomedical Science, 28(41), doi:10.1186/s12929-021-00737-3.

Journal of Hematology & Oncology

Lee, J.-W., Hur, J., Kwon, Y.-W., Chae, C.-W., Choi, J.-I., Hwang, I.J., Yun J.-Y., Kang, J.-A., Choi, Y.-E., Kim, Y.H., Lee, S.E., Lee, C.,Jo, D.H., Seok, H.Y., Cho, B.S., Baek, S.H., Kim, H.-S. (2021). KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state. Journal of Hematology & Oncology, 14(148), doi: 10.1186/s13045-021-01147-6.

Journal of Investigative Dermatology

Park, K.C., Lee, M.K., Jeon, Y., Jeon, R., Baek, S.H., Lee, H., and Kim, K.I. (2017). Skin-Specific Deletion of Mis18α Impedes Proliferation and Stratification of Epidermal Keratinocytes. Journal of Investigative Dermatology, 137(2), 414–421.

Journal of Molecular Cell Biology

Shin, D.K., Kim, I.S., Lee, J.M., Shin, S.Y., Lee, J.H., Baek, S.H., and Cho, K.H. (2014). The Hidden Switches Underlying RORα-mediated Circuits that Critically Regulate Uncontrolled Cell Proliferation. Journal of Molecular Cell Biology, 6(4), 338-348.

Journal of the national academy of sciences republic of korea

Baek, S.H. (2020). Epigenetic Regulation of Autophagy. Journal of the national academy of sciences republic of korea, 59(2), 503-516.

Journal of Viral Hepatitis

Lee, H.S., Lim, Y.S., Park, E.M., Baek, S.H., and Hwang, S.B. (2014). SUMOylation of Nonstructural 5A Protein Regulates Hepatitis C Virus Replication. Journal of Viral Hepatitis, 21(10), 108-117.

Korean J. Biol. Sci.

Woo, S.K., Baek, S.H., Shin, D.H., Kim, H.S., Yoo, Y.J., Cho, J.M., Kang, M.S., and Chung, C.H. (1997). A Novel Ubiquitin C-terminal Hydrolase (UCH-9) from Chick Skeletal Muscle: It's Purification and Characterization. Korean J. Biol. Sci., 1(2), 323-328.

Mol. Biol. Cell

Jeon, Y.J., Choi, J.S., Lee, J.Y., Yu, K.R., Ka, S.H., Cho, Y., Choi, E.-J., Baek, S.H., Seol, J.H., Park, D., Bang, O.S., and Chung, C.H. (2008). Filamin B Serves as a Molecular Scaffold for Type I Interferon-induced JNK Signaling Pathway. Mol. Biol. Cell, 19(12), 5116-5130.

Mol. Cell Biol.

Wagner, B.L., Balledor, A.F., Shao, G., Daige, C.L., Bischoff, E.D., Petrowski, M., Jepsen, K., Baek, S.H., Heyman, R.A., Rosenfeld, M.G., Schulman, I.G., and Glass, C.K. (2003). Promoter-specific Roles for Liver X Receptor/Corepressor Complexes in the Regulation of ABCA1 and SREBP1 Gene Expression. Mol. Cell Biol., 23(16), 5780-5789.

Molecular Brain

Choi, J.H., Yu, N.K., Baek, G.C., Bakes, J., Seo, D., Nam, H.J., Baek, S.H., Lim, C.S., Lee, Y.S., and Kaang, B.K. (2014). Optimization of AAV Expression Cassettes to Improve Packaging Capacity and Transgene Expression in Neurons. Molecular Brain, 7(17), doi:10.1186/1756-6606-7-17.

Yu, N-K., Baek, S.H., and Kaang, B-K. (2011). DNA Methylation-mediated Control of Learning and Memory. Molecular Brain, 4(5), 1-9.

Molecular Cell

Kim, D.H., Nam, H.j., Lee, W.H., Yim, H.Y., Ahn, J.-Y., Park, S.W., Shin, H.J., Yu, R., Won, K.-J., Bae, J.-S., Kim, K.I.*, and Baek, S.H.* (* co-corresponding authors) (2018). PKCα-LSD1-NF-κB Signaling Cascade is Crucial for Epigenetic Control of the Inflammatory Response. Molecular Cell, 69(3), 398-411.

Baek, S.H., and Kim, K.I. (2017). Epigenetic Control of Autophagy: Nuclear Events Gain More Attention. Molecular Cell, 65(5), 781–785.

Yoo, H.M., Kang, S.H., Kim, J.Y., Lee, J.E., Seong, M.W., Lee, S.W., Ka, S.H., Sou, Y.S., Komatsu, M., Tanaka, K., Lee, S.T., Noh, D.Y., Baek, S.H., Jeon, Y.J., and Chung, C.H. (2014). Modification of ASC1 by UFM1 is Crucial for ERa Transactivation and Breast Cancer Development. Molecular Cell, 56(2), 261-274.

Kim, I.S., Lee, M.K., Park, K.C., Jeon, Y., Park, J.H., Hwang, E.J., Jeon, T.I., Ko, S.Y., Lee, H., Baek, S.H.*, and Kim, K.I.* (*co-correspondingauthor) (2012). Roles of Mis18a in Epigenetic Regulation of Centromeric Chromatin and CENP-A Loading. Molecular Cell, 46(3), 260-273.

Baek, S.H. (2011). When Signaling Kinases Meet Histones and Histone Modifiers in the Nucleus. Molecular Cell, 42(3), 274-284.

Kim, K.I., and Baek, S.H. (2006). SUMOylation Code in Cancer Development and Metastasis. Molecular Cell, 22(3), 247-253.

Molecular Cell (Molecular Cell Cover)

Nam, H.J., Boo, K.J., Kim, D.H., Han, D.H., Choe, H.K., Kim, C.R., Sun, W., Kim, H., Kim, K.J., Lee, H., Metzger, E., Schuele, R., Yoo, S.H., Takahashi, J.S., Cho, S.H., Son, G.H., and Baek, S.H. (2014). Phosphorylation of LSD1 by PKCα is Crucial for Circadian Rhythmicity and Phase Resetting. Molecular Cell (Molecular Cell Cover) , 53(5), 791-805.

Lee, J.M., Lee, J.S., Kim, H.K., Kim, K.K., Park, H.J., Kim, J.-Y., Lee, S.H., Kim, I.S., Kim, J.M., Lee, M.K., Chung, C.H., Seo, S.-B., Yoon, J.-B., Ko, E.Y., Noh, D.-Y., Kim, K.I., Kim, K.K., and Baek, S.H. (2012). EZH2 Generates a Methyl Degron That is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex. Molecular Cell (Molecular Cell Cover) , 48(4), 572-586.

Kim, H.K., Lee, J.M., Lee, G.N., Bhin, J.H., Oh, S.K., Kim, K.K., Pyo, K.E., Lee, J.S., Yim, H.Y., Kim, K.I., Hwang, D.H., Chung, J.K.,and Baek, S.H. (2011). DNA Damage-Induced RORa is Crucial for p53 Stabilization and Increased Apoptosis. Molecular Cell (Molecular Cell Cover) , 44(5), 797-810.

Lee, J.S., Kim, Y., Kim, I.S., Kim, B., Choi, H.J., Lee, J.M., Shin, H-J.R., Kim, J.H., Kim, J.-Y., Seo, S.-B., Lee, H., Binda, O., Gozani, O., Semenza, G.L., Kim, M., Kim, K.I., Hwang, D.H., and Baek, S.H. (2010). Negative Regulation of Hypoxic Responses via Induced Reptin Methylation. Molecular Cell (Molecular Cell Cover) , 39(1), 71-85.

Molecular Cell (Top Ranking 2nd)

Lee, J.M., Kim, I.S., Kim, H.K., Lee, J.S., Kim, K.K., Yim, H.Y., Jeong, J.Y., Kim, J.H., Kim, J.Y., Lee, H.N., Seo, S.B., Kim, H.G., Rosenfeld, M., Kim, K.I., and Baek, S.H. (2010). ROR alpha Attenuates Wnt/beta-Catenin Signaling by PKC alpha-Dependent Phosphorylation in Colon Cancer. Molecular Cell (Top Ranking 2nd) , 37(2), 183-195.

Nature Cancer

Baek, S. H. (2023). Proteogenomic analysis of human pancreatic ductal adenocarcinoma. Nature Cancer, 4(2), 163-164.

Hyeon, D.Y.*, Nam, D.W.*, Han, Y.M.*, Kim, D.K.*, Kim, G.B.*, Kim, D.E.*, Bae, J.G., Back, S.H., Mun, D.-G., Madar, I.H., Lee, H.G.R., Kim, S.-J., Kim, H.K., Hyun, S.Y., Kim, C.R., Choi, S.A., Kim, Y.R., Jeong, J.H., Jeon, S.W., Choo, Y.W., Lee, K.B., Kwon, W.I., Choi, S.H., Goo, T.W., Park, T.S., Suh, Y.-A., Kim, H.B., Ku, J.-L., Kim, M.-S., Paek, E.O., Park, D.C.#, Jung, K.H.#, Baek, S.H.#, Jang, J.-Y.#, Hwang, D.H.#, and Lee, S.-W.# (* co-first authors, # co-corresponding authors) (2022). Proteogenomic landscape of human pancreatic ductal adenocarcinoma in an Asian population reveals tumor cell-enriched and immune-rich subtypes. Nature Cancer, 4(2), 290-307.

Nature Cell Biol.

Lee, M.H., Lee, E.J., Choi, S.J., Lee, S.W., Chung, S.S., Seol, J.H., Baek, S.H., Kim, K.I., Chiba, T., Tanaka, K., Bang, O.S., and Chung, C.H. (2006). SUMO-Specific Protease SUSP4 Positively Regulates p53 Tumor Suppressor by Promoting Self-Ubiquitination of Mdm2. Nature Cell Biol., 8(12), 1424-1431.

Kim, J.H., Choi, H.J., Kim, B., Kim, M.H., Lee, J.M., Kim, I.S., Lee, M.H., Choi, S.J., Kim, K.I., Kim, S.-I., Chung, C.H., and Baek, S.H. (2006). Roles of SUMOylation of a Reptin Chromatin Remodeling Complex in Cancer Metastasis. Nature Cell Biol., 8(6), 631-639.

Nature Cell Biology

Ignacio Sancho-Martinez, Sung Hee Baek and Juan Carlos Izpisua Belmonte (2012). Lineage Conversion Methodologies Meet the Reprogramming Toolbox. Nature Cell Biology, 14(9), 892-899.

Nature Communications

Kim, J.B.*, Yu, Y.S.*, Choi, Y.H., Lee, D.H., Han, S.B., Kwon, J.H., Noda, T., Ikawa, M., Kim, D.H., Kim H.K., Ballabio, A., Kim, K.I.#, and Baek, S.H.# (* co-first authors, # co-corresponding authors) (2024). USF2 and TFEB compete in regulating lysosomal and autophagy genes. Nature Communications, 15(8334), doi.org/10.1038/s41467-024-52600-2.

Kim, Y.R.*, Joo, J.G.*, Lee, H.J., Kim, C.L., Park, J.-C., Yu, Y.S., Kim, C.R., Lee, D.H., Cha, J.W., Kwon, H.M., Hanssen, K.M., Grünewald, T.G.P., Choi, M.R., Han, I.K., Baek, S.S., Jung, I.K.#, Shin, Y.D.#, and Baek, S.H.# (* co-first authors, # co-corresponding authors) (2024). Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing’s sarcoma. Nature Communications, 15(6569), doi:10.1038/s41467-024-51050-0.

Lee, S.M.‡, Kim,H.K.‡, Kim, B.S.‡, Chae, S.H.‡, Lee, J.S., Jung S.M., Yu, J., Son, K.M., Chung, M.H., Kim, J.K.*, Hwang, D.H.*, Baek, S.H.*, and Jeon, N.L.* (‡ co-first authors, * co-corresponding authors) (2024). Angiogenesis-on-a-chip coupled with single-cell RNA sequencing reveals spatially differential activations of autophagy along angiogenic sprouts. Nature Communications, 15(230), doi:10.1038/s41467-023-44427-0.

Lee, J.M., Hammarén, H.M., Savitski, M.M., and Baek, S.H. (2023). Control of Protein Stability by Post-translational Modifications. Nature Communications, 14(201), doi:10.1038/s41467-023-35795-8.

Yu, Y.S., Shin, H.R., Kim, D.H., Baek, S.A., Choi, S.A., Ahn, H.J., Shamim, A., Kim, J.H., Kim, I.S., Kim, K.K., Won, K.-J., and Baek, S.H. (2020). Pontin Arginine Methylation by CARM1 Is Crucial for Epigenetic Regulation of Autophagy. Nature Communications, 11(6297), doi:10.1038/s41467-020-20080-9.

Kim, K.K., Boo, K.J., Yu, Y.S., Oh, S.K., Kim, H.K., Jeon, Y., Bhin, J.H., Hwang, D.H., Kim, K.I., Lee, J.-S., Im, S.-S., Yoon, S.G., Kim, I.Y., Seong, J.K., Lee, H., Fang, S.S.*, and Baek, S.H.* (* co-corresponding authors) (2017). RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network. Nature Communications, 8(162), doi:10.1038/s41467-017-00215-1.

Kim, Y., Nam, H.J., Lee, J., Park, D.Y., Kim, C., Yu, Y.S., Kim, D., Park S.W., Bhin, J., Hwang, D., Lee, H., Koh, G.Y., and Baek, S.H. (2015). Methylation-dependent Regulation of HIF-1alpha Stability Restricts Retinal and Tumor Angiogenesis. Nature Communications, 7(10347), doi:10.1038/ncomms10347.

Boo, K.J., Bhin, J.H., Jeon, Y., Kim, J.M., Shin, H.J., Park, J.E., Kim, K.K., Kim, C.R., Jang, H.C., Kim, I.H., Kim, V.N., Hwang, D.H., Lee, H., and Baek, S.H. (2015). Pontin Functions As an Essential Coactivator for Oct4-Dependent LincRNA Expression in Mouse Embryonic Stem Cells. Nature Communications, 6(6810), doi:10.1038/ncomms7810..

Nature Medicine

Chen, C.D., Welsbie, D.S., Tran, C., Baek, S.H., Chen, R., Vessella, R., Rosenfeld, M.G., and Sawyers, C.L. (2004). Molecular Determinants of Resistance to Antiandrogen Therapy. Nature Medicine, 10(1), 33-39.

Nature Protocols

Kim, J.H., Kim, K.I., and Baek, S.H. (2006). SUMOylation and DeSUMOylation Assays for a Chromatin Remodeling Complex invivo and invitro. Nature Protocols, 2006(), doi:10.1038/nprot.2006.369.

Nature

Shin, H-J., Kim, H.K., Oh, S.R., Lee, J-G., Kee, M.J., Ko, H-J., Kweon, M-N., Won, K.J., and Baek, S.H. (2016). AMPK-Skp2-CARM1 Signaling Cascade in Transcriptional Regulation of Autophagy. Nature, 534(7608), 553–557.

Kim, J.H., Kim, B., Ling, C., Choi, H.J., Ohgi, K.A., Chen, C., Chung, C.H., Huber, O., Rose, D.W., Sawyers, C.L, Rosenfeld, M.G., and Baek, S.H. (2005). Transcriptional Regulation of a Metastasis Suppressor Gene by Tip60 and β-Catenin Complexes. Nature, 434(7035), 921-926.

Neurobiology of Learning and Memory

Ko, H.-G., Kim, J.-I., Sim, S.-E., Kim, T.H., Yoo, J.Y., Choi, S.-L., Baek, S.H., Yu, W.-J., Yoon, J.-B., Sacktor, T.C., Kaang, B.-K. (2016). The Role of Nuclear PKMζ in Memory Maintenance. Neurobiology of Learning and Memory, 135(2016), 50-56.

Neuron

Gold , D.A., Baek, S.H., Schork, N.J., Rose, D.W., Larsen, D.D., Sachs, B.D., Rosenfeld, M.G., and Hamilton, B.A. (2003). RORalpha Coordinates Reciprocal Signaling in Cerebellar Development through Sonic Hedgehog and Caldium-dependent Pathways. Neuron, 40(6), 1119-1131.

Neuropharmacology

Lim, C.-S., Kim, H., Yu, N.-K., Kang, S.J., Kim, T., Ko, H.-G., Lee, J., Yang, J.-e., Ryu, H.-H., Park, T., Gim, J., Nam, H.J., Baek, S.H., Wegener, S., Schmitz, D., Boeckers, T.M., Lee, M.G., Kim, E., Lee, J.-H., Lee, Y.-S., Kaang, B.-K. (2016). Enhancing Inhibitory Synaptic Function Reverses Spatial Memory Deficits in Shank2 Mutant Mice. Neuropharmacology, 112(2017), 104-112.

Nucleic Acids Research

Park, S.W., Kim, J.H., Oh, S.R., Lee, J.Y., Cha, J.W., Lee, H.S., Kim, K.I., Park, D.C.*, and Baek, S.H.* (* co-corresponding authors) (2022). PHF20 Is Crucial for Epigenetic Control of Starvation-Induced Autophagy through Enhancer Activation. Nucleic Acids Research, 50(14), 7856-7872.

Kim, D.H., Kim, J.I., Yu, Y.S., Kim, Y.R., Baek, S.H.* and Won, K.-J.* (* co-corresponding authors) (2022). Systemic approaches using single cell transcriptome reveal that C/EBP γ regulates autophagy under amino acid starved condition. Nucleic Acids Research, 50(13), 7298–7309.

Oh, S.R., Boo, K.J., Kim, J.B., Baek, S.A., Jeon, Y., You J.H., Lee, H., Choi, H.J., Park, D.C.*, Lee, J.M.*, and Baek, S.H.* (* co-corresponding authors) (2020). The chromatin-binding protein PHF6 functions as an E3 ubiquitin ligase of H2BK120 via H2BK12Ac recognition for activation of trophectodermal genes. Nucleic Acids Research, 48(16), 9037–9052.

Proc. Natl. Acad. Sci. USA

Oh, S.K., Kim, D.H., Kim, K.K., Boo, K.J., Yu, Y.S., Kim, I.S., Jeon, Y., Lee, H., Im, S.-K., Lee, S.-H., Lee, J.M., Ko, Y.H., Park, D.C.*, Fang, S.S.*, and Baek, S.H.* (* co-corresponding authors) (2019). RORα Is Crucial for Attenuated Inflammatory Response to Maintain Intestinal Homeostasis. Proc. Natl. Acad. Sci. USA, 116(42), 21140-21149.

Kim, H.K., Kim, D.H., Choi, S.A., Kim, C.R., Oh, S.K., Pyo, K.E., Kim, J.M., Lee, S.H., Yoon, J.-B., Zhang, Y., and Baek, S.H. (2018). KDM3A Histone Demethylase Functions as an Essential Factor for Activation of JAK2-STAT3. Proc. Natl. Acad. Sci. USA, 115(46), 11766-11771.

Lee, J.S., Kim, Y., Bhin, J., Shin,H-J.R., Nam, H.J., Lee, S.H., Yoon, J.-B., Binda, O., Gozani, O., Hwang, D.H.,and Baek, S.H. (2011). Hypoxia-Induced Methylation of a Pontin Chromatin Remodelling Factor. Proc. Natl. Acad. Sci. USA, 108(33), 13510-13515.

Kim, J.H., Lee, J.M., Nam, H.J., Choi, H.J., Yang, J.W., Lee, J.S., Kim, M.H., Kim, S.-I., Chung, C.H., Kim, K.I., and Baek, S.H. (2007). SUMOylation of a Pontin Chromatin-remodeling Complex Reveals a New Signal Integration Code in Prostate Cancer. Proc. Natl. Acad. Sci. USA, 104(52), 20793-20798.

Baek, S.H.*, Ohgi, K.A., Nelson, C.A., Welsbie, D., Chen, C., Sawyers, C.L., Rose, D. W., and Rosenfeld, M.G.*(*co-coresponding author) (2006). Ligand-specific Allosteric Regulation of Coactivator Functions of Androgen Receptor in Prostate Cancer Cells. Proc. Natl. Acad. Sci. USA, 103(9), 3100-3105.

Baek, S.H., Kioussi, C., Briata, P., Wang, D., Nguyen, H.D., Ohgi, K.A., Glass, C.K., Wynshaw-Boris, A., Rose, D.W., and Rosenfeld, M.G. (2003). Regulated Subset of G1 Growth-control Genes in Response to Derepression by the Wnt Pathway. Proc. Natl. Acad. Sci. USA, 100(6), 3245-3250.

Park, K.C., Kim, J.H., Choi, E-J., Min, S.W., Rhee, S., Baek, S.H., Chung, S.S., Bang, O., Park, D., Chiba, T., Tanaka, K., and Chung, C.H. (2002). Antagonistic Regulation of Myogen sis by Two Deubiquitinating Enzymes, UBP45 and UBP69. Proc. Natl. Acad. Sci. USA, 99(15), 9733-9738.

Protocol Exchange

Hyeon, D.Y.*, Nam, D.W.*, Han, Y.M.*, Kim, D.K.*, Kim, G.B.*, Kim, D.E.*, Bae, J.G., Back, S.H., Mun, D.-G., Madar, I.H., Lee, H.G.R., Kim, S.-J., Kim, H.K., Hyun, S.Y., Kim, C.R., Choi, S.A., Kim, Y.R., Jeong, J.H., Jeon, S.W., Choo, Y.W., Lee, K.B., Kwon, W.I., Choi, S.H., Goo, T.W., Park, T.S., Suh, Y.-A., Kim, H.B., Ku, J.-L., Kim, M.-S., Paek, E.O., Park, D.C.#, Jung, K.H.#, Baek, S.H.#, Jang, J.-Y.#, Hwang, D.H.#, and Lee, S.-W.# (* co-first authors, # co-corresponding authors) (2023). Mass spectrometry-based proteomic analysis of PDAC samples. Protocol Exchange, (), doi:10.21203/rs.3.pex-2063/v1..

Science Signaling

Rosenbaum, J., Baek, S.H., Dutta, A., Houry, W. A., Huber, O., Hupp, T.R., and Matias, P.M. (2013). The Emergence of the Conserved AAA+ ATPases Pontin and Reptin on the Signaling Landscape. Science Signaling, 6(266), 1-6.

Scientific Reports

Kim, K.K., Lee, J.M., Yu, Y.S., Kim, H.K., Nam, H.J., Moon, H.-G., Noh, D.-Y., Kim, K.I., Fang, S.S., and Baek, S.H. (2017). RORα2 Requires LSD1 to Enhance Tumor Progression in Breast Cancer. Scientific Reports, 7(11994), doi:10.1038/s41598-017-12344-0.

Lim, C.-S., Nam, H.J., Lee, J.H., Kim, D.H., Choi, J.E., Kang, S.J., Kim, S.M., Kim, H.P., Kwak, C.J., Shim, K.-W., Kim, S.Y., Ko, H.-G., Lee, R.U., Jang, E.-H., Yoo, J.Y., Shim, J.H., Islam, M.A., Lee, Y.-S., Lee, J.-H., Baek, S.H.*, and Kaang, B.-K.* (* co-corresponding authors) (2017). PKCα-mediated Phosphorylation of LSD1 is Required for Presynaptic Plasticity and Hippocampal Learning and Memory. Scientific Reports, 7(4912), doi:10.1038/s41598-017-05239-7.

STAR Protocols

Kim, C.R., Noda, T., Okada, Y., Ikawa, M.*, and Baek, S.H.* (* co-corresponding authors) (2021). Protocol for Isolation of Spermatids from Mouse Testes. STAR Protocols, 2(1), doi:10.1016/j.xpro.2020.100254.

Stem Cell Investigation

Hur, J., Nham, P., Choi, J-I., Baek, S.H.*, Kim, H-S.* (* co-corresponding authors) (2017). Shedding Light on the DARC Knight as a Guardian of Hematopoietic Stem Cell Quiescence. Stem Cell Investigation, 4(8), doi:10.21037/sci.2017.01.05.

Translational Research in Breast Cancer

Nam, H.J., and Baek, S.H. (2021). Epigenetic Regulation in Breast Cancer. Translational Research in Breast Cancer, 1187(2021), 103-119.