Professor
Baek, Sung Hee 백성희
Research
Cell Biology
Genetics
Molecular Biology
We will study epigenetic diseases, investigate causality of the relationship between the epigenetic code and diseases, perform epigenetic drug screenings for therapeutic applications, and validate the efficacy and toxicity of the drug. We will initiate new challenging projects to identify novel epigenetic code and regulators and determine their in vivo functions using mouse models. The results will be integrated at the epigenomic, transcriptomic, and proteomic level. Big data and deep-learning will be applied for multidisciplinary research.
Specific Aims
Specific Aims
- Specific Aim 1: To understand the roles of the epigenetic code in homeostasis and molecular mechanisms of its perturbations leading to epigenetic diseases
- Specific Aim 2: To understand the roles of the epigenetic code in regulation and molecular mechanisms of cancers, autophagy and inflammation
- Specific Aim 3: To identify novel epigenetic regulators and determine their physiological and pathological functions using mouse models
- Specific Aim 4: To chart a functional 3D map of epigenetic diseases and develop ‘Epigenetic diseases-on-a-chip’ to perform screening of epigenetic drugs for range of therapeutic applications
Education/Carrer
Education
- - 1996.3-1999.2 Ph.D. : Seoul National University
- - 1994.3-1996.2 Master : Seoul National University
- - 1990.3-1994.2 Bachelor : Seoul National University
Career
- - 2023-present Section Editor, Molecular Oncology, FEBS
- - 2023-2024 Member, Committee for Future Generation, The Korean Federation of Science and Technology Societies
- - 2023-2024 Member, Committee for Persons of Distinguished Service to Science and Technology(Life Science),
The Korean Academy of Science and Technology(Hanlimwon) - - 2022-present Advisor, Foundation for Medical Innovation, Seoul National University Hospital
- - 2022-2024 Member, Committee for Academic Affairs, The Korean Academy of Science and Technology(Hanlimwon)
- - 2022-2025 Member, Committee for External Relations, The Korean Academy of Science and Technology(Hanlimwon)
- - 2022-2024 Member, Committee for Gender Issues, The Korean Academy of Science and Technology(Hanlimwon)
- - 2020-2023 Non-executive Director, Korea Evaluation Institute of Industrial Technology
- - 2020-2021 Advisory Member, Presidential Advisory Council on Science & Technology
- - 2020-present Fellow, Department of Science, The Korean Academy of Science and Technology(Hanlimwon)
- - 2017-2018 1st Presidential committee on the fourth industrial revolution, Ministry of Science and ICT
- - 2017-present Head of Epigenetic Code and Diseases Creative Research Center
- - 2016-2022 Non-executive Director, Foundation for Medical Innovation, Seoul National University Hospital
- - 2015-present Review Board Council Member, Division of Life Sciences, National Research Foundation of Korea
- - 2015-present Asian Advisory Committee, Keystone Symposia
- - 2015-present Editor, DNA and Cell Biology
- - 2013-2018 Review Committee member, Human Frontier Science Program
- - 2013-present Professor, School of Biological Sciences, Seoul National University
- - 2010-present Guest Editor, Annual Review of Physiology
- - 2009-2019 Associate Member, Department of Science, The Korean Academy of Science and Technology(Hanlimwon)
- - 2009-2017 Head of Chromatin Dynamics Creative Research Center
- - 2008-present Editor, BBA Molecular Basis of Disease (Elsevier)
- - 2008-2012 Associate Professor (guaranteed regular retirement), School of Biological Sciences, Seoul National University
- - 2006-present Managing Editor, Frontiers in Biosciences
- - 2006-2015 Adjunct Professor, The Interdisciplinary Program of Cancer Biology, Seoul National University College of Medicine
- - 2003-2007 Assistant Professor, School of Biological Sciences, Seoul National University
- - 2002-2003 Research Professor, School of Medicine, University of California, San Diego
- - 2000-2002 Post-doc research fellow, School of Medicine, University of California, San Diego
- - 1999-2000 Post Doctorate, Molecular Biology, Seoul National University
Publications
- Shin, H-J., Kim H.K., Oh, S.R., Lee, J-G., Kee, M.J., Ko, H-J., Kweon, M-N., Won, K.J., and Baek, S.H. (2016)
AMPK-Skp2-CARM1 Signaling Cascade in Transcriptional Regulation of Autophagy. Nature 534(7608), 553–557. - Nam, H.J., Boo, K.J., Kim, D.H., Han, D.H., Choe, H.K., Kim, C.R., Sun, W., Kim, H., Kim, K.J., Lee, H., Metzger, E., Schuele, R., Yoo, S.H., Takahashi, J.S., Cho, S.H., Son, G.H., and Baek, S.H. (2014) Phosphorylation of LSD1 by PKCα Is Crucial for Circadian Rhythmicity and Phase Resetting. Molecular Cell 53(5), 791-805. (Cover Article)
- Lee, J.M., Lee, J.S., Kim, H.K., Kim, K.K., Park, H.J., Kim, J.-Y., Lee, S.H., Kim, I.S., Kim, J.M., Lee, M.K., Chung, C.H., Seo, S.-B., Yoon, J.-B., Ko, E.Y., Noh, D.-Y., Kim, K.I., Kim, K.K., and Baek, S.H. (2012) EZH2 Generates a Methyl Degron That Is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex.
Molecular Cell 48(4), 572-586. (Cover Article) - Kim, H., Lee, J.M., Lee, G., Bhin, J., Oh, S.K., Kim, K., Pyo, K.E., Lee, J.S., Yim, H.Y., Kim, K.I., Hwang, D., Chung, J., and Baek, S.H. (2011) DNA Damage-Induced RORα is Crucial for p53 Stabilization and Increased Apoptosis.
Molecular Cell 44(5), 797-810. (Cover Article) - Lee, J. S., Kim, Y., Kim, I.S., Kim, B., Choi, H.J., Lee, J.M., Shin, H-J. R., Kim, J.H., Kim, J.-Y., Seo, S.-B., Lee, H., Binda, O., Gozani, O., Semenza, G.L., Kim, M., Kim, K.I., Hwang, D.H., and Baek, S.H. (2010) Negative Regulation of Hypoxic Responses via Induced Reptin Methylation. Molecular Cell 39(1), 71-85. (Cover Article)
- Kim, J.H., Kim, B., Ling, C., Choi, H.J., Ohgi, K.A., Tran, C, Chen, C., Chung, C.H., Huber, O., Rose, D.W., Sawyers, C.L., Rosenfeld, M.G., and Baek, S.H. (2005) Transcriptional Regulation of a Metastasis Suppressor Gene by Tip60 and β-Catenin Complexes. Nature 434(7035), 921-926.