Seoul National University Biological Sciences Website

Publications

Laboratory of Microbial Physiology

Acta Crystallogr., Sect. D: Biol. Crystallogr.

Park, Y. H. Um, S. H. Song, S. Seok, Y. J. and Ha, N. C. (2015). Structural basis for the sequestration of the anti-σ⁷⁰ factor Rsd from σ⁷⁰ by the histidine-containing phosphocarrier protein HPr.. Acta Crystallogr., Sect. D: Biol. Crystallogr., 71(10), 1998-2008.

Adv. Mater.

Lee, W. H., Yoon, C. K., Park, H., Park, G. H., Jeong, J. H., Cha, G. D., Lee, B. H., Lee, J., Lee, C. W., Bootharaju, M. S., Sunwoo, S. H., Ryu, J., Lee, C., Cho, Y. J., Nam, T. W., Ahn, K. H., Hyeon, T.,* Seok, Y. J.,* Kim, D. H. (2023). Highly Efficient Nitrogen-Fixing Microbial Hydrogel Device for Sustainable Solar Hydrogen Production. Adv. Mater., 35(52), 2306092.

Arch. Biochem. Biophys.

Piszczek, G., Lee, J. C., Tjandra, N., Lee, C. R., Seok, Y. J., Levine, R. L. and Peterkofsky, A. (2011). Deuteration of Escherichia coli enzyme I^Ntr alters its stability. Arch. Biochem. Biophys., 507(2), 332-342.

Peterkofsky, A., Wang, G., and Seok, Y. J. (2006). Parallel PTS system. Arch. Biochem. Biophys., 453(1), 101-107.

Biochem. Biophys. Res. Commun.

Kim, H. J., Lee, C. R. Kim, M. Peterkofsky, A. and Seok, Y. J. (2011). Dephosphorylated NPr of the nitrogen PTS regulates lipid A biosynthesis by direct interaction with LpxD.. Biochem. Biophys. Res. Commun., 409(), 556-561.

Shin, D., Cho, N., Kim, Y. J., Seok, Y. J., and Ryu, S. (2008). Up-regulation of the cellular level of Escherichia coli PTS components by stabilizing reduced transcripts of the genes in response to the low oxygen level.. Biochem. Biophys. Res. Commun., 370(4), 609-612.

Seok, Y. J., Zhu, P. P., Koo, B. M., and Peterkofsky, A. (1998). Autophosphorylation of Enzyme I of the Escherichia coli Phosphoenolpyruvate:sugar Phosphotransferase System Requires Dimerization. Biochem. Biophys. Res. Commun., 250(2), 381-384.

Biochemistry

Sondej, M., Seok, Y. J., Badawi, P., Koo, B. M., Nam, T. W., and Peterkofsky, A (2000). Topography of the surface of the Escherichia coli Phosphotransferase Protein Enzyme IIA^glc that interacts with Lactose Permease. Biochemistry, 39(), 2931-2939.

Nosworthy, N. J., Peterkofsky, A., König, S., Seok, Y. J., Szczepanowski, R.H. and Ginsburg, A. (1998). Phosphorylation destabilizes the amino-terminal domain of enzyme I of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system. Biochemistry, 37(19), 6718-6726.

Biochim. Biophys. Acta

Lee, C. H., Jeong, S. Y., Kim, B. J., Choi, C. H., Kim, J. S., Koo, B. M., Seok, Y. J., Yim, H. S., and Kang, S. O. (2005). Dictyostelium CBP3 associates with actin cytoskeleton and is related to slug migration. Biochim. Biophys. Acta, 1743(3), 281-290.

Biodesign

Jang, Y. D., Park, Y. H., Lee, J. W., Jo, I., Park, C., Seok, Y. J., and Ha, N. C. (2017). Purification, crystallization and preliminary X-ray crystallographic analysis of VCA0593 with a c-di-GMP binding activity in Vibrio cholerae. Biodesign, (5), 70-73.

Dig. Dis. Sci.

Choi, Y., Choi, S. I., Kim, N., Nam, R. H., Jang, J. Y., Na, H. Y., Shin, C. M., Lee, D. H., Min, H., Kim, Y. R., Seok, Y. J.* (2023). Effect of Clostridium butyricum on High-Fat Diet-Induced Intestinal Inflammation and Production of Short-Chain Fatty Acids. Dig. Dis. Sci., 68(6), 2427–2440.

EMBO J.

Nam, T. W., Cho, S. H., Shin, D., Kim, J. H., Jeong, J. Y., Lee, J. H., Roe, J. H., Peterkofsky, A., Kang, S. O., and Seok, Y. J. (2001). The Escherichia coli glucose transporter enzyme IICB^Glc recruits the global repressor Mlc. EMBO J., 20(3), 491-498.

Wang, G., Louis, J. M., Sondej, M., Seok, Y. J., Peterkofsky, A., and Clore, G.M. (2000). Solution structure of the phosphoryl transfer complex between the signal transducing proteins HPr and EIIA^Glucose of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system. EMBO J., 19(21), 5635-5649.

Kang, J. G., Paget, M. S. B., Seok, Y. J., Hahn, M. Y., Bae, J. B., Hahn, J. S., Kleanthous, C., Buttner, M.J., and Roe, J.-H. (1999). RsrA, an anti-sigma factor regulated by redox change. EMBO J., 18(15), 4292-4298.

Environ. Microbiol.

Min, H., Seok, Y. J.* (2022). Phosphotransferase system sugars immediately induce mutations of Cra in an Escherichia coli ptsH mutant. Environ. Microbiol., 24(11), 5425-5436.

Yoon, J. H., Jeon, M. S., Eyun, S. I., and Seok, Y. J.* (2021). Evidence for reciprocal evolution of the global repressor Mlc and its cognate phosphotransferase system sugar transporter. Environ. Microbiol., (), .

Kang, D., Ham, H. I., Lee, S. H., Cho, Y. J., Kim, Y. R., Yoon, C. K., and Seok, Y. J.* (2021). Functional dissection of the phosphotransferase system provides insight into the prevalence of Faecalibacterium prausnitzii in the host intestinal environment. Environ. Microbiol., 23(8), 4726-4740.

Eukaryot. Cell

Choe, Y. J., Ryu, Y., Kim, H. J., and Seok, Y. J. (2009). Increased [PSI⁺] appearance by fusion of Rnq1 with the prion domain of Sup35 in Saccharomyces cerevisiae. Eukaryot. Cell, 8(7), 968-976.

FASEB J.

Hwang, I. Park, Y. J. Kim, Y. R. Kim, Y. N. Ka, S. Lee, H. Y. Seong, J. K. Seok, Y. J. and Kim, J. B. (2015). Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity. FASEB J., 29(), 2397-2411.

FEBS Lett.

Kim, Y. J., Ryu, Y., Koo, B. M., Lee, N.-Y., Chun, S. J., Park, S. J., Lee, K.-H., and Seok, Y. J. (2010). A mammalian insulysin homolog is regulated by enzyme IIA^Glc of the glucose transport system in Vibrio vulnificus. FEBS Lett., 584(22), 4537-4544.

FEMS Microbiol. Lett.

Choi, U., Park, Y. H., Kim, Y. R., Seok, Y. J., and Lee, C. R. (2016). Increased expression of genes involved in uptake and degradation of murein tripeptide under nitrogen starvation in Escherichia coli. FEMS Microbiol. Lett., 363(14), fnw136.

Front. Microbiol.

Park, S. H., Kim, Y. J., Lee, H. B., Seok, Y. J., and Lee, C. R. (2020). Genetic Evidence for Distinct Functions of Peptidoglycan Endopeptidases in Escherichia coli. Front. Microbiol., 11(), 2174.

Kim, H. M., Yoon, C. K., Ham, H. I., Seok, Y. J and Park, Y. H. (2018). Stimulation of Vibrio vulnificus Pyruvate Kinase in the Presence of Glucose to Cope With H₂O₂ Stress Generated by Its Competitors. Front. Microbiol., 9(), 1112.

Genes Dev.

Shin, M., Song, M., Rhee, J. H., Hong, Y., Kim, Y. J., Seok, Y. J., Ha, K. S., Jeong, S. H., and Choy, H. E. (2005). DNA looping-mediated repression by histone-like protein H-NS: specific requirement of Eσ⁷⁰ as a cofactor for looping. Genes Dev., 19(19), 2388-98.

Gut and Liver

Song, C. H., Kim, N., Nam, R. H., Choi, S. I., Jang, J. Y., Kim, E. H., Choi, J., Choi, Y., Yoon, H., Lee, S. M., Seok, Y. J.* (2024). The Possible Preventative Role of Lactate- and Butyrate-Producing Bacteria in Colorectal Carcinogenesis. Gut and Liver, 18(4), 654-666.

Gut Liver

Shin, C. M., Kim, N., Kim, Y. S., Nam, R. H., Park, J. H., Lee, D. H., Seok, Y. J., Kim, Y. R., Kim, J. H., Kim, J. M., Kim, J. S. and Jung, H. C (2016). Impact of Long-Term Proton Pump Inhibitor Therapy on Gut Microbiota in F344 Rats: Pilot Study. Gut Liver, 10(6), 896.

Helicobacter

Jo, H. J., Kim, J., Kim, N., Park, J. H., Nam, R. H., Seok, Y. J., Kim, Y. R., Kim, J. S., Kim, J. M., Kim, J. M, Lee, D. H., and Jung, H. C. (2016). Analysis of Gastric Microbiota by Pyrosequencing: Minor Role of Bacteria Other Than Helicobacter pylori in the Gastric Carcinogenesis. Helicobacter, 21(5), 364-374.

J. Am. Chem. Soc

Rhee, H. W., Lee, C. R., Cho, S. H., Song, M. R., Cashel, M., Choy, H. E., Seok, Y. J., and Hong, J. I. (2008). Selective fluorescent chemosensor for the bacterial alarmone (p)ppGpp. J. Am. Chem. Soc, 130(3), 784-785.

J. Bacteriol.

Park, J. H. Cho, Y. J. Chun, J. Seok, Y.-J, Lee, J. K. Kim, K. S. Lee, K. H. Park, S. J. and Choi, S. H. (2011). Complete genome sequence of Vibrio vulnificus MO6-24/O. J. Bacteriol., 193(8), 2062-2063.

J. Biol. Chem.

Heo, K., Lee, J. W., Jang, Y., Kwon, S., Lee, J., Seok, C., Ha, N.C., Seok, Y. J.* (2022). A pGpG-specific phosphodiesterase regulates cyclic di-GMP signaling in Vibrio cholerae. J. Biol. Chem., 298(3), 101626.

Roh, J. B., Lee, M. A., Lee, H. J., Kim, S. M., Cho, Y., Kim, Y. J., Seok, Y. J., Park, S. J., and Lee, K. H. (2006). Transcriptional regulatory cascade for elastase production in Vibrio vulnificus: LuxO activates luxT expression and LuxT represses smcR expression.. J. Biol. Chem., 281(46), 34775-34784.

Park, Y. H., Lee, B. R., Seok, Y. J., and Peterkofsky, A. (2006). In Vitro Reconstitution of Catabolite repression in Escherichia coli. J. Biol. Chem., 281(10), 6448-6454.

Koo, B. M., Yoon, M. J., Lee, C. R., Nam, T. W., Choe, Y. J., Jaffe, H., Peterkofsky, A., and Seok, Y. J. (2004). A novel fermentation/respiration switch protein regulated by enzyme IIA^Glc in Escherichia coli. J. Biol. Chem., 279(30), 3613-31621.

Jeong, J. Y., Kim, Y. J., Cho, N., Shin, D., Nam, T. W., Ryu, S., and Seok, Y. J. (2004). Expression of ptsG encoding the major glucose transporter is regulated by ArcA in Escherichia coli. J. Biol. Chem., 279(37), 38513-38518.

Shin, D., Lim, S., Seok, Y. J., and Ryu, S (2001). Heat shock RNA polymerase (Eσ³²) is involved in the transcription of mlc and crucial for induction of the Mlc regulon by glucose in Escherichia coli. J. Biol. Chem., 276(28), 25871-25875.

Kim, S. Y., Nam, T. W., Shin, D., Koo, B. M., Seok, Y. J., and Ryu, S (1999). Purification of Mlc and Analysis of Its Effects on the pts Expression in Escherichia coli. J. Biol. Chem., 274(36), 25398-25402.

Seok, Y. J., Sondej, M., Badawi, P., Lewis, M. S., Briggs, M. C., Jaffe, H., and Peterkofsky, A. (1997). High affinity binding and allosteric regulation of Escherichia coli glycogen phosphorylase by the histidine phosphocarrier protein, HPr. J. Biol. Chem., 272(42), 26511-26521.

J. Cancer Prev.

Choi, S. I., Kim, N., Nam, R. H., Jang, J. Y., Kim, E. H., Ha, S. C., Kang, K., Lee, W., Choi, H. L., Kim, Y. R., Seok, Y. J.*, Shin, C. M., Lee, D. H. (2023). The Protective Effect of Roseburia faecis Against Repeated Water Avoidance Stress-induced Irritable Bowel Syndrome in a Wister Rat Model. J. Cancer Prev., 28(3), 93-105.

Choi, S., Kim, N Y., Lee, S., Nam, R., Kang, S., Song, C. H., Park, Y. T., Min, H., Kim, Y. R. and Seok, Y. J. (2019). Rat Intestinal Acetic Acid and Butyric acid and Effects of Age, Sex, and High-fat Diet on the Intestinal Levels in Rats. J. Cancer Prev., 24(1), 20-25.

Sohn, S. H., Kim, N., Jo, H. J., Kim, J., Park, J. H., Nam, R. H., Seok, Y. J., Kim, Y. R. and Lee, D. H. (2017). Analysis of Gastric Body Microbiota by Pyrosequencing: Possible Role of Bacteria Other Than Helicobacter pylori in the Gastric Carcinogenesis. J. Cancer Prev., 22(4), 267.

Sung, J., Kim, N., Kim, J., Jo, H. J., Park, J. H., Nam, R. H., Seok, Y. J. Kim, Y. R., Lee, D. H. and Jung, H. C. (2016). Comparison of Gastric Microbiota Between Gastric Juice and Mucosa by Next Generation Sequencing Method. J. Cancer Prev., 21(1), 60.

J. Microbiol.

Lee, C. R., Park, Y. H., Min, H., Kim, Y. R., and Seok, Y. J. (2019). Determination of protein phosphorylation by polyacrylamide gel electrophoresis. J. Microbiol., 57(2), 93-100.

Koo, B. M., and Seok, Y. J. (2001). Regulation of glycogen concentration by the histidine-containing phosphocarrier protein HPr in Escherichia coli. J. Microbiol., 39(1), 24-30.

J. Mol. Microbiol. Biotechnol.

Peterkofsky, A., Wang, G., Garrett, D. S., Lee, B. R., Seok, Y. J., and Clore, G.M. (2001). Three-Dimensional Structures of Protein-Protein Complexes in the E. coli PTS. J. Mol. Microbiol. Biotechnol., 3(3), 347-354.

Seok, Y. J., Koo, B. M., Sondej, M., and Peterkofsky, A. (2001). Regulation of E. coli glycogen phosphorylase activity by HPr. J. Mol. Microbiol. Biotechnol., 3(3), 385-393.

J. Oral Microbiol.

Min, H., Baek, K., Lee, A., Seok, Y. J.,* and Choi, Y. (2021). Genomic characterization of four Escherichia coli strains isolated from oral lichen planus biopsies. J. Oral Microbiol., 13(1), .

mBio

Choi, J. S., Seok, Y. J., Cho, Y. H., Roe, J. H. (2022). Iron-Induced Respiration Promotes Antibiotic Resistance in Actinomycete Bacteria. mBio, 13(2), e0042522.

Microb. Biotechnol.

Park, Y. T., Kim, T., Ham, J., Choi, J., Lee, H. S., Yeon, Y. J., Choi, S., I., Kim, N., Kim, Y. R., Seok, Y. J.* (2021). Physiological activity of E. coli engineered to produce butyric acid. Microb. Biotechnol., 15(3), 832-843.

Microb. Cell Fact.

Kim, H. A., Kim, H., Park J., Choi, A. R., Heo, K., Jeong, H., Jung, K. H., Seok, Y. J., Kim, P. and Lee, S. J. (2017). An evolutionary optimization of a rhodopsin-based phototrophic metabolism in Escherichia coli. Microb. Cell Fact., 16(111), .

Microbiology

Lee, J. Park, Y. H. Kim, Y. R. Seok, Y. J. and Lee, C. R. (2015). Dephosphorylated NPr is involved in an envelope stress response of Escherichia coli. Microbiology, 161(), 1113-1123.

Ryu, Y., Kim, Y. J. Kim, Y. R. and Seok, Y. J. (2012). Expression of Vibrio vulnificus insulin-degrading enzyme is regulated by the cAMP-CRP complex.. Microbiology, 158(), 1294-1303.

Mol. Microbiol.

Park, S., Yoon, J., Lee, C. R., Lee, J., Kim, Y., Jang, K. S., Lee, K. H. and Seok, Y. J. (2019). Polar landmark protein HubP recruits flagella assembly protein FapA under glucose limitation in Vibrio vulnificus. Mol. Microbiol., 112(1), 266-279.

Park, S., Park, Y. H., Lee, C. R., Kim, Y. R. and Seok, Y. J. (2016). Glucose induces delocalization of a flagellar biosynthesis protein from the flagellated pole. Mol. Microbiol., 101(5), 795–808.

Kim, H. M. Park, Y. H. Yoon, C. K. and Seok, Y. J. (2015). Histidine phosphocarrier protein regulates pyruvate kinase A activity in response to glucose in Vibrio vulnificus. Mol. Microbiol., 96(2), 293-305.

Lee, C. R., Park, Y. H., Kim, M., Kim, Y. R., Park, S., Peterkofsky, A., and Seok, Y.-S. (2013). Reciprocal regulation of the autophosphorylation of enzyme I^Ntr by glutamine and α-ketoglutarate in Escherichia coli (Selected by Faculty of 1000 prime) . Mol. Microbiol., 88(3), 473-485.

Lee, C. R, Cho, S. H. Kim, H. J. Kim, M. Peterkofsky, A., and Seok, Y. J. (2010). Potassium mediates Escherichia coli enzyme IIA^Ntr-dependent regulation of sigma factor selectivity. Mol. Microbiol., 78(6), 1468-1483.

Lee, C. R., Koo, B. M., Cho, S. H., Kim, Y. J., Yoon, M. J., Peterkofsky, A, and Seok, Y. J. (2005). Requirement of the dephospho-form of enzyme IIA^Ntr for derepression of Escherichia coli K-12 ilvBN expression. Mol. Microbiol., 58(1), 334-344.

Nat. Chem. Biol.

Lee, K. J, Jeong, C. S. An, Y. J. Lee, H. J. Park, S. J. Seok, Y. J. Kim, P. Lee, J. H. Lee, K. H. and Cha, S. S. (2011). FrsA functions as a cofactor-independent decarboxylase to control metabolic flux.. Nat. Chem. Biol., 7(), 434-436.

Nat. Commun.

Heo, K., Park, Y. H., Lee, K. A., Kim, J., Ham, H. I., Kim, B. G Lee, W. J. and Seok, Y. J. (2019). Sugar-mediated regulation of a c-di-GMP phosphodiesterase in Vibrio cholerae. Nat. Commun., 10(1), 1-10.

Nat. Struct. Biol.

Garrett, D. S., Seok, Y. J., Peterkofsky, A., Gronenborn, A. M., and Clore, G.M. (1999). Solution Structure of the 40,000 Mr phosphoryl Transfer Complex Between the N-terminal Domain of Enzyme I and HPr. Nat. Struct. Biol., 6(2), 166-173.

npj Biofilms and Microbiomes

Lee, H. Y., Yoon, C. K., Cho, Y. J., Lee, J. W., Lee, K. A., Lee, W. J., Seok, Y. J.* (2022). A mannose-sensing AraC-type transcriptional activator regulates cell–cell aggregation of Vibrio cholerae. npj Biofilms and Microbiomes, 8(1), .

Nucleic Acids Res.

Yoon, C. K., Lee, S. H., Zhang, J., Lee, H. Y., Kim, M. K., Seok, Y. J.* (2023). HPr prevents FruR-mediated facilitation of RNA polymerase binding to the fru promoter in Vibrio cholerae. Nucleic Acids Res., 51(11), 5432-5448.

Yoon, C. K., Kang, D., Kim, M. K., and Seok, Y. J.* (2021). Vibrio cholerae FruR facilitates binding of RNA polymerase to the fru promoter in the presence of fructose 1-phosphate. Nucleic Acids Res., 49(3), 1397-1410.

Lee, C. R. Kim, M. Park, Y. H. Kim, Y. R. and Seok, Y. J. (2014). RppH-dependent pyrophosphohydrolysis of mRNAs is regulated by direct interaction with DapF in Escherichia coli.. Nucleic Acids Res., 42(20), 12746-12757.

Park, M. A., Seok, Y. J., Jeong, G., and Lee, J. S. (2008). SUMO1 negatively regulates BRCA1-mediated transcription, via modulation of promoter occupancy. Nucleic Acids Res., 36(1), 263-283.

Nam, T. W., Park, Y. H., Jeong, H. J., Ryu, S., and Seok, Y. J. (2005). Glucose repression of the Escherichia coli sdhCDAB operon, revisited: regulation by the CRP-cAMP complex.. Nucleic Acids Res., 33(21), 6712-6722.

Proc. Natl. Acad. Sci. U.S.A.

Lee, J. W., Park, Y. H. and Seok, Y. J. (2018). Rsd balances (p)ppGpp level by stimulating the hydrolase activity of SpoT during carbon source downshift in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A., 115(29), E6845–E6854.

Kim, M., Kim, H. J., Son, S. H., Yoon, H. J., Lim, Y., Lee, J. W., Seok, Y. J., Jin, K. S., Yu, Y. G., Kim, S. K., Ryu, S, and Lee, H. H. (2016). Noncanonical DNA-binding mode of repressor and its disassembly by antirepressor. Proc. Natl. Acad. Sci. U.S.A., 113(18), E2480-E2488.

Park, Y. H. Lee, C. R. Choe, M. and Seok, Y. J. (2013). HPr antagonizes the anti-σ⁷⁰ activity of Rsd in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A., 110(52), 21142-21147.

Choi, J. Shin, D. Yoon, H. Kim, J. Lee, C. R., Kim, M. Seok, Y. J. and Ryu, S. (2010). Salmonella pathogenicity island 2 expression negatively controlled by EIIA^Ntr-SsrB interaction is required for Salmonella virulence. Proc. Natl. Acad. Sci. U.S.A., 107(47), 20506-20511.

Nam, T. W. Jung, H. I., An, Y. J., Park, Y. H., Lee, S. H., Seok, Y. J., and Cha, S. S. (2008). Analyses of Mlc-IIB^Glc interaction and a plausible molecular mechanism of Mlc inactivation by membrane sequestration.. Proc. Natl. Acad. Sci. U.S.A., 105(10), 3751-3756.

Lee, C. R., Cho, S. H., Yoon, M. J., Peterkofsky, A., and Seok, Y. J. (2007). Escherichia coli enzyme IIA^Ntr regulates the K⁺transporter TrkA. Proc. Natl. Acad. Sci. U.S.A., 104(10), 4124-4129.

Sondej, M., Sun, J., Seok, Y. J., Kaback, H.R., and Peterkofsky, A. (1999). Deduction of a Consensus Binding Sequence for IIA^glc of the Phosphoenolpyruvate:sugar Phosphotransferase System by Cysteine Scanning Mutagenesis of Escherichia coli Lactose Permease. Proc. Natl. Acad. Sci. U.S.A., 96(), 3525-3530.

Seok, Y. J., Sun, J., Kaback, H. R., and Peterkofsky, A. (1997). Topology of allosteric regulation of lactose permease. Proc. Natl. Acad. Sci. U.S.A., 94(25), 13515-13519.

Protein Sci.

Garrett, D. S., Seok, Y. J., Peterkofsky, A., Clore, G. M., and Gronenborn, A. M. (1998). Tautomeric state and pKa of the phosphorylated active site histidine in the N-terminal domain of enzyme I of the Esherichia coli phosphoenolpyruvate:sugar phosphotransferase system. Protein Sci., 7(3), 789-793.

Sci. Rep.

Park, W. J., Yoon, Y. K., Park, J. S., Pansuriya, R., Seok, Y. J.,* Ganapathy, R. (2021). Rotavirus spike protein ΔVP8* as a novel carrier protein for conjugate vaccine platform with demonstrated antigenic potential for use as bivalent vaccine. Sci. Rep., 11(), 22037.

Choe, M., Min, H., Park, Y. J., Kim, Y. R., Woo, J. S. and Seok, Y. J. (2019). Structural insight into glucose repression of the mannitol operon. Sci. Rep., 9(1), .

Lee, S., Kim, N. Y., Nam, R., Park, J., Choi, S., Park, Y. T., Kim, Y. R., Seok, Y. J., Shin, C., and Lee, D. (2019). Gut microbiota and butyrate level changes associated with the long-term administration of proton pump inhibitors to old rats. Sci. Rep., 9(), .

Choe, M., Park, Y. H., Lee, C. R., Kim, Y. R. and Seok, Y. J. (2017). The general PTS component HPr determines the preference for glucose over mannitol. Sci. Rep., 7(1), 1-11.

Yoo, W., Yoon, H., Seok, Y. J., Lee, C. R., Lee, H. H., and Ryu, S. (2016). Fine-tuning of amino sugar homeostasis by EIIA^Ntr in Salmonella Typhimurium. Sci. Rep., 6(1), 1-13.

Vaccine

Park, W. J., Yoon, Y. K., Kim, Y., Park, J. S., Pansuriya, R., Cho, S. N., Seok, Y. J.* and Ravi, G. (2021). Development of a bivalent conjugate vaccine candidate against rotaviral diarrhea and tuberculosis using polysaccharide from Mycobacterium tuberculosis conjugated to ΔVP8* protein from rotavirus. Vaccine, 39(45), 6644-6652.