Laboratory of Microbial Physiology

Laboratory of Microbial Physiology

Seoul National University
Laboratory of Microbial Physiology

Laboratory of Microbial Physiology

Seoul National University
Laboratory of Microbial Physiology

Laboratory of Microbial Physiology

Seoul National University

Publications+ more

(2021) Genomic characterization of four Escherichia coli strains isolated from oral lichen planus biopsies, Journal of Oral Microbiology
(2021) Vibrio cholerae FruR facilitates binding of RNA polymerase to the fru promoter in the presence of fructose 1-phosphate, Nucleic Acids Research
(2019) Sugar-mediated regulation of a c-di-GMP phosphodiesterase in Vibrio cholerae, Nature Communications
(2019) Structural insight into glucose repression of the mannitol operon, Scientific Reports
(2019) Polar landmark protein HubP recruits flagella assembly protein FapA under glucose limitation in Vibrio vulnificus, Molecular Microbiology

Welcome to the
"Laboratory of Microbial Physiology"

Research overview Bacteria have the capacity to efficiently adapt to environmental changes by sensing the availability of nutrients. Because glucose is one of the most abundant carbon sources in the environment, it is the most favored carbohydrate in most organisms. Although different organisms employ different uptake systems for glucose, many organisms, including yeasts and E. coli, show preferential growth on glucose when presented with mixtures of glucose and other carbon sources. It is known that glucose, sensed by its transporters or metabolizing enzymes, inhibits the uptake of certain other sugars into the cell or represses the synthesis of enzymes required to grow on those alternative carbon sources such as lactose. In most bacteria, glucose and many other carbohydrates are transported via the phosphoenolpyruvate (PEP):sugar phosphotransferase system (PTS). This multi-component system carries out a PEP-dependent transport and phosphorylation of numerous sugars (group translocation; Fig. 1).