교수
김재범 Kim, Jae Bum
연구분야
분자생물학
세포생물학
유전학
1. Mechanism of Adipocyte Differentiation
2. Gene Expression Regulation of Lipogenesis and Insulin-dependent Genes
3. Molecular Mechanisms for Obesity and Diabetes
2. Gene Expression Regulation of Lipogenesis and Insulin-dependent Genes
3. Molecular Mechanisms for Obesity and Diabetes
학력/경력
학력
- - 1984 - 1988 서울대학교 자연대학 동물학과 학사
- - 1988 - 1990 서울대학교 자연대학 동물학과 (분자생물학 전공) 석사
- - 1991 - 1996 하버드대학교 분자유전학 박사
경력
- - 1996 - 1997 하버드대학교 Dana-Farber Cancer Institute 박사후연구원
- - 1997 - 2000 MIT Cancer Institute 박사후연구원
- - 2000 - Present 서울대학교 생명과학부 조교수, 부교수, 정교수
- - 2004 - Present 한국과학기술한림원 준회원, 정회원
- - 2005 - 2008 보건복지부 국가생명윤리심의위원회 전문위원
- - 2007 - 2008 Univ. of California, San Diego 초빙교수
- - 2009 - 2011 서울대학교 실험동물자원관리원장
- - 2010 - 2014 서울대학교 SPARC 부주임교수
- - 2011 - 2012 서울대학교 유전공학연구소장
- - 2011 - Present 지방조직 리모델링 창의연구단 단장, 지방세포 구조-기능 리더연구단장
- - 2013 - 2014 국가과학기술자문위원회 자문위원
- - 2014 - 2015 Univ. of California, Los Angeles 초빙교수
- - 2021 - Present 한국분자세포생물학회지 (Molecules and Cells) 편집위원장 (Editor-in-Chief)
주요논문
- Y. S. Lee, P. Li, J. Y. Huh, I. J. Hwang, M. Lu, J. I. Kim, M. Ham, S. Talukdar, A. Chen, W. Lu, G. Bandyopadhyay, R. Schwendener, J. Olefsky, and J. B. Kim*. Inflammation is necessary for long term but not short term HFD-induced insulin resistance. Diabetes, 60:2474-2483. 2011. 10
- I. Hwang, Y. J. Park, Y. R. Kim, Y. N. Kim, S Ka, H. Y. Lee, J. K. Seong, Y. J. Seok, and J. B. Kim*. Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity. FASEB J., 29:2397-411, 2015. 06. (** This paper has been highlighted in Nat. Rev. Endo. 11:254 [2015])
- J. I. Kim, J. Y. Huh, J. H. Sohn, S. S. Choe, Y. S. Lee, C. Y. Lim, A Jo, S. B. Park, W. Han, and J. B. Kim*. Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation. Mol. Cell. Biol., 35:1686-99, 2015.05 (** This paper is selected as a “Spotlight” paper. In the same issue (May 2015, Vol 35, Issue 10), Cover Figure has been selected with our data.)
- A. Y. Kim, Y. J. Park, X. Pan, K. C. Shin, S. H. Kwak, A. F. Bassas, R. M. Sallam, K. S. Park, A. A. Alfadda, A. Xu, and J. B. Kim*. Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance. Nat Commun., 6:7585, 2015. 07. (** This paper has been highlighted in Nat. Rev. Endo. 11:504 [2015])
- H. Jang, G. Y. Lee, C. P. Selby, G. Lee, Y. G. Jeon, J. H. Lee, K. K. Y. Cheng, P. Titchenell, M. J. Birnbaum, A. Xu, A. Sancar and J. B. Kim* . SREBP1c-CRY1 signaling represses hepatic glucose production by promoting FOXO1 degradation during refeeding. Nat. Commun., 7:12180, 2016.07. (** This paper was invited from Cell Cycle journal for a Commentary Article.)
- J. Y. Huh, J. Park, J. I. Kim, Y. J. Park, Y. K. Lee and J. B. Kim*. Deletion of CD1d in Adipocytes Aggravates Adipose Tissue Inflammation and Insulin Resistance in Obesity. Diabetes, 66:835-847, 2017.04. (** This paper was invited from Adipocyte Journal for a Commentary Review.)
- K. C. Shin, S. S. Choe, I. J. Hwang, J. Park, J. Yul, J. I. Kim, J. Ching, J.-P. Kovalik and J. B. Kim*. Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation. Nat Commun., 8:1087, 2017. 10.
- I. Hwang, K. Jo, K. C. Shin, J. I. Kim, Y. Ji, Y. J. Park, J. Park, Y. G. Jeon, S. Ka, S. Suk, H. L. Noh, S. S. Choe, A. Alfadda, J. K. Kim, S. Kim and J. B. Kim*. GABA stimulated adipose-derived stem cells suppress subcutaneous adipose tissue inflammation in obesity. Proc. Natl. Acad. Sci., 116:11936-11945, 2019. 06.
- J. Park, J. Y. Huh, J. Oh, J. I. Kim, S. M. Han, K. C. Shin, Y. G. Jeon, S. S. Choe, J. Park, and J. B. Kim*. Activation of invariant natural killer T cells stimulates adipose tissue remodeling via adipocyte death and birth in obesity. Genes & Dev., 33:1657-1672, 2019. 10.
- J. Kong, Y. Ji, Y. G. Jeon, J. S. Han, K. H. Han, J. H. Lee, G. Lee, H. Jang, S. S. Choe, M. Baes and J. B. Kim*. Spatiotemporal contact between peroxisome and lipid droplet regulates fasting-induced lipolysis via PEX5. Nat Commun., DOI: 10.1038/s41467-019-14176-0, 2020. 01.