Seoul National University Biological Sciences Website

Publications

Laboratory of Development & Disease Modeling

2022

Young-Woo Jo, Inkuk Park, Kyusang Yoo, Hyun-Young Woo, Ye Lynne Kim, Yea-Eun Kim, Ji-Hoon Kim, Young-Yun Kong (2022). Notch1 and Notch2 Signaling Exclusively but Cooperatively Maintain Fetal Myogenic Progenitors. Stem Cells, (), .

Ji-Hoon Kim, Jong-Seol Kang, Kyusang Yoo, Jinguk Jeong, Inkuk Park, Jong Ho Park, Joonwoo Rhee, Shin Jeon, Young-Woo Jo, Sang-Hyeon Hann, Minji Seo, Seungtae Moon, Soo-Jong Um, Rho Hyun Seong, and Young-Yun Kong (2022). Bap1/SMN axis in Dpp4+ skeletal muscle mesenchymal cells regulates the neuromuscular system. JCI Insight, (), .

2021

Ji-Yun Seo, Jong-Seol Kang, Ye Lynne Kim, Young-Woo Jo, Ji-Hoon Kim, Sang-Hyeon Hann, Jieon Park, Inkuk Park, Hyerim Park, Kyusang Yoo, Joonwoo Rhee, Jung-Wee Park, Yong Chan Ha, Young-Yun Kong (2021). Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis. Nature Communication, (), .

Ji-Hoon Kim, Inkuk Park, Hijai R Shin, Joonwoo Rhee, Ji-Yun Seo, Young-Woo Jo, Kyusang Yoo, Sang-Hyeon Hann, Jong-Seol Kang, Jieon Park, Ye Lynne Kim, Ju-Yeon Moon, Man Ho Choi, Young-Yun Kong (2021). The hypothalamic-pituitary-gonadal axis controls muscle stem cell senescence through autophagosome clearance. J Cachexia Sarcopenia Muscle, (), .

2019

Ji-Yun Seo, Ji-Hoon Kim, Young-Yun Kong (2019). Unraveling the Paradoxical Action of Androgens on Muscle Stem Cells. Mol Cells, (), .

2018

Changsun Yu, Bok-seok Kim, Minyoung Park, Yun-Ju Do, Young-Yun Kong & Eunhee Kim (2018). FAF1 mediates necrosis through JNK1-mediated mitochondrial dysfunction leading to retinal degeneration in the ganglion cell layer upon ischemic insult.. Cell Commun Signal, (), .

In Kyu Lee, Min Jeong Gu, Kwang Hyun Ko, Suhan Bae, Girak Kim, Gwi-Deuk Jin, Eun Bae Kim, Young-Yun Kong, Tae Sub Park, Byung-Chul Park, Hyun Jung Jung, Seung Hyun Han & Cheol-Heui Yun (2018). Regulation of CD4+CD8−CD25+ and CD4+CD8+CD25+ T cells by gut microbiota in chicken. Scientific reports, 8(8627), .

Jinwoo Seong, Nam-Shik Kim, Jee-Ah Kim, Wonbin Lee, Ji-Yun Seo, Min Kyu Yum, Ji-Hoon Kim, Inkuk Park, Jong-Seol Kang, Sung-Hwan Bae, Cheol-Heui Yun, Young-Yun Kong (2018). Side branching and luminal lineage commitment by ID2 in developing mammary glands. Development, 145(14), .

2017

Taejeong Ha, Kyeong Hwan Moon, Le Dai, Jun Hatakeyama, Keejung Yoon, Hee-Sae Park, Young-Yoon Kong, Kenji Shimamura, Jin Woo Kim (2017). The Retinal Pigment Epithelium is a Notch Signaling in the Mouse Retina. Cell Report, 19(2), 351-63.

2016

Minji Seo, Seong-Ok Lee, Ji-Hoon Kim, Yujin Hong, Seongchan Kim, Yeumin Kim, Dal-Hee Min, Young-Yun Kong, Jinwook Shin, and Kwangseog Ahn (2016). MAP4-Regulated Dynein-Dependent Trafficking of BTN3A1 Controls the TBK1-IRF3 Signaling Axis. Proc. Batl Acad Sci, 113(50), 14390-95.

Ji-Hoon Kim, Gi-Chan Han, Ji-Yun Seo, Inkuk Park,Wookjin Park, Hyun-Woo Jeong, Su Hyeon Lee, Sung-hwan Bae, Jinwoo Seong,Min-Kyu Yum, Sang-Hyeon Hann, Young-Guen Kwon, Daekwan Seo, Man Ho Choi and Young-Yun Kong (2016). Sex hormones establish a reserve pool of adult muscle stem cells. Nature Cell Biology, 18(), 930-940.

Ryuta Tobe, Bradley A. Carlson, Jang Hoe Huh, Nadia P. Castro, Xue-Ming Xu, Petra A. Tsuji, Sang-Goo Lee, Jeyoung Bang, Ji-Woon Na, Young-Yun Kong, Daniel Beaglehole, Eileen Southon, Harold Seifried, Lino Tessarollo, David S. Salomon, Ulrich Schweizer, Vadim N. Gladyshev, Dolph L. Hatfield, Byeong Jae Lee (2016). Selenophosphate Synthetase 1 is an Essential Protein with Roles in Regulation of Redox Homeostasis in Mammals. Biochem J, 473(13), 2141-54.

Jong Ho Park, Seung Wook Yang, Jung Mi Park, Seung Hyeun Ka, Ji-Hoon Kim, Young-Yun Kong, Young Joo Jeon, Jae Hong Seol & Chin Ha Chung (2016). Positive Feedback Regulation of p53 Transactivity by DNA Damage-Induced ISG15 Modification. Nature Communication, (), .

Min Kyu Yum, Jong-Seol Kang, Al-Eum Lee, Young-Woo Jo, Ji Yun Seo, Hyun-A Kim, Yoon-Young Kim, Jinwoo Seong, Eun Byul Lee, Ji-Hoon Kim, Jung Min Han, Sunghoon Kim, Young-Yun Kong (2016). AIMP2 controls intestinal stem cell compartments and tumorigenesis by modulating Wnt/β-catenin signaling. Cancer res, 76(15), 4559-68.

2015

Somi Kim,* TaeHyun Kim,* Hye-Ryeon Lee, Young-Yun Kong, and Bong-Kiun Kaang (2015). Mind Bomb-2 Regulates Hippocampus-Dependent Memory Formation and Synaptic Plasticity. Korean J Physiol Pharmacol, 19(6), 515-22.

2014

Kim YY, Moon JS, Kwon MC, Shin J, Im SK, Kim HA, Han JK, Kong YY (2014). Meteorin regulates mesendoderm development by enhancing nodal expression. PLoS One, 18;9(2), e88811.

2013

Shin J, Lee SH, Kwon MC, Yang DK, Seo HR, Kim J, Kim YY, Im SK, Abel ED, Kim KT, Park WJ, Kong YY (2013). Cardiomyocyte specific deletion of crif1 causes mitochondrial cardiomyopathy in mice. PLoS One, 8(1), e53577.

Sul JW, Park MY, Shin J, Kim YR, Yoo SE, Kong YY, Kwon KS, Lee YH, Kim E (2013). Accumulation of the parkin substrate, FAF1, plays a key role in the dopaminergic neurodegeneration. Hum mol genet, 15;22(8), 1558-73.

Capoccia BJ, Jin RU, Kong YY, Peek RM Jr, Fassan M, Rugge M, Mills JC (2013). The ubiquitin ligase Mindbomb 1 coordinates gastrointestinal secretory cell maturation. J Clin Invest, 1;123(4), 1475-91.

Sun-Kyoung Im, HyoBin Jeong, Hyun-Woo Jeong, Kyong-Tai Kim, Daehee Hwang,Machiko Ikegami, Young-Yun Kong (2013). Disruption of Sorting Nexin 5 Causes Respiratory Failure Associated with Undifferentiated Alveolar Epithelial Type I Cells in Mice. PLoS One, 8(3), e58511.

Luxan G, Casanova JC, Martinez-Poveda B, Prados B, D'Amato G, MacGrogan D, Gonzalez-Rajal A, Dobarro D, Torroja C, Martinez F, Izquierdo-Garcia JL, Fernandez-Friera L, Sabater-Molina M, Kong YY, Pizarro G, Ibanez B, Medrano C, Garc?a-Pavia P, Gimeno JR, M (2013). Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. Nat Med, 19(2), 193-201.

2012

Ki-Jun Yoon†, Hye-Ryeon Lee†, Yong Sang Jo, Kyongman An, Sang-Yong Jung, Min-Woo Jeong, Seok-Kyu Kwon, Nam-Shik Kim, Hyun-Woo Jeong, Seo-Hee Ahn, Kyong-Tai Kim, Kyungmin Lee, Eunjoon Kim, Joung-Hun Kim, June-Seek Choi, Bong-Kiun Kaang and Young-Yun Kong (2012). Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway. Molecular Brain, 5(1), 40.

Hyun-A Kim*, Bon-Kyoung Koo*, Ji-Hoon Cho, Yoon-Young Kim, Jinwoo Seong, Hee Jin Chang, Young-Min Oh, Daniel E. Stange, Jae-Gahb Park, Daehee Hwang and Young-Yun Kong (*Co-first authors) (2012). NOTCH1 counteracts WNT-b-catenin signaling through chromatin modification in colorectal cancer. J Clin Invest, 122(9), 3248-59.

Soung Jung Kim*, Min-chul Kwon*, Min Jeong Ryu, Hyo Kyun Chung, Surendar Tadi, Yong Kyung Kim, Jin Man Kim, Sang Hee Lee, Ji Hoon Park, Gi Ryang Kweon, Seung-Wook Ryu, Young Suk Jo, Chul-Ho Lee, Hideyuki Hatakeyama, Yu-ichi Goto, Yong-Hyeon Yim, Jongkyeon (2012). CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane. Cell Metabolism, 16(2), 274-83.

Jeong HW, Kim JH, Kim JY, Ha SJ, Kong YY (2012). Mind Bomb-1 in Dendritic Cells Is Specifically Required for Notch-mediated T Helper Type 2 Differentiation. PLoS One, 7(4), e36359.

Horn S, Kobberup S, Jørgensen MC, Kalisz M, Klein T, Kageyama R, Gegg M, Lickert H, Lindner J, Magnuson MA, Kong YY, Serup P, Ahnfelt-Rønne J, Jensen JN (2012). Mind bomb 1 is required for pancreatic β-cell formation. Proc Natl Acad Sci U S A, 109(19), 7356-61.

2011

Rock JR, Gao X, Xue Y, Randell SH, Kong YY, Hogan BL (2011). Notch-dependent differentiation of adult airway basal stem cells. Cell Stem Cell, 3;8(6), 639-48.

Li S, Wang L, Berman M, Kong YY, Dorf ME (2011). Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production. Immunity, 35(3), 426-40.

Kim NS, Kim HT, Kwon MC, Choi SW, Kim YY, Yoon KJ, Koo BK, Kong MP, Shin J, Cho Y, Kong YY (2011). Survival and differentiation of mammary epithelial cells in mammary gland development require nuclear retention of Id2 due to RANK signaling. Mol Cell Biol, 31(23), 4775-88.

2010

Yoon Ha Choi, Choon-Ho Park, Wanil Kim, Hua Ling, Aram Kang, Matthew Wook Chang, Sun-Kyoung Im, Hyun-Woo Jeong, Young-Yun Kong, Kyong-Tai Kim (2010). Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells. PLoS One, 5(12), e15254.

2009

Min-chul Kwon, Bon-Kyoung Koo, Yoon-Young Kim, Sang-Hee Lee, Jae-Hwan Kim, and Young-Yun Kong (2009). Essential role of CR6-interacting factor 1 (CRIF1) in E74-like factor-3 (ELE3)-mediated intestinal development. J Biol Chem, 284(48), 33634-41.

Hyun-Woo Jeong, Un Sil Jeon, Bon-Kyoung Koo, Wan-Young Kim, Sun-Kyoung Im, Juhee Shin, Yunje Cho, Jin Kim, and Young-Yun Kong (2009). Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. J Clin Invest, 119(11), 3290-300.

Sangphil Oh, Dongjun Lee, Tackhoon Kim, Tae-Shin Kim, Hyun Jung Oh, Chae Young Hwang, Young-Yun Kong, Ki-Sun Kwon, and Dae-Sik Lim (2009). A Crucial Role For Mst1 and Mst2 Kinases in Early Embryonic Development of the Mouse. Mol. Cell. Biol, 29(23), 6309-20.

Yu Jin Jung, Yu Shin Park, Ki Jun Yoon, Young-Yun Kong, Joon Won Park, and Hong Gil Nam (2009). Molecule-level imaging of Pax6mRNA distribution in mouse embryonic neocortex by molecular interaction force microscopy. Nucleic Acids Res, 37(2), e10.

Bon-Kyoung Koo, Hyoung-Soo Lim, Heejin Chang, Mi-Jeong Yoon, Yongwook Choi, Myung-Phil Kong, Cheol-Hee Kim, Jin-Man Kim, Jae-Gahb Park and Young-Yun Kong (2009). Notch Signaling Promotes the Generation of EphrinB1-Positive Intestinal Epithelial Cells. Gastroenterology, 137(), 145-55.

2008

Kim YW, Koo BK, Jeong HW, Yoon MJ, Song R, Shin J, Jeong DC, Kim SH, and Kong YY (2008). Defective Notch activation in microenvironment leads to myeloproliferative disease. Blood, 112(), 4628.

Song R, Kim YW, Koo BK, Jeong HW, Yoon MJ, Yoon KJ, Jun DJ, Im SK, Shin J, Kong MP, Kim KT, Yoon K, and Kong YY (2008). Mind bomb-1 in the lymphopoietic niches is essential for T and marginal zone B cell development. J Exp Med, 205(), 2525.

Lee JH, Kim TS, Yang TH, Koo BK, Oh SP, Lee KP, Oh HJ, Lee SH, Kong YY, Kim JM, Lim DS (2008). A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J, 27(), 1231-42.

Yoon MJ, Koo BK, Song R, Jeong HW, Shin J, Kim YW, Kong YY*, and Suh PG(*corresponding author) (2008). Mind bomb-1 is essential for intra-embryonic hematopoiesis in the aortic endothelium and the SAPs. Mol Cell Biol, 28(), 4794-4804.

Yoon KJ, Koo BK, Im SK, Jeong HW, Ghim J, Kwon MC, Moon JS, Miyata T, and Kong YY (2008). Mind bomb 1-expressing intermediate progenitors generate Notch signaling to maintain radial glial cells. Neuron, 58(), 519-31.

Kwon MC, Koo BK, Moon JS, Kim YY, Park KC, Kim NS, Kwon MY, Kong MP, Yoon KJ, Im SK, Ghim J, Han YM, Jang SK, Shong M, Kong YY (2008). Crif1 is a novel transcriptional coactivator of STAT3. EMBO J, 27(), 642-53.

Lee SH, Song R, Lee MN, Kim CS, Lee H, Kong YY, Kim H, Jang SK (2008). A molecular chaperone glucose-regulated protein 94 blocks apoptosis induced by virus infection. Hepatology, 47(), 854-866.

Sungmin Song, Huikyong Lee, Tae-in Kam, Mei Ling Tai, Joo-Yong Lee, Jee-Yeon Noh, Sang Mi Shim, Soo Jung Seo,Young-Yun Kong, Toshiyuki Nakagawa, Chul-Woong Chung, Deog-Young Choi, Hammou Oubrahim, and Yong-Keun Jung (2008). E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Aβ neurotoxicity. J Cell Biol, 182(4), 675.

2007

Koo BK, Yoon MJ, Yoon KJ, Im SK, Kim YY, Kim CH, Suh PG, Jan YN,?and Kong YY (2007). An Obligatory Role of Mind Bomb-1 in Notch Signaling of Mammalian Development. PLoS ONE, 2(), e1221.

Jun DJ, Kim J, Jung SY, Song R, Noh JH, Park YS, Ryu SH, Kim JH, Kong YY, Chung JM, Kim KT (2007). Extracellular ATP mediates necrotic cell swelling in SN4741 dopaminergic neurons through P2X7 receptors. J Biol Chem, 282(), 37350-8.

2006

Song R, Koo BK, Yoon KJ, Yoon MJ, Yoo KW, Kim HT, Oh HJ, Kim YY, Han JK, Kim CH, and Kong YY (2006). Neuralized-2 regulates notch ligand in cooperation with mind-bomb-1. J Biol Chem, 281(), 36391-36400.

Lee S, Lee DK, Dou Y, Lee J, Lee B, Kwak E, Kong YY, Lee SK, Roeder RG, Lee JW (2006). Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci USA, 103(), .

Yoo KW, Kim EH, Jung SH, Rhee M, Koo BK, Yoon KJ, Kong YY, Kim CH (2006). Snx5, as a Mindb-binding protein, is expressed in hematopoietic and endothelial precursor cells in zebrafish. FEBS Lett, 580(), 4409-16.

Kim GH, Park E, Kong YY, Han JK (2006). Novel function of POSH, a JNK scaffold, as an E3 ubiquitin ligase for the Hrs stability on early endosomes. Cell Signaling, 18(), 553-63.

Kim NS, Kim HJ, Koo BK, Kwon MC, Cho Y, Yokota Y, Penninger JM, and Kong YY (2006). Receptor activator of NF-κB ligand regulates the proliferation of mammary epithelial cells via Id2. Mol. Cell. Biol, 26(), 1002-13.

Jones DH, Nakashima T, Sanchez OH, Kozieradzki I, Komarova SV, Sarosi I, Morony S, Rubin E, Sarao R, Hojilla CV, Komnenovic V, Kong YY, Schreiber M, Dixon SJ, Sims SM, Khokha R, Wada T and Penninger JM (2006). Regulation of cancer cell migration and bone metastasis by RANKL. Nature, 440(), 692-6.

2005

Koo BK, Lim HS, Song R, Yoon MJ, Yoon KJ, Moon JS, Kim YW, Kwon MC, Yoo KW, Kong MP, Lee J, Chitnis AB, Kim CH, and Kong YY (2005). Mind-Bomb 1 is essential for generating functional Notch Ligand to activate Notch signaling. Development, 132(), 3459-70.

Koo BK, Yoon KJ, Yoo KW, Lim, HS Song R, So JH, Kim CH, and Kong YY (2005). Mind Bomb-2 is an E3 Ligase for Notch Ligand. J BioL Chem, 280(), 22335-42.

Min JK, Kim YM, Kim SW, Kwon MC, Kong YY, Hwang IK, Won MH, Rho J, Kwon YG (2005). TNF-related activation-induced cytokine enhances leukocyte adhesiveness: induction of ICAM-1 and VCAM-1 via TNF receptor-associated factor and protein kinase C-dependent NF-kappaB activation in endothelial cells. J Immunol, 175(), 531.

2003

Min JK, Kim YM, Kim YM, Kim EC, Gho YS, Kang IJ, Lee SY, Kong YY, Kwon YG (2003). Vascular endothelial growth factor up-regulates expression of receptor activator of NF-kappa B (RANK) in endothelial cells. Concomitant increase of angiogenic responses to RANK ligand. J Biol Chem, 278(41), 39548-57.

Kim SW, Park K, Kwak E, Choi E, Lee S, Ham J, Kang H, Kim JM, Hwang SY, KongYY, Lee K, Lee JW (2003). Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice. Mol Cell Biol, 23(), 3583-92.

Sohn YC, Kim SW, Lee S, Kong YY, Na DS, Lee SK, Lee JW (2003). Dynamic inhibition of nuclear receptor activation by corepressor binding. Mol Endocrinol, 17(), 366-72.

2002

Jones DH, Kong YY, Penninger JM (2002). Role of RANKL and RANK in bone loss and arthritis. Ann Rheum Dis, 61(), 32-9.

Kim HJ, Yoon MJ, Lee J, Penninger JM, Kong YY (2002). Osteoprotegerin ligand induces beta-casein gene expression through the transcription factor CCAAT/enhancer-binding protein beta. J Biol Chem, 277(), 5339-44.

2001

Griffiths EK, Krawczyk C, Kong YY, Raab M, Hyduk SJ, Bouchard D, Chan VS, Kozieradzki I, Oliveira-Dos-Santos AJ, Wakeham A, Ohashi PS, Cybulsky MI, Rudd CE, Penninger JM (2001). Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science, 293(), 2260-3.

Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, Sasaki T, Elia AJ, Cheng HY, Ravagnan L, Ferri KF, Zamzami N, Wakeham A, Hakem R, Yoshida H, Kong YY, Mak TW, Zuniga-Pflucker JC, Kroemer G, Penninger JM (2001). Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature, 410(), 549-54.

2000

Teng YT, Nguyen H, Gao X, Kong YY, Gorczynski RM, Singh B, Ellen RP, Penninger JM (2000). Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection. J Clin Invest, 106(6), 59-67.

Kong YY, Penninger JM (2000). Molecular control of bone remodeling and osteoporosis. Exp Gerontol, 35(), 947-56.

Kong YY, Boyle WJ and Penninger JM (2000). Osteoprotegerin ligand: a regulator of immune responses and bone physiology. Immunol Today, 21(), 497.

Fata JE, Kong YY, Li J, Sasaki T, Irie-Sasaki J, Moorehead RA, Elliott R, Scully S, Voura EB, and Penninger JM (2000). The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell, 103(), 41-50.

Liu P, Aitken K, Kong YY, Opavsky MA, Martino T, Dawood F, Wen WH, Kozieradzki I, Bachmaier K, Straus D, Mak TW, Penninger JM (2000). The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease. Nat Med, 6(), 429.

Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H, Liu D, Elledge SJ, Mak TW (2000). DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science, 287(), 1824.

Bachmaier K, Krawczyk C, Kozieradzki I, Kong YY, Sasaki T, Oliveira-dos-Santos A, Mariathasan S, Bouchard D, Wakeham A, Itie A, Le J, Ohashi PS, Sarosi I, Nishina H, Lipkowitz S, Penninger JM (2000). Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature, 403(), 211.

1999

Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, Capparelli C, Li J, Elliott R, McCabe S, Wong T, Campagnuolo G, Moran E, Bogoch ER, Van G, Nguyen LT, Ohashi PS, Lacey DL, Fish E, Boyle WJ, Penninger JM (1999). Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature, 402(), 304.

Kong YY, Boyle WJ, Penninger JM (1999). Osteoprotegerin ligand: a common link between osteoclastogenesis, lymph node formation and lymphocyte development. Immunol Cell Biol, 77(), 188.

Eto M, Kong YY, Uozumi J, Naito S, Nomoto K (1999). Importance of intrathymic mixed chimerism for the maintenance of skin allograft tolerance across fully allogeneic antigens in mice. Immunology, 96(), 440.

Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM (1999). OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature, 397(), 315.

Uchiyama, H., Kong, Y.Y., Kishihara, K., Sugimachi, K. Nomoto, K (1999). Approach to withdarwal from tacrolomus in a fully allogeneic murine skine graft model. Immunology, 97(), 294.

Umesue M, Mayumi H, Kong YY, Omoto K, Muranaka H, Nakanishi R, Kohno H, Yasumoto K, Kishihara K, Nomoto K (1999). Rejection of discordant skin xenografts by CD4- CD8- TCR alpha beta+ cells in CD4- and CD8-deficient mice. Transplant Proc, 31(), 890.

1998

Kong YY, Fischer KD, Bachmann MF, Mariathasan S, Kozieradzki I, Nghiem MP, Bouchard D, Bernstein A, Ohashi PS, Penninger (1998). Vav regulates peptide-specific apoptosis in thymocytes. J Exp Med, 188(), 2099.

Yada S, Kishihara K, Kong YY, Nomoto K (1998). Differential requirements of CD45 protein tyrosine phosphatase for cytolytic activities and intrathymic and extrathymic development of intestinal intraepithelial lymphocytes. J Immunol, 161(), 2208.

Fischer KD, Kong YY, Nishina H, Tedford K, Mareng?re LE, Kozieradzki I, Sasaki T, Starr M, Chan G, Gardener S, Nghiem MP, Bouchard D, Barbacid M, Bernstein A, Penninger JM (1998). Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr Biol, 8(), 554.

Yoshida H, Nishina H, Takimoto H, Mareng?re LE, Wakeham AC, Bouchard D, Kong YY, Ohteki T, Shahinian A, Bachmann M, Ohashi PS, Penninger JM, Crabtree GR, Mak TW (1998). The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity, 8(), 115.

1997

Yoshida H, Kong YY, Yoshida R, Elia AJ, Hakem A, Hakem R, Penninger JM, Mak TW (1997). Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell, 94(), 739.

Yamada H, Kong YY, Kishihara K, Mak TW, Nomoto K (1997). p56lck is not essential for the T-cell response to allo-MHC antigens. Immunology, 92(), 33.

Speiser DE, Lee SY, Wong B, Arron J, Santana A, Kong YY, Ohashi PS, Choi Y (1997). A regulatory role for TRAF1 in antigen-induced apoptosis of T cell. J Exp Med, 185(), 1777.

Okamoto T, Harada M, Tamada K, Yoshida H, Ito O, Kong YY, Takenoyama M, Hirashima C, Matsuzaki G, Nomoto K (1997). Local injection of OK432 can augment the TH1-type T-cell response in tumor-draining lymph node cells and increase their immunotherapeutical potential. Int J Cancer, 70(), 598.

1996

Kong YY, Eto M, Omoto K, Umesue M, Hashimoto A, Nomoto K (1996). Regulatory T cells in maintenance and reversal of peripheral tolerance in vivo. J Immunol, 157(), 5284.

Yamada H, Kishihara K, Kong YY, Nomoto K (1996). Enhanced generation of NK cells with intact cytotoxic function in CD45 exon 6-deficient mice. J Immunol, 157(), 1523.

Omoto K, Kong YY, Nomoto K, Umesue M, Murakami Y, Eto M, Nomoto K (1996). Sensitization of T-cell receptor-alpha beta+ T cells recovered from long-term T-cell receptor downmodulation. Immunology, 88(), 230.

Omoto K, Nishimura Y, Nomoto K, Kong YY, Umesue M, Murakami Y, Tomita Y, Nomoto K (1996). Anti-CD4 monoclonal antibody reduces the dose of cyclophosphamide required to induce tolerance to H-2 haplotype identical skin allografts in mice. Immunobiology, 95(), 16.

Umesue M, Mayumi H, Nishimura Y, Kong YY, Omoto K, Murakami Y, Nomoto K (1996). Donor-specific prolongation of rat skin graft survival induced by rat-donor cells and cyclophosphamide under coadministration of monoclonal antibodies against T cell receptor alpha beta and natural killer cells in mice. Transplantation, 61(1), 116-24.

1995

Kong YY, Kishihara K, Sumichika H, Nakamura T, Kaneko M, Nomoto K (1995). Differential requirements of CD45 for lymphocyte development and function. Eur J Immunol, 25(), 3431.

Murakami Y, Kong YY, Nishimura Y, Nomoto K, Umesue M, Omoto K, Maeda T, Nomoto K (1995). Prevention of anti-T-cell receptor alpha beta monoclonal antibody-induced side-effects by treatment with cyclosporin A without interference of monoclonal antibody-induced immunosuppression in mice. Immunology, 86(), 238.

Nishimura Y, Eto M, Maeda T, Hiromatsu K, Nomoto K, Kong YY, Nomoto K (1995). The induction of skin xenograft tolerance in rat-to-mouse combination could be affected by DFR mediating cells and antibodies against rat bone marrow cells as well as NK cells in the cyclophosphamide-induced tolerance system. Immunobiology, 193(), 420.

Kong YY, Kishihara K, Yoshida H, Mak TW, Nomoto K (1995). Generation of T cells with differential responses to alloantigens in CD45 exon 6-deficient mice. J Immunol, 154(), 5725.

Nomoto K, Kong YY, Omoto K, Umesue M, Murakami Y, Matsuzaki G, Nomoto K (1995). Tolerance induction in a fully allogeneic combination using anti-T cell receptor-alpha beta monoclonal antibody, low dose irradiation, and donor bone marrow transfusion. Transplantation, 59(3), 395-401.

Umesue M, Mayumi H, Nishimura Y, Kong YY, Omoto K, Murakami Y, Nomoto K, Nomoto K (1995). Xenogeneic (rat to mouse) skin tolerance induced by monoclonal antibodies, xenogeneic cells, and cyclophosphamide. Transplant Proc, 27(), 315.

1994

Eto M, Nishimura Y,Kong YY, Maeda T, Nomoto K, Kumazawa J, Nomoto K (1994). Importance of intrathymic mixed chimerism for maintenance of skin allograft tolerance across fully allogeneic (entire major H-2 plus multiminor histocompatibility antigen barriers in mice. Transplant Proc, 26(), 841.

Maeda T, Eto M, Lin T, Nishimura Y, Kong YY, Nomoto K, Nomoto K (1994). Amelioration of acute graft-versus-host disease and re-establishment of tolerance by short-term treatment with an anti-TCR antibody. J Immunol,, 153(), 4311.

Nishimura Y, Eto M, Maeda T, Hiromatsu K, Kobayashi N, Nomoto K, Kong YY, Nomoto K (1994). Inhibition of skin xenograft rejection by depleting T-cell receptor alpha beta-bearing cells without T-cell receptor gamma delta-bearing cells or natural killer cells by monoclonal antibody. Immunology, 83(), 196.

Eto M, Yoshikai Y, Nishimura Y, Hiromatsu K, Maeda T, Nomoto K, Kong YY, Kubo RT, Kumazawa J, Nomoto K (1994). Inhibition of allograft rejection by anti-T-cell receptor-alpha beta monoclonal antibodies preserving resistance to bacterial infection. Immunology, 81(), 198.

Maeda T, Eto M, Nishimura Y, Kong YY, Nomoto K, Nomoto K (1994). Evidence that donor-specific suppressor cells can be produced independently of the thymus. Transplantation, 57(), 461.

Maeda T, Eto M, Nishimura Y, Nomoto K, Kong YY, Nomoto K (1994). Role of peripheral hemopoietic chimerism in achieving donor-specific tolerance in adult mice. J Immunol, 150(), 753.

1993

Maeda T, Eto M, Nishimura Y, Nomoto K, Kong YY, Nomoto K (1993). Direct evidence for clonal destruction of allo-reactive T cells in the mice treated with cyclophosphamide after allo-priming. Immunology, 78(), 113.