Seoul National University Biological Sciences Website

Publications

Laboratory of Immune Regulation

2024

Hwang, S-Y*., Kim, H*., Denisko, D*., Zhao, B*., Lee, D., Jeong, J., Kim, J., Park, K., Park, J., Jeong, D., Park, S., Choi, H-J., Kim, S., Lee, EA., & Ahn, K. (2024). Human cytomegalovirus harnesses host L1 retrotransposon for efficient replication. Nature Communications. 15:7640. *These authors contributed equally. Nature Communications., 15(), 7640.

Park, K., Lee, D., Jeong, J., Lee, S., Kim, Sun & Ahn, K (2024). Human immunodeficiency virus-1 induces and targets host genomic R-loops for viral genome integration.. eLife, (), .

2022

Sungwon Lee, Hyewon Kim, Ari Hong, Jaewon Song, Sungyul Lee, Myeonghwan Kim, Sung-yeon Hwang, Dongjoon Jeong, Jeesoo Kim, Ahyeon Son, Young-suk Lee, V. Narry Kim, Jong-seo Kim, Hyeshik Chang & Kwangseog Ahn (2022). Functional and molecular dissection of HCMV long non-coding RNAs. Scientific Reports, (), .

2021

안광석 외 (기초과학연구원) (2021). [도서] 코로나 사이언스: 팬데믹에서 엔데믹으로. 동아시아, (), 1-259.

Yujin Hong*, Seong-Ok Lee*, Changhoon Oh*, Kwonyoon Kang, Jeongmin Ryoo, Dongyoung Kim, and Kwangseog Ahn (*equal contribution) (2021). USP21 deubiquitinase regulates AIM2 inflammasome activation. The Journal of Immunology, 207(7), 1926-1936.

Yujin Hong, Heena Jeong, Kiwon Park, Sungwon Lee, Jae Youn Shim, Hyewon Kim, Yang Song, Seowoo Park, Hye Yoon Park, V Narry Kim, Kwangseog Ahn (2021). STING facilitates nuclear import of herpesvirus genome during infection. PNAS, 118(33), e2108631118.

Kiwon Park* ,Jeongmin Ryoo* ,Heena Jeong,Minsu Kim,Sungwon Lee,Sung-Yeon Hwang,Jiyoung Ahn,Doyeon Kim,Hyungseok C. Moon,Daehyun Baek,Kwangsoo Kim,Hye Yoon Park,Kwangseog Ahn (*equal contribution) (2021). Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription–replication conflict regions. PLOS Genetics, 17(4), .

Ji-Seon Lee, Seongchan Kim, Sungchul Kim, Kwangseog Ahn, Dal-Hee Min (2021). Fluorometric Viral miRNA Nanosensor for Diagnosis of Productive (Lytic) Human Cytomegalovirus Infection in Living Cells. ASC sensors, 6(3), 815-822.

Sung-Yeon Hwang, Hyunchul Jung, Seyoung Mun, Sungwon Lee, Kiwon Park, S. Chan Baek, Hyungseok C. Moon, Hyewon Kim, Baekgyu Kim, Yongkuk Choi, Young-Hyun Go, Wanxiangfu Tang, Jongsu Choi, Jung Kyoon Choi, Hyuk-Jin Cha, Hye Yoon Park, Ping Liang, V. Narry Kim, Kyudong Han & Kwangseog Ahn (2021). L1 retrotransposons exploit RNA m 6 A modification as an evolutionary driving force. Nature Communications, 12(1), .

2020

김범준, Jerome H. Kim, 김홍빈, 김훈, 류왕식, 박도준, 안광석, 이준호, 지희정 (2020). 코로나19 위기-대응-미래 (도서). 이음 (최종현학술원), (), .

안광석 외 11명, 기초과학연구원 (2020). 코로나 사이언스 (도서). 동아시아, (), .

안광석 (2020). 팬데믹 시대를 위한 바이러스+면역 특강 (도서). 반니, (), .

Dongwan Kim, Young-Suk Lee, Soo-Jin Jung, Jinah Yeo, Jenny J Seo, Young-Yoon Lee, Jaechul Lim, Hyeshik Chang, Jaewon Song, Jihye Yang, Jong-Seo Kim, Guhung Jung, Kwangseok Ahn, V Narry Kim (2020). Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing. Nat Struct Mol Biol, 27(6), 581-588.

2019

Song, J., Lee, S-H., Cho, D., Lee, S-W., Kim, H., Yu, N., Lee, S-H. and Ahn, K. (2019). Human cytomegalovirus induces and exploits Roquin to counteract the IRF1-mediated antiviral state. PNAS, 116(37), 18619-18628.

2018

Jaechul Lim, Dongwan Kim, Young-Suk Lee, Minju Ha, Mihye Lee, Jinah Yeo, Hyeshik Chang, Jaewon Song, Kwangseog Ahn, V Narry Kim (2018). Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation. Science, 361(6403), 701-704.

Choi, J., Hwang, S-Y. and Ahn, K. (2018). Interplay between RNASEH2 and MOV10 controls LINE-1 retrotransposition. doi:10.1093/nar/gkx1312. Nucleic Acids Research, 46(4), 1912-1926.

Oh, C., Ryoo, J., Park K-W, Kim B., Michele B. Daly, Cho D-Y., & Ahn, K. (2018). A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature.. Scientific Reports, 8(84), .

2016

Seo, M., Lee, S-O., Kim, J-H., Hong, Y., Kim, S., Kim, Y., Min, D-H., Kong, Y-Y., Shin, J. and Ahn, K (2016). MAP4-regulated dynein-dependent trafficking of BTN3A1 controls the TBK1-IRF3 signaling axis. Proc. Natl. Acad. Sci. USA, 113(50), 14390-14395.

Kim, S. and Ahn, K. (2016). ACE-score-based Analysis of Temporal miRNA Targetomes During Human Cytomegalovirus Infection Using AGO-CLIP-seq. Bio-protocol, 6(8), .

Ryoo, J., Hwang, S-Y., Choi, J., Oh, C. and Ahn, K (2016). Correspondence. Nature Medicine, 22(), 1074-1075.

Hwang, S-Y., Ryoo, J., Choi, J., Oh, C & Ahn, K. (2016). SAMHD1, the Aicradi-Goutieres syndrome gene and retroviral restriction factor, is a phosphorolytic ribonuclease rather than a hydrolytic ribonuclease (The first two authors contributed equally to this work). Biochem. Biophys. Res. Comm., 477(), 977-981.

Jeong, G., Park, I., Ahn, K. & Ahn, B. (2016). Inhibition of hepatitis B virus replication by a dNTPase-dependent function of the host restriction factor SAMHD1. Virology, 495(), 71-78.

2015

Kim, S., Seo, D., Kim, D., Hong, Y., Chang, H., Baek, D., Kim, V.N., Lee, S., and Ahn, K. (2015). Temporal landscape of microRNA-mediated host-virus crosstalk during productive human cytomegalovirus infection (Highlighted as 'Featured Ariticle'). Cell Host & Microbe, 17(), 838-851.

Choi, J., Ryoo, J., Oh, C., Hwang, S., and Ahn, K. (2015). SAMHD1 specifically restricts retroviruses through its RNase activity. Retrovirology, 12(46), .

2014

Ryoo, J., Choi, J., Oh, C., Kim, S., Seo, M., Kim, S., Seo, D., Kim, J., White, TE, Brandariz-Nunez, A., Diaz-Griffero, F., Yun, CH, Hollenbaugh, JA., Kim, B., Baek, D., and Ahn, K. (2014). The ribonuclease activity of SAMHD1 is required for HIV-1 restriction. Highlighted in NEWS AND VIEWS of the issue. Nature Medicine, 20(8), 936-931.

2013

Cho, S., Kim, B., Ahn, K., and Jun, Y. (2013). The C-terminal amino acid of the MHC-I heavy chain is critical for binding to Derlin-1 in human cytomegalovirus US11-induced MHC-I degradation. PLoS One, 8(), e72356.

Sanghyun Lee, Jaewon Song, Sungchul Kim, Jongkyu Kim, Yujin Hong, Youngkyun Kim, Donghyun Kim, Daehyun Baek and Kwangseog Ahn (2013). Selective Degradation of host MicroRNAs by an Intergenic HCMV Non-Coding RNA Accelerates Virus Production. Selected as Faculty of 1000 RECOMMENDED paper. Cell Host & Microbe, 13(6), 678-690.

2012

Youngkyun Kim#, Sanghyun Lee#, Sungchul Kim, Donghyun Kim, Jin-Hyun Ahn and Kwangseog Ahn (2012). Human Cytomegalovirus Clinical Strain-Specific microRNA miR-UL148D Targets the Human Chemokine RANTES during Infection. (# These authors contributed equally to this work). PLoS Pathog, 8(3), 1-12.

2011

Sungchul Kim, Sanghyun Lee, Jinwook Shin, Youngkyun Kim, Irini Evnouchidou, Donghyun Kim, Young-Kook Kim, Young-Eui Kim, Jin-Hyun Ahn, Stanley R Riddell, Efstratios Stratikos, V Narry Kim & Kwangseog Ahn (2011). Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1. Selected as Faculty of 1000 EXCEPTIONAL paper. Nature Immunology, 12(10), 984-991.

Jun Y, Ahn K. (2011). Tmp21, a novel MHC-I interacting protein, preferentially binds to Β2-microglobulin-free MHC-I heavy chains. BMB Rep, (), 44(6):369-74..

Cho K, Cho S, Lee SO, Oh C, Kang K, Ryoo J, Lee S, Kang S, Ahn K. (2011). Redox-regulated peptide transfer from the transporter associated with antigen processing to major histocompatibility complex class I molecules by protein disulfide isomerase. Antioxid Redox Signal, (), 1;15(3):621-33. (IF=8.2).

2010

Cho S, Ryoo J, Jun Y, Ahn K (2010). Receptor-Mediated ER Export of Human MHC Class I Molecules Is Regulated by the C-Terminal Single Amino Acid. Traffic, (), doi: 10.1111/j.1600-0854.2010..

Lee SO, Cho K, Cho S, Kim I, Oh C, Ahn K (2010). Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation. EMBO J, (), 20;29(2):363-75.

2009

Kim E, Kwak H, Ahn K (2009). Cytosolic aminopeptidases influence MHC class I-mediated antigen presentation in an allele-dependent manner. J Immunol, (), 183(11):7379-87.

Kang K, Park B, Oh C, Cho K, Ahn K (2009). A role for protein disulfide isomerase in the early folding and assembly of MHC class I molecules. Antioxid Redox Signal, (), (10):2553-61.

Lee S, Park B, Kang K, Ahn K (2009). Redox-regulated export of the major histocompatibility complex class I-peptide complexes from the endoplasmic reticulum. Mol Biol Cell, (), (14):3285-94.

Kim Y, Kang K, Kim I, Lee YJ, Oh C, Ryoo J, Jeong E, Ahn K (2009). Molecular mechanisms of MHC class I-antigen processing: redox considerations. Antioxid Redox Signal, (), (4):907-36. Review..

2008

Kim Y, Park B, Cho S, Shin J, Cho K, Jun Y, Ahn K (2008). Human cytomegalovirus UL18 utilizes US6 for evading the NK and T-cell responses. PLoS Pathog, (), 4(8):e1000123.

2006

Park B, Lee S, Kim E, Cho K, Riddell SR, Cho S, Ahn K (2006). Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing. Selected as "Featured Article" and Faculty of 1000 EXCEPTIONAL paper.. Cell, 127(2), 369-82.

Shin J, Park B, Lee S, Kim Y, Biegalke BJ, Kang S, Ahn K (2006). A short isoform of human cytomegalovirus US3 functions as a dominant negative inhibitor of the full-length form. J Virol, (), 80(11):5397-404.

2005

Lee SO, Hwang S, Park J, Park B, Jin BS, Lee S, Kim E, Cho S, Kim Y, Cho K, Shin J, Ahn K (2005). Functional dissection of HCMV US11 in mediating the degradation of MHC class I molecules. Biochem Biophys Res Commun, (), 330(4):1262-7.

Pande NT, Powers C, Ahn K, Früh K (2005). Rhesus cytomegalovirus contains functional homologues of US2, US3, US6, and US11. J Virol, (), 79(9):5786-98.

Jin BS, Lee WK, Ahn K, Lee MK, Yu YG (2005). High-throughput screening method of inhibitors that block the interaction between 2 helical regions of HIV-1 gp41. J Biomol Screen, (), 10(1):13-9.

2004

Kim S, Kim T, Ahn K, Park WK, Nah SY, Rhim H (2004). Ginsenoside Rg3 antagonizes NMDA receptors through a glycine modulatory site in rat cultured hippocampal neurons. Biochem Biophys Res Commun, (), 323(2):416-24.

Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase (2004). Shin J, Park B, Cho S, Lee S, Kim Y, Lee SO, Cho K, Lee S, Jin BS, Ahn JH, Choi EJ, Ahn K. J Biol Chem, (), 279(39):40994-1003.

Kim H, Jeong W, Ahn K, Ahn C, Kang S (2004). Siah-1 interacts with the intracellular region of polycystin-1 and affects its stability via the ubiquitin-proteasome pathway. J Am Soc Nephrol, (), 15(8):2042-9..

Park GM, Lee S, Park B, Kim E, Shin J, Cho K, Ahn K (2004). 19.Soluble HLA-G generated by proteolytic shedding inhibits NK-mediated cell lysis. Biochem Biophys Res Commun, (), 313(3):606-11.

Park B, Kim Y, Shin J, Lee S, Cho K, Früh K, Lee S, Ahn K (2004). Human cytomegalovirus inhibits tapasin-dependent peptide loading and optimization of the MHC class I peptide cargo for immune evasion. Immunity, (), 20(1):71-85.

2003

Park B, Ahn K (2003). An essential function of tapasin in quality control of HLA-G molecules. J Biol Chem, (), 278(16):14337-45.

Lee S, Park B, Ahn K (2003). Determinant for endoplasmic reticulum retention in the luminal domain of the human cytomegalovirus US3 glycoprotein. J Virol, (), 77(3):2147-56.

Park B, Lee S, Kim E, Ahn K (2003). A single polymorphic residue within the peptide-binding cleft of MHC class I molecules determines spectrum of tapasin dependence. J Immunol, (), 170(2):961-8.

2002

Kim S, Ahn K, Oh TH, Nah SY, Rhim H (2002). Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons. Biochem Biophys Res Commun, (), 296(2):247-54.

Chang SK, Park B, Shin J, Ahn JH, Kim IH, Ahn K (2002). Proto-oncogene PML enhances antigen presentation by MHC class I molecules in human lung cancer cells. Mol Cells, (), 14(1):130-5.

Park B, Oh H, Lee S, Song Y, Shin J, Sung YC, Hwang SY, Ahn K (2002). The MHC class I homolog of human cytomegalovirus is resistant to down-regulation mediated by the unique short region protein (US)2, US3, US6, and US11 gene products. J Immunol, (), 168(7):3464-9.

Jin M, Park J, Lee S, Park B, Shin J, Song KJ, Ahn TI, Hwang SY, Ahn BY, Ahn K (2002). Hantaan virus enters cells by clathrin-dependent receptor-mediated endocytosis. Virology, (), 294(1):60-9.