Host-virus interactions are complex processes that span binding to cells, entry, dissemination and finally lytic or latent infection. During infection, host innate immune system restricts viral replication. However, mechanisms underlying viral propagation out of the host surveillance remain unclear. Our research goal is to understand the molecular basis of virus latency
establishment and how it plays a critical role in cellular immune evasion and/or viral reactivation. In addition, we are interested in understanding the role of “the endogenous parasites”, retroelements in host-virus interaction and innate immunity.
Ongoing research projects include:
● HCMV nuclear entry and Latency establishment
● Discover the role of viral long non-coding RNAs in HCMV latency-reactivation.
● Epitranscriptomic features of HCMV latency-reactivation.
● Investigate therapeutic targets of HCMV latent-infected cells.
● Interaction between L1 retrotransposon and HCMV
● Landscape of HIV-1 latent infection integration sites
● RNA biology of Hepatitis B virus