Seoul National University Biological Sciences Website

Publications

Laboratory of Molecular Microbiology

. Mol Microbiol.

Lee, J.H., Yeo, W.S., Roe, J.H. (2004). Induction of the sufA operon encoding Fe-S assembly proteins by superoxide generators and hydrogen peroxide: involvement of OxyR, IHF and an unidentified oxidant-responsive factor.. . Mol Microbiol.

Acta Crystallogr Sect F Struct Biol Cryst Commun.

An YJ, Ahn BE, Roe JH, Cha SS. (2008). Crystallization and preliminary X-ray crystallographic analyses of Nur, a nickel-responsive transcription regulator from Streptomyces coelicolor.. Acta Crystallogr Sect F Struct Biol Cryst Commun.

Aging (Albany NY)

Kim JY, Kim EJ, Lopez-Maury L, Bähler J, Roe JH. (2014). A metabolic strategy to enhance long-term survival by Phx1 through stationary phase-specific pyruvate decarboxylases in fission yeast.. Aging (Albany NY)

Biochem Biophys Res Commun

Jung SJ, Choi Y, Lee D, Roe JH. (2019). Nuclear aconitase antagonizes heterochromatic silencing by interfering with Chp1 binding to DNA. Biochem Biophys Res Commun

Kim HJ, Lee KL, Kim KD, Roe JH. (2016). The iron uptake repressor Fep1 in the fission yeast binds Fe-S cluster through conserved cysteines.. Biochem Biophys Res Commun

Kim KD, Kim HJ, Lee KC, Roe JH. (2011). Multi-domain CGFS-type glutaredoxin Grx4 regulates iron homeostasis via direct interaction with a repressor Fep1 in fission yeast.. Biochem Biophys Res Commun

Biochem Biophys Res Commun.

Kim KD, Chung WH, Kim HJ, Lee KC, Roe JH. (2010). Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeast.. Biochem Biophys Res Commun.

Kim EK, Cha CJ, Cho YJ, Cho YB, Roe JH. (2008). Synthesis of gamma-glutamylcysteine as a major low-molecular-weight thiol in lactic acid bacteria Leuconostoc spp.. Biochem Biophys Res Commun.

Lee SY, Song JY, Kwon ES, Roe JH (2008). Gpx1 is a stationary phase-specific thioredoxin peroxidase in fission yeast.. Biochem Biophys Res Commun.

Chung WH, Kim KD, Roe JH. (2005). Localization and function of three monothiol glutaredoxins in Schizosaccharomyces pombe.. Biochem Biophys Res Commun.

Chung WH, Kim KD, Cho YJ, Roe JH (2004). Differential expression and role of two dithiol glutaredoxins Grx1 and Grx2 in Schizosaccharomyces pombe.. Biochem Biophys Res Commun.

Biochem. Biophys. Res. Comm.

Jeong, J.H., Kwon, E.S., and Roe, J.H. (2001). Characterization of the manganese-containing superoxide dismutase and its gene regulation in stress response of Schizosaccharomyces pombe.. Biochem. Biophys. Res. Comm.

Biochem. Biophysic. Res. Comm.

Lee, J., Kwon, E.S., Kim, D.W., Cha, J.S., and Roe, J.H. (2002). Regulation and the role of Cu,Zn-containing superoxide dismutase in cell cycle progression of Schizosaccharomyces pombe.. Biochem. Biophysic. Res. Comm.

BMC Genomics

Ji-Nu Kim, Yujin Jeong, Ji Sun Yoo, Jung-Hye Roe, Byung-Kwan Cho and Byung-Gee Kim (2015). Genome-scale analysis reveals a role for NdgR in the thiol oxidative stress response in Streptomyces coelicolor. BMC Genomics

BMC Microbiology

Kim JY, Kwon ES, Roe JH (2012). A homeobox protein Phx1 regulates long-term survival and meiotic sporulation in Schizosaccharomyces pombe.. BMC Microbiology

Curr. Genet.

Kim, E.K., Jeong, J.H., Yoon, H.S., Koo, Y.B., and Roe, J.H. (2000). Gene structure and expression of the linear mitochondrial plasmid pMNP1 from white-rot fungus Pleurotus ostreatus.. Curr. Genet.

EMBO J.

Koo, M.S., Lee, J.H., Rah, S.Y., Yeo, W.S., Lee, J.W., Lee, K.L., Koh, Y.S., Kang, S.O., Roe, J.H. (2003). A reducing system of the superoxide sensor SoxR in Escherichia coli.. EMBO J.

Nam, T.W., Cho, S.H., Shin, D., Kim, J.H., Jeong, J.Y., Lee, J.H., Roe, J.H., Peterkofsdy, A.,Kang, S.O., Ryu, S., and Seok, Y.J. (2001). The Escherichia coli glucose transporter enzyme IICBGlc recruits the global repressor Mlc.. EMBO J.

Kang, J.G., Paget, M.S.B., Seok, Y.J., hahn, M.Y., Bae, J.B., Hahn, J.S. Kleanthous, C., Buttner, M.J., and Roe, J.H. (1999). RsrA, an anti-sigma factor regulated by redox change.. EMBO J.

Paget, M.S.B., Kang, J.G., Roe, J.H., and Buttner, M.J. (1998). SigR, an RNA polymerase sigma factor that activates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor.. EMBO J.

Eukaryot Cell.

Song JY, Kim KD, Roe JH. (2008). Thiol-independent action of mitochondrial thioredoxin to support the urea cycle of arginine biosynthesis in Schizosaccharomyces pombe.. Eukaryot Cell.

Song JY, Cha J, Lee J, Roe JH. (2006). Glutathione reductase and a mitochondrial thioredoxin play overlapping roles in maintaining iron-sulfur enzymes in fission yeast.. Eukaryot Cell.

FEBS J

Eun-Jung Kim, Yong-Joon Cho, Woo-Hyun Chung, and Jung-Hye Roe. (2020). The role of Rsv1 in the transcriptional regulation of genes involved in sugar metabolism for long-term survival. FEBS J

FEBS Lett

Jung SJ, Seo Y, Lee KC, Lee D, Roe JH. (2015). Essential Function of Aco2, a fusion protein of aconitase and mitochondrial ribosomal protein bL21, in mitochondrial translation in fission yeast.. FEBS Lett

Front Microbiol

Lee KL, Yoo JS, Oh GS, Singh AK, Roe JH. (2017). Simultaneous Activation of Iron- and Thiol-Based Sensor-Regulator Systems by Redox-Active Compounds.. Front Microbiol

Gene.

Chung, H.J., Kim, E.J., Suh, B., Choi, J.H., and Roe, J.H. (1999). Duplicate gene for Fe-containing superoxide dismutase in Streptomyces coelicolor A3(2).. Gene.

J Bacteriol

Hahn, J.S., Oh, S.Y., Roe, J.H. (2002). Role of OxyR as a peroxide-sensing positive regulator in Streptomyces coelicolor A3(2).. J Bacteriol

J Bacteriol.

Shin JH, Singh AK, Cheon DJ, Roe JH. (2010). Activation of SoxR Regulon by Extracellular Pigmented Antibiotic Actinorhodin in Streptomyces coelicolor.. J Bacteriol.

Oh HM, Cho YJ, Kim BK, Roe JH, Kang SO, Nahm BH, Jeong G, Han HU, Chun J. (2010). Complete genome sequence analysis of Leuconostoc kimchii IMSNU 11154.. J Bacteriol.

Lee JH, Lee KL, Yeo WS, Park SJ, Roe JH. (2009). SoxRS-mediated lipopolysaccharide modification enhances resistance against multiple drugs in Escherichia coli.. J Bacteriol.

Lin YR, Hahn MY, Roe JH, Huang TW, Tsai HH, Lin YF, Su TS, Chan YJ, Chen CW. (2009). Streptomyces telomeres contain a promoter.. J Bacteriol.

Lee KC, Yeo WS, Roe JH (2008). Oxidant-responsive induction of the suf operon, encoding a Fe-S assembly system, through Fur and IscR in Escherichia coli.. J Bacteriol.

Oh SY, Shin JH, Roe JH. (2007). Dual role of OhrR as a repressor and an activator in response to organic hydroperoxides in Streptomyces coelicolor.. J Bacteriol.

Shin JH, Oh SY, Kim SJ, Roe JH. (2007). The zinc-responsive regulator Zur controls a zinc uptake system and some ribosomal proteins in Streptomyces coelicolor A3(2).. J Bacteriol.

Lee EJ, Cho YH, Kim HS, Ahn BE, Roe JH. (2004). Regulation of sigmaB by an anti- and an anti-anti-sigma factor in Streptomyces coelicolor in response to osmotic stress.. J Bacteriol.

Cho, Y.H., Kim, E.J., Chung, H.J., Choi, J.H., Chater, K.F., Ahn, B.E., Shin, J.H., Roe, J.H. (2003). The pqrAB operon is responsible for paraquat resistance in Streptomyces coelicolor.. J Bacteriol.

J Biol Chem.

Kwon ES, Jeong JH, Roe JH. (2006). Inactivation of homocitrate synthase causes lysine auxotrophy in copper/zinc-containing superoxide dismutase-deficient yeast Schizosaccharomyces pombe.. J Biol Chem.

J Ind Microbiol Biiotechnol

Cho HS, Jo JC, Shin CH, Lee N, Choi JS, Cho BK, Roe JH, Kim CW, Kwon HJ, Yoon YJ. (2019). Improved production of clavulanic acid by reverse engineering and overexpression of the regulatory genes in an industrial Streptomyces clavuligerus strain. J Ind Microbiol Biiotechnol

J Microbiol

Kim JE, Choi JS, Roe JH. (2019). Growth and differentiation properties of pikromycin-producing Streptomyces venezuelae ATCC15439. J Microbiol

J Microbiol Biotechnol

Kim JN, Kim Y, Jeong Y, Roe JH, Kim BG, Cho BK. (2015). Comparative genomics reveals the core and accessory genomes of Streptomyces species.. J Microbiol Biotechnol

J Microbiol.

Song JY, Roe JH (2008). The role and regulation of Trxl, a cytosolic thioredoxin in Schizosaccharomyces pombe.. J Microbiol.

Hahn MY, Roe JH. (2007). Partial purification of factors for differential transcription of the rrnD promoters for ribosomal RNA synthesis in Streptomyces coelicolor.. J Microbiol.

Park JH, Cha CJ, Roe JH. (2006). Identification of genes for mycothiol biosynthesis in Streptomyces coelicolor A3(2).. J Microbiol.

Lee EJ, Cho YH, Kim HS, Roe JH (2004). Identification of SigB-dependent promoters using consensus-directed search of Streptomyces coelicolor genome.. J Microbiol.

J Mol Biol.

Bae, J.B., Park, J.H., Hahn, M.Y., Kim, M.S., Roe, J.H. (2004). Redox-dependent changes in RsrA, an anti-sigma factor in Streptomyces coelicolor: zinc release and disulfide bond formation.. J Mol Biol.

J. Bacteriol.

Hahn, J.S., Oh, S.Y., and Roe, J.H. (2000). Regulation of the furA and catC operon encoding ferric uptake regulator homologue and catalase-peroxidase in Streptomyces coelicolor A3(2).. J. Bacteriol.

Chung, H.J., Choi, J.H., Kim, E.J., Cho, Y.H., and Roe, J.H. (1999). Negative regulation of the gene for Fe-containing superoxide dismutase by an Ni-responsive factor in Streptomyces coelicolor.. J. Bacteriol.

Kim, E.J., Chung, H.J., Suh, B., Hah, Y.C., and Roe, J.H. (1998). Expression of sodF gene encoding iron- and zinc-containing superoxide dismutase from Streptomyces coelicolor Müller.. J. Bacteriol.

Cho, Y.H. and Roe, J.H. (1997). Isolation and expression of the catA gene encoding the major vegetative catalase in Streptomyces coelicolor Müller.. J. Bacteriol.

J. Biol. Chem.

Kim, H.P., Roe, J.H., Chock, P.B., Yim, M.B. (1999). Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate.. J. Biol. Chem.

Lee, J., Dawes, I., and Roe, J.H. (1997). Isolation, expression, and regulation of the pgr1+ gene encoding glutathione reductase absolutely required for the aerobic growth of Schizosaccharomyces pombe.. J. Biol. Chem.

J. Biol.Chem.

Hahn, J.S., Oh, S.Y., Chater, K.F., Cho, Y.H. and Roe, J.H. (2000). H2O2-sensitive Fur-like repressor CatR regulating the major catalase gene in Streptomyces coelicolor.. J. Biol.Chem.

J. Microbiol.

Cho, Y.H., Hahn, J.S., and Roe, J.H. (2000). Analysis of the dual promoters and the negative cis-element, HRE controlling H2O2-responsive expression of Streptomyces coelicolor catA.. J. Microbiol.

Hahn, J.S., Oh, S.Y., Chater, K.F., and Roe, J.H. (2000). Isolation of the regulator gene responsible for overproduction of catalase A in H2O2-resistant mutant of Streptomyces coelicolor.. J. Microbiol.

Lee, S.I., Lee, J., and Roe, J.H. (2000). Subcellular localization of catalse encoded by the ctt1+ gene in Schizosaccharomyces pombe.. J. Microbiol.

Kim E.K. and Roe J.H. (1999). The function of mORF1 protein as a terminal recognition factor for the linear mitochondrial plasmid pMLP1 from Pleurotus ostreatus.. J. Microbiol.

Lee, J.H., and Roe, J.H. (1997). Isolation and characterization of paraquat-inducible promoters from Escherichia coli.. J. Microbiol.

Kim, E.K., Youn, H.S., Koo, Y.B., and Roe, J.H. (1997). The genetic organization of the linear mitochondrial plasmid mlp1 from Pleurotus ostreatus NFFA2.. J. Microbiol.

Journal of Biotechnology

Ju Yeon Song, Young Ji Yoo, Si-Kyu Lim, Sun Ho Cha, Ji-Eun Kim, Jung-Hye Roe, Jihyun F. Kim, Yeo Joon Yoon (2015). Complete genome sequence of Streptomyces venezuelae ATCC 15439, a promising cell factory for production of secondary metabolites. Journal of Biotechnology

mBio

Ju-Hyung Lee, Ji-Sun Yoo, Yeonbum Kim, Jong-Seo Kim, Eun-Jin Lee, and Jung-Hye Roe (2020). The WblC/WhiB7 transcription factor controls intrinsic resistance to translation-targeting antibiotics by altering ribosome composition. mBio

Metallomics

Kim HM, Ahn BE, Lee JH, Roe JH. (2015). Regulation of a nickel-cobalt efflux system and nickel homeostasis in a soil actinobacterium Streptomyces coelicolor.. Metallomics

Methods Enzymol.

Hahn, M.Y., Bae, J.B., Park, J.H., Roe, J.H. (2003). Isolation and characterization of Streptomyces coelicolor RNA polymerase, its sigma, and antisigma factors.. Methods Enzymol.

Lee, J.W., Roe, J.H., Kang, S.O. (2002). Nickel-containing superoxide dismutase.. Methods Enzymol.

Mol Microbiol

Park JH, Lee JH, Roe JH. (2019). SigR, a hub of multilayered regulation of redox and antibiotic stress responses. Mol Microbiol

Kim MS, Hahn MY, Cho Y, Cho SN, Roe JH. (2009). Positive and negative feedback regulatory loops of thiol-oxidative stress response mediated by an unstable isoform of sigma in actinomycetes.. Mol Microbiol

Mol Microbiol.

Lee KL, Singh AK, Heo L, Seok C, Roe JH. (2015). Factors affecting redox potential and differential sensitivity of SoxR to redox-active compounds.. Mol Microbiol.

Singh AK, Shin JH, Lee KL, Imlay JA, Roe JH (2013). Comparative study of SoxR activation by redox-active compounds.. Mol Microbiol.

Park JH, Roe JH (2008). Mycothiol regulates and is regulated by a thiol-specific antisigma factor RsrA and sigma(R) in Streptomyces coelicolor.. Mol Microbiol.

Yeo WS, Lee JH, Lee KC, Roe JH. (2006). IscR acts as an activator in response to oxidative stress for the suf operon encoding Fe-S assembly proteins.. Mol Microbiol.

Ahn BE, Cha J, Lee EJ, Han AR, Thompson CJ, Roe JH. (2006). Nur, a nickel-responsive regulator of the Fur family, regulates superoxide dismutases and nickel transport in Streptomyces coelicolor.. Mol Microbiol.

Lee EJ, Karoonuthaisiri N, Kim HS, Park JH, Cha CJ, Kao CM, Roe JH. (2005). A master regulator sigmaB governs osmotic and oxidative response as well as differentiation via a network of sigma factors in Streptomyces coelicolor.. Mol Microbiol.

Mol. Gen Genet.

Koh, Y.S., Chung, W.H., Lee, J.H., Roe, J.H. (1999). The reversed SoxS-binding site upstream of the ribA promoter in Escherichia coli. Mol. Gen Genet.

Mol. Microbiol.

Cho,Y.H., Lee,E.J., Ahn,B.E., and Roe, J.H. (2001). SigB, an RNA polymerase sigma factor required for osmoprotection and proper differentiation of Streptomyces coelicolor.. Mol. Microbiol.

Cho, Y.H., Lee, E.J., and Roe, J.H. (2000). A developmentally regulated catalase required for proper differentiation and osmoprotection of Streptomyces coelicolor.. Mol. Microbiol.

Kim, E.J., Chung, H.J., Suh, B., Hah, Y.C., and Roe, J.H. (1998). Transcriptional and post-transcriptional regulation of sodN gene encoding nickel-containing superoxide dismutase from Streptomyces coelicolor Müller.. Mol. Microbiol.

Mol.Microbiol.

Paget, M.S.B., Bae, J.B., Hahn, M.Y., Li, W., Kleanthous, C., Roe, J.H., and Buttner, M.J. (2001). Mutational analysis of RsrA, a zinc-binding anti-sigma factor with a thiol-disulphide redox switch.. Mol.Microbiol.

Molecular Microbiology

Kim MS, Dufour YS, Yoo JS, Cho YB, Park JH, Nam GB, Kim HM, Lee KL, Donohue TJ, Roe JH (2012). Conservation of thiol-oxidative stress responses regulated by SigR orthologues in actinomycetes.. Molecular Microbiology

Nat Commun

Choi SH, Lee KL, Shin JH, Cho YB, Cha SS, Roe JH. (2017). Zinc-dependent regulation of zinc import and export genes by Zur.. Nat Commun

NATURE COMMUNICATIONS

Yujin Jeong, Ji-Nu Kim, Min Woo Kim, Giselda Bucca, Suhyung Cho, Yeo Joon Yoon, Byung-Gee Kim, Jung-Hye Roe, Sun Chang Kim, Colin P. Smith & Byung-Kwan Cho (2016). The dynamic transcriptional and translational landscape of the model antibiotic producer Streptomyces coelicolor A3(2). NATURE COMMUNICATIONS

nov. Int. J. Syst. Evol. Microbiol.

Lee S.D., Kim E.S., Roe J.H., Kim J.H., Kang S.O., and Hah Y.C. (2000). Saccharothrix violacea sp. nov., isolated from a gold mine cave, and Sachcarothrix albidocapillata comb.. nov. Int. J. Syst. Evol. Microbiol.

Nucleic Acids Res

Ji-Eun Kim, Joon-Sun Choi, Jong-Seo Kim, You-Hee Cho, and Jung-Hye Roe. (2020). Lysine acetylation of the housekeeping sigma factor enhances the activity of the RNA polymerase holoenzyme. Nucleic Acids Res

Jung YG, Cho YB, Kim MS, Yoo JS, Hong SH, Roe JH. (2011). Determinants of redox sensitivity in RsrA, a zinc-containing anti-sigma factor for regulating thiol oxidative stress response. Nucleic Acids Res

Nucleic Acids Res.

Kim HM, Shin JH, Cho YB, Roe JH. (2013). Inverse regulation of Fe- and Ni-containing SOD genes by a Fur family regulator Nur through small RNA processed from 3'UTR of the sodF mRNA.. Nucleic Acids Res.

An YJ, Ahn BE, Han AR, Kim HM, Chung KM, Shin JH, Cho YB, Roe JH, Cha SS. (2009). Structural basis for the specialization of Nur, a nickel-specific Fur homolog, in metal sensing and DNA recognition.. Nucleic Acids Res.

Kang, J.G., Hanh, M.Y., Ishihama, A., and Roe, J.H. (1997). Identification of sigma factors for growth phase-related promoter selectivity of RNA polymerases from Streptomyces coelicolor A3(2).. Nucleic Acids Res.

Proc Natl Acad Sci U S A

Shin JH, Jung HJ, An YJ, Cho YB, Cha SS, Roe JH (2011). Graded expression of zinc-responsive genes through two regulatory zinc-binding sites in Zur. Proc Natl Acad Sci U S A

Proteins

Heo L, Cho YB, Lee MS, Roe JH, Seok C. (2013). Alternative zinc-binding sites explain the redox sensitivity of zinc-containing anti-sigma factors.. Proteins

Res Microbiol

Kim HS, Lee EJ, Cho YH, Roe JH. (2012). Post-translational regulation of a developmental catalase, CatB, involves a metalloprotease, SmpA and contributes to proper differentiation and osmoprotection of Streptomyces coelicolor.. Res Microbiol

Scientific Reports

Ji-Sun Yoo, Gyeong-Seok Oh, Sungweon Ryoo & Jung-Hye Roe (2016). Induction of a stable sigma factor SigR by translation-inhibiting antibiotics confers resistance to antibiotics. Scientific Reports