Seoul National University Biological Sciences Website

Publications

Laboratory of Cancer Cell Biology

2025

Su Hyun Lee, Mi-Sun Kwon , Taerim Lee , Sungchul Hohng and Hyunsook Lee (2025). Kinesin‐like protein KIF18A is required for faithful coordination of chromosome congression. FEBS Journal, (), .

2024

So Young Joo, Keewon Sung, Hyunsook Lee (2024). Balancing act: BRCA2's elaborate management of telomere replication through control of G-quadruplex dynamicity. BioEssays, (), .

Jennifer J. Lee, Hyungmin Kim, Haemin Park, UkJin Lee, Chaelim Kim, Min Lee, Yongdae Shin, Ji-Jung Jung, Han-Byoel Lee, Wonshik Han and Hyunsook Lee (2024). Disruption of G-quadruplex dynamicity by BRCA2 abrogation instigates phase separation and break-induced replication at telomeres. Nucleic Acid Research, (), .

Hyemin Kim, Ph.D, Jinho Jang, Ph.D, Jin Ho Choi, MD, Ph.D, Joo Hye Song, MD, Ph.D, Su Hyun Lee, BS, Jiho Park, Ph.D, Si Kyong Ryoo, MD, Eun Mi Lee, MS, Hyoung-oh Jeong, Ph.D, Seunghoon Kim, BS, Se-Hoon Lee, MD, Ph.D, Kwang Hyuck Lee, MD, Ph.D, Kyu Taek Lee, MD, Ph.D, Kyoung Mee Kim, MD, Ph.D, KeeTaek Jang, MD, Ph.D, Hyunsook Lee, Ph.D, Semin Lee, Ph.D, Jong Kyun Lee, MD, Ph.D, Joo Kyung Park, MD, Ph.D (2024). Establishment of a patient-specific avatar organoid model derived from endoscopic ultrasonography-guided fine needle biopsy for timely clinical application in pancreatic ductal adenocarcinoma. Gastrointestinal Endoscopy, (), .

Jeonghwan Youk, Hyun Woo Kwon, Joonoh Lim, Eunji Kim, Taewoo Kim, Ryul Kim, Seongyeol Park, Kijong Yi , Chang Hyun Nam, Sara Jeon, Yohan An, Jinwook Choi, Hyelin Na, Eon-Seok Lee, Youngwon Cho, Dong-Wook Min, HyoJin Kim, Yeong-Rok Kang, Si Ho Choi, Min Ji Bae, Chang Geun Lee, Joon-Goon Kim, Young Seo Kim, Tosol Yu, Won-Chul Lee, Jong-Yeon Shin, Dong Soo Lee, Tae-You Kim, Taeyun Ku, Su Yeon Kim, Joo-Hyeon Lee, Bon-Kyoung Koo, Hyunsook Lee... Ji Hyun Chang, Kyung Su Kim, Tae Gen Son, Young Seok Ju (2024). Quantitative and qualitative mutational impact of ionizing radiation on normal cells. Cell Genomics, (), .

2023

Youngil Koh, Hyemin Kim, So Young Joo, Seulki Song, Young Hoon Choi, Hyung Rae Kim, Byul Moon, Jamin Byun, Junshik Hong, Dong-Yeop Shin, Solip Park, Kwang Hyuck Lee, Kyu Taek Lee, Jong Kyun Lee, Daechan Park, Se-Hoon Lee, Jin-Young Jang, Hyunsook Lee, Jung-Ae Kim, Sung-Soo Yoon &Joo Kyung Park (2023). Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma. Journal of Translational Medicine, (), .

2022

Junyeop Lee, Keewon Sung, So Young Joo, Jun-Hyeon Jeong, Seong Keun Kim, Hyunsook Lee (2022). Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis. Nature Communications, (), .

Youngran Kim, Junhyeon Park, So Young Joo, Byung-Gyu Kim, Aera Jo, Hyunsook Lee, Yunje Cho (2022). Structure of the Human TELO2-TTI1-TTI2 Complex. Journal of Molecular Biology, 434(2), .

2021

Jiho Park, Song Y. Yeu, Sangjin Paik, Hyungmin Kim, Si-Young Choi, Junyeop Lee, Jinho Jang, Semin Lee, Youngil Koh, Hyunsook Lee (2021). Loss of BubR1 acetylation provokes replication stress and leads to complex chromosomal rearrangements. The FEBS journal, (), .

2020

Jennifer J. Lee, Junyeop Lee, Hyunsook Lee. (2020). Alternative paths to telomere elongation. Seminars in Cell & Developmental Biology,, (), .

2019

Mi‐Sun Kwon, Jennifer J. Lee, Jaewon Min, Kwangwoo Hwang, Seung Gu Park, Eun‐Hye Kim, Byung Chul Kim, Jong Bhak, Hyunsook Lee. (2019). Brca2 abrogation engages with the alternative lengthening of telomeres via break‐induced replication. THE FEBS journal, (), .

Xingyi Ma, Sojin Song, Soohyun Kim, Mi-sun Kwon, Hyunsook Lee, Wounjhang Park & Sang Jun Sim (2019). Single gold-bridged nanoprobes for identification of single point DNA mutations. nature communication, (), .

2018

Hyeshik Chang, Jinah Yeo, Jeong-gyun Kim, Hyunjoon Kim, Jaechul Lim, Mihye Lee, Hyun Ho Kim, Jiyeon Ohk, Hee-Yeon Jeon, Hyunsook Lee, Hosung Jung, Kyu-WonKim, V. NarryKim. (2018). Terminal Uridylyltransferases Execute Programmed Clearance of Maternal Transcriptome in Vertebrate Embryos.. Molecular cell, 70(1), 72-82..

Jinyoung Park, Mi-Sun Kwon, Eunice EunKyeong Kim, Hyunsook Lee & Eun Joo Song (2018). USP35 regulates mitotic progression by modulating the stability of Aurora B. nature communication, (), .

2017

Inai Park*, Mi-Sun Kwon*, Sangjin Paik, Hyeonjong Kim, Hae-Ock Lee, Eunhee Choi, and Hyunsook Lee (2017). HDAC2/3 binding and deacetylation of BubR1 initiates the spindle assembly checkpoint silencing. The FEBS Journal, (), .

2016

Mi-Sun Kwon, Jaewon Min, Hee-Yeon Jeon, Kwangwoo Hwang, Chuna Kim, Junho Lee, Je-Gun Joung, Woong-Yang Park and Hyunsook Lee (2016). Paradoxical delay of senescence upon depletion of BRCA2 in telomerase-deficient worms. FEBS Open Bio, (), .

2015

Yoo-Kyung Lee, Noh-Hyun Park, Hyunsook Lee (2015). Clinicopathological values of NBS1 and DNA damage response genes in epithelial ovarian cancers. Experimental & Molecular Medicine, 47(), .

Jun-hyeon Jeong, Areum Jo, Pilgu Park , Hyunsook Lee , Hae-Ock Lee (2015). Brca2 Deficiency Leads to T Cell Loss and Immune Dysfunction. MOLECULES AND CELLS, 38(3), 251-258.

2014

Yoo Kyung Lee ; Inai Park; Hyunsook Lee (2014). Partial Hepatectomy in Acetylation-Deficient BubR1 Mice Corroborates that Chromosome Mis-Segregation Initiates Tumorigenesis. Endocrinology Metabolism, 10(3803), 1-5.

Hyunsook Lee (2014). Cycling with BRCA2 from DNA repair to Mitosis. EXPERIMENTAL CELL RESEARCH, 329(2014), 78-84.

Hyunsook Lee (2014). How Chromosome Missegregation Leads to Cancer Lessons from BubR1 Mouse Models. MOLECULES AND CELLS, 37(10), 713-718.

Da-Hye Kim, Junho Seong, Hyunsook Lee, Keun-Hyeung Lee (2014). Ratiometric fluorescence detection of Hg(II) in aqueous solutions atphysiological pH and live cells with a chemosensor based on tyrosine. Sensors and Actuators B: Chemical, 196(), 421-428.

2013

Inai Park, Hae-ock Lee,Eunhee Choi, Yoo-Kyung Lee, Mi-Sun Kwon, Jaewon Min, Pil-Gu Park, Seonju Lee, Hyunsook Lee (2013). Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation. The journal of Cell Biology, 202(2), 295-309.

Hee-Yeon Jeon, Hyunsook Lee (2013). Depletion of Aurora-A in zebrafish causes growth retardation due to mitotic delay and p53-dependent cell death. The FEBS Journal, 280(6), 1518-1530.

2012

Sujung Jang, Ponnaboina Thirupathi, Lok Nath Neupane, Junho Seong, Hyunsook Lee, Wan In Lee, and Keun-Hyeung Lee (2012). Highly Sensitive Ratiometric Fluorescent Chemosensor for Silver lon and Silver Nanoparticles in Aqueous Solution. ORGANIC LETTERS, 14(18), 4746-4749.

Yang-Seok Chae, Hyunji Kim, Dongsung Kim, Hyunsook Lee, Hae-ock Lee (2012). Cell density-dependent acetylation of Delta Np63 alpha is associated with p53-dependent cell cycle arrest. FEBS Letters, 586(8), 1128-1134.

Jaewon Min, Eun Shik Choi, Kwangwoo Hwang, Jimi Kim, Srihari Sampath, Ashok R. Venkitaraman, and Hyunsook Lee (2012). The Breast Cancer Susceptibility Gene BRCA2 is required for the maintenance of telomere Homeostasis.. Journal of Biological Chemistry, 287(7), 5091-5101.

Eunhee Choi, Pil-Gu Park, Hae-ock Lee, Yoo-Kyung Lee, Gyeong Hoon Kang, Jong Won Lee, Wonshik Han, Ho Chang Lee, Dong-Young Noh, Sergey Lekomtsev, and Hyunsook Lee (2012). BRCA2 Fine-Tunes the Spindle Assembly Checkpoint through Reinforcement of BubR1 Acetylation. Developmental Cell, 22(2), 295-308.

Yoo-Kyung Lee, Noh-Hyun Park, and Hyunsook Lee (2012). Prognostic Value of Alternative Lengthening of Telomeres-Associated Biomarkers in Uterine Sarcoma and Uterine Carcinosarcoma.. International Journal of Gynecological Cancer, (), In press.

2010

KilHun Jeong, Jae-Yeon Jeong, Hae-Ock Lee, Eunhee Choi, Hyunsook Lee (2010). Inhibition of Plk1 induces mitotic inﬁdelity and embryonic growth defects in developing zebraﬁsh embryos. Developmental Biology, 345(1), 34-48.

2009

Y-K Lee, E Choi, MA Kim, P-G Park, N-H Park and H Lee (2009). BubR1 as a prognostic marker for recurrence-free survival rates in epithelial ovarian cancers. British Journal of Cancer, 101(3), 504-10.

Eunhee Choi, Hyerim Choe, Jaewon Min, Ji Yoon Choi, Jimi Kim and Hyunsook Lee (2009). BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis. The EMBO Journal, 28(14), 2077-89.

2008

Eunkyong Ko, Junho Lee, and Hyunsook Lee (2008). Essential Role of brc-2 in Chromosome Integrity of Germ Cells in C. elegans. Mol. Cells, 26(2), 590-4.

Pil-Gu Park and Hyunsook Lee (2008). Development of thymic lymphomas in mice disrupted of Brca2 allele in the thymus. EXPERIMENTAL and MOLECULAR MEDICINE, 40(3), 339-44.

Eunhee Choi, Hyunsook Lee (2008). Chromosome damage in mitosis induces BubR1 activation and prometaphase arrest. FEBS Letters, 582(12), 1700-6.

2007

Hae-ock Lee, Mioh Cho, Jung-Hwa Lee, Hyo-Sil Kim, Yungdae Yun, Hyunsook Lee (2007). SuPr-1-mediated desumoylation regulates the repressor activity of DeltaNp63alpha.. FEBS Letters, 581(29), 5640-4.

Hae-ock Lee, Jung-Hwa Lee, Tae-You Kim, Hyunsook Lee (2007). Regulation of DeltaNp63alpha by tumor necrosis factor-alpha in epithelial homeostasis.. FEBS Journal, 274(24), 6511-22.

Jaewon Min, Pil-gu Park, Eunkyong Ko, Eunhee Choi and Hyunsook Lee (2007). Identification of Rad51 regulation by BRCA2 using Caenorhabditis elegans BRCA2 and bimolecular fluorescence complementation analysis. Biochemical and Biophysical Research Communications, 362(4), 958-64.

2006

Hae-ock Lee, Jung-Hwa Lee, Eunhee Choi, Ja Young Seol, Yungdae Yun and Hyunsook Lee (2006). A dominant negative form of p63 inhibits apoptosis in a p53-independent manner. Biochemical and Biophysical Research Communications, 344(1), 166-72.

2003

Eun Mi Hur, Myoungsun Son, Ok-Hee Lee, Young Bong Choi, Changwon Park, Hyunsook Lee, and Yungdae Yun (2003). LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation.. The Journal of Experimental Medicine, 198(10), 1463-73.

Hyunsook Lee (2003). Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas.. EXPERIMENTAL and MOLECULAR MEDICINE, 35(5), 448-53.