백성희

교수

백성희 Baek, Sung Hee

백성희
연구분야
분자생물학 세포생물학 유전학
Our research center is interested in “Chromatomics” as studying dynamic protein-DNA interaction, chromatin structure and its dynamic changes and analyzing chromatome, which includes genome and epigenome in in vivo systems. The aim of Chromatin Dynamics Research Center is to investigate the chromatin code in tumorigenesis and metastasis through chromatin dynamics and to develop disease control technique.
1. Elucidation of chromatin code of prostate and breast cancer inducing factors and establishment of mouse model
2. Elucidation of signal transduction pathway and regulatory protein network in prostate/breast tumorigenesis and metastasis
3. Application of chromatin code in the development of disease control techniques and therapeutic reagents for the control of prostate/breast cancer
학력/경력
학력
  • - 1996.3-1999.2 이학박사: 서울대학교
  • - 1994.3-1996.2 이학석사: 서울대학교
  • - 1990.3-1994.2 이학사: 서울대학교
경력
  • - 2015-현재 국가과학기술자문회의 전문위원
  • - 2015-현재 한국연구재단 기초연구본부, 생명과학단 전문위원
  • - 2015-현재 Asian Advisory Committee, Keystone Symposia
  • - 2015-현재 Editor, DNA and Cell Biology
  • - 2013-현재 Review Committee member, Human Frontier Science Program
  • - 2013-현재 서울대학교 생명과학부, 교수
  • - 2010-현재 Guest Editor, Annual Review of Physiology
  • - 2009-현재 크로마틴 다이나믹스 창의연구단장
  • - 2009-현재 한림원 이학부 준회원
  • - 2008-현재 Editor, BBA Molecular Basis of Disease (Elsevier)
  • - 2008-2012 서울대학교 생명과학부, 부교수(조기정년보장)
  • - 2006-현재 Managing Editor, Frontiers in Biosciences
  • - 2003-2007 서울대학교 생명과학부, 조교수
  • - 2002-2003 Research Professor, University of California, San Diego
  • - 2000-2002 Post-doctoral research fellow, University of California, San Diego
  • - 1999-2000 서울대학교 분자생물학과, post-doc.
주요논문
  1. Shin, H-J., Kim H.K., Oh, S.R., Lee, J-G., Kee, M.J., Ko, H-J., Kweon, M-N., Won, K.J., and Baek, S.H. (2016)
    AMPK-Skp2-CARM1 Signaling Cascade in Transcriptional Regulation of Autophagy. Nature 534(7608), 553–557.
  2. Nam, H.J., Boo, K.J., Kim, D.H., Han, D.H., Choe, H.K., Kim, C.R., Sun, W., Kim, H., Kim, K.J., Lee, H., Metzger, E., Schuele, R., Yoo, S.H., Takahashi, J.S., Cho, S.H., Son, G.H., and Baek, S.H. (2014) Phosphorylation of LSD1 by PKCα Is Crucial for Circadian Rhythmicity and Phase Resetting. Molecular Cell 53(5), 791-805. (Cover Article)
  3. Lee, J.M., Lee, J.S., Kim, H.K., Kim, K.K., Park, H.J., Kim, J.-Y., Lee, S.H., Kim, I.S., Kim, J.M., Lee, M.K., Chung, C.H., Seo, S.-B., Yoon, J.-B., Ko, E.Y., Noh, D.-Y., Kim, K.I., Kim, K.K., and Baek, S.H. (2012) EZH2 Generates a Methyl Degron That Is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex.
    Molecular Cell 48(4), 572-586. (Cover Article)
  4. Kim, H., Lee, J.M., Lee, G., Bhin, J., Oh, S.K., Kim, K., Pyo, K.E., Lee, J.S., Yim, H.Y., Kim, K.I., Hwang, D., Chung, J., and Baek, S.H. (2011) DNA Damage-Induced RORα is Crucial for p53 Stabilization and Increased Apoptosis.
    Molecular Cell 44(5), 797-810. (Cover Article)
  5. Lee, J. S., Kim, Y., Kim, I.S., Kim, B., Choi, H.J., Lee, J.M., Shin, H-J. R., Kim, J.H., Kim, J.-Y., Seo, S.-B., Lee, H., Binda, O., Gozani, O., Semenza, G.L., Kim, M., Kim, K.I., Hwang, D.H., and Baek, S.H. (2010) Negative Regulation of Hypoxic Responses via Induced Reptin Methylation. Molecular Cell 39(1), 71-85. (Cover Article)
  6. Kim, J.H., Kim, B., Ling, C., Choi, H.J., Ohgi, K.A., Tran, C, Chen, C., Chung, C.H., Huber, O., Rose, D.W., Sawyers, C.L., Rosenfeld, M.G., and Baek, S.H. (2005) Transcriptional Regulation of a Metastasis Suppressor Gene by Tip60 and β-Catenin Complexes. Nature 434(7035), 921-926.