Laboratory of Membrane Biology

Laboratory of Membrane Biology

Seoul National University
Laboratory of Membrane Biology

Laboratory of Membrane Biology

Seoul National University

Publications+ more

(2019) The Mgr2 subunit of the TIM23 complex regulates membrane insertion of marginal stop-transfer signals in the mitochondrial inner membrane, FEBS letters
(2019) Proper insertion and topogenesis of membrane proteins in the ER depend on Sec63, BBA – General Subjects
(2018) Profiling of signal sequence characteristics and requirement of different translocation components, BBA-Mol. Cell Res
(2017) Molecular insights into the m-AAA protease mediated dislocation of transmembrane helices in the mitochondrial inner membrane, J. Biol. Chem.
(2017) Refined topology model of the STT3/Stt3 protein subunit of the oligosaccharyl transferase complex, J. Biol. Chem.
(2015) Use of carbonate extraction in analyzing moderately hydrophobic transmembrane proteins in the mitochondrial inner membrane, Protein. Sci.
(2014) The Sec62/Sec63 translocon facilitates the Cout orientation of membrane proteins, J. Cell. Sci.
(2014) Membrane topology of transmembrane proteins: determinants and experimental tools, Biochem. Biophys. Res. Commun.
(2014) Mode of membrane insertion of individual transmembrane segments in Mdl1 and Mdl2, multi-spanning mitochondrial ABC transporters, FEBS Lett.
(2014) Live-cell topology assessment of URG7, MRP6₁₀₂ and SP-C using glycosylatable green fluorescent protein in mammalian cells, Biochem. Biophys. Res. Commun.

Welcome to the
"Laboratory of Membrane Biology"

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This is a laboratory of membrane biology. 

Membrane proteins comprise ~30-40% of the prteome in eukaryotic cells. Some are trafficked to the plasma membrane whereas others are destined to the intracellular organelles such as mitochondria and endoplasmic reticulum (ER), Golgi, lysosomes. Since therapeutic drugs need to pass through the plasma membrane, membrane proteins are major drug targets. In spite of the importance, experimental challenge impedes progress of understanding of membrane proteins.  

Membrane proteins are sorted to two structure types: a helical and b barrel membrane proteins. B barrals are found in the outermembranes of bacteria, mitochondria and chloroplasts. A helical membrane proteins are universally found in all organisms.

Our research interests lie on how a helical membrane proteins are targeted to correct membrane compartments, inserted and translocated, and what and how the cellular components mediate these processes in the cell. We use a baker’s yeast, Saccharomyces cerevisiae as a model eukaryotic organism and mammalian tissue cultured cells.