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This is a laboratory of membrane biology.
Membrane proteins comprise ~30-40% of the prteome in eukaryotic cells. Some are trafficked to the plasma membrane whereas others are destined to the intracellular organelles such as mitochondria and endoplasmic reticulum (ER), Golgi, lysosomes. Since therapeutic drugs need to pass through the plasma membrane, membrane proteins are major drug targets. In spite of the importance, experimental challenge impedes progress of understanding of membrane proteins.
Membrane proteins are sorted to two structure types: a helical and b barrel membrane proteins. B barrals are found in the outermembranes of bacteria, mitochondria and chloroplasts. A helical membrane proteins are universally found in all organisms.
Our research interests lie on how a helical membrane proteins are targeted to correct membrane compartments, inserted and translocated, and what and how the cellular components mediate these processes in the cell. We use a baker’s yeast, Saccharomyces cerevisiae as a model eukaryotic organism and mammalian tissue cultured cells.