Seoul National University Biological Sciences Website

Publications

Laboratory of Molecular Genomics

2024

Daewon Lee, Eunju Yoon, Su Jin Ham, Kunwoo Lee, Hansaem Jang, Daihn Woo, Da Hyun Lee, Sehyeon Kim, Sekyu Choi, Jongkyeong Chung (2024). Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila. Nature Communications, 15(1), 468.

2023

Su Jin Ham, Heesuk Yoo, Daihn Woo, Da Hyun Lee, Kyu-Sang Park, Jongkyeong Chung (2023). PINK1 and Parkin regulate IP3R-mediated ER calcium release. Nature Communications, 14(1), 5202.

Jong-Seol Kang, Dongha Kim, Joonwoo Rhee, Ji-Yun Seo, Inkuk Park, Ji-Hoon Kim, Daewon Lee, WonUk Lee, Ye Lynne Kim, Kyusang Yoo, Sunghwan Bae, Jongkyeong Chung, Rho Hyun Seong, Young-Yun Kong (2023). Baf155 regulates skeletal muscle metabolism via HIF-1a signaling. PLOS Biology, 21(7), e3002192.

Andrew J Lee, Changyoun Kim, Seongwan Park, Jaegeon Joo, Baekgyu Choi, Dongchan Yang, Kyoungho Jun, Junghyun Eom, Seung-Jae Lee, Sun Ju Chung, Robert A Rissman, Jongkyeong Chung, Eliezer Masliah, Inkyung Jung (2023). Characterization of altered molecular mechanisms in Parkinson's disease through cell type-resolved multiomics analyses. Science Advances, 9(15), eabo2467.

Kyeonghwan Roh, Jeonghwan Noh, Yeonju Kim, Yeji Jang, Jaejin Kim, Haebeen Choi, Yeonghyeon Lee, Moongi Ji, Donghyun Kang, Mi-Sung Kim, Man-Jeong Paik, Jongkyeong Chung, Jin-Hong Kim, Chanhee Kang (2023). Lysosomal control of senescence and inflammation through cholesterol partitioning. Nature Metabolism, 5(3), 398-413.

Mari Kim, Gwang-Ic Son, Yun-Ho Cho, Gye-Hyeong Kim, Sung-Eun Yoon, Young-Joon Kim, Jongkyeong Chung, Eunil Lee, Joong-Jean Park (2023). Reduced branched-chain aminotransferase activity alleviates metabolic vulnerability caused by dim light exposure at night in Drosophila. J Neurogenet., 37(1-2), 25-35.

2022

Soon-Young Na, Ki-Sun Kim, Yoon Seok Jung, Don-Kyu Kim, Jina Kim, Sung Jin Cho, In-Kyu Lee, Jongkyeong Chung, Jeong-Sun Kim, Hueng-Sik Choi (2022). An Inverse Agonist GSK5182 Increases Protein Stability of the Orphan Nuclear Receptor ERRγ via Inhibition of Ubiquitination. International Journal of Molecular Sciences, 24(1), 96.

Woongchang Yoon*, Soohong Min*, Ho-Sung Ryu, Sun Ju Chung, Jongkyeong Chung (2022). Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses. Commun Biol., 5(1), 872.

Sonn SK, Song EJ, Seo S, Kim YY, Um JH, Yeo FJ, Lee DS, Jeon S, Lee MN, Jin J, Kweon HY, Kim TK, Kim S, Moon SH, Rhee SG, Chung J, Yang J, Han J, Choi EY, Lee SB, Yun J, Oh GT. (2022). Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control. Redox Biol., 51(), 102275.

2021

Su Jin Ham*, Daewon Lee*, Wen Jun Xu, Eunjoo Cho, Sekyu Choi, Soohong Min, Sunghyouk Park, Jongkyeong Chung (2021). Loss of UCHL1 rescues the defects related to Parkinson's disease by suppressing glycolysis. Science Advances, 7(28), eabg4574.

Saeyan Choi, Bokyeong Song, Hyewon Shin, Chihyun Won, Taejoon Kim, Hideki Yoshida, Daewon Lee, Jongkyeong Chung, Kyoung Sang Cho, Im-Soon Lee (2021). Drosophila NSD deletion induces developmental anomalies similar to those seen in Sotos syndrome 1 patients. Genes Genomics, 43(7), 737-748.

Hiroshi Nishida, Morihiro Okada, Lynna Yang, Tomomi Takano, Sho Tabata, Tomoyoshi Soga, Diana M Ho, Jongkyeong Chung, Yasuhiro Minami, Sa Kan Yoo (2021). Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila. eLife, 10(4), e59809.

Jina Park*, Kyoungho Jun*, Yujin Choi*, Eunju Yoon, Wonho Kim, Yoon-Gu Jang, Jongkyeong Chung (2021). CORO7 functions as a scaffold protein for the core kinase complex assembly of the Hippo pathway. Journal of Biological Chemistry, 296(53), 100040.

2020

Yoon-Gu Jang*, Yujin Choi*, Kyoungho Jun, Jongkyeong Chung (2020). Mislocalization of TORC1 to lysosomes caused by KIF11 inhibition leads to aberrant TORC1 activity. Molecules and Cells, 43(8), 705-717.

Su Jin Ham*, Daewon Lee*, Heesuk Yoo, Kyoungho Jun, Heejin Shin, Jongkyeong Chung (2020). Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination. Proc Natl Acad Sci USA, 117(8), 4281-4291.

Sun-Hong Hwang*, Sunhoe Bang*, Wonho Kim, Jongkyeong Chung (2020). Von Hippel-Lindau tumor suppressor (VHL) stimulates TOR signaling by interacting with phosphoinositide 3-kinase (PI3K). Journal of Biological Chemistry, 295(8), 2336-2347.

Luong Dai Ly, Dat Da Ly, Nhung Thi Nguyen, Ji-Hee Kim, Heesuk Yoo, Jongkyeong Chung, Myung-Shik Lee, Seung-Kuy Cha, Kyu-Sang Park (2020). Mitochondrial Ca2+ uptake relieves palmitate-induced cytosolic Ca2+ overload in MIN6 cells. Molecules and Cells, 43(1), 66-75.

2019

Young Yeon Kim, Jee-Hyun Um, Jeong-Hyun Yoon, Hyunjin Kim, Da-Ye Lee, Yoon Jung Lee, Hye Jin Jee, Young Mi Kim, Jae Sung Jang, Yoon-Gu Jang, Jongkyeong Chung, Hwan Tae Park, Toren Finkel, Hyongjong Koh, Jeanho Yun (2019). Assessment of mitophagy in mt-Keima Drosophila revealed an essential role of the PINK1-Parkin pathway in mitophagy induction in vivo. FASEB Journal, 33(9), 9742-9751.

Isabelle K Vila, Mi Kyung Park, Stephanie Rebecca Setijono, Yixin Yao, Hyejin Kim, Pierre-Marie Badin, Sekyu Choi, Vihang Narkar, Sung-Woo Choi, Jongkyeong Chung, Cedric Moro, Su Jung Song, Min Sup Song (2019). A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity. JCI Insight, 4(13), 2379-3708.

Woongchang Yoon*, Sun-Hong Hwang*, Sang-Hee Lee, Jongkyeong Chung (2019). Drosophila ADCK1 is critical for maintaining mitochondrial structures and functions in the muscle. PLoS Genetics, 15(5), e1008184.

Sun-Hong Hwang, Sunhoe Bang, Kyung Shin Kang, Deborah Kang, Jongkyeong Chung (2019). ULK1 negatively regulates Wnt signaling by phosphorylating Dishevelled. Biochemical and Biophysical Research Communications, 508(1), 308-313.

2018

Tae-Yong Choi, Seung-Hyun Lee, Yoon-Jung Kim, Jae Ryul Bae, Kwang Min Lee, Youhwa Jo, Soo-Jeong Kim, A-Ram Lee, Sekyu Choi, La-Mee Choi, Sunhoe Bang, Mi-Ryoung Song, Jongkyeong Chung, Kyung Jin Lee, Sung Hyun Kim, Chul-Seung Park, Se-Young Choi (2018). Cereblon maintains synaptic and cognitive function by regulating BK channel. Journal of Neuroscience, 38(14), 3571-3583.

2017

Soohong Min, Woongchang Yoon, Hyunho Cho, Jongkyeong Chung (2017). Misato underlies visceral myopathy in Drosophila. Scientific Reports, 7(1), 17700.

Jinsung Yang, Min Ju Kim, Woongchang Yoon, Eun Young Kim, Hyunjin Kim, Yoonjeong Lee, Boram Min, Kyung Shin Kang, Jin H. Son, Hwan Tae Park, Jongkyeong Chung, Hyongjong Koh (2017). Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH). PLoS Genetics, 13(8), e1006975.

Wonho Kim, Yoon-Gu Jang, Jinsung Yang, Jongkyeong Chung (2017). Spatial activation of TORC1 is regulated by Hedgehog and E2F1 signaling in the Drosophila eye. Developmental Cell, 42(4), 363-375.

Sekyu Choi, Xianglan Quan, Sunhoe Bang, Heesuk Yoo, Jiyoung Kim, Jiwon Park, Kyu-Sang Park, and Jongkyeong Chung (2017). Mitochondrial calcium uniporter in Drosophila transfers calcium between the endoplasmic reticulum and mitochondria in oxidative stress-induced cell death. Journal of Biological Chemistry, 292(35), 14473-14485.

2016

Ji-Eun Bae, Sunhoe Bang, Soohong Min, Sang-Hyup Lee, Soon-Hwan Kwon, Youngseok Lee, Yong-Ho Lee, Jongkyeong Chung, Kwon-Seok Chae (2016). Positive geotactic behaviors induced by geomagnetic field in Drosophila. Molecular Brain, 9(1), 55.

Soohong Min, Hyoseok Chae, Yong-Hoon Jang, Sekyu Choi, Sion Lee, Yong Taek Jeong, Walton D. Jones, Seok Jun Moon, Young-Joon Kim and Jongkyeong Chung (2016). Identification of a peptidergic pathway critical to satiety responses in Drosophila. Current Biology, 26(6), 814-820.

Hyunjin Kim, Jinsung Yang, Min Ju Kim, Sekyu Choi, Ju-Ryung Chung, Jong-Min Kim, Young Hyun Yoo, Jongkyeong Chung, Hyongjong Koh (2016). Tumor necrosis factor receptor-associated protein 1 (TRAP1) mutation and TRAP1 inhibitor gamitrinib-triphenylphosphonium (G-TPP) induce a forkhead box O (FOXO)-dependent cell protective signal from mitochondria. Journal of Biological Chemistry, 291(4), 1841-1853.

Su Jin Ham, Soo Young Lee, Saera Song, Ju-Ryung Chung, Sekyu Choi and Jongkyeong Chung (2016). Interaction between RING1 (R1) and ubiquitin-like (UBL) domain is critical for the regulation of Parkin activity. Journal of Biological Chemistry, 291(4), 1803-1816.

2015

Junguee Lee, Sujin Ham, Min Hee Lee, Soung Jung Kim, Ji Hoon Park, Seong Eun Lee, Joon Young Chang, Kyong Hye Joung, Tae Yong Kim, Jin Man Kim, Hae Joung Sul, Gi Ryang Kweon, Young Suk Jo, Koon Soon Kim, Young Kee Shong, Giuseppe Gasparre, Jongkyeong Chung, Anna Maria Porcelli, Minho Shong (2015). Dysregulation of Parkin-mediated mitophagy in thyroid Hürthle cell tumors. Carcinogenesis, 36(11), 1407-1418.

Sekyu Choi, Dae-Sik Lim, Jongkyeong Chung (2015). Feeding and fasting signals converge on the LKB1-SIK3 pathway to regulate lipid metabolism in Drosophila. PLoS Genetics, 11(5), e1005263.

Wonho Kim, Hag Dong Kim, Youjin Jung, Joon Kim, Jongkyeong Chung (2015). Drosophila LTV1 (Low Temperature Viability Protein 1) is required for ribosome biogenesis and cell growth downstream of dMyc. Journal of Biological Chemistry, 290(21), 13591-604.

Kang-Min Lee, Ivana Daubnerová, R Elwyn Isaac, Chen Zhang, Sekyu Choi, Jongkyeong Chung, Young-Joon Kim (2015). A neuronal pathway that controls sperm ejection and storage in female Drosophila. Current Biology, 25(6), 790-797.

2014

Gha Young Lee, Hagoon Jang, Jae Ho Lee, Jin Young Huh, Sekyu Choi, Jongkyeong Chung, Jae Bum Kim (2014). PIASy-mediated sumoylation of SREBP1c regulates hepatic lipid metabolism upon fasting signaling. Molecular and Cellular Biology, 34(6), 926-938.

2013

Min Jeong Ryu, Soung Jung Kim, Yong Kyung Kim, Min Jeong Choi, Surendar Tadi, Min Hee Lee, Seong Eun Lee, Hyo Kyun Chung, Saet Byel Jung, Hyun-Jin Kim, Young Suk Jo, Koon Soon Kim, Sang-Hee Lee, Jin Man Kim, Gi Ryang Kweon, Ki Cheol Park, Jung Uee Lee, Young Yun Kong, Chul-Ho Lee, Jongkyeong Chung, Minho Shong (2013). Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice. PLoS Genetics, 9(3), e1003356.

Saera Song, Seoyeon Jang, Jeehye Park, Sunhoe Bang, Sekyu Choi, Kyum-Yil Kwon, Xiaoxi Zhuang, Eunjoon Kim, Jongkyeong Chung (2013). Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila. Journal of Biological Chemistry, 288(8), 5660-5672.

2012

Han SY, Lee M, Hong YK, Hwang S, Choi G, Suh YS, Park SH, Lee S, Lee SH, Chung J, Baek SH, Cho KS (2012). Tsp66E, the Drosophila KAI1 homologue, and Tsp74F function to regulate ovarian follicle cell and wing development by stabilizing integrin localization.. FEBS Letters, 586(22), 4031-4037.

Ng CH, Guan MS, Koh C, Ouyang X, Yu F, Tan EK, O'Neill SP, Zhang X, Chung J, Lim KL (2012). AMP kinase activation mitigates dopaminergic dysfunction and mitochondrial abnormalities in Drosophila models of Parkinson's disease. Journal of Neuroscience, 32(41), 14311-14317.

Kim SJ, Kwon MC, Ryu MJ, Chung HK, Tadi S, Kim YK, Kim JM, Lee SH, Park JH, Kweon GR, Ryu SW, Jo YS, Lee CH, Hatakeyama H, Goto Y, Yim YH, Chung J, Kong YY, Shong M (2012). CRIF1 is essential for the synthesis and insertion of oxidative phosphorylation polypeptides in the mammalian mitochondrial membrane. Cell Metab., 16(2), 274-83.

Koh H, Chung J (2012). PINK1 as a molecular checkpoint in the maintenance of mitochondrial function and integrity. Mol Cells, 34(1), 7-13.

Kim JJ, Lee HM, Shin DM, Kim W, Yuk JM, Jin HS, Lee SH, Cha GH, Kim JM, Lee ZW, Shin SJ, Yoo H, Park YK, Park JB, Chung J, Yoshimori T, Jo EK (2012). Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action. Cell Host Microbe., 11(5), 457-68.

Maeng O, Son W, Chung J, Lee KS, Lee YH, Yoo OJ, Cha GH, Paik SG (2012). The BTB/POZ-ZF transcription factor dPLZF is involved in Ras/ERK signaling during Drosophila wing development. Mol Cells, 33(5), 457-63.

Koh H, Kim H, Kim MJ, Park J, Lee HJ, Chung J (2012). Silent information regulator 2 (Sir2) and forkhead box O (FOXO) complement mitochondrial dysfunction and dDopaminergic neuron loss in Drosophila PTEN-induced kinase 1 (PINK1) null mutant. J. Biol. Chem., 287(16), 12750-8.

2011

Kim H, Lee JM, Lee G, Bhin J, Oh SK, Kim K, Pyo KE, Lee JS, Yim HY, Kim KI, Hwang D, Chung J, Baek SH (2011). DNA damage-induced RORα is crucial for p53 stabilization and increased apoptosis. Mol Cell, 44(5), 797-810.

Lee G, Liang C, Park G, Jang C, Jung JU, Chung J (2011). UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila. Dev. Biol., 15;356(2), 588-97.

Bang S, Hyun S, Hong ST, Kang J, Jeong K, Park JG, Choe J, and Chung J (2011). Dopamine signalling in mushroom bodies regulates temperature preference behaviour in Drosophila. PLoS GENETICS, 7(3), e1001346.

Choi S, Kim W, and Chung J (2011). Drosophila salt-inducible kinase (SIK) regulates starvation resistance through cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC). J. Biol. Chem., 286(4), 2658-64.

2010

Park J, Kim Y, Choi S, Koh H, Lee SH, Kim JM, Chung J (2010). Drosophila Porin/VDAC affects mitochondrial morphology. PLoS ONE., 5(10), e13151.

Sun D, Lee G, Kim HY, Rhee HW, Park SY, Kim KJ, Kim Y, Kim BY, Hong JI, Park C, Choy HE, Kim JH, Jeon YH & Chung J (2010). A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. Nat. Struc. Mol. Biol., 17(10), 1188-1194.

Kim S, Kim Y, Lee J, and Chung J (2010). Regulation of FOXO1 by TAK1-Nemo-like kinase pathway. J. Biol. Chem., 285(11), 8122-8129.

Lee YS, Park Y, Choi W, Park EM, Lee EY, Lee JS, Kim GD, Chung J, Choi TJ (2010). Sequence and expression analysis of extracellular signal-regulated kinase 1 from flounder (Paralichthys olivaceous). Fish Shellfish Immunol., 28(1), 65-71.

2009

Hyun S, Lee JH, Jin H, Nam J, Namkoong B, Lee G, Chung J, Kim VN. (2009). Conserved microRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K. Cell., 139(6), 1096-1108.

Park J, Kim Y, Chung J. (2009). Mitochondrial dysfunction and Parkinson's disease genes: insights from Drosophila.. Dis Model Mech., 2(7-8), 336-340.

Daniel J.M. Fernandez-Ayala, Alberto Sanz, Suvi Vartiainen ,Kia K. Kemppainen, Marek Babusiak, Eero Mustalahti, Rodolfo Costa, Tea Tuomela, Massimo Zeviani, Chung J, Kevin M.C. O'Dell, Pierre Rustin, Howard T. Jacobs (2009). Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation. Cell Metabolism, 9(5), 449-460.

Park J, Lee G, Chung J. (2009). The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process.. Biochem Biophys Res Commun., 378(3), 518-523.

2008

Kim Y, Park J, Kim S, Song S, Kwon SK, Lee SH, Kitada T, Kim JM, Chung J. (2008). PINK1 controls mitochondrial localization of Parkin through direct phosphorylation.. Biochem Biophys Res Commun., 377(3), 975-980.

Jang C, Lee G, Chung J. (2008). LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melan.. The Journal of Cell Biology., 183(1), 11-17.

Abeliovich H, Agostinis P, Agrawal DK, Chung J, Klionsky DJ, et al. (2008). Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.. Autophagy., 4(2), 151-175.

2007

Kim DW, Chung HK, Park KC, Hwang JH, Jo YS, Chung J, Kalvakolanu DV, (2007). Tumor suppressor LKB1 inhibits activation of signal transducer and activator of transcription 3 (STAT3) by thyroid oncogenic tyrosine kinase rearranged in transformation (RET)/papillary thyroid carcinoma (PTC).. Molecular Endocrinology., 12(), 3039-3049.

Koh H, Chung J. (2007). AMPK links energy status to cell structure and mitosis.. Biochem Biophys Res Commun., 362(4), 789-792.

Park MY, Moon JH, Lee KS, Choi HI, Chung J, Hong HJ, Kim E. (2007). FAF1 suppresses IKK activation by disrupting the IKK complex assembly.. J Biol Chem., 282(38), 27572-27577.

Lee SB, Kim W, Lee S, Chung J. (2007). Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila.. Biochem Biophys Res Commun., 358(2), 534-539.

Lee JH, Koh H, Kim M, Kim Y, Lee SY, Karess RE, Lee SH, Shong MH, Kim JM, Kim J, Chung J (2007). Energy-dependent regulation of cell structure by AMP-activated protein kinase.. Nature., 447(7147), 1017-1020.

Lee G, Chung J. (2007). Discrete functions of rictor and raptor in cell growth regulation in Drosophila.. Biochem Biophys Res Commun., 357(4), 1154-1159.

Lee SB, Kim S, Lee J, Park J, Lee G, Kim Y, Kim JM, Chung J. (2007). ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase.. EMBO Rep., 8(4), 360-365.

2006

Kim M, Lee JH, Lee SY, Kim E, Chung J. (2006). Caspar, a suppressor of antibacterial immunity in Drosophila.. Proc Natl Acad Sci USA., 103(44), 16358-16363.

Cho DH, Choi YJ, Jo SA, Ryou J, Kim JY, Chung J , Jo I. (2006). Troglitazone acutely inhibits protein synthesis in endothelial cells via a novel mechanism involving protein phosphatase 2A-dependent p70 S6 kinase inhibition.. Am. J. Physiol. Cell Physiol., 291(2), C317-326.

Kim M, Lee JH, Koh H, Lee SY, Jang C, Chung CJ, Sung JH, Blenis J, Chung J. (2006). Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development.. EMBO J., 25(13), 3056-3067.

Lee JH, Koh H, Kim M, Park J, Lee SY, Lee S, Chung J. (2006). JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila. Cell Death Differ., 13(7), 1110-1122.

Park J, Lee SB, Lee SK, Kim Y, Song SR, Kim SH, Bae EK, Kim J, Shong MH, Kim JM, Chung J (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin.. Nature., 441(), 1157-1161.

Lee Y, Paik D, Bang S, Kang J, Chun B, Lee S, Bae E, Chung J, Kim J. (2006). Loss of spastic paraplegia gene atlastin induces age-dependent death of dopaminergic neurons in Drosophila.. Neurobiol Aging., 29(1), 84-89.

2005

Park J, Kim SY, Cha GH, Lee SB, Kim S, Chung J. (2005). Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction.. Gene., 361(), 133-139.

Cha GH, Kim S, Park J, Lee E, Kim M, Lee SB, Kim JM, Chung J, Cho KS. (2005). Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila.. Proc Natl Acad Sci USA., 102(29), 10345-10350.

Lee SB, Park J, Jung JU, Chung J. (2005). Nef induces apoptosis by activating JNK signaling pathway and inhibits NF-kappaB-dependent immune responses in Drosophila.. J Cell Sci., 118(9), 1851-1859.

2004

Kim M, Cha GH, Kim S, Lee JH, Park J, Koh H, Choi KY, Chung J. (2004). MKP-3 has essential roles as a negative regulator of the Ras/MAPK pathway during Drosophila development.. Mol. Cell. Biol., 24(2), 573-583.

2003

Cha GH, Cho KS, Lee JH, Kim M, Kim E, Park J, Lee SB, Chung J. (2003). Discrete functions of TRAF1 and TRAF2 in Drosophila mediated by JNK- and NF-kB-dependent signaling pathways.. Mol. Cell. Biol., 23(22), 7982-7991.

Yun J, Chae HD, Choi TS, Kim EH, Bang YJ, Chung J, Choi KS, Mantovani R, Shin DY. (2003). Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway.. J. Biol. Chem., 278(38), 36966-36972.

Lee SB, Cho KS, Kim E, Chung J. (2003). blistery encodes Drosophila tensin protein and interacts with integrin and the JNK signaling pathway during wing development.. Development., 130(17), 4001-4010.

Kim S, Lee J, Park J, Chung J. (2003). BP75, bromodomain-containing M-r 75,000 protein, binds dishevelled-1 and enhances Wnt signaling by inactivating glycogen synthase kinase-3 beta.. Cancer Research., 63(), 4792-4795.

Lee JH, Lee E, Park J, Kim E, Kim J, Chung J. (2003). In vivo p53 function is indispensable for DNA damage-induced apoptosis signaling in Drosophila.. FEBS Lett., 550(), 5-10.

Suh JM, Song JH, Kim DW, Kim H, Chung HK, Hwang JH, Kim JM, Hwang ES, Chung J, Han JH, Cho BY, Ro HK, Shong M. (2003). Regulation of the PI3K, Akt/PKB, FRAP/mTOR, and S6K1 signaling pathways by thyroid stimulating hormone and stimulating-type TSH receptor antibodies in the thyroid gland.. J. Biol. Chem., 278(24), 21960-21971.

2002

Lee JH, Cho KS, Lee J, Kim D, Lee SB, Yoo J, Cha GH, Chung J. (2002). Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the MAP kinase signaling pathway.. Mol. Cell. Biol., 22(21), 7658-7666.

Ju JW, Bandyopadhyay A, Im WB, Chung J, Kwon HB, Choi HS. (2002). Involvement of phosphatidylinositol 3 kinase in the progesterone-induced oocyte maturation in Rana dybowskii.. Gen. Comp. Endocrinol., 126(2), 213-220.

Park HS, Kim MS, Huh SH, Park J, Chung J, Kang SS, Choi EJ. (2002). Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation.. J. Biol. Chem., 277(4), 2573-2578.

Yoon SO, Kim MM, Park SJ, Kim D, Chung J, Chung AS. (2002). Selenite suppresses hydrogen peroxide-induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3-K/Akt pathways.. FASEB J., 16(1), 111-113.

Kim D, Chung J. (2002). Akt: versatile mediator of cell survival and beyond.. J. Biochem .Mol. Biol., 35(1), 106-115.

2001

Kim D, Kim S, Koh H, Yoon SO, Chung AS, Cho KS, Chung J. (2001). Akt/PKB promotes cancer cell invasion via increased motility and Metalloproteinase production.. FASEB J., 15(11), 1953-1962.

Lee JH, Cho KS, Lee J, Yoo J, Lee J, Chung J. (2001). Diptericin-like protein: an immune response gene regulated by the anti-bacterial gene induction pathway in Drosophila.. Gene., 271(2), 233-238.

Cho KS, Lee JH, Kim S, Kim D, Koh H, Lee J, Kim C, Kim J, Chung J. (2001). Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphatidylinositide 3-kinase-dependent signaling pathway.. Proc. Natl. Acad. Sci., 98(11), 6144-6149.

Kim S, Jee K, Kim D, Koh H, Chung J. (2001). Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1. J. Biol. Chem., 276(16), 12864-12870.

2000

Koh H, Lee KH, Kim D, Kim S, Kim JW, Chung J. (2000). Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced PRK2 cleavage.. J. Biol. Chem., 275(44), 34451-34458.

Kim S, Jung Y, Kim D, Koh H, Chung J. (2000). Extracellular zinc activates p70 S6 kinase through the phosphatidylinositol 3-kinase signaling pathway.. J. Biol. Chem., 275(34), 25979-25984.

Kim J, Kim D, Chung J. (2000). Replication protein a 32 kDa subunit (RPA p32) binds the SH2 domain of STAT3 and regulates its transcriptional activity.. Cell Biol Int., 24(7), 467-473.

Chung J, Park ES, Kim D, Suh JM, Chung HK, Kim J, Kim H, Park SJ, Kwon OY, (2000). Thyrotropin modulates interferon-gamma-mediated intercellular adhesion molecule-1 gene expression by inhibiting Janus kinase-1 and signal transducer and activator of transcription-1 activation in thyroid cells.. Endocrinol., 141(6), 2090-2097.

Park ES, Kim H, Suh JM, Park SJ, You SH, Chung HK, Lee KW, Kwon OY, (2000). Involvement of JAK/STAT (Janus kinase/signal transducer and activator of transcription) in the thyrotropin signaling pathway.. Mol. Endocrinol, 14(5), 662-670.

Park, J., Lee, D., Seo, T., Chung, J., Choe, J. (2000). Kaposi's sarcoma-associated herpesvirus (human herpes virus-8) open reading frame 36 protein is a serine protein kinase.. J. Gen. Virol., 81(Pt 4), 1067-1071.

Park ES, Kim H, Suh JM, Park SJ, Kwon OY, Kim YK, Ro HK, Cho BY, Chung J, Shong M. (2000). Thyrotropin induces suppressors of cytokine signaling SOCS-1 and SOCS-3 in FRTL-5 thyroid cells.. Mol. Endocrinol., 14(3), 440-448.

1999

Yun J, Chae HD, Choy HE, Chung J, Yoo HS, Han MH. Shin DY. (1999). p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor.. J. Biol. Chem., 274(42), 29677-29682.

Koh H, Jee K, Lee B, Kim J, Kim D, Yoon YH, Kim JW, Choi HS, Chung J. (1999). Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); A novel nuclear target of Akt.. Oncogene., 18(36), 5115-5119.

Bandyopadhyay, A., Bandyopadhyay, J., Chung, J., Choi, H. S., Kwon, H. B. (1999). Inhibition of S6 kinase by rapamycin blocks maturation of Rana dybowskii oocytes. Gen. Comp. Endocrinol., 113(2), 230-239.

1997

Chung J, Uchida E, Grammer TC, Blenis J. (1997). STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol. Cell. Biol., 17(11), 6508-6516.

1995

Park I, Chung J, Walsh CT, Yun Y, Strominger JL, Shin J. (1995). Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region. Proc. Natl. Acad. Sci. USA, 92(26), 12338-12342.

Monfar M, Lemon KP, Grammer TC, Cheatham L, Chung J, Vlahos CJ, Blenis J. (1995). Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. Mol. Cell. Biol., 15(1), 326-337.

1994

Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J. (1994). PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature, 370(6484), 71-75.

Dumont FJ, Altmeyer A, Kastner C, Fischer PA, Lemon KP, Chung J, Blenis J, Staruch MJ. (1994). Relationship between multiple biologic effects of rapamycin and the inhibition of pp70S6 protein kinase activity. Analysis in mutant clones of a T cell lymphoma. J Immunol, 152(3), 992-1003.

1992

Kuo CJ, Chung J, Fiorentino DF, Flanagan WM, Blenis J, Crabtree GR. (1992). Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature, 358(6381), 70-73.

Chung J, Kuo CJ, Crabtree GR, Blenis J. (1992). Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell, 69(7), 1227-1236.

1991

Jurivich DA, Chung J, Blenis J. (1991). Heat shock induces two distinct S6 protein kinase activities in quiescent mammalian fibroblasts.. J. Cell. Physiol., 148(2), 252-259.

Chung J, Pelech SL, Blenis J. (1991). Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity.. Proc. Natl. Acad. Sci., 88(11), 4981-85.

Blenis J, Chung J, Erikson E, Alcorta DA, Erikson RL. (1991). Distinct mechanisms for the activation of the RSK kinases/MAP2 kinase/pp90rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis.. Cell Growth Differ., 2(6), 279-85.

Chen RH, Chung J, Blenis J. (1991). Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transduction.. Mol. Cell. Biol., 11(4), 1861-67.

Chung J, Chen RH, Blenis J. (1991). Coordinate regulation of pp90rsk and a distinct protein-serine/threonine kinase activity that phosphorylates recombinant pp90rsk in vitro.. Mol. Cell. Biol., 11(4), 1868-74.