Laboratory of Molecular Genomics

Laboratory of Molecular Genomics

Seoul National University
Laboratory of Molecular Genomics

Laboratory of Molecular Genomics

Seoul National University
Laboratory of Molecular Genomics

Laboratory of Molecular Genomics

Seoul National University

Publications+ more

(2021) Loss of UCHL1 rescues the defects related to Parkinson's disease by suppressing glycolysis, Science Advances
(2021) Drosophila NSD deletion induces developmental anomalies similar to those seen in Sotos syndrome 1 patients, Genes Genomics
(2021) Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila, eLife
(2020) CORO7 functions as a scaffold protein for the core kinase complex assembly of the Hippo pathway, Journal of Biological Chemistry
(2020) Mislocalization of TORC1 to lysosomes caused by KIF11 inhibition leads to aberrant TORC1 activity, Molecules and Cells

Welcome to the
"Laboratory of Molecular Genomics"

Cell growth regulation Our laboratory studies various signal transduction pathways involved in the regulation of cell proliferation and differentiation. Specifically, we focus on ERK-MAPK pathway mediating growth factor-dependent cell growth regulation, TOR/S6K and LKB1/AMPK pathways mediating nutrient-dependent cell growth regulation, and JNK-MAPK pathway regulating cell death. To understand detailed functional mechanisms of cell growth regulation, we have generated various gain-of-function and loss-of-function mutants for the components of each signaling in Drosophila and characterized their roles in cell growth regulation. By examining their genetic interactions with each other, we are trying to expand our understanding for the global signaling network regulating cell growth. Moreover, through biochemical approaches using mammalian cell culture system, we study the detailed molecular mechanisms on how these molecules function and interact with each other in the process of cell growth regulation.