Seoul National University Biological Sciences Website

Publications

Laboratory of Molecular Regenerative Medicine

2022

Kang D*, Lee J*, Jung J, Carlson BA, Chang MJ, Chang CB, Kang SB, Lee BC, Gladyshev VN, Hatfield DL, Lee BJ^#, and Kim JH^# (2022), Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis, Nature Communications

Cho Y*, Kim HS*, Kang D, Kim H, Lee N, Yun J, Kim YJ , Lee KM , Kim J, Kim HR, Hwang YI, Jo CH, and Kim JH^#, CTRP3 exacerbates tendinopathy by dysregulating tendon stem cell differentiation and altering extracellular matrix composition, Science Advances

2020

Kim H*, Cho Y*, Kim HS, Kang D, Cheon D, Kim YJ, Chang MJ, Lee KM, Chang CB, Kang SB, Kang HG, and Kim JH^# (2020). A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression. Nature communications, (), .

Kang D*, Lee J*, Wu C, Guo X, Lee BJ, Chun JS, Kim JH^# (2020). The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies. Experimental & Molecular Medicine, 52(8), 1198-1208.

2019

Kim S*, Han S*, Kim Y, Kim HS, Gu YR, Kang D, Cho Y, Kim H, Lee J, Seo Y, Chang MJ, Chang CB, Kang SB, and Kim JH^# (2019). Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation. Nature Communications, 10(4898), .

Kang D*, Shin J*, Cho Y, Kim HS, Gu YR, Kim H, You KT, Chang MJ, Chang CB, Kang SB, Kim JS, Kim VN, and Kim JH^# (2019). Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development. Science Translational Medicine, 11(486), .

Lee SH, Kim S, Lee N, Lee J, Yu SS, Kim JH, Kim S. (2019). Intrathecal delivery of recombinant AAV1 encoding hepatocyte growth factor improves motor functions and protects neuromuscular system in the nerve crush and SOD1-G93A transgenic mouse models. Acta Neuropathologica Communications, 7(1), 96.

Lee SH, Lee N, Kim S, Lee J, Choi W, Yu SS, Kim JH, Kim S. (2019). Intramuscular delivery of HGF-expressing recombinant AAV improves muscle integrity and alleviates neurological symptoms in the nerve crush and SOD1-G93A transgenic mouse models. Biochemical and Biophysical Research Communications, 517(3), 452-457.

2017

Jin-Hee Kim†, Ji Hyun Sim†, Sunkyung Lee, Min A. Seol, Sang-Kyu Ye, Hyun Mu Shin, Eun Bong Lee, Yun Jong Lee, Yun Jung Choi, Wan-Hee Yoo, Jin Hyun Kim, Wan-Uk Kim, Dong-Sup Lee, Kim JH, Insoo Kang, Seong Wook Kang,* and Hang-Rae Kim* (2017). Interleukin-7 Induces Osteoclast Formation via STAT5, Independent of Receptor Activator of NF-kappaB Ligand. Frontiers In Immunology, 8(1376), .

2016

Won Y, Shin Y, CH Chun, Cho Y, Ha C, Kim JH^#, and Chun JS^# (2016). Pleiotropic roles of metallothioneins as regulators of chondrocyte apoptosis and catabolic and anabolic pathways during osteoarthritis pathogenesis. Annals of the Rheumatic Diseases, 75(11), 2045-2052.

2015

Lee M, Won Y, Shin Y, Kim JH^#, and Chun JS^# (2015). Reciprocal activation of hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis.. Osteoarthritis and Cartilage, 24(1), 134-45.

Kim H, Kang D, Cho Y, and Kim JH^# (2015). Epigenetic regulation of chondrocyte catabolism and anabolism in osteoarthritis. Mol Cells, 38(8), 677-684.

Oh H, Kwak JS, Yang S, Gong MK, Kim JH, Rheea J, Kim SK, Kim HE, Ryu JH, Chun JS. (2015). Reciprocal regulation by hypoxia-inducible factor-2α and the NAMPT-NAD+-SIRT axis in articular chondrocytes is involved in osteoarthritis.. Osteoarthritis and Cartilage, 23(12), 2288-2296.

Kim JH, Lee G, Won Y, Lee M, Kwak JS, Chun CH, Chun JS (2015). Matrix crosslinking-mediated mechanotransduction promotes post-traumatic osteoarthritis. Proc Natl Acad Sci U S A, 112(30), 9424-9429.

2014

Kim JH, Jeon J, Shin M, Won Y, Lee M, Kwak JS, Lee G, Rhee J, Ryu JH, Chun CH, Chun JS (2014). Regulation of the catabolic cascade in osteoarthritis by the zinc•ZIP8•MTF1 axis. Cell, 156(4), 730-743.

2013

Yang S, Ryu JH, Oh H, Jeon J, Kwak JS, Kim JH, Kim HA, Chun CH, Chun JS (2013). Nampt (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis. Annals of the Rheumatic Diseases, 74(3), 595-602.

2012

Rhee J, Ryu JH, Kim JH Chun CH, Chun JS. (2012). α-Catenin inhibits β-catenin-T-cell factor/lymphoid enhancing factor transcriptional activity and collagen type II expression in articular chondrocytes through formation of Gli3R.α-catenin.β-catenin ternary complex.. Journal of Biological Chemistry, 287(15), 11751-60.

Notbohm J, Kim JH, Asthagiri AR, Ravichandran G (2012). Three-dimensional analysis of the effect of epidermal growth factor on cell-cell adhesion in epithelial cell clusters.. Biophysics Journal, 102(6), 1323-30.

2011

Jeon J, Oh H, Lee G, Ryu JH, Rhee J, Kim JH, Chung KH, Song WK, Chun CH, Chun JS. (2011). Cytokine-like 1 knock-out mice (Cytl1-/-) show normal cartilage and bone development but exhibit augmented osteoarthritic cartilage destruction.. Journal of Biological Chemistry, 286(31), 27206-13.

Kim JH and Asthagiri AR (2011). Matrix stiffening sensitizes epithelial cells to EGF and enables the loss of contact inhibition of proliferation. Journal of Cell Science, 124(Pt 8), 1280-7.

2010

Kim JH, Dooling L, Asthagiri AR (2010). Intercellular mechanotransduction during multicellular morphodynamics.. Journal of Royal Society Interface, 7(Suppl 3), S341-50.

2009

Kim JH, Kushiro K, Graham NA, Asthagiri AR (2009). Tunable interplay between epidermal growth factor and cell-cell contact governs the spatial dynamics of epithelial growth. Proc Natl Acad Sci U S A, 106(27), 11149-53.