Seoul National University Biological Sciences Website

Publications

Laboratory of Molecular Immunology

2022

J. Nah and R. H. Seong (2022). Krüppel-like factor 4 regulates the cytolytic effector function of exhausted CD8 T cells. Science Advances

H. Min, W. Kim, S. Hong, S. Lee, J. Jeong, S. Kim, and R. H. Seong (2022). Differentiation and homeostasis of effector Treg cells are regulated by inositol polyphosphates modulating Ca2+ influx. Proc Natl Acad Sci U S A

J. Jeong, I. Jung, J. Kim, S. Jeon, D. Y. Hyeon, H. Min, B. Kang, J. Nah, D. Hwang, S. Um, M. Ko, and R. H. Seong (2022). BAP1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cells. Cell Death Diff

B. Kang, B. Kang, T. Y. Roh, R. H. Seong*, W. Kim*. (*co-corresponding authors) (2022). The Chromatin Accessibility Landscape of Nonalcoholic Fatty Liver Disease Progression. Mol Cells

2020

S. Lee, J. Kim, H. Min, R.H. Seong (2020). RORgt-driven TH17 Cell Differentiation Requires Epigenetic Control by the Swi/Snf Chromatin Remodeling Complex. iScience

S. Hwang, C. Lee, K. Park, S. Oh, S. Jeon, B. Kang, Y. Kim, J. Oh, S.H. Jeon, Masanobu Satake, Ichiro Taniuchi, H. Lee & R.H. Seong (2020). Twist2 promotes CD8+ T-cell differentiation by repressing ThPOK expression. Cell Death Diff

2019

W. Kim, E. Kim, H. Min, M.G. Kim, Verena B. Eisenbeis, Amit K. Dutta, Igor Pavlovic, Henning J. Jessen, S. Kim, and R.H. Seong (2019). Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton's tyrosine kinase. Proc Natl Acad Sci U S A.

2018

Lee S, Park K, Kim J, Min H, Seong RH. (2018). Foxp3 expression in induced regulatory T cells is stabilized by C/EBP in inflammatory environments.. EMBO Rep.

2017

Kim, E., J. Beon, S. Lee, S.J. Park, H. Ahn, M.G. Kim, J.E. Park, W. Kim, J.-M. Yuk, S.-J Kang, S.-H Lee, E.-K. Jo, R.H. Seong*, S. Kim* (*co-corresponding authors) (2017). Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6. Science Advances

2016

Panamarova, M., A. Cox, K. Wicher, R. Butler, N.A. Bulgakova, S. Jeon, B. Rosen, R.H. Seong, W. Scarnes, G. Crabtree, and M. Zernicka-Goetz (2016). BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo. Development

Oh, S., J. Oh, C. Lee, S.-J. Oh, S. Jeon, S.-S. Hwang, Y. Lee, and R.H. Seong (2016). Expression of twist2 is controlled by T-cell receptor signaling and determines the survival and death during thymocyte selection. Cell Death Diff

Choi, J., Y.-K. Kim, K. Park, D.-W. Kim, V.N. Kim and R.H. Seong (2016). MicroRNA-139 controls proliferation and differentiation of myeloid progenitors and is associated with hematopoietic malignancy. Blood

Bachmann, C, H. Nguyen , J. Rosenbusch , L. Pham, T. Rabe, M. Patwa, G. Sokpor, R.H. Seong, R. Ashery-Padan, A. Mansouri, A. Stoykova, J.F. Staiger, T. Tuoc (2016). mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium. PLoS Genet

Jeong SM, Hwang S, Seong RH (2016). SIRT4 regulates cancer cell survival and growth after stress. Biochem Biophys Res Commun

Jeong SM, Hwang S, Seong RH (2016). Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation.. Biochem Biophys Res Commun

Jeon S, Seong RH (2016). Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway. PLoS Genet.

2015

Choi J, Jeon S, Choi S, Park K, Seong RH. (2015). The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression. Proc Natl Acad Sci U S A

Narayanan, R., M. Pirouz, C. Kerimoglu, L. Pham, R. Wagener, K. Kiszka, J. Rosenbusch, R.H. Seong, M. Kessel, A. Fischer, A. Stoykova, J.F. Staiger, and T. Tuoc (2015). Loss of entire multi-subunit BAF (mSWI/SNF) complexes impairs global epigenetic programs in forebrain development. Cell Reports

Lee SW, Park HJ, Jeon SH, Lee C, Seong RH, Park SH, Hong S (2015). Ubiquitous Over-Expression of Chromatin Remodeling Factor SRG3 Ameliorates the T Cell-Mediated Exacerbation of EAE by Modulating the Phenotypes of both Dendritic Cells and Macrophages. PLoS One

2014

Park T, Park S, Cho J, Moon J, Kim N, Park K, Seong RH, Lee S, Morio T, Bothwell AL, Lee S. (2014). RORγt-specific transcriptional interactomic inhibition suppresses autoimmunity associated with TH17 cells. Proc Natl Acad Sci U S A.

Kim S, Park K, Choi J, Jang E, Paik DJ, Seong RH, Youn J. (2014). Foxp3+ regulatory T cells ensure B lymphopoiesis by inhibiting the granulopoietic activity of effector T cells in mouse bone marrow.. Eur J Immunol.

Kim J, Lee SK, Jeon Y, Kim Y, Lee C, Jeon SH, Shim J, Kim IH, Hong S, Kim N, Lee H, Seong RH. (2014). TopBP1 deficiency impairs V(D)J recombination during lymphocyte development.. EMBO J.

2013

Moon S, Shin J, Lee D, Seong RH, Lee W (2013). 1H, 15N, and 13C resonance assignments and secondary structure of the SWIRM domain of human BAF155, a chromatin remodeling complex component.. Mol Cells

Huh JY1, Kim JI, Park YJ, Hwang IJ, Lee YS, Sohn JH, Lee SK, Alfadda AA, Kim SS, Choi SH, Lee DS, Park SH, Seong RH, Choi CS, Kim JB. (2013). A novel function of adipocytes in lipid antigen presentation to iNKT cells.. Mol Cell Biol.

2012

Choi J, Ko M, Jeon S, Jeon Y, Park K, Lee C, Lee H, Seong RH. (2012). The SWI/SNF-like BAF complex is essential for early B cell development.. J Immunol.

Jung I, Sohn DH, Choi J, Kim JM, Jeon S, Seol JH, Seong RH. (2012). SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking CHFR mediated ubiquitination and degradation of its major components.. Biochem Biophys Res Commun.

2011

Oh KH1, Lee C, Lee SW, Jeon SH, Park SH, Seong RH, Hong S. (2011). Activation of natural killer T cells inhibits the development of induced regulatory T cells via IFNγ.. Biochem Biophys Res Commun

Son YS1, Seong RH, Ryu CJ, Cho YS, Bae KH, Chung SJ, Lee B, Min JK, Hong HJ. (2011). Brief report: L1 cell adhesion molecule, a novel surface molecule of human embryonic stem cells, is essential for self-renewal and pluripotency.. Stem Cells

Choi SK1, Lee C, Lee KS, Choe SY, Mo IP, Seong RH, Hong S, Jeon SH. (2011). DNA aptamers against the receptor binding region of hemagglutinin prevent avian influenza viral infection. Mol Cells

2010

Jeong SM, Lee C, Lee SK, Kim J, Seong RH (2010). The SWI/SNF chromatin-remodeling complex modulates peripheral T cell activation and proliferation by controlling AP-1 expression. J Biol Chem

Ahn J, Ko M, Lee C, Kim J, Yoon H, Seong RH (2010). Srg3, a mouse homolog of BAF155, is a novel p53 target and acts as a tumor suppressor by modulating p21(WAF1/CIP1) expression. Oncogene

2009

Koh HS, Lee C, Lee KS, Park EJ, Seong RH, Hong S, Jeon SH. (2009). Twist2 regulates CD7 expression and galectin-1-induced apoptosis in mature T-cells.. Mol Cells.

2008

Oh J, Sohn DH, Ko M, Chung H, Jeon SH, Seong RH. (2008). BAF60a interact with p53 to recruit the SWI/SNF complex. J Biol Chem.

Koh HS, Lee C, Lee KS, Ham CS, Seong RH, Kim SS, Jeon SH. (2008). CD7 expression and galectin-1-induced apoptosis of immature thymocytes are directly regulated by NF-kappaB upon T-cell activation.. Biochem Biophys Res Commun.

Ko M, Sohn DH, Chung H, Seong RH (2008). Chromatin remodeling, development and disease.. Mutat Res

Daehee Han, Shin Jeon, Dong Hyun Sohn, Changjin Lee, Sangil Ahn, Won Kyu Kim, Heekyoung Chung and Rho Hyun Seong. (2008). SRG3, a core component of mouse SWI/SNF complex, is essential for extra-embryonic vascular development.. Dev. Biol. doi:10.1016

2007

Lee YS, Sohn DH, Han D, Lee HW, Seong RH, Kim JB. (2007). Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression.. Mol Cell Biol

Lee KY, Choi YI, Kim J, Choi JW, Sohn DH, Lee C, Jeon SH, Seong RH (2007). Down-Regulation of the SWI/SNF Chromatin Remodeling Activity by TCR Signaling Is Required for Proper Thymocyte Maturation. J Immunol.

Sohn DH, Lee KY, Lee C, Oh J, Chung H, Jeon SH, Seong RH (2007). SRG3 Interacts Directly with the Major Components of the SWI/SNF Chromatin Remodeling Complex and Protects Them from Proteasomal Degradation. J Biol Chem.

2006

Jang J, Choi YI, Choi J, Lee KY, Chung H, Jeon SH, and Seong RH. (2006). Notch1 confers thymocytes a resistance to GC-induced apoptosis through Deltex1 by blocking the recruitment of p300 to the SRG3 promoter. Cell death and differentiation.

Joung JG, Shin D, Seong RH, Zhang BT. (2006). Identification of regulatory modules by co-clustering latent variable models: stem cell differentiation. Bioinformatics.

2005

Ahn J, Ko M, Lee K, Oh J, Jeon SH, and Seong RH (2005). Expression of SRG3, a core component of mouse SWI/SNF chromatin-remodeling complex, is regulated by cooperative interactions between Sp1/Sp3 and Ets transcription factors. Biochemical and biophysical research communications. Biochem Biophys Res Commun.

Hong CY, Suh JH, Kim K, Gong EY, Jeon SH, Ko M, Seong RH, Kwon HB, Lee K (2005). Modulation of androgen receptor transactivation by the SWI3-related gene product (SRG3) in multiple ways. Mol Cell Biol.

2004

S.M. Jeong, K.Y. Lee, D. Shin, H. Chung, S.H. Jeon, and R.H. Seong. (2004). Nitric oxide inhibits glucocorticoid-induced apoptosis of thymocytes by repressing the SRG3 expression. J. Biol. Chem.

Ko, M., J. Ahn, C. Lee, H. Chung, S.H. Jeon, H.-Y. Chung, and R.H. Seong. (2004). E2A/HEB and Id3 proteins control the sensitivity to glucocorticoid -induced apoptosis in thymocytes by regulating the SRG3 Expression.. J. Biol. Chem.

Ko, M., J. Jang, J. Ahn, K. Lee, H. Chung, S.H. Jeon, and R.H. Seong. (2004). T-cell receptor signaling inhibits glucocorticoid-induced apoptosis by repressing the SRG3 expression via Ras activation. J. Biol. Chem.

2003

Lee, Y.S., H.H. Lee, J. Park, E.J. Yoo, C.A. Glackin, Y.I. Choi, S.H. Jeon, R. H. Seong, S.D. Park, and J.B. Kim. (2003). Twist2, a novel Add1/SREBP1c interacting protein, represses the transcriptional activity of Add1/SREBP1c.. Nucleic Acids Res

2002

Kim, W.J., E.J. Park, H. Lee, R.H. Seong, and S.D. Park. (2002). Physical interaction between recombinational proteins Rhp51 and Rad22 in Schizosaccharomyces pombe.. J. Biol. Chem.

Yoo, E.J., Y.K. Jang, M.A. Lee, P. Bjerling, J.B. Kim, K. Ekwall, R.H. Seong, and S.D. Park. (2002). Hrp3, a chromatin helicase/ATPase DNA binding protein, is required for heterochromatin silencing in fission yeast.. Biochem. Biophy. Res. Comm.

2001

Kim, J.K., Huh, S.O., Choi, H.S., Lee, K.S., Shin, D.H., Lee, C.J., Nam, J.S., Kim, H., Chung, H.K., Park, S.D. and Seong, R.H. (2001). SRG3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development.. Molecular and Cellular Biology

Choi, Y.I., S.H. Jeon, J.H. Jang, S.M. Han, J.K. Kim, H.K. Chung, H.W. Lee, H.Y. Chung, S.D. Park, and R.H. Seong. (2001). Notch1 confers a resistance to glucocorticoid induced apoptosis by down-regulating SRG3 expression.. Proc. Nat. Acad. Sci.

Han, S.M., H.S. Choi, M.G. Ko, Y.I. Choi, D.H. Sohn, J.K. Kim, D.H. Shin, H.K. Chung, H.W. Lee, J.B. Kim, S.D. Park, and R.H. Seong (2001). Peripheral T cells become sensitive to glucocorticoid- and stress-induced apoptosis in transgenic mice overexpressing SRG3. Journal of Immunology

2000

Shim, Y. S., Y. K. Jang, M. S. Lim, J. S. Lee, R. H. Seong, S. H. Hong, and S. D. Park (2000). Rdp1, a novel zinc finger protein, regulates the DNA damage response of rhp51+ from Schizosaccharomyces pombe. Mol. Cell. Biol.

O'Neill, D. W., S. S. Schoetz, R. A. Lopez, M. Castle, L. Rabinowitz, E. Shor, D. Krawchuk, M. G. Goll, M. Renz, H.-P. Seelig, S. Han, R. H. Seong, S. D. Park, T. Agalioti, N. Munshi, D. Thanos, H. Erdjument-Bromage, P. Tempst, and A. Bank (2000). An Ikaros-containing chromatin-remodeling complex in adult-type erythroid cells.. Mol. Cell. Biol.

Kim, M. K., W. Lee, J. Park, J. B. Kim, Y. K. Jang, R. H. Seong, S. Y. Choe, and S. D. Park (2000). The stress-activated MAP kinase Sty1/Spc1 and a 3'regulatory element mediate UV-induced expression of the uvi15+ gene at the post-transcriptional level. Nuc. Acids Res.

1999

Yoon, J. H., J. K. Kim, K. B. Rha, M. Oh, S. H. Park, R. H. Seong, S. H. Hong, and S. D. Park. (1999). Sp1 mediates cell proliferation-dependent regulation of rat DNA topoisomerase II alpha gene promoter.. Biochem. J.

Kim SJ, Sadelain M, Lee JS, Seong RH, Yun YS, Jang YJ, Chung HY. (1999). Adoptive-transfer therapy of tumors with the tumor-specific primary cytotoxic T cells induced in vitro with the B7.1-transduced MCA205 cell line.. Cancer Immunol Immunother.

Park, E. J., J. H. Kim, R. H. Seong, C. G. Kim, S. D. Park, S. H. Hong. (1999). Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells.. Nucleic Acids Research.

Kim SJ, Sadelain M, Lee JS, Seong RH, Yun YS, Jang YJ, Chung HY. (1999). Adoptive-transfer therapy of tumors with the tumor-specific primary cytotoxic T cells induced in vitro with the B7.1-transduced MCA205 cell line.. Cancer Immunol Immunother.

Park, E. J., J. H. Kim, R. H. Seong, C. G. Kim, S. D. Park, S. H. Hong. (1999). Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells.. Nucleic Acids Research.

1998

Zhang, X.-L., R. H. Seong, R. Piracha, M. Larijani, M. Heeney, J. R. Parnes, and J. W. Chamberlain. (1998). Distinct stage-specific cis-active transcriptional mechanisms control expression of T cell coreceptor CD8α at double- and single-positive stages of thymic development.. Journal of Immunology.

Jeon, S,H., S. Jeong, C. Lee, J.K. Kim, H.Y. Chung, S.D. Park, and R.H. Seong. (1998). Expression of Tcf-1 mRNA and surface TCR/CD3 complexes and reduced during apoptosis of T-cells.. Int. Immunol.

Jin, Y.H., E.J. Yoo, Y.K. Jang, S.H. Kim, M.J. Kim, Y.S. Shim, J.S. Lee, I.S. Choi, R.H. Seong, S.H. Hong, and S.D. Park. (1998). Isolation and characterization of hrp1+, a new member of the SNF2/SWI2 gene family from the fission yeast Schizosaccharomyces pombe.. Mol. Gen. Genet.

1997

Kim, S-H., M. Kim, J.K. Lee, M.J. Kim, Y.H. Jin, R.H. Seong, S.H. Hong, and S.D. Park. (1997). Identification and expression of uvi31+, a UV-inducible gene from Schizosaccharomyces pombe.. Environmental and Molecular Mutagenesis.

Jeon, S.H., M.G. Kang, Y.H. Kim, Y.H. Jin, C. Lee, H.Y. Chung, H. Kwon, S.D. Park, and R.H. Seong. (1997). A new mouse gene, SRG3, related to the SWI3 of Saccharomyces cerevisiae, is required for apoptosis induced by glucocorticoids in a thymoma cell line.. J. Exp. Med.

1996

Yoon, J.H., S.H. Park, H.-A. Cho, R.H. Seong, S.H. Hong, S.D. Park. (1996). Complementation of a yeast top2ts mutation by a cDNA encoding rat DNA topoisomerase Ⅱa.. Mol. Gen. Genet.

Jang, Y.K., Y.H. Jin, Y.S. Shim, M.J. Kim, E.J. Yoo, I.S. Choi, J.S. Lee, R.H. Seong, S.H. Hong, and S.D. Park. (1996). Identification of the DNA damage-responsive elements of the rhp51+ gene, a recA and RAD51 homolog in the fission yeast Schizosaccharomyces pombe.. Mol. Gen. Genet.

Jang, Y. K., Y. H. Jin, K. Myung, E.M. Kim, R. H. Seong, S. H. Hong and S. D. Park. (1996). Differential expression of the rhp51+ gene, a recA and RAD51 homolog from the fission yeast Schizosaccharomyces pombe.. Gene.

1995

Jin, Y. H., Y. K. Jang, M. J. Kim, M. R. Rad, L. Kirchrath, R. H. Seong, S. H. Hong, C. P. Hollenberg, and S. D. Park. (1995). Characterization of SFP2, a putative sulfate permease gene of Saccharomyces cerevisiae.. Biochem. Biophys. Res. Co.

Jang, Y. K., Y. H. Jin, Y. S. Sim, M. J. Kim, E. J. Yoo, R. H. Seong, S. H. Hong, and S. D. Park. (1995). Evidence for possible involvement of RHP51 protein in mitotic events including chromosome segregation.. Biochem. & Mol. Biol. Int.

Jang, Y. K., Y. H. Jin, M. J. Kim, R. H. Seong, S. H. Hong, and S. D. Park. (1995). A simple and efficient method for the isolation of total RNA from fission yeast Schizosaccharomyces pombe.. Biochem. & Mol. Biol. Int.

Park, S. -H., J. H. Yoon, H. -A. Cho, Y. D. Kwon, R. H. Seong, S. H. Hong, and S. D. Park. (1995). Cloning and characterization of the 5'-flanking region of the rat DNA topoisomerase II gene.. J. Biochem.

Lee, J. K., M. Kim, J. Choe, R. H. Seong, S. H. Hong, and S. D. Park. (1995). Characterization of uvi15+, a stress-inducible gene from Schizosaccharomyces pombe.. Mol. Gen. Genet.

Kim, D. S., J. H. Yoon, S. K. Ahn, K. E. Kim, R. H. Seong, S. H. Hong, K. Kim, K. Rhu, and S. D. Park. (1995). A 33 kDa Pit-1-like protein binds to the distal region of the human thyrotrophin -subunit gene.. J. Mol. Endo.

Chamberlain, J.W., R.H. Seong, C.W. Liw, S.Michie, and J.R. Parnes. (1995). Effects of high level constitutive expression of transgenic CD8 on thymic selection.. Transgenics.

1994

Parnes, J. R. and R. H. Seong. (1994). CD4 and CD8 in T cell lineage commitment: alterations induced by expression of a CD8/CD4 chimeric transgene.. Semin Immunol.

1993

McCarrick III, J. W., J. R. Parnes, R. H. Seong, D. Solter, and B. B. Knowles. 1993. (1993). Positive-negative selection gene targeting with the diphtheria toxin A-chain gene in mouse embryonic stem cells.. Transgenic Res.

1992

Seong, R. H., J. W. Chamberlain, and J. R. Parnes. (1992). CD4 transmembrane region and/or cytoplasmic tail delivers a specific signal for T cell differentiation to a CD4 cell lineage.. Nature

Seong, R. H. and J. R. Parnes. (1992). Alteration of T cell lineage commitment by expression of a hybrid CD8/CD4 transgene.. Adv. Exp. Med. Biol.

1988

Seong, R. H., C. A. Clayberger, A. M. Krensky, and J. R. Parnes. (1988). Rescue of Daudi cell HLA expression by transfection of the mouse 2-microglobulin gene.. J. Exp. Med.

1985

Park, S. D., R. H. Seong, W. F. Morgan, and J. E. Cleaver. (1985). Single strand breaks in DNA of hamster and human cells exposed to methyl methanesulfonate and ultraviolet light.. Chem-Biol. Interactions.