Sunghwa Choe Lab

Sunghwa Choe Lab

Seoul National University
Sunghwa Choe Lab

Sunghwa Choe Lab

Seoul National University
Sunghwa Choe Lab

Sunghwa Choe Lab

Seoul National University

Publications+ more

(2016) Overexpression of the 3’ half of the PHYB partially suppresses dwarfism in the brassinosteroid-insensitive bri1-5 mutant, Journal of Plant Biology
(2015) DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins, Nature biotechnology
(2015) Analysis of anti-BZR1 antibody reveals the roles BES1 in maintaining the BZR1 levels in Arabidopsis, Journal of Plant Biology
(2014) Antagonistic Regulation of Arabidopsis Growth by Brassinosteroids and Abiotic Stresses, Molecules and Cells
(2014) Arabidopsis gulliver1/superroot2-7 identifies a metabolic basis for auxin and brassinosteroid synergy, Plant Journal
(2014) Darkness and gulliver2/phyB mutation decrease the abundance of phosphorylated BZR1 to activate brassinosteroid signaling in Arabidopsis, Plant Journal
(2014) The Arabidopsis gulliver2/phyB Mutant Exhibits Reduced Sensitivity to Brassinazole, Journal of Plant Biology
(2013) Brassinosteroids Regulate Plant Growth through Distinct Signaling Pathways in Selaginella and Arabidopsis, PLoS One
(2013) The Regulation of Brassinosteroid Biosynthesis in Arabidopsis, Critical Reviews in Plant Sciences
(2013) Arabidopsis Brassinosteroid-overproducing gulliver3-D/dwarf4-D mutants exhibit altered responses to Jasmonic acid and pathogen., Plant Cell Rep.

Welcome to the
"Sunghwa Choe Lab"

Our lab, Genome Editing Lab (GEL), is interested in understanding the biological importance of the thousands of GE enzymes cataloged in microbial genome databases. Through modern bioinformatics tools, we systematically classify the sequences and associate them with the biochemical functions. This study should lead us to identification of the GE enzymes with enhanced function but lower off-target effects. In addition, we apply the GE technologies as a tool of synthetic biology. In plant system, we showed that plant genome can be edited in non-GMO way. In other words, without using DNA encoding for the GE enzymes and sgRNA, we could directly introduce pre-assembled ribonucleoproteins (RNP) to plant nucleus, edit genomes and regenerate whole plants. Using the revolutionizing GE systems as gene screening technology, we are also actively searching for the genes that are essential in plant regeneration as well as cancer cell development. Through the research, we aim to narrow down to a couple of genes that are responsible for the process of plant cell regeneration and reveal novel targets for cancer treatments.